BR112018073626B1 - Uso cosmético de composto e uso de composição farmacêutica - Google Patents
Uso cosmético de composto e uso de composição farmacêutica Download PDFInfo
- Publication number
- BR112018073626B1 BR112018073626B1 BR112018073626-0A BR112018073626A BR112018073626B1 BR 112018073626 B1 BR112018073626 B1 BR 112018073626B1 BR 112018073626 A BR112018073626 A BR 112018073626A BR 112018073626 B1 BR112018073626 B1 BR 112018073626B1
- Authority
- BR
- Brazil
- Prior art keywords
- methyl
- together form
- sandalwood
- hydrogen
- double bond
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title claims abstract description 27
- 239000002537 cosmetic Substances 0.000 title claims abstract description 7
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract 3
- 210000004761 scalp Anatomy 0.000 claims abstract description 17
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims abstract description 16
- 230000003779 hair growth Effects 0.000 claims abstract description 13
- 239000001257 hydrogen Substances 0.000 claims abstract description 12
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 12
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims abstract description 12
- 201000004384 Alopecia Diseases 0.000 claims abstract description 9
- 230000003676 hair loss Effects 0.000 claims abstract description 9
- 208000024963 hair loss Diseases 0.000 claims abstract description 9
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims abstract description 8
- 230000001737 promoting effect Effects 0.000 claims abstract description 6
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims abstract description 4
- 239000000203 mixture Substances 0.000 claims description 16
- NGYMOTOXXHCHOC-UHFFFAOYSA-N 3-methyl-5-(2,2,3-trimethylcyclopent-3-en-1-yl)pentan-2-ol Chemical compound CC(O)C(C)CCC1CC=C(C)C1(C)C NGYMOTOXXHCHOC-UHFFFAOYSA-N 0.000 claims description 13
- 239000004615 ingredient Substances 0.000 claims description 7
- 238000011200 topical administration Methods 0.000 claims description 5
- 239000003814 drug Substances 0.000 claims description 2
- MTVBNJVZZAQKRV-BJMVGYQFSA-N (e)-2-methyl-4-(2,2,3-trimethylcyclopent-3-en-1-yl)but-2-en-1-ol Chemical compound OCC(/C)=C/CC1CC=C(C)C1(C)C MTVBNJVZZAQKRV-BJMVGYQFSA-N 0.000 claims 2
- QZFSNJAQFWEXEA-MDZDMXLPSA-N (e)-3,3-dimethyl-5-(2,2,3-trimethylcyclopent-3-en-1-yl)pent-4-en-2-ol Chemical compound CC(O)C(C)(C)\C=C\C1CC=C(C)C1(C)C QZFSNJAQFWEXEA-MDZDMXLPSA-N 0.000 claims 2
- RNLHVODSMDJCBR-VURMDHGXSA-N (z)-3-methyl-5-(2,2,3-trimethylcyclopent-3-en-1-yl)pent-4-en-2-ol Chemical compound CC(O)C(C)\C=C/C1CC=C(C)C1(C)C RNLHVODSMDJCBR-VURMDHGXSA-N 0.000 claims 2
- CYVGAJHMMVDTDZ-UHFFFAOYSA-N 2-methyl-4-(2,2,3-trimethylcyclopent-3-en-1-yl)butan-1-ol Chemical compound OCC(C)CCC1CC=C(C)C1(C)C CYVGAJHMMVDTDZ-UHFFFAOYSA-N 0.000 claims 2
- OAKFACUIGQLOCA-UHFFFAOYSA-N [1-methyl-2-[(1,2,2-trimethyl-3-bicyclo[3.1.0]hexanyl)methyl]cyclopropyl]methanol Chemical compound OCC1(C)CC1CC1C(C)(C)C2(C)CC2C1 OAKFACUIGQLOCA-UHFFFAOYSA-N 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 1
- 230000000699 topical effect Effects 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 abstract description 3
- AMQJEAYHLZJPGS-UHFFFAOYSA-N N-Pentanol Chemical compound CCCCCO AMQJEAYHLZJPGS-UHFFFAOYSA-N 0.000 description 70
- 240000000513 Santalum album Species 0.000 description 47
- 235000008632 Santalum album Nutrition 0.000 description 47
- 210000003780 hair follicle Anatomy 0.000 description 35
- 101710153620 Olfactory receptor 2AT4 Proteins 0.000 description 29
- 102100035503 Olfactory receptor 2AT4 Human genes 0.000 description 29
