CN110691849A - 用于调节htra1表达的反义寡核苷酸 - Google Patents

用于调节htra1表达的反义寡核苷酸 Download PDF

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Publication number
CN110691849A
CN110691849A CN201880036053.5A CN201880036053A CN110691849A CN 110691849 A CN110691849 A CN 110691849A CN 201880036053 A CN201880036053 A CN 201880036053A CN 110691849 A CN110691849 A CN 110691849A
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oligonucleotide
nucleotides
seq
nucleosides
htra1
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CN201880036053.5A
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Chinese (zh)
Inventor
鲁文·阿尔瓦雷斯·桑切斯
罗伯托·依阿哥尼
彼得·哈哲多恩
苏珊娜·凯姆乐
索仁·奥托森
辛德瑞·特劳斯塔森
海迪·赖伊·胡德布施
吕克·彼泽森
马尔科·贝雷拉
安德雷斯·迪克曼
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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Publication of CN110691849A publication Critical patent/CN110691849A/zh
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/712—Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21108—HtrA2 peptidase (3.4.21.108)
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/11—Antisense
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/323—Chemical structure of the sugar modified ring structure
    • C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/341—Gapmers, i.e. of the type ===---===
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    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/32—Special delivery means, e.g. tissue-specific

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  • Animal Behavior & Ethology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
CN201880036053.5A 2017-06-01 2018-05-30 用于调节htra1表达的反义寡核苷酸 Pending CN110691849A (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
EP17173964.2 2017-06-01
EP17173964 2017-06-01
EP17209407.0 2017-12-21
EP17209535.8 2017-12-21
EP17209535 2017-12-21
EP17209407 2017-12-21
PCT/EP2018/064221 WO2018220034A1 (en) 2017-06-01 2018-05-30 Antisense oligonucleotides for modulating htra1 expression

Publications (1)

Publication Number Publication Date
CN110691849A true CN110691849A (zh) 2020-01-14

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CN201880036053.5A Pending CN110691849A (zh) 2017-06-01 2018-05-30 用于调节htra1表达的反义寡核苷酸

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US (3) US20190055564A1 (https=)
EP (1) EP3630976A1 (https=)
JP (1) JP7169995B2 (https=)
KR (1) KR20200015608A (https=)
CN (1) CN110691849A (https=)
AU (1) AU2018277219A1 (https=)
BR (1) BR112019025290A2 (https=)
CA (1) CA3062590A1 (https=)
CL (1) CL2019003337A1 (https=)
CO (1) CO2019013317A2 (https=)
CR (1) CR20190543A (https=)
IL (1) IL271039A (https=)
MA (1) MA49278A (https=)
MX (1) MX2019014187A (https=)
PE (1) PE20191845A1 (https=)
PH (1) PH12019502636A1 (https=)
RU (1) RU2019143004A (https=)
TW (1) TW201907008A (https=)
WO (1) WO2018220034A1 (https=)

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AU2017289204A1 (en) 2016-07-01 2019-01-17 F. Hoffmann-La Roche Ag Antisense oligonucleotides for modulating HTRA1 expression
AU2019218987B2 (en) 2018-02-12 2025-04-24 Ionis Pharmaceuticals, Inc. Modified compounds and uses thereof
CN116507741A (zh) * 2020-08-20 2023-07-28 基因组评论股份有限公司 年龄相关性黄斑变性诊断用生物标记物及其用途
CA3199951A1 (en) * 2020-10-30 2022-05-05 Hideaki Hara Gdf15 modulators for use in inhibiting ocular tissue fibrosis

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US20090012030A1 (en) * 2007-07-02 2009-01-08 Alcon Research, Ltd. RNAi-MEDIATED INHIBITIN OF HTRA1 FOR TREATMENT OF MACULAR DEGENERATION
US20090221671A1 (en) * 2005-05-24 2009-09-03 Sanjay Pandey Modulation of lmw-ptpase expression
US20110052602A1 (en) * 2006-07-26 2011-03-03 Yale University Diagnosis and Treatment of Age Related Macular Degeneration

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AU9063398A (en) 1997-09-12 1999-04-05 Exiqon A/S Oligonucleotide analogues
WO2000008134A2 (en) * 1998-08-03 2000-02-17 Novartis Ag HUMAN HtrA SERINE PROTEASE
CZ296576B6 (cs) 1999-02-12 2006-04-12 Sankyo Company Limited Nukleosidový analog a oligonukleotidový analog a farmaceutický prostredek, sonda a primer s jeho obsahem
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US20090221671A1 (en) * 2005-05-24 2009-09-03 Sanjay Pandey Modulation of lmw-ptpase expression
US20110052602A1 (en) * 2006-07-26 2011-03-03 Yale University Diagnosis and Treatment of Age Related Macular Degeneration
US20090012030A1 (en) * 2007-07-02 2009-01-08 Alcon Research, Ltd. RNAi-MEDIATED INHIBITIN OF HTRA1 FOR TREATMENT OF MACULAR DEGENERATION

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Publication number Publication date
KR20200015608A (ko) 2020-02-12
TW201907008A (zh) 2019-02-16
JP7169995B2 (ja) 2022-11-11
EP3630976A1 (en) 2020-04-08
BR112019025290A2 (pt) 2020-06-23
CR20190543A (es) 2020-02-10
PH12019502636A1 (en) 2020-06-08
MA49278A (fr) 2020-04-08
CO2019013317A2 (es) 2020-01-17
MX2019014187A (es) 2020-01-27
PE20191845A1 (es) 2019-12-31
RU2019143004A (ru) 2021-07-09
WO2018220034A1 (en) 2018-12-06
US20200157546A1 (en) 2020-05-21
US20220042022A1 (en) 2022-02-10
CA3062590A1 (en) 2018-12-06
AU2018277219A1 (en) 2019-12-19
IL271039A (en) 2020-01-30
JP2020521491A (ja) 2020-07-27
US20190055564A1 (en) 2019-02-21
CL2019003337A1 (es) 2020-05-15

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