BR112019025290A2 - Oligonucleotídeos anti-sentido para modulação da expressão de htra1 - Google Patents
Oligonucleotídeos anti-sentido para modulação da expressão de htra1 Download PDFInfo
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- BR112019025290A2 BR112019025290A2 BR112019025290-8A BR112019025290A BR112019025290A2 BR 112019025290 A2 BR112019025290 A2 BR 112019025290A2 BR 112019025290 A BR112019025290 A BR 112019025290A BR 112019025290 A2 BR112019025290 A2 BR 112019025290A2
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- oligonucleotide
- nucleosides
- seq
- htra1
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Classifications
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- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
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- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21108—HtrA2 peptidase (3.4.21.108)
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/315—Phosphorothioates
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- C12N2310/334—Modified C
- C12N2310/3341—5-Methylcytosine
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- C12N2320/30—Special therapeutic applications
- C12N2320/32—Special delivery means, e.g. tissue-specific
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
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- Biophysics (AREA)
- Ophthalmology & Optometry (AREA)
- Plant Pathology (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
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| EP17173964.2 | 2017-06-01 | ||
| EP17173964 | 2017-06-01 | ||
| EP17209407.0 | 2017-12-21 | ||
| EP17209535.8 | 2017-12-21 | ||
| EP17209535 | 2017-12-21 | ||
| EP17209407 | 2017-12-21 | ||
| PCT/EP2018/064221 WO2018220034A1 (en) | 2017-06-01 | 2018-05-30 | Antisense oligonucleotides for modulating htra1 expression |
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| BR112019025290A2 true BR112019025290A2 (pt) | 2020-06-23 |
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| AU2019218987B2 (en) | 2018-02-12 | 2025-04-24 | Ionis Pharmaceuticals, Inc. | Modified compounds and uses thereof |
| CN116507741A (zh) * | 2020-08-20 | 2023-07-28 | 基因组评论股份有限公司 | 年龄相关性黄斑变性诊断用生物标记物及其用途 |
| CA3199951A1 (en) * | 2020-10-30 | 2022-05-05 | Hideaki Hara | Gdf15 modulators for use in inhibiting ocular tissue fibrosis |
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| JP3756313B2 (ja) | 1997-03-07 | 2006-03-15 | 武 今西 | 新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体 |
| AU9063398A (en) | 1997-09-12 | 1999-04-05 | Exiqon A/S | Oligonucleotide analogues |
| WO2000008134A2 (en) * | 1998-08-03 | 2000-02-17 | Novartis Ag | HUMAN HtrA SERINE PROTEASE |
| CZ296576B6 (cs) | 1999-02-12 | 2006-04-12 | Sankyo Company Limited | Nukleosidový analog a oligonukleotidový analog a farmaceutický prostredek, sonda a primer s jeho obsahem |
| EP1178999B1 (en) | 1999-05-04 | 2007-03-14 | Santaris Pharma A/S | L-ribo-lna analogues |
| US6617442B1 (en) | 1999-09-30 | 2003-09-09 | Isis Pharmaceuticals, Inc. | Human Rnase H1 and oligonucleotide compositions thereof |
| US9045518B2 (en) | 2002-11-18 | 2015-06-02 | Santaris Pharma A/S | Amino-LNA, thio-LNA and alpha-L-oxy-LN |
| EP2462937A1 (en) * | 2005-05-24 | 2012-06-13 | Isis Pharmaceuticals, Inc. | Modulation of LMW-PTPase Expression |
| WO2007031091A2 (en) | 2005-09-15 | 2007-03-22 | Santaris Pharma A/S | Rna antagonist compounds for the modulation of p21 ras expression |
| JP5342881B2 (ja) | 2006-01-27 | 2013-11-13 | アイシス ファーマシューティカルズ， インコーポレーテッド | ６−修飾された二環式核酸類似体 |
| AU2007249349B2 (en) | 2006-05-11 | 2012-03-08 | Isis Pharmaceuticals, Inc. | 5'-Modified bicyclic nucleic acid analogs |
| US7666854B2 (en) | 2006-05-11 | 2010-02-23 | Isis Pharmaceuticals, Inc. | Bis-modified bicyclic nucleic acid analogs |
| AU2007277125B2 (en) * | 2006-07-26 | 2013-08-01 | Yale University | Diagnosis and treatment of age related macular degeneration |
| EP2081596A4 (en) * | 2006-10-06 | 2010-07-21 | Univ Utah Res Found | METHOD FOR THE DETECTION OF EYE DISEASES AND PATHOLOGICAL CONDITIONS AND TREATMENT THEREFOR |
