MX2022010220A - Intermedio util para la sintesis de un inhibidor de sglt y metodo para preparar un inhibidor de sglt utilizando el mismo. - Google Patents
Intermedio util para la sintesis de un inhibidor de sglt y metodo para preparar un inhibidor de sglt utilizando el mismo.Info
- Publication number
- MX2022010220A MX2022010220A MX2022010220A MX2022010220A MX2022010220A MX 2022010220 A MX2022010220 A MX 2022010220A MX 2022010220 A MX2022010220 A MX 2022010220A MX 2022010220 A MX2022010220 A MX 2022010220A MX 2022010220 A MX2022010220 A MX 2022010220A
- Authority
- MX
- Mexico
- Prior art keywords
- chemical formula
- purification
- sglt inhibitor
- compound
- synthesis
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 6
- 229940121377 sodium-glucose co-transporter inhibitor Drugs 0.000 title abstract 4
- 230000015572 biosynthetic process Effects 0.000 title abstract 3
- 238000003786 synthesis reaction Methods 0.000 title abstract 3
- 239000000126 substance Substances 0.000 abstract 8
- 238000000746 purification Methods 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 4
- 230000002194 synthesizing effect Effects 0.000 abstract 2
- 238000010924 continuous production Methods 0.000 abstract 1
- CZZYITDELCSZES-UHFFFAOYSA-N diphenylmethane Chemical class C=1C=CC=CC=1CC1=CC=CC=C1 CZZYITDELCSZES-UHFFFAOYSA-N 0.000 abstract 1
- 239000012467 final product Substances 0.000 abstract 1
- 238000011065 in-situ storage Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000003908 quality control method Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- C07H1/02—Phosphorylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
- C07H7/06—Heterocyclic radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
La presente invención proporciona un producto intermedio útil para la síntesis de un inhibidor de SGLT y un método para preparar un inhibidor de SGLT usando el mismo. Según la presente invención, al desarrollar un compuesto de fórmula química 5 correspondiente a un producto intermedio novedoso, puede resolverse la dificultad de purificación con los procedimientos existentes, pueden satisfacerse los requisitos de calidad para sustancias relacionadas con una única etapa de purificación y puede resolverse el problema de control de calidad en cada etapa realizando varias etapas in situ. El método para sintetizar un compuesto de fórmula química 1 mediante el uso de un compuesto de fórmula química 5, según la presente invención, permite la purificación en la etapa de síntesis de un compuesto de fórmula química 5, resolviendo de ese modo los problemas de los procedimientos de síntesis existentes, en los que los requisitos de calidad para sustancias relacionadas eran difíciles de controlar etapa por etapa debido a un procedimiento continuo, y minimizando la cantidad de sustancias relacionadas en el producto final. Además, a medida que aumenta el número de etapas de purificación, el procedimiento puede simplificarse porque la purificación no se realiza necesariamente dos o más veces en una etapa como en la técnica anterior, maximizando de ese modo el rendimiento de producción de un derivado de difenilmetano según la fórmula química 1.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20200024525 | 2020-02-27 | ||
| PCT/KR2021/002507 WO2021172955A1 (ko) | 2020-02-27 | 2021-02-26 | Sglt 저해제의 합성에 유용한 중간체 및 이를 이용한 sglt 저해제의 제조 방법 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2022010220A true MX2022010220A (es) | 2022-10-10 |
Family
ID=77490302
