CL2019000703A1 - Compuestos y métodos para la reducción de la expresión de tau. - Google Patents

Compuestos y métodos para la reducción de la expresión de tau.

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Publication number
CL2019000703A1
CL2019000703A1 CL2019000703A CL2019000703A CL2019000703A1 CL 2019000703 A1 CL2019000703 A1 CL 2019000703A1 CL 2019000703 A CL2019000703 A CL 2019000703A CL 2019000703 A CL2019000703 A CL 2019000703A CL 2019000703 A1 CL2019000703 A1 CL 2019000703A1
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CL
Chile
Prior art keywords
methods
compounds
amount
animal
cell
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CL2019000703A
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English (en)
Spanish (es)
Inventor
Holly Kordasiewicz
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Ionis Pharmaceuticals Inc
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=61760152&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2019000703(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ionis Pharmaceuticals Inc filed Critical Ionis Pharmaceuticals Inc
Publication of CL2019000703A1 publication Critical patent/CL2019000703A1/es

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/341—Gapmers, i.e. of the type ===---===
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    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/345—Spatial arrangement of the modifications having at least two different backbone modifications
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/352—Nature of the modification linked to the nucleic acid via a carbon atom
    • C12N2310/3525—MOE, methoxyethoxy

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  • Animal Behavior & Ethology (AREA)
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  • Epidemiology (AREA)
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  • Wood Science & Technology (AREA)
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  • Dermatology (AREA)
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  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
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CL2019000703A 2016-09-29 2019-03-18 Compuestos y métodos para la reducción de la expresión de tau. CL2019000703A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662401723P 2016-09-29 2016-09-29
US201762450469P 2017-01-25 2017-01-25

Publications (1)

Publication Number Publication Date
CL2019000703A1 true CL2019000703A1 (es) 2019-08-09

Family

ID=61760152

Family Applications (2)

Application Number Title Priority Date Filing Date
CL2019000703A CL2019000703A1 (es) 2016-09-29 2019-03-18 Compuestos y métodos para la reducción de la expresión de tau.
CL2020000183A CL2020000183A1 (es) 2016-09-29 2020-01-21 Compuestos y métodos para la reducción de la expresión de tau. (divisional solicitud 201900703)

Family Applications After (1)

Application Number Title Priority Date Filing Date
CL2020000183A CL2020000183A1 (es) 2016-09-29 2020-01-21 Compuestos y métodos para la reducción de la expresión de tau. (divisional solicitud 201900703)

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US (3) US10407680B2 (enExample)
EP (2) EP3519572B1 (enExample)
JP (4) JP6738004B2 (enExample)
KR (2) KR102286223B1 (enExample)
CN (2) CN113481201A (enExample)
AU (3) AU2017336093B2 (enExample)
BR (2) BR122020019785B1 (enExample)
CA (1) CA3038891C (enExample)
CL (2) CL2019000703A1 (enExample)
CO (1) CO2019001385A2 (enExample)
CR (2) CR20190214A (enExample)
DK (1) DK3519572T5 (enExample)
ES (1) ES2963428T3 (enExample)
FI (1) FI3519572T3 (enExample)
HR (1) HRP20231606T1 (enExample)
HU (1) HUE065170T2 (enExample)
IL (3) IL299615A (enExample)
JO (1) JOP20190065A1 (enExample)
LT (1) LT3519572T (enExample)
MD (1) MD3519572T2 (enExample)
MX (2) MX2019003633A (enExample)
MY (1) MY210293A (enExample)
NZ (1) NZ750642A (enExample)
PE (1) PE20190655A1 (enExample)
PL (1) PL3519572T3 (enExample)
PT (1) PT3519572T (enExample)
RS (1) RS64941B1 (enExample)
SG (1) SG11201901140QA (enExample)
SI (1) SI3519572T1 (enExample)
SM (1) SMT202300441T1 (enExample)
WO (1) WO2018064593A1 (enExample)
ZA (2) ZA201900920B (enExample)

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CA3247235A1 (en) 2018-07-03 2025-11-29 F. Hoffmann-La Roche Ag Oligonucleotides for modulating tau expression
US20220195437A1 (en) * 2020-12-11 2022-06-23 Eisai R&D Management Co., Ltd. Tau-targeting oligonucleotide gapmers
CN117337168A (zh) 2021-04-01 2024-01-02 渤健马萨诸塞州股份有限公司 向中枢神经系统的核酸递送
CA3223192A1 (en) * 2021-06-18 2022-12-22 Ionis Pharmaceuticals, Inc. Compounds and methods for reducing ifnar1 expression
EP4373936A1 (en) * 2021-07-23 2024-05-29 Biogen MA Inc. Methods for reducing tau expression
US20240401055A1 (en) * 2021-07-23 2024-12-05 University Of Kentucky Research Foundation Inhibition of neurofibrillary tangles using oligonucleotides against circular rnas from the microtubule associated protein tau (mapt) locus
KR20240067943A (ko) 2021-09-24 2024-05-17 알닐람 파마슈티칼스 인코포레이티드 미소관 연관 단백질 타우(MAPT) iRNA 제제 조성물 및 이의 사용 방법
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