- 210000002510 keratinocyte Anatomy 0.000 description 18
- 239000011159 matrix material Substances 0.000 description 16
- 239000003205 fragrance Substances 0.000 description 13
- 230000000638 stimulation Effects 0.000 description 13
- 210000004209 hair Anatomy 0.000 description 11
- 108050002069 Olfactory receptors Proteins 0.000 description 10
- 230000003778 catagen phase Effects 0.000 description 10
- 238000010586 diagram Methods 0.000 description 10
- 239000003981 vehicle Substances 0.000 description 10
- 102000012547 Olfactory receptors Human genes 0.000 description 9
- 230000000694 effects Effects 0.000 description 9
- 230000014509 gene expression Effects 0.000 description 9
- 238000010166 immunofluorescence Methods 0.000 description 8
- 239000000556 agonist Substances 0.000 description 7
- 230000003698 anagen phase Effects 0.000 description 7
- 230000006907 apoptotic process Effects 0.000 description 7
- 210000004919 hair shaft Anatomy 0.000 description 7
- 230000035755 proliferation Effects 0.000 description 7
- 239000010671 sandalwood oil Substances 0.000 description 7
- 238000012360 testing method Methods 0.000 description 6
- CYVGAJHMMVDTDZ-JQWIXIFHSA-N (2s)-2-methyl-4-[(1s)-2,2,3-trimethylcyclopent-3-en-1-yl]butan-1-ol Chemical compound OC[C@@H](C)CC[C@H]1CC=C(C)C1(C)C CYVGAJHMMVDTDZ-JQWIXIFHSA-N 0.000 description 5
- 230000007423 decrease Effects 0.000 description 5
- 210000003491 skin Anatomy 0.000 description 5
- 210000001519 tissue Anatomy 0.000 description 5
- 239000001306 (7E,9E,11E,13E)-pentadeca-7,9,11,13-tetraen-1-ol Substances 0.000 description 4
- RGSFGYAAUTVSQA-UHFFFAOYSA-N Cyclopentane Chemical compound C1CCCC1 RGSFGYAAUTVSQA-UHFFFAOYSA-N 0.000 description 4
- 239000005557 antagonist Substances 0.000 description 4
- 239000003102 growth factor Substances 0.000 description 4
- 238000011534 incubation Methods 0.000 description 4
- 210000001208 inner root sheath cell Anatomy 0.000 description 4
- 239000002453 shampoo Substances 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- FWBHETKCLVMNFS-UHFFFAOYSA-N 4',6-Diamino-2-phenylindol Chemical compound C1=CC(C(=N)N)=CC=C1C1=CC2=CC=C(C(N)=N)C=C2N1 FWBHETKCLVMNFS-UHFFFAOYSA-N 0.000 description 3
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 3
- 238000012313 Kruskal-Wallis test Methods 0.000 description 3
- 230000004913 activation Effects 0.000 description 3
- OJYKYCDSGQGTRJ-INLOORNJSA-N beta-Santalol Natural products C1C[C@H]2C(=C)[C@](CC\C=C(CO)/C)(C)[C@@H]1C2 OJYKYCDSGQGTRJ-INLOORNJSA-N 0.000 description 3
- OJYKYCDSGQGTRJ-GQYWAMEOSA-N beta-santalol Chemical compound C1C[C@H]2C(=C)[C@@](CC/C=C(CO)/C)(C)[C@@H]1C2 OJYKYCDSGQGTRJ-GQYWAMEOSA-N 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 238000011260 co-administration Methods 0.000 description 3
- 230000006698 induction Effects 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 210000000056 organ Anatomy 0.000 description 3
- 239000002304 perfume Substances 0.000 description 3
- 238000010149 post-hoc-test Methods 0.000 description 3
- 210000004918 root sheath Anatomy 0.000 description 3
- 230000029663 wound healing Effects 0.000 description 3
- OSCJHTSDLYVCQC-UHFFFAOYSA-N 2-ethylhexyl 4-[[4-[4-(tert-butylcarbamoyl)anilino]-6-[4-(2-ethylhexoxycarbonyl)anilino]-1,3,5-triazin-2-yl]amino]benzoate Chemical compound C1=CC(C(=O)OCC(CC)CCCC)=CC=C1NC1=NC(NC=2C=CC(=CC=2)C(=O)NC(C)(C)C)=NC(NC=2C=CC(=CC=2)C(=O)OCC(CC)CCCC)=N1 OSCJHTSDLYVCQC-UHFFFAOYSA-N 0.000 description 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 241000195940 Bryophyta Species 0.000 description 2
