BR112019019117A2 - métodos e composições para induzir respostas imunes contra clostridium difficile - Google Patents

métodos e composições para induzir respostas imunes contra clostridium difficile Download PDF

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Publication number
BR112019019117A2
BR112019019117A2 BR112019019117A BR112019019117A BR112019019117A2 BR 112019019117 A2 BR112019019117 A2 BR 112019019117A2 BR 112019019117 A BR112019019117 A BR 112019019117A BR 112019019117 A BR112019019117 A BR 112019019117A BR 112019019117 A2 BR112019019117 A2 BR 112019019117A2
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BR
Brazil
Prior art keywords
toxin
fact
protein
fraction
multivalent immunogenic
Prior art date
Application number
BR112019019117A
Other languages
English (en)
Portuguese (pt)
Inventor
Flyer David
Smith Gale
Glenn Gregory
tian Jing-hui
Liu Ye
Original Assignee
Novavax Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novavax Inc filed Critical Novavax Inc
Publication of BR112019019117A2 publication Critical patent/BR112019019117A2/pt

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/02Bacterial antigens
    • A61K39/08Clostridium, e.g. Clostridium tetani
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/02Bacterial antigens
    • A61K39/116Polyvalent bacterial antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/39Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/33Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505Inorganic adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55577Saponins; Quil A; QS21; ISCOMS
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/70Multivalent vaccine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/55Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
BR112019019117A 2017-03-15 2018-03-15 métodos e composições para induzir respostas imunes contra clostridium difficile BR112019019117A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762471636P 2017-03-15 2017-03-15
US201762474434P 2017-03-21 2017-03-21
PCT/US2018/022597 WO2018170238A2 (en) 2017-03-15 2018-03-15 Methods and compositions for inducing immune responses against clostridium difficile

Publications (1)

Publication Number Publication Date
BR112019019117A2 true BR112019019117A2 (pt) 2020-05-05

Family

ID=63523217

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112019019117A BR112019019117A2 (pt) 2017-03-15 2018-03-15 métodos e composições para induzir respostas imunes contra clostridium difficile

Country Status (12)

Country Link
US (2) US11123419B2 (enExample)
EP (1) EP3595709A4 (enExample)
JP (2) JP7149285B2 (enExample)
KR (1) KR102640722B1 (enExample)
CN (1) CN110691609B (enExample)
AU (1) AU2018236352B2 (enExample)
BR (1) BR112019019117A2 (enExample)
CA (1) CA3056090A1 (enExample)
IL (1) IL269258B2 (enExample)
MX (1) MX2019010948A (enExample)
SG (1) SG11201908376UA (enExample)
WO (1) WO2018170238A2 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103619871B (zh) 2011-04-22 2016-12-14 惠氏有限责任公司 涉及突变体难辨梭菌毒素的组合物及其方法
BR122016023101B1 (pt) 2012-10-21 2022-03-22 Pfizer Inc Polipeptídeo, composição imunogênica que o compreende, bem como célula recombinante derivada de clostridium difficile
WO2018170238A2 (en) * 2017-03-15 2018-09-20 Novavax, Inc. Methods and compositions for inducing immune responses against clostridium difficile
WO2021255690A2 (en) * 2020-06-19 2021-12-23 Pfizer Inc. Immunogenic compositions against clostridioides (clostridium) difficile and methods thereof
US20250213667A1 (en) 2022-06-01 2025-07-03 Valneva Austria Gmbh Clostridium difficile vaccine

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPM873294A0 (en) 1994-10-12 1994-11-03 Csl Limited Saponin preparations and use thereof in iscoms
WO1999011711A1 (en) * 1997-09-04 1999-03-11 Eastman Chemical Company Thermoplastic polyurethane additives for enhancing solid state polymerization rates
CA2733425A1 (en) * 2008-08-06 2010-02-11 Emergent Product Development Uk Limited Vaccines against clostridium difficile and methods of use
US10046040B2 (en) * 2009-11-16 2018-08-14 University Of Maryland, Baltimore Multivalent live vector vaccine against Clostridium difficile-associated disease
US20130039973A1 (en) * 2011-08-03 2013-02-14 Henry J. Smith Viral Immunogenic Compositions
JP2014530010A (ja) 2011-09-30 2014-11-17 ノババックス,インコーポレイテッド 呼吸器合胞体ウイルス用の組み換えナノ粒子rsvfワクチン
AR089797A1 (es) * 2012-01-27 2014-09-17 Merck Sharp & Dohme Vacunas contra clostridum difficile que comprenden toxinas recombinantes
ES2939307T3 (es) 2012-12-05 2023-04-20 Glaxosmithkline Biologicals Sa Composición inmunogénica
GB201223342D0 (en) * 2012-12-23 2013-02-06 Glaxosmithkline Biolog Sa Immunogenic composition
WO2014176276A1 (en) 2013-04-22 2014-10-30 Board Of Regents Of The University Of Oklahoma Clostridium difficile vaccine and methods of use
CA2928908C (en) * 2013-11-01 2021-01-12 Pfizer Inc. Vectors for expression of prostate-associated antigens
WO2015197737A1 (en) * 2014-06-25 2015-12-30 Glaxosmithkline Biologicals S.A. Clostridium difficile immunogenic composition
CN106220737B (zh) * 2016-07-21 2020-11-10 中国人民解放军军事医学科学院微生物流行病研究所 融合蛋白及其在治疗艰难梭菌相关疾病中的应用
WO2018170238A2 (en) * 2017-03-15 2018-09-20 Novavax, Inc. Methods and compositions for inducing immune responses against clostridium difficile

Also Published As

Publication number Publication date
CN110691609A (zh) 2020-01-14
JP2020509770A (ja) 2020-04-02
EP3595709A2 (en) 2020-01-22
WO2018170238A3 (en) 2018-10-18
IL269258B1 (en) 2023-05-01
KR20190125470A (ko) 2019-11-06
US11123419B2 (en) 2021-09-21
RU2019132111A (ru) 2021-04-15
MX2019010948A (es) 2020-01-09
US11938179B2 (en) 2024-03-26
RU2019132111A3 (enExample) 2021-06-29
AU2018236352A1 (en) 2019-10-03
JP2022179543A (ja) 2022-12-02
SG11201908376UA (en) 2019-10-30
CA3056090A1 (en) 2018-09-20
EP3595709A4 (en) 2020-12-23
KR102640722B1 (ko) 2024-02-26
US20220211834A1 (en) 2022-07-07
AU2018236352B2 (en) 2024-04-04
IL269258B2 (en) 2023-09-01
JP7149285B2 (ja) 2022-10-06
CN110691609B (zh) 2024-04-19
IL269258A (en) 2019-11-28
JP7397145B2 (ja) 2023-12-12
US20200085934A1 (en) 2020-03-19
WO2018170238A2 (en) 2018-09-20

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