CN110691609B - 用于诱导针对艰难梭菌的免疫应答的方法和组合物 - Google Patents

用于诱导针对艰难梭菌的免疫应答的方法和组合物 Download PDF

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CN110691609B
CN110691609B CN201880025192.8A CN201880025192A CN110691609B CN 110691609 B CN110691609 B CN 110691609B CN 201880025192 A CN201880025192 A CN 201880025192A CN 110691609 B CN110691609 B CN 110691609B
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CN110691609A (zh
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J-H.田
刘晔
G.史密斯
G.格伦
D.弗莱尔
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Novavax Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/116—Polyvalent bacterial antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/08—Clostridium, e.g. Clostridium tetani
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN201880025192.8A 2017-03-15 2018-03-15 用于诱导针对艰难梭菌的免疫应答的方法和组合物 Active CN110691609B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762471636P 2017-03-15 2017-03-15
US62/471,636 2017-03-15
US201762474434P 2017-03-21 2017-03-21
US62/474,434 2017-03-21
PCT/US2018/022597 WO2018170238A2 (en) 2017-03-15 2018-03-15 Methods and compositions for inducing immune responses against clostridium difficile

Publications (2)

Publication Number Publication Date
CN110691609A CN110691609A (zh) 2020-01-14
CN110691609B true CN110691609B (zh) 2024-04-19

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US (2) US11123419B2 (enExample)
EP (1) EP3595709A4 (enExample)
JP (2) JP7149285B2 (enExample)
KR (1) KR102640722B1 (enExample)
CN (1) CN110691609B (enExample)
AU (1) AU2018236352B2 (enExample)
BR (1) BR112019019117A2 (enExample)
CA (1) CA3056090A1 (enExample)
IL (1) IL269258B2 (enExample)
MX (1) MX2019010948A (enExample)
SG (1) SG11201908376UA (enExample)
WO (1) WO2018170238A2 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE047085T2 (hu) 2011-04-22 2020-04-28 Wyeth Llc Clostridium difficile mutáns toxinjához kapcsolódó készítmények és eljárásai
BR122016023101B1 (pt) 2012-10-21 2022-03-22 Pfizer Inc Polipeptídeo, composição imunogênica que o compreende, bem como célula recombinante derivada de clostridium difficile
CA3056090A1 (en) * 2017-03-15 2018-09-20 Novavax, Inc. Methods and compositions for inducing immune responses against clostridium difficile
EP4168032A2 (en) * 2020-06-19 2023-04-26 Pfizer Inc. Immunogenic compositions against clostridioides (clostridium) difficile and methods thereof
WO2023232901A1 (en) 2022-06-01 2023-12-07 Valneva Austria Gmbh Clostridium difficile vaccine

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120282293A1 (en) * 2009-11-16 2012-11-08 University Of Maryland, Baltimore Multivalent Live Vector Vaccine against Clostridium difficile-Associated Disease
CN104039816A (zh) * 2012-01-27 2014-09-10 默沙东公司 包含重组毒素的针对艰难梭菌的疫苗
US20150328305A1 (en) * 2011-08-03 2015-11-19 Henry J. Smith Viral Immunogenic Compositions
CN105120892A (zh) * 2012-12-23 2015-12-02 葛兰素史密丝克莱恩生物有限公司 包含艰难梭菌cdtb和/或cdta蛋白的元件的免疫原性组合物
CN105682679A (zh) * 2013-11-01 2016-06-15 辉瑞公司 用于表达前列腺相关抗原的载体
CN106220737A (zh) * 2016-07-21 2016-12-14 中国人民解放军军事医学科学院微生物流行病研究所 融合蛋白及其在治疗艰难梭菌相关疾病中的应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPM873294A0 (en) 1994-10-12 1994-11-03 Csl Limited Saponin preparations and use thereof in iscoms
JP2002509943A (ja) * 1997-09-04 2002-04-02 イーストマン ケミカル カンパニー 固相重合速度を高める熱可塑性ポリウレタン添加剤
US20120020996A1 (en) * 2008-08-06 2012-01-26 Jonathan Lewis Telfer Vaccines against clostridium difficile and methods of use
AU2013201495B2 (en) * 2011-09-30 2015-12-03 Novavax, Inc. Recombinant nanoparticle RSV F vaccine for respiratory syncytial virus
DK2928489T3 (en) * 2012-12-05 2019-04-23 Glaxosmithkline Biologicals Sa IMMUNOGENE COMPOSITION
CN105451762A (zh) * 2013-04-22 2016-03-30 俄克拉荷马州大学评议会 艰难梭菌疫苗及使用方法
LT3160500T (lt) * 2014-06-25 2019-10-25 Glaxosmithkline Biologicals Sa Clostridium difficile imunogeninė kompozicija
CA3056090A1 (en) 2017-03-15 2018-09-20 Novavax, Inc. Methods and compositions for inducing immune responses against clostridium difficile

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120282293A1 (en) * 2009-11-16 2012-11-08 University Of Maryland, Baltimore Multivalent Live Vector Vaccine against Clostridium difficile-Associated Disease
US20150328305A1 (en) * 2011-08-03 2015-11-19 Henry J. Smith Viral Immunogenic Compositions
CN104039816A (zh) * 2012-01-27 2014-09-10 默沙东公司 包含重组毒素的针对艰难梭菌的疫苗
CN105120892A (zh) * 2012-12-23 2015-12-02 葛兰素史密丝克莱恩生物有限公司 包含艰难梭菌cdtb和/或cdta蛋白的元件的免疫原性组合物
CN105682679A (zh) * 2013-11-01 2016-06-15 辉瑞公司 用于表达前列腺相关抗原的载体
CN106220737A (zh) * 2016-07-21 2016-12-14 中国人民解放军军事医学科学院微生物流行病研究所 融合蛋白及其在治疗艰难梭菌相关疾病中的应用

Also Published As

Publication number Publication date
JP7397145B2 (ja) 2023-12-12
IL269258A (en) 2019-11-28
SG11201908376UA (en) 2019-10-30
BR112019019117A2 (pt) 2020-05-05
US11123419B2 (en) 2021-09-21
JP2022179543A (ja) 2022-12-02
US20220211834A1 (en) 2022-07-07
US20200085934A1 (en) 2020-03-19
US11938179B2 (en) 2024-03-26
IL269258B1 (en) 2023-05-01
WO2018170238A2 (en) 2018-09-20
CA3056090A1 (en) 2018-09-20
KR102640722B1 (ko) 2024-02-26
WO2018170238A3 (en) 2018-10-18
EP3595709A4 (en) 2020-12-23
KR20190125470A (ko) 2019-11-06
CN110691609A (zh) 2020-01-14
JP7149285B2 (ja) 2022-10-06
JP2020509770A (ja) 2020-04-02
IL269258B2 (en) 2023-09-01
AU2018236352A1 (en) 2019-10-03
MX2019010948A (es) 2020-01-09
EP3595709A2 (en) 2020-01-22
RU2019132111A3 (enExample) 2021-06-29
RU2019132111A (ru) 2021-04-15
AU2018236352B2 (en) 2024-04-04

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