- 241000283707 Capra Species 0.000 description 2
- 102000003952 Caspase 3 Human genes 0.000 description 2
- 108090000397 Caspase 3 Proteins 0.000 description 2
- 241000282412 Homo Species 0.000 description 2
- 101150116725 OR2AT4 gene Proteins 0.000 description 2
- 108020004459 Small interfering RNA Proteins 0.000 description 2
- 238000000692 Student's t-test Methods 0.000 description 2
- 150000001298 alcohols Chemical class 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 230000001640 apoptogenic effect Effects 0.000 description 2
- 230000034720 apoptotic signaling pathway Effects 0.000 description 2
- 230000000903 blocking effect Effects 0.000 description 2
- 230000012292 cell migration Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000000723 chemosensory effect Effects 0.000 description 2
- 229940125904 compound 1 Drugs 0.000 description 2
- 230000001934 delay Effects 0.000 description 2
- 239000002781 deodorant agent Substances 0.000 description 2
- 230000001877 deodorizing effect Effects 0.000 description 2
- 230000002500 effect on skin Effects 0.000 description 2
- 210000002322 enterochromaffin cell Anatomy 0.000 description 2
- 230000030279 gene silencing Effects 0.000 description 2
- 238000012226 gene silencing method Methods 0.000 description 2
- 230000031774 hair cycle Effects 0.000 description 2
- DMEGYFMYUHOHGS-UHFFFAOYSA-N heptamethylene Natural products C1CCCCCC1 DMEGYFMYUHOHGS-UHFFFAOYSA-N 0.000 description 2
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
- 230000029411 keratinocyte apoptotic process Effects 0.000 description 2
- 239000002609 medium Substances 0.000 description 2
- 235000011929 mousse Nutrition 0.000 description 2
- 238000011201 multiple comparisons test Methods 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 235000019198 oils Nutrition 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 230000002062 proliferating effect Effects 0.000 description 2
- 235000018102 proteins Nutrition 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 102000005962 receptors Human genes 0.000 description 2
- 108020003175 receptors Proteins 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 238000010186 staining Methods 0.000 description 2
- UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 2
- PDEQKAVEYSOLJX-YHYXMXQVSA-N α-santal-10-en-12-ol Chemical compound C1C2C3(C)C2CC1C3(C)CC/C=C(CO)/C PDEQKAVEYSOLJX-YHYXMXQVSA-N 0.000 description 2
- MJTPMXWJHPOWGH-UHFFFAOYSA-N 2-Phenoxyethyl isobutyrate Chemical compound CC(C)C(=O)OCCOC1=CC=CC=C1 MJTPMXWJHPOWGH-UHFFFAOYSA-N 0.000 description 1
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 1
- 240000001606 Adenanthera pavonina Species 0.000 description 1
- 235000011470 Adenanthera pavonina Nutrition 0.000 description 1
- 244000061520 Angelica archangelica Species 0.000 description 1
- 241000213006 Angelica dahurica Species 0.000 description 1
- 244000024251 Aralia cordata Species 0.000 description 1
- 235000014722 Aralia cordata Nutrition 0.000 description 1
- 235000004446 Aralia racemosa Nutrition 0.000 description 1
- 241000208340 Araliaceae Species 0.000 description 1
- 208000001840 Dandruff Diseases 0.000 description 1
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 description 1
- 244000303040 Glycyrrhiza glabra Species 0.000 description 1
- 235000001287 Guettarda speciosa Nutrition 0.000 description 1
- 235000017443 Hedysarum boreale Nutrition 0.000 description 1
- 235000007858 Hedysarum occidentale Nutrition 0.000 description 1
- 235000000177 Indigofera tinctoria Nutrition 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 1
