IL269258B2 - Methods and compositions for inducing immune responses against Clostridium difficile - Google Patents

Methods and compositions for inducing immune responses against Clostridium difficile

Info

Publication number
IL269258B2
IL269258B2 IL269258A IL26925819A IL269258B2 IL 269258 B2 IL269258 B2 IL 269258B2 IL 269258 A IL269258 A IL 269258A IL 26925819 A IL26925819 A IL 26925819A IL 269258 B2 IL269258 B2 IL 269258B2
Authority
IL
Israel
Prior art keywords
toxin
protein
fraction
proteins
multivalent immunogenic
Prior art date
Application number
IL269258A
Other languages
English (en)
Hebrew (he)
Other versions
IL269258B1 (en
IL269258A (en
Inventor
Gale Smith
Ye Liu
Jing-Hui Tian
Gregory Glenn
David Flyer
Original Assignee
Novavax Inc
Gale Smith
Ye Liu
Tian jing hui
Gregory Glenn
David Flyer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novavax Inc, Gale Smith, Ye Liu, Tian jing hui, Gregory Glenn, David Flyer filed Critical Novavax Inc
Publication of IL269258A publication Critical patent/IL269258A/en
Publication of IL269258B1 publication Critical patent/IL269258B1/en
Publication of IL269258B2 publication Critical patent/IL269258B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/08—Clostridium, e.g. Clostridium tetani
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/116—Polyvalent bacterial antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
IL269258A 2017-03-15 2018-03-15 Methods and compositions for inducing immune responses against Clostridium difficile IL269258B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762471636P 2017-03-15 2017-03-15
US201762474434P 2017-03-21 2017-03-21
PCT/US2018/022597 WO2018170238A2 (en) 2017-03-15 2018-03-15 Methods and compositions for inducing immune responses against clostridium difficile

Publications (3)

Publication Number Publication Date
IL269258A IL269258A (en) 2019-11-28
IL269258B1 IL269258B1 (en) 2023-05-01
IL269258B2 true IL269258B2 (en) 2023-09-01

Family

ID=63523217

Family Applications (1)

Application Number Title Priority Date Filing Date
IL269258A IL269258B2 (en) 2017-03-15 2018-03-15 Methods and compositions for inducing immune responses against Clostridium difficile

Country Status (12)

Country Link
US (2) US11123419B2 (enExample)
EP (1) EP3595709A4 (enExample)
JP (2) JP7149285B2 (enExample)
KR (1) KR102640722B1 (enExample)
CN (1) CN110691609B (enExample)
AU (1) AU2018236352B2 (enExample)
BR (1) BR112019019117A2 (enExample)
CA (1) CA3056090A1 (enExample)
IL (1) IL269258B2 (enExample)
MX (1) MX2019010948A (enExample)
SG (1) SG11201908376UA (enExample)
WO (1) WO2018170238A2 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR086199A1 (es) 2011-04-22 2013-11-27 Wyeth Llc Composiciones relacionadas con una toxina de clostridium difficile mutante y sus metodos
BR122016023101B1 (pt) 2012-10-21 2022-03-22 Pfizer Inc Polipeptídeo, composição imunogênica que o compreende, bem como célula recombinante derivada de clostridium difficile
CN110691609B (zh) * 2017-03-15 2024-04-19 诺瓦瓦克斯股份有限公司 用于诱导针对艰难梭菌的免疫应答的方法和组合物
WO2021255690A2 (en) * 2020-06-19 2021-12-23 Pfizer Inc. Immunogenic compositions against clostridioides (clostridium) difficile and methods thereof
WO2023232901A1 (en) 2022-06-01 2023-12-07 Valneva Austria Gmbh Clostridium difficile vaccine

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013112867A1 (en) * 2012-01-27 2013-08-01 Merck Sharp & Dohme Corp. Vaccines against clostridium difficile comprising recombinant toxins
WO2015063647A1 (en) * 2013-11-01 2015-05-07 Pfizer Inc. Vectors for expression of prostate-associated antigens
US20150328305A1 (en) * 2011-08-03 2015-11-19 Henry J. Smith Viral Immunogenic Compositions

Family Cites Families (11)

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Publication number Priority date Publication date Assignee Title
AUPM873294A0 (en) * 1994-10-12 1994-11-03 Csl Limited Saponin preparations and use thereof in iscoms
WO1999011711A1 (en) * 1997-09-04 1999-03-11 Eastman Chemical Company Thermoplastic polyurethane additives for enhancing solid state polymerization rates
WO2010017383A1 (en) * 2008-08-06 2010-02-11 Emergent Product Development Uk Limited Vaccines against clostridium difficile and methods of use
WO2011060431A2 (en) 2009-11-16 2011-05-19 University Of Maryland Baltimore Multivalent live vector vaccine against clostridium difficile-associated disease
SG10201602434UA (en) 2011-09-30 2016-05-30 Novavax Inc Recombinant nanoparticle rsv f vaccine for respiratory syncytial virus
EP2928489B1 (en) 2012-12-05 2019-02-27 GlaxoSmithKline Biologicals S.A. Immunogenic composition
GB201223342D0 (en) * 2012-12-23 2013-02-06 Glaxosmithkline Biolog Sa Immunogenic composition
CN105451762A (zh) 2013-04-22 2016-03-30 俄克拉荷马州大学评议会 艰难梭菌疫苗及使用方法
BE1022949B1 (fr) * 2014-06-25 2016-10-21 Glaxosmithkline Biologicals S.A. Composition immunogene
CN106220737B (zh) * 2016-07-21 2020-11-10 中国人民解放军军事医学科学院微生物流行病研究所 融合蛋白及其在治疗艰难梭菌相关疾病中的应用
CN110691609B (zh) 2017-03-15 2024-04-19 诺瓦瓦克斯股份有限公司 用于诱导针对艰难梭菌的免疫应答的方法和组合物

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20150328305A1 (en) * 2011-08-03 2015-11-19 Henry J. Smith Viral Immunogenic Compositions
WO2013112867A1 (en) * 2012-01-27 2013-08-01 Merck Sharp & Dohme Corp. Vaccines against clostridium difficile comprising recombinant toxins
WO2015063647A1 (en) * 2013-11-01 2015-05-07 Pfizer Inc. Vectors for expression of prostate-associated antigens

Also Published As

Publication number Publication date
US20200085934A1 (en) 2020-03-19
CN110691609A (zh) 2020-01-14
WO2018170238A3 (en) 2018-10-18
EP3595709A4 (en) 2020-12-23
SG11201908376UA (en) 2019-10-30
RU2019132111A (ru) 2021-04-15
CN110691609B (zh) 2024-04-19
IL269258B1 (en) 2023-05-01
CA3056090A1 (en) 2018-09-20
JP2022179543A (ja) 2022-12-02
IL269258A (en) 2019-11-28
US11938179B2 (en) 2024-03-26
WO2018170238A2 (en) 2018-09-20
EP3595709A2 (en) 2020-01-22
US11123419B2 (en) 2021-09-21
MX2019010948A (es) 2020-01-09
AU2018236352A1 (en) 2019-10-03
US20220211834A1 (en) 2022-07-07
RU2019132111A3 (enExample) 2021-06-29
JP7149285B2 (ja) 2022-10-06
JP7397145B2 (ja) 2023-12-12
KR102640722B1 (ko) 2024-02-26
BR112019019117A2 (pt) 2020-05-05
AU2018236352B2 (en) 2024-04-04
JP2020509770A (ja) 2020-04-02
KR20190125470A (ko) 2019-11-06

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