CO2022011686A2 - Intermedio útil para la síntesis de un inhibidor de sglt y método para preparar un inhibidor de sglt utilizando el mismo - Google Patents

Intermedio útil para la síntesis de un inhibidor de sglt y método para preparar un inhibidor de sglt utilizando el mismo

Info

Publication number
CO2022011686A2
CO2022011686A2 CONC2022/0011686A CO2022011686A CO2022011686A2 CO 2022011686 A2 CO2022011686 A2 CO 2022011686A2 CO 2022011686 A CO2022011686 A CO 2022011686A CO 2022011686 A2 CO2022011686 A2 CO 2022011686A2
Authority
CO
Colombia
Prior art keywords
purification
chemical formula
synthesis
sglt inhibitor
compound
Prior art date
Application number
CONC2022/0011686A
Other languages
English (en)
Inventor
Youn Jung Yoon
Hee Kyoon Yoon
Original Assignee
Daewoong Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daewoong Pharmaceutical Co Ltd filed Critical Daewoong Pharmaceutical Co Ltd
Publication of CO2022011686A2 publication Critical patent/CO2022011686A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/02—Phosphorylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/06—Heterocyclic radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

La presente invención proporciona un producto intermedio útil para la síntesis de un inhibidor de SGLT y un método para preparar un inhibidor de SGLT usando el mismo. Según la presente invención, al desarrollar un compuesto de fórmula química 5 correspondiente a un producto intermedio novedoso, puede resolverse la dificultad de purificación con los procedimientos existentes, pueden satisfacerse los requisitos de calidad para sustancias relacionadas con una única etapa de purificación y puede resolverse el problema de control de calidad en cada etapa realizando varias etapas in situ. El método para sintetizar un compuesto de fórmula química 1 mediante el uso de un compuesto de fórmula química 5, según la presente invención, permite la purificación en la etapa de síntesis de un compuesto de fórmula química 5, resolviendo de ese modo los problemas de los procedimientos de síntesis existentes, en los que los requisitos de calidad para sustancias relacionadas eran difíciles de controlar etapa por etapa debido a un procedimiento continuo, y minimizando la cantidad de sustancias relacionadas en el producto final. Además, a medida que aumenta el número de etapas de purificación, el procedimiento puede simplificarse porque la purificación no se realiza necesariamente dos o más veces en una etapa como en la técnica anterior, maximizando de ese modo el rendimiento de producción de un derivado de difenilmetano según la fórmula química 1
CONC2022/0011686A 2020-02-27 2022-08-19 Intermedio útil para la síntesis de un inhibidor de sglt y método para preparar un inhibidor de sglt utilizando el mismo CO2022011686A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20200024525 2020-02-27
PCT/KR2021/002507 WO2021172955A1 (ko) 2020-02-27 2021-02-26 Sglt 저해제의 합성에 유용한 중간체 및 이를 이용한 sglt 저해제의 제조 방법

Publications (1)

Publication Number Publication Date
CO2022011686A2 true CO2022011686A2 (es) 2022-08-30

Family

ID=77490302

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2022/0011686A CO2022011686A2 (es) 2020-02-27 2022-08-19 Intermedio útil para la síntesis de un inhibidor de sglt y método para preparar un inhibidor de sglt utilizando el mismo

Country Status (13)

Country Link
US (1) US20230096670A1 (es)
EP (1) EP4112612A4 (es)
JP (1) JP7442663B2 (es)
KR (1) KR102572714B1 (es)
CN (1) CN115087649A (es)
BR (1) BR112022014762A2 (es)
CA (1) CA3169604A1 (es)
CL (1) CL2022002326A1 (es)
CO (1) CO2022011686A2 (es)
EC (1) ECSP22067279A (es)
MX (1) MX2022010220A (es)
PE (1) PE20221498A1 (es)
WO (1) WO2021172955A1 (es)

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5530124A (en) * 1994-06-30 1996-06-25 The Dupont Merck Pharmaceutical Company Method for preparing cyclic ureas and their use for the synthesis of HIV protease inhibitors
ME02702B (me) * 2008-08-22 2017-10-20 Theracos Sub Llc Postupci za pripremu inhibitora sgl t2
WO2012033390A2 (en) * 2010-09-10 2012-03-15 Green Cross Corporation Novel thiophene derivative as sglt2 inhibitor and pharmaceutical composition comprising same
WO2012165914A2 (en) * 2011-06-01 2012-12-06 Green Cross Corporation Novel diphenylmethane derivatives as sglt2 inhibitors
US9340521B2 (en) * 2013-03-18 2016-05-17 Green Cross Corporation Method for dual inhibition of SGLT1 and SGLT2 using diphenylmethane derivatives
US10174010B2 (en) * 2014-03-19 2019-01-08 Hangzhou Pushai Pharmaceutical Technology Co., Ltd. Canagliflozin monohydrate and its crystalline forms, preparation methods and uses thereof
WO2016098016A1 (en) * 2014-12-17 2016-06-23 Dr. Reddy’S Laboratories Limited Process for the preparation of sglt2 inhibitors
ES2898336T3 (es) 2016-06-17 2022-03-07 Dae Woong Pharma Derivado de difenilmetano en forma cristalina
CN108530408A (zh) * 2018-04-13 2018-09-14 海门慧聚药业有限公司 制备达格列净的方法
BR112021002523A2 (pt) * 2018-08-13 2021-05-04 Daewoong Pharmaceutical Co., Ltd. método para preparar um composto

Also Published As

Publication number Publication date
PE20221498A1 (es) 2022-09-29
CL2022002326A1 (es) 2023-02-10
KR102572714B1 (ko) 2023-08-31
ECSP22067279A (es) 2022-09-30
MX2022010220A (es) 2022-10-10
BR112022014762A2 (pt) 2022-10-11
CN115087649A (zh) 2022-09-20
KR20210109476A (ko) 2021-09-06
CA3169604A1 (en) 2021-09-02
JP2023514754A (ja) 2023-04-07
JP7442663B2 (ja) 2024-03-04
EP4112612A1 (en) 2023-01-04
EP4112612A4 (en) 2024-04-03
WO2021172955A1 (ko) 2021-09-02
US20230096670A1 (en) 2023-03-30
AU2021225706A1 (en) 2022-09-01

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