PE20221498A1 - Intermedio util para la sintesis de un inhibidor de sglt y metodo para preparar un inhibidor de sglt utilizando el mismo - Google Patents

Intermedio util para la sintesis de un inhibidor de sglt y metodo para preparar un inhibidor de sglt utilizando el mismo

Info

Publication number
PE20221498A1
PE20221498A1 PE2022001824A PE2022001824A PE20221498A1 PE 20221498 A1 PE20221498 A1 PE 20221498A1 PE 2022001824 A PE2022001824 A PE 2022001824A PE 2022001824 A PE2022001824 A PE 2022001824A PE 20221498 A1 PE20221498 A1 PE 20221498A1
Authority
PE
Peru
Prior art keywords
sglt inhibitor
synthesis
preparing
same
intermediate useful
Prior art date
Application number
PE2022001824A
Other languages
English (en)
Inventor
Youn Jung Yoon
Hee Kyoon Yoon
Original Assignee
Daewoong Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daewoong Pharmaceutical Co Ltd filed Critical Daewoong Pharmaceutical Co Ltd
Publication of PE20221498A1 publication Critical patent/PE20221498A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/02—Phosphorylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/06—Heterocyclic radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA QUIMICA 5 DERIVADO DE [(2R,3S,4R,5R)-1-(2,3-DIHIDROBENZOFURAN-4-IL)-2,3,4,5, 6-PENTAHIDROXIHEXAN-1-ONA)] EL CUAL ES UN COMPUESTO INTERMEDIARIO PARA LA SINTESIS DE UN INHIBIDOR DE SGLT.
PE2022001824A 2020-02-27 2021-02-26 Intermedio util para la sintesis de un inhibidor de sglt y metodo para preparar un inhibidor de sglt utilizando el mismo PE20221498A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20200024525 2020-02-27
PCT/KR2021/002507 WO2021172955A1 (ko) 2020-02-27 2021-02-26 Sglt 저해제의 합성에 유용한 중간체 및 이를 이용한 sglt 저해제의 제조 방법

Publications (1)

Publication Number Publication Date
PE20221498A1 true PE20221498A1 (es) 2022-09-29

Family

ID=77490302

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2022001824A PE20221498A1 (es) 2020-02-27 2021-02-26 Intermedio util para la sintesis de un inhibidor de sglt y metodo para preparar un inhibidor de sglt utilizando el mismo

Country Status (14)

Country Link
US (1) US20230096670A1 (es)
EP (1) EP4112612A4 (es)
JP (1) JP7442663B2 (es)
KR (1) KR102572714B1 (es)
CN (1) CN115087649B (es)
AU (1) AU2021225706B2 (es)
BR (1) BR112022014762A2 (es)
CA (1) CA3169604A1 (es)
CL (1) CL2022002326A1 (es)
CO (1) CO2022011686A2 (es)
EC (1) ECSP22067279A (es)
MX (1) MX2022010220A (es)
PE (1) PE20221498A1 (es)
WO (1) WO2021172955A1 (es)

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5530124A (en) * 1994-06-30 1996-06-25 The Dupont Merck Pharmaceutical Company Method for preparing cyclic ureas and their use for the synthesis of HIV protease inhibitors
ES2599330T3 (es) * 2008-08-22 2017-02-01 Theracos Sub, Llc Proceso para la preparación de inhibidores de SGLT2
KR101513234B1 (ko) * 2010-09-10 2015-04-17 주식회사 녹십자 Sglt2 억제제로서의 신규 티오펜 유도체 및 이를 포함하는 약학 조성물
US9034921B2 (en) * 2011-06-01 2015-05-19 Green Cross Corporation Diphenylmethane derivatives as SGLT2 inhibitors
US9340521B2 (en) * 2013-03-18 2016-05-17 Green Cross Corporation Method for dual inhibition of SGLT1 and SGLT2 using diphenylmethane derivatives
US10174010B2 (en) * 2014-03-19 2019-01-08 Hangzhou Pushai Pharmaceutical Technology Co., Ltd. Canagliflozin monohydrate and its crystalline forms, preparation methods and uses thereof
WO2016098016A1 (en) 2014-12-17 2016-06-23 Dr. Reddy’S Laboratories Limited Process for the preparation of sglt2 inhibitors
EP3473621B1 (en) 2016-06-17 2021-08-04 Daewoong Pharmaceutical Co., Ltd. Method for producing diphenylmethane derivative
CN108530408A (zh) * 2018-04-13 2018-09-14 海门慧聚药业有限公司 制备达格列净的方法
EP3838894B1 (en) * 2018-08-13 2024-03-13 Daewoong Pharmaceutical Co., Ltd. Method for producing intermediate useful for synethesis of sglt inhibitor

Also Published As

Publication number Publication date
US20230096670A1 (en) 2023-03-30
AU2021225706A1 (en) 2022-09-01
AU2021225706B2 (en) 2024-06-13
JP2023514754A (ja) 2023-04-07
MX2022010220A (es) 2022-10-10
BR112022014762A2 (pt) 2022-10-11
CN115087649B (zh) 2024-07-05
CO2022011686A2 (es) 2022-08-30
CL2022002326A1 (es) 2023-02-10
EP4112612A4 (en) 2024-04-03
ECSP22067279A (es) 2022-09-30
JP7442663B2 (ja) 2024-03-04
KR102572714B1 (ko) 2023-08-31
CA3169604A1 (en) 2021-09-02
KR20210109476A (ko) 2021-09-06
CN115087649A (zh) 2022-09-20
WO2021172955A1 (ko) 2021-09-02
EP4112612A1 (en) 2023-01-04

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