BR112019003162B1 - Oligonucleotídeo modificado, composto compreendendo um oligonucleotídeo modificado, população quiralmente enriquecida, composições farmacêuticas e duplex oligomérico - Google Patents

Oligonucleotídeo modificado, composto compreendendo um oligonucleotídeo modificado, população quiralmente enriquecida, composições farmacêuticas e duplex oligomérico Download PDF

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Publication number
BR112019003162B1
BR112019003162B1 BR112019003162-6A BR112019003162A BR112019003162B1 BR 112019003162 B1 BR112019003162 B1 BR 112019003162B1 BR 112019003162 A BR112019003162 A BR 112019003162A BR 112019003162 B1 BR112019003162 B1 BR 112019003162B1
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Brazil
Prior art keywords
certain embodiments
modified
modified oligonucleotide
oligonucleotide
nucleosides
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BR112019003162-6A
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English (en)
Portuguese (pt)
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BR112019003162A2 (pt
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Holly Kordasiewicz
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Ionis Pharmaceuticals, Inc
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Application filed by Ionis Pharmaceuticals, Inc filed Critical Ionis Pharmaceuticals, Inc
Priority to BR122020019785-4A priority Critical patent/BR122020019785B1/pt
Publication of BR112019003162A2 publication Critical patent/BR112019003162A2/pt
Publication of BR112019003162B1 publication Critical patent/BR112019003162B1/pt

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/11—Antisense
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    • C12N2310/31—Chemical structure of the backbone
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
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    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
    • C12N2310/334—Modified C
    • C12N2310/3341—5-Methylcytosine
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/341—Gapmers, i.e. of the type ===---===
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/345—Spatial arrangement of the modifications having at least two different backbone modifications
    • C—CHEMISTRY; METALLURGY
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/352—Nature of the modification linked to the nucleic acid via a carbon atom
    • C12N2310/3525—MOE, methoxyethoxy

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  • General Chemical & Material Sciences (AREA)
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  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
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BR112019003162-6A 2016-09-29 2017-09-29 Oligonucleotídeo modificado, composto compreendendo um oligonucleotídeo modificado, população quiralmente enriquecida, composições farmacêuticas e duplex oligomérico BR112019003162B1 (pt)

Priority Applications (1)

Application Number Priority Date Filing Date Title
BR122020019785-4A BR122020019785B1 (pt) 2016-09-29 2017-09-29 Uso do oligonucleotídeo modificado, composto ou composições farmacêuticas

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662401723P 2016-09-29 2016-09-29
US62/401,723 2016-09-29
US201762450469P 2017-01-25 2017-01-25
US62/450,469 2017-01-25
PCT/US2017/054540 WO2018064593A1 (en) 2016-09-29 2017-09-29 Compounds and methods for reducing tau expression

Publications (2)

Publication Number Publication Date
BR112019003162A2 BR112019003162A2 (pt) 2019-07-09
BR112019003162B1 true BR112019003162B1 (pt) 2022-03-15

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BR122020019785-4A BR122020019785B1 (pt) 2016-09-29 2017-09-29 Uso do oligonucleotídeo modificado, composto ou composições farmacêuticas
BR112019003162-6A BR112019003162B1 (pt) 2016-09-29 2017-09-29 Oligonucleotídeo modificado, composto compreendendo um oligonucleotídeo modificado, população quiralmente enriquecida, composições farmacêuticas e duplex oligomérico

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BR122020019785-4A BR122020019785B1 (pt) 2016-09-29 2017-09-29 Uso do oligonucleotídeo modificado, composto ou composições farmacêuticas

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US (3) US10407680B2 (enExample)
EP (2) EP4335923A3 (enExample)
JP (4) JP6738004B2 (enExample)
KR (2) KR20210097228A (enExample)
CN (2) CN113481201A (enExample)
AU (3) AU2017336093B2 (enExample)
BR (2) BR122020019785B1 (enExample)
CA (1) CA3038891C (enExample)
CL (2) CL2019000703A1 (enExample)
CO (1) CO2019001385A2 (enExample)
CR (2) CR20190214A (enExample)
DK (1) DK3519572T5 (enExample)
ES (1) ES2963428T3 (enExample)
FI (1) FI3519572T3 (enExample)
HR (1) HRP20231606T1 (enExample)
HU (1) HUE065170T2 (enExample)
IL (3) IL299615A (enExample)
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PE (1) PE20190655A1 (enExample)
PL (1) PL3519572T3 (enExample)
PT (1) PT3519572T (enExample)
RS (1) RS64941B1 (enExample)
SG (1) SG11201901140QA (enExample)
SI (1) SI3519572T1 (enExample)
SM (1) SMT202300441T1 (enExample)
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EP2839006B1 (en) * 2012-04-20 2018-01-03 Ionis Pharmaceuticals, Inc. Oligomeric compounds comprising bicyclic nucleotides and uses thereof
MX2015012621A (es) 2013-03-14 2016-05-31 Ionis Pharmaceuticals Inc Composiciones y metodos para modular la expresion de tau.
TW202246503A (zh) 2013-07-19 2022-12-01 美商百健Ｍａ公司 用於調節τ蛋白表現之組合物
JOP20190065A1 (ar) * 2016-09-29 2019-03-28 Ionis Pharmaceuticals Inc مركبات وطرق لتقليل التعبير عن tau
AU2019208011B2 (en) 2018-01-12 2025-06-05 Bristol-Myers Squibb Company Antisense oligonucleotides targeting alpha-synuclein and uses thereof
WO2019140231A1 (en) 2018-01-12 2019-07-18 Bristol-Myers Squibb Company Antisense oligonucleotides targeting alpha-synuclein and uses thereof
CR20210178A (es) * 2018-07-03 2021-05-11 Hoffmann La Roche OLIGONUCLEÓTIDOS PARA MODULAR LA EXPRESIÓN DE TAU (Divisional 2021-0058)
WO2022125984A1 (en) * 2020-12-11 2022-06-16 Eisai R&D Management Co., Ltd. Tau-targeting oligonucleotide gapmers
US20240167031A1 (en) 2021-04-01 2024-05-23 Biogen Ma Inc. Nucleic acid delivery to the central nervous system
AU2022293556A1 (en) * 2021-06-18 2024-01-18 Ionis Pharmaceuticals, Inc. Compounds and methods for reducing ifnar1 expression
EP4373938A2 (en) * 2021-07-23 2024-05-29 University Of Kentucky Research Foundation Inhibition of neurofibrillary tangles using oligonucleotides against circular rnas from the microtubule associated protein tau (mapt) locus
KR20240040759A (ko) * 2021-07-23 2024-03-28 바이오젠 엠에이 인코포레이티드 타우 발현을 감소시키는 방법
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