- 229930182816 L-glutamine Natural products 0.000 description 1
- 235000010658 Lavandula latifolia Nutrition 0.000 description 1
- 241000218378 Magnolia Species 0.000 description 1
- 235000010676 Ocimum basilicum Nutrition 0.000 description 1
- 240000007926 Ocimum gratissimum Species 0.000 description 1
- 101710200212 Olfactory receptor 1 Proteins 0.000 description 1
- 235000006484 Paeonia officinalis Nutrition 0.000 description 1
- 244000170916 Paeonia officinalis Species 0.000 description 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- 229930040373 Paraformaldehyde Natural products 0.000 description 1
- 229930182555 Penicillin Natural products 0.000 description 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
- 102000003992 Peroxidases Human genes 0.000 description 1
- 235000008331 Pinus X rigitaeda Nutrition 0.000 description 1
- 241000018646 Pinus brutia Species 0.000 description 1
- 235000011613 Pinus brutia Nutrition 0.000 description 1
- 206010060862 Prostate cancer Diseases 0.000 description 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 description 1
- 238000011529 RT qPCR Methods 0.000 description 1
- 241000220317 Rosa Species 0.000 description 1
- 244000178231 Rosmarinus officinalis Species 0.000 description 1
- 235000017276 Salvia Nutrition 0.000 description 1
- 240000007164 Salvia officinalis Species 0.000 description 1
- 244000297179 Syringa vulgaris Species 0.000 description 1
- 235000004338 Syringa vulgaris Nutrition 0.000 description 1
- 102000011117 Transforming Growth Factor beta2 Human genes 0.000 description 1
- 101800000304 Transforming growth factor beta-2 Proteins 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 238000012197 amplification kit Methods 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000003542 behavioural effect Effects 0.000 description 1
- 229960002685 biotin Drugs 0.000 description 1
- 239000011616 biotin Substances 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 239000005018 casein Substances 0.000 description 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
- 235000021240 caseins Nutrition 0.000 description 1
- 210000005056 cell body Anatomy 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 230000035605 chemotaxis Effects 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 239000010634 clove oil Substances 0.000 description 1
- 235000019864 coconut oil Nutrition 0.000 description 1
- 239000003240 coconut oil Substances 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 229940125898 compound 5 Drugs 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- -1 cyclopenten-l-yl Chemical group 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000012350 deep sequencing Methods 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 230000003828 downregulation Effects 0.000 description 1
- 230000005014 ectopic expression Effects 0.000 description 1
- 239000003974 emollient agent Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 210000002919 epithelial cell Anatomy 0.000 description 1
- 239000010642 eucalyptus oil Substances 0.000 description 1
- 229940044949 eucalyptus oil Drugs 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 235000008434 ginseng Nutrition 0.000 description 1
- 239000001947 glycyrrhiza glabra rhizome/root Substances 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 230000037308 hair color Effects 0.000 description 1
- 239000000118 hair dye Substances 0.000 description 1
- 239000008266 hair spray Substances 0.000 description 1
- 210000005260 human cell Anatomy 0.000 description 1
- 229960000890 hydrocortisone Drugs 0.000 description 1