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2022010220A MX2022010220A (es) | 2020-02-27 | 2021-02-26 | Intermedio util para la sintesis de un inhibidor de sglt y metodo para preparar un inhibidor de sglt utilizando el mismo. |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20230096670A1 (es) |
| EP (1) | EP4112612A4 (es) |
| JP (1) | JP7442663B2 (es) |
| KR (1) | KR102572714B1 (es) |
| CN (1) | CN115087649A (es) |
| AU (1) | AU2021225706A1 (es) |
| BR (1) | BR112022014762A2 (es) |
| CA (1) | CA3169604A1 (es) |
| CL (1) | CL2022002326A1 (es) |
| CO (1) | CO2022011686A2 (es) |
| EC (1) | ECSP22067279A (es) |
| MX (1) | MX2022010220A (es) |
| PE (1) | PE20221498A1 (es) |
| WO (1) | WO2021172955A1 (es) |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5530124A (en) * | 1994-06-30 | 1996-06-25 | The Dupont Merck Pharmaceutical Company | Method for preparing cyclic ureas and their use for the synthesis of HIV protease inhibitors |
| UA103050C2 (ru) * | 2008-08-22 | 2013-09-10 | Теракос, Инк. | Способ получения ингибиторов sglt2 |
| US9006187B2 (en) * | 2010-09-10 | 2015-04-14 | Green Cross Corporation | Thiophene derivative as SGLT2 inhibitor and pharmaceutical composition comprising same |
| WO2012165914A2 (en) * | 2011-06-01 | 2012-12-06 | Green Cross Corporation | Novel diphenylmethane derivatives as sglt2 inhibitors |
| US9340521B2 (en) * | 2013-03-18 | 2016-05-17 | Green Cross Corporation | Method for dual inhibition of SGLT1 and SGLT2 using diphenylmethane derivatives |
| CN105121434B (zh) * | 2014-03-19 | 2017-08-29 | 杭州普晒医药科技有限公司 | 坎格列净一水合物及其晶型、它们的制备方法和用途 |
| WO2016098016A1 (en) * | 2014-12-17 | 2016-06-23 | Dr. Reddy’S Laboratories Limited | Process for the preparation of sglt2 inhibitors |
| MX2018015647A (es) * | 2016-06-17 | 2019-04-11 | Daewoong Pharmaceuticals Co Ltd | Metodo para producir derivado de difenilmetano. |
| CN108530408A (zh) * | 2018-04-13 | 2018-09-14 | 海门慧聚药业有限公司 | 制备达格列净的方法 |
| PE20211206A1 (es) * | 2018-08-13 | 2021-07-05 | Dae Woong Pharma | Preparacion de intermedio util para la sintesis de inhibidor de sglt |
-
2021
- 2021-02-26 JP JP2022550984A patent/JP7442663B2/ja active Active
- 2021-02-26 WO PCT/KR2021/002507 patent/WO2021172955A1/ko active Application Filing
- 2021-02-26 AU AU2021225706A patent/AU2021225706A1/en active Pending
- 2021-02-26 PE PE2022001824A patent/PE20221498A1/es unknown
- 2021-02-26 MX MX2022010220A patent/MX2022010220A/es unknown
- 2021-02-26 CA CA3169604A patent/CA3169604A1/en active Pending
- 2021-02-26 BR BR112022014762A patent/BR112022014762A2/pt unknown
- 2021-02-26 EP EP21761658.0A patent/EP4112612A4/en active Pending
- 2021-02-26 CN CN202180013608.6A patent/CN115087649A/zh active Pending
- 2021-02-26 KR KR1020210026669A patent/KR102572714B1/ko active IP Right Grant
- 2021-02-26 US US17/799,054 patent/US20230096670A1/en active Pending
-
2022
- 2022-08-19 CO CONC2022/0011686A patent/CO2022011686A2/es unknown
- 2022-08-25 CL CL2022002326A patent/CL2022002326A1/es unknown
- 2022-08-26 EC ECSENADI202267279A patent/ECSP22067279A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP4112612A1 (en) | 2023-01-04 |
| BR112022014762A2 (pt) | 2022-10-11 |
| KR20210109476A (ko) | 2021-09-06 |
| CO2022011686A2 (es) | 2022-08-30 |
| US20230096670A1 (en) | 2023-03-30 |
| EP4112612A4 (en) | 2024-04-03 |
| JP7442663B2 (ja) | 2024-03-04 |
| JP2023514754A (ja) | 2023-04-07 |
| WO2021172955A1 (ko) | 2021-09-02 |
| PE20221498A1 (es) | 2022-09-29 |
| AU2021225706A1 (en) | 2022-09-01 |
| CL2022002326A1 (es) | 2023-02-10 |
| CA3169604A1 (en) | 2021-09-02 |
| ECSP22067279A (es) | 2022-09-30 |
| KR102572714B1 (ko) | 2023-08-31 |
| CN115087649A (zh) | 2022-09-20 |
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