| EP2170917B1 (en) | 2007-05-30 | 2012-06-27 | Isis Pharmaceuticals, Inc. | N-substituted-aminomethylene bridged bicyclic nucleic acid analogs |
| EP2173760B2 (en) | 2007-06-08 | 2015-11-04 | Isis Pharmaceuticals, Inc. | Carbocyclic bicyclic nucleic acid analogs |
| TW200911290A (en) | 2007-07-02 | 2009-03-16 | Alcon Res Ltd | RNAI-mediated inhibition of HTRA1 for treatment of macular degeneration |
| CA2692579C (en) | 2007-07-05 | 2016-05-03 | Isis Pharmaceuticals, Inc. | 6-disubstituted bicyclic nucleic acid analogs |
| EP2217720A4 (en) * | 2007-11-01 | 2010-12-08 | Univ Iowa Res Found | RNA LOCUS ANALYSIS TO ASSESS THE STUNNING FOR AMD AND MPGNII |
| US8546556B2 (en) | 2007-11-21 | 2013-10-01 | Isis Pharmaceuticals, Inc | Carbocyclic alpha-L-bicyclic nucleic acid analogs |
| WO2010036698A1 (en) | 2008-09-24 | 2010-04-01 | Isis Pharmaceuticals, Inc. | Substituted alpha-l-bicyclic nucleosides |
| EP2462153B1 (en) | 2009-08-06 | 2015-07-29 | Isis Pharmaceuticals, Inc. | Bicyclic cyclohexose nucleic acid analogs |
| EP2580228B1 (en) | 2010-06-08 | 2016-03-23 | Ionis Pharmaceuticals, Inc. | Substituted 2'-amino and 2'-thio-bicyclic nucleosides and oligomeric compounds prepared therefrom |
| FR2965278B1 (fr) * | 2010-09-23 | 2014-10-10 | Univ Caen Basse Normandie | Procede d'obtention in vitro ou ex vivo de chondrocytes et leurs utilisations |
| CN104136451A (zh) | 2011-09-07 | 2014-11-05 | 玛瑞纳生物技术有限公司 | 具有构象限制的单体的核酸化合物的合成和用途 |
| EP2850092B1 (en) | 2012-04-09 | 2017-03-01 | Ionis Pharmaceuticals, Inc. | Tricyclic nucleic acid analogs |
| US20150141320A1 (en) * | 2012-05-16 | 2015-05-21 | Rana Therapeutics, Inc. | Compositions and methods for modulating gene expression |
| US10077443B2 (en) | 2012-11-15 | 2018-09-18 | Roche Innovation Center Copenhagen A/S | Oligonucleotide conjugates |
| US20190284621A1 (en) * | 2016-11-11 | 2019-09-19 | Roche Innovation Center Copenhagen A/S | Therapeutic oligonucleotides capture and detection |
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- 2018-05-30 MX MX2019014187A patent/MX2019014187A/es unknown
- 2018-05-30 WO PCT/EP2018/064221 patent/WO2018220034A1/en not_active Ceased
- 2018-05-30 CR CR20190543A patent/CR20190543A/es unknown
- 2018-05-30 BR BR112019025290-8A patent/BR112019025290A2/pt not_active Application Discontinuation
- 2018-05-30 CA CA3062590A patent/CA3062590A1/en not_active Abandoned
- 2018-05-30 MA MA049278A patent/MA49278A/fr unknown
- 2018-05-30 AU AU2018277219A patent/AU2018277219A1/en not_active Abandoned
- 2018-05-30 JP JP2019566236A patent/JP7169995B2/ja active Active
- 2018-05-30 RU RU2019143004A patent/RU2019143004A/ru unknown
- 2018-05-30 KR KR1020197038723A patent/KR20200015608A/ko not_active Withdrawn
- 2018-05-30 EP EP18727310.7A patent/EP3630976A1/en active Pending
- 2018-05-30 CN CN201880036053.5A patent/CN110691849A/zh active Pending
- 2018-05-31 TW TW107118609A patent/TW201907008A/zh unknown
-
2019
- 2019-10-28 US US16/665,317 patent/US20200157546A1/en not_active Abandoned
- 2019-11-20 CL CL2019003337A patent/CL2019003337A1/es unknown
- 2019-11-22 PH PH12019502636A patent/PH12019502636A1/en unknown
- 2019-11-27 CO CONC2019/0013317A patent/CO2019013317A2/es unknown
- 2019-11-28 IL IL271039A patent/IL271039A/en unknown
-
2021
- 2021-08-17 US US17/404,989 patent/US20220042022A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| KR20200015608A (ko) | 2020-02-12 |
| TW201907008A (zh) | 2019-02-16 |
| JP7169995B2 (ja) | 2022-11-11 |
| CN110691849A (zh) | 2020-01-14 |
| EP3630976A1 (en) | 2020-04-08 |
| CR20190543A (es) | 2020-02-10 |
| PH12019502636A1 (en) | 2020-06-08 |
| MA49278A (fr) | 2020-04-08 |
| CO2019013317A2 (es) | 2020-01-17 |
| MX2019014187A (es) | 2020-01-27 |
| PE20191845A1 (es) | 2019-12-31 |
| RU2019143004A (ru) | 2021-07-09 |
| WO2018220034A1 (en) | 2018-12-06 |
| US20200157546A1 (en) | 2020-05-21 |
| US20220042022A1 (en) | 2022-02-10 |
| CA3062590A1 (en) | 2018-12-06 |
| AU2018277219A1 (en) | 2019-12-19 |
| IL271039A (en) | 2020-01-30 |
| JP2020521491A (ja) | 2020-07-27 |
| US20190055564A1 (en) | 2019-02-21 |
| CL2019003337A1 (es) | 2020-05-15 |
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