- 238000002991 immunohistochemical analysis Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 229940097275 indigo Drugs 0.000 description 1
- COHYTHOBJLSHDF-UHFFFAOYSA-N indigo powder Natural products N1C2=CC=CC=C2C(=O)C1=C1C(=O)C2=CC=CC=C2N1 COHYTHOBJLSHDF-UHFFFAOYSA-N 0.000 description 1
- 239000000411 inducer Substances 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 238000000021 kinase assay Methods 0.000 description 1
- 239000000171 lavandula angustifolia l. flower oil Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 238000001531 micro-dissection Methods 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 238000010232 migration assay Methods 0.000 description 1
- 230000003278 mimic effect Effects 0.000 description 1
- 210000002850 nasal mucosa Anatomy 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 210000001331 nose Anatomy 0.000 description 1
- 229920002866 paraformaldehyde Polymers 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- 108040007629 peroxidase activity proteins Proteins 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000011533 pre-incubation Methods 0.000 description 1
- 230000003658 preventing hair loss Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 239000000018 receptor agonist Substances 0.000 description 1
- 229940044601 receptor agonist Drugs 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 150000004354 sesquiterpene derivatives Chemical group 0.000 description 1
- 230000019491 signal transduction Effects 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 238000001256 steam distillation Methods 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 229960005322 streptomycin Drugs 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 230000002381 testicular Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 238000013042 tunel staining Methods 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/02—Preparations for cleaning the hair
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Birds (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITUA2016A003604A ITUA20163604A1 (it) | 2016-05-19 | 2016-05-19 | Composti atti a promuovere la crescita dei capelli nell'uomo e/o a fermarne o ritardarne la caduta, e composizioni per tali usi |
| IT102016000051626 | 2016-05-19 | ||
| PCT/EP2017/062110 WO2017198818A1 (en) | 2016-05-19 | 2017-05-19 | Compounds for promoting hair growth and/or inhibiting or delaying hair loss in humans, and compositions for such uses |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112018073626A2 BR112018073626A2 (pt) | 2019-02-26 |
| BR112018073626B1 true BR112018073626B1 (pt) | 2022-02-08 |
Family
ID=56990747
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112018073626-0A BR112018073626B1 (pt) | 2016-05-19 | 2017-05-19 | Uso cosmético de composto e uso de composição farmacêutica |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US10898419B2 (enExample) |
| EP (1) | EP3458020B1 (enExample) |
| JP (1) | JP7034944B2 (enExample) |
| KR (1) | KR102452350B1 (enExample) |
| CN (1) | CN109310597B (enExample) |
| AU (1) | AU2017267278B2 (enExample) |
| BR (1) | BR112018073626B1 (enExample) |
| CA (1) | CA3024001C (enExample) |
| CY (1) | CY1123780T1 (enExample) |
| DK (1) | DK3458020T3 (enExample) |
| ES (1) | ES2851899T3 (enExample) |
| HR (1) | HRP20210223T1 (enExample) |
| HU (1) | HUE053265T2 (enExample) |
| IT (1) | ITUA20163604A1 (enExample) |
| LT (1) | LT3458020T (enExample) |
| MA (1) | MA45043B1 (enExample) |
| MD (1) | MD3458020T2 (enExample) |
| MX (1) | MX379050B (enExample) |
| PL (1) | PL3458020T3 (enExample) |
| PT (1) | PT3458020T (enExample) |
| RS (1) | RS61407B1 (enExample) |
| RU (1) | RU2741021C2 (enExample) |
| SG (2) | SG10202011357RA (enExample) |
| SI (1) | SI3458020T1 (enExample) |
| SM (1) | SMT202100139T1 (enExample) |
| UA (1) | UA124236C2 (enExample) |
| WO (1) | WO2017198818A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT201800005585A1 (it) * | 2018-05-22 | 2019-11-22 | Composti per prevenire e trattare affezioni della pelle o della mucosa con componente infiammatoria | |
| US20210393545A1 (en) * | 2018-09-29 | 2021-12-23 | Robert John Petcavich | Natural product composition for stimulating hair growth |
| FR3110425B1 (fr) * | 2020-05-19 | 2022-09-09 | Isp Investments Llc | Procede d’obtention d’un extrait de bois de santal, compositions le comprenant et ses utilisations cosmetiques |
| JP7629096B2 (ja) | 2020-11-30 | 2025-02-12 | ウェラ ジャーマニー ゲーエムベーハー | 抗脱毛組成物 |
| US11999691B2 (en) | 2020-12-19 | 2024-06-04 | Actera Ingredients, Inc. | Odorless active agents |
| JP7642955B2 (ja) * | 2021-02-04 | 2025-03-11 | 株式会社ファンケル | 嗅覚受容体発現促進用組成物 |
| WO2022202714A1 (ja) | 2021-03-22 | 2022-09-29 | 株式会社 資生堂 | メルケル細胞活性化剤、シナプス小胞の増強剤、神経伝達物質放出促進剤、メルケル細胞の神経伝達物質放出活性の評価方法、並びにメルケル細胞の神経伝達物質放出促進剤のスクリーニング方法 |
| US20240374497A1 (en) * | 2021-10-01 | 2024-11-14 | Coty Inc. | Compositions comprising or2at4 agonists |
| IT202200010358A1 (it) * | 2022-05-18 | 2023-11-18 | Giuliani Spa | Agonista del recettore olfattivo 2a4/7 per promuovere la crescita di capelli e migliorare l’aspetto estetico / olfactory receptor 2a4/7 agonist for promoting hair growth and improving aesthetic aspect |
| EP4531801A1 (en) | 2022-05-25 | 2025-04-09 | Wella Germany GmbH | Improving hair structure |
| EP4545063A1 (en) * | 2023-10-23 | 2025-04-30 | Wella Germany GmbH | Cosmetical use of a topically applicable rinse-of composition (rc) |
| EP4620463A1 (en) * | 2024-03-22 | 2025-09-24 | CUTANEON - Skin & Hair Innovations GmbH | Active agent for use in hair growth regulation |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4052341A (en) | 1976-04-29 | 1977-10-04 | Givaudan Corporation | 3-methyl-5-(2,2,3-trimethylcyclopent-3-en-1-yl)pentan-2-ol compound and perfume compositions |
| CN1075250A (zh) | 1992-10-27 | 1993-08-18 | 海南南洋实业有限公司 | 香波的生产方法 |
| JP4020284B2 (ja) * | 1999-05-27 | 2007-12-12 | 株式会社マンダム | 育毛剤原料及び育毛剤組成物 |
| JP2001151644A (ja) * | 1999-11-29 | 2001-06-05 | Kao Corp | 頭皮臭用香料組成物 |
| JP3877537B2 (ja) * | 2001-03-07 | 2007-02-07 | 高砂香料工業株式会社 | 口腔用組成物用抗菌剤およびそれを含む口腔用組成物 |
| JP2003277246A (ja) * | 2002-03-22 | 2003-10-02 | Takasago Internatl Corp | 消臭剤組成物 |
| JP3947149B2 (ja) | 2002-10-28 | 2007-07-18 | 高砂香料工業株式会社 | 消臭剤組成物 |
| JP2006160698A (ja) * | 2004-12-10 | 2006-06-22 | Noevir Co Ltd | Vegf産生促進剤、育毛剤、及び創傷治癒剤 |
| US7879910B1 (en) * | 2006-10-10 | 2011-02-01 | Jan Marini Skin Research, Inc. | Compositions and methods for promoting lush hair growth |
| US20090197939A1 (en) | 2008-02-01 | 2009-08-06 | Mary Kay Inc. | Methods of treating skin with aromatic skin-active ingredients |
| CN102000293A (zh) | 2010-12-05 | 2011-04-06 | 孟凡伟 | 一种中药养发配方 |
| US9585826B2 (en) | 2012-11-07 | 2017-03-07 | Kimberly-Clark Worldwide, Inc. | Triggerable compositions for two-stage, controlled release of active chemistry |
| CN103735443A (zh) | 2013-12-10 | 2014-04-23 | 河南孟诜堂药业有限公司 | 一种止脱柔顺洗发液及其制备方法 |
| EP2957283B1 (de) * | 2014-06-19 | 2022-12-21 | Symrise AG | Verfahren zur Identifizierung von Medikamenten zur Beschleunigung der Wundheilung |
-
2016
- 2016-05-19 IT ITUA2016A003604A patent/ITUA20163604A1/it unknown
-
2017
- 2017-05-19 PL PL17730678T patent/PL3458020T3/pl unknown
- 2017-05-19 HU HUE17730678A patent/HUE053265T2/hu unknown
- 2017-05-19 DK DK17730678.4T patent/DK3458020T3/da active
- 2017-05-19 RS RS20210106A patent/RS61407B1/sr unknown
- 2017-05-19 JP JP2018559992A patent/JP7034944B2/ja active Active
- 2017-05-19 MA MA45043A patent/MA45043B1/fr unknown
- 2017-05-19 AU AU2017267278A patent/AU2017267278B2/en active Active
- 2017-05-19 SG SG10202011357RA patent/SG10202011357RA/en unknown
- 2017-05-19 CN CN201780030965.7A patent/CN109310597B/zh active Active
- 2017-05-19 SM SM20210139T patent/SMT202100139T1/it unknown
- 2017-05-19 CA CA3024001A patent/CA3024001C/en active Active
- 2017-05-19 EP EP17730678.4A patent/EP3458020B1/en active Active
- 2017-05-19 LT LTEP17730678.4T patent/LT3458020T/lt unknown
- 2017-05-19 BR BR112018073626-0A patent/BR112018073626B1/pt active IP Right Grant
- 2017-05-19 US US16/302,472 patent/US10898419B2/en active Active
- 2017-05-19 SI SI201730632T patent/SI3458020T1/sl unknown
- 2017-05-19 ES ES17730678T patent/ES2851899T3/es active Active
- 2017-05-19 PT PT177306784T patent/PT3458020T/pt unknown
- 2017-05-19 RU RU2018144755A patent/RU2741021C2/ru active
- 2017-05-19 MD MDE20190369T patent/MD3458020T2/ro unknown
- 2017-05-19 WO PCT/EP2017/062110 patent/WO2017198818A1/en not_active Ceased
- 2017-05-19 HR HRP20210223TT patent/HRP20210223T1/hr unknown
- 2017-05-19 SG SG11201810318RA patent/SG11201810318RA/en unknown
- 2017-05-19 UA UAA201811736A patent/UA124236C2/uk unknown
- 2017-05-19 KR KR1020187035315A patent/KR102452350B1/ko active Active
- 2017-05-19 MX MX2018013763A patent/MX379050B/es unknown
-
2021
- 2021-02-05 CY CY20211100098T patent/CY1123780T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR112018073626B1 (pt) | Uso cosmético de composto e uso de composição farmacêutica | |
| Fu et al. | Dihydrotestosterone-induced hair regrowth inhibition by activating androgen receptor in C57BL6 mice simulates androgenetic alopecia | |
| US8025893B2 (en) | Use of a specific inhibitor of hedgehog/smoothened signaling on hyperpigmented skin to obtain decrease of pigmentation | |
| ES2895660T3 (es) | Composición para estimular el crecimiento del cabello | |
| JP6923927B2 (ja) | 脱毛および白毛化を抑制もしくは改善するための組成物ならびにその使用 | |
| JP2003171240A (ja) | 白髪予防改善剤及び毛髪有効成分のスクリーニング方法 | |
| KR20190075192A (ko) | 며느리밑씻개 추출물을 포함하는 건선 예방 또는 치료용 조성물 | |
| JP5784499B2 (ja) | 5α−レダクターゼ酵素活性を阻害するための化合物の使用、並びにそれを含有する医薬及び化粧品組成物 | |
| WO2002022088A1 (en) | Hair nourishments and method of screening the same | |
| CN1946372B (zh) | 使用热休克蛋白抑制剂制备减少毛发生长的制剂的用途 | |
| WO2021147740A1 (zh) | Mapk/erk通路抑制剂在拮抗皮肤老化与辐射性皮肤早衰中的应用 | |
| HK40006226A (en) | Compounds for promoting hair growth and/or inhibiting or delaying hair loss in humans, and compositions for such uses | |
| HK40006226B (en) | Compounds for promoting hair growth and/or inhibiting or delaying hair loss in humans, and compositions for such uses | |
| JP4268329B2 (ja) | 養毛料、毛髪退行期移行抑制剤等の予防あるいは治療用組成物 | |
| KR101587612B1 (ko) | 피노카베올을 유효성분으로 포함하는 탈모 예방 또는 치료용, 또는 발모 또는 육모 촉진용 조성물 | |
| WO2023056029A1 (en) | Beta3-adrenergic agonists for treatment of disorders of hair growth | |
| JP2002114700A (ja) | メラノサイト活性化剤 | |
| KR20190075193A (ko) | 애기수영 추출물을 포함하는 건선 예방 또는 치료용 조성물 | |
| KR20140131193A (ko) | 태반성장인자를 표적으로 하는 모발 성장 조절 방법 및 조성물 | |
| BR102015007993B1 (pt) | composição cosmecêutica e/ou dermatológica, seu processo de produção e seu uso |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06W | Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette] | ||
| B350 | Update of information on the portal [chapter 15.35 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 19/05/2017, OBSERVADAS AS CONDICOES LEGAIS. |