BR112018073613A2 - composição veterinária monodose para aplicação tópica (spot on) para caninos e uso de uma quantidade eficaz de imidacloprido, moxidectina, praziquantel e um solvente aprótico - Google Patents

composição veterinária monodose para aplicação tópica (spot on) para caninos e uso de uma quantidade eficaz de imidacloprido, moxidectina, praziquantel e um solvente aprótico

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Publication number
BR112018073613A2
BR112018073613A2 BR112018073613-9A BR112018073613A BR112018073613A2 BR 112018073613 A2 BR112018073613 A2 BR 112018073613A2 BR 112018073613 A BR112018073613 A BR 112018073613A BR 112018073613 A2 BR112018073613 A2 BR 112018073613A2
Authority
BR
Brazil
Prior art keywords
praziquantel
moxidectin
imidacloprid
aprotic solvent
canines
Prior art date
Application number
BR112018073613-9A
Other languages
English (en)
Inventor
D. Corrales Carlos
A. Dale Jorge
Original Assignee
Labyes Usa, Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Labyes Usa, Llc filed Critical Labyes Usa, Llc
Publication of BR112018073613A2 publication Critical patent/BR112018073613A2/pt

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A61K9/0017—Non-human animal skin, e.g. pour-on, spot-on
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/14—Ectoparasiticides, e.g. scabicides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Dermatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

a presente invenção refere-se a uma composição veterinária monodose para aplicação tópica (spot on) para caninos, a dita composição compreendendo: (a) imidacloprido, entre 8,18 e 10,00%, (b) moxidectina, entre 2,86 e 3,50%, (c) praziquantel, entre 8,18 e 10,00 % e (d) um solvente aprótico selecionado a partir de dimetilsulfóxido (dmso), n,n-dimetilacetamida (dmac), n,n-dimetilformamida (dmf) e suas misturas, entre 65,45 e 80,00%; em conjunto com excipientes aceitáveis do ponto de vista veterinário, em que as porcentagens se referem ao peso total da composição. o uso de uma quantidade eficaz de (a) imidacloprido, (b) moxidectina; (c) praziquantel; e (d) um solvente aprótico selecionado a partir de dimetilsulfóxido (dmso), n,n-dimetilacetamida (dmac), n,n-dimetilformamida (dmf) e misturas destes, em conjunto com excipientes veterinários aceitáveis.
BR112018073613-9A 2016-05-18 2017-05-16 composição veterinária monodose para aplicação tópica (spot on) para caninos e uso de uma quantidade eficaz de imidacloprido, moxidectina, praziquantel e um solvente aprótico BR112018073613A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ARP160101448A AR104691A1 (es) 2016-05-18 2016-05-18 Composición veterinaria de imidacloprid, moxidectina y praziquantel de administración tópica cutánea (spot on) para tratamiento y prevención de las ecto y endoparasitosis que afectan a los perros
AR20160101448 2016-05-18
PCT/US2017/032851 WO2017201010A1 (en) 2016-05-18 2017-05-16 Veterinary composition comprising imidacloprid, moxidectin and praziquantel for cutaneous topical application (spot on), for the treatment and prevention of ecto and endoparasitoses affecting dogs

Publications (1)

Publication Number Publication Date
BR112018073613A2 true BR112018073613A2 (pt) 2019-02-26

Family

ID=59714807

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018073613-9A BR112018073613A2 (pt) 2016-05-18 2017-05-16 composição veterinária monodose para aplicação tópica (spot on) para caninos e uso de uma quantidade eficaz de imidacloprido, moxidectina, praziquantel e um solvente aprótico

Country Status (9)

Country Link
US (1) US10695331B2 (pt)
EP (1) EP3458051B1 (pt)
JP (2) JP2019516793A (pt)
CN (3) CN115645412A (pt)
AR (1) AR104691A1 (pt)
BR (1) BR112018073613A2 (pt)
ES (1) ES2954856T3 (pt)
MX (1) MX2018013630A (pt)
WO (1) WO2017201010A1 (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20220331314A1 (en) * 2019-08-14 2022-10-20 Vetoquinol Sa Compositions comprising tigolaner for controlling parasites
CN110772509A (zh) * 2019-10-17 2020-02-11 广东省农业科学院动物卫生研究所 一种吡虫啉与莫昔克丁二元醇质体及其制备方法和应用
EP3815677B1 (en) 2019-10-30 2023-08-30 KRKA, d.d., Novo mesto Stable veterinary composition comprising moxidectin and imidacloprid
CN114259464B (zh) * 2021-11-25 2022-11-22 吉林大学 一种复方莫昔克丁外用滴剂

Family Cites Families (11)

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US4447414A (en) * 1982-12-21 1984-05-08 Cutter Laboratories, Inc. Carnivore anthelmintics
JPS6058914A (ja) * 1983-09-12 1985-04-05 Shionogi & Co Ltd イミダゾ−ル系抗真菌性外用ゲル製剤
HUE032009T2 (en) * 2003-04-04 2017-09-28 Merial Inc Veterinary preparations for topical veterinary use
US8247423B2 (en) * 2007-07-12 2012-08-21 Tragara Pharmaceuticals, Inc. Methods and compositions for the treatment of cancer, tumors, and tumor-related disorders
KR20100038118A (ko) * 2007-07-31 2010-04-12 와이어쓰 엘엘씨 체내구충 국소 조성물
GB0905365D0 (en) * 2009-03-27 2009-05-13 Norbrook Lab Ltd A topical parasiticide composition
CN101933929A (zh) * 2009-07-02 2011-01-05 天津瑞普生物技术股份有限公司 一种驱除犬、猫体内外寄生虫的复方制剂及其制备方法
CA2784141C (en) 2009-12-17 2017-10-24 Merial Limited Compositions comprising macrocyclic lactone compounds and spirodioxepinoindoles
JO3626B1 (ar) * 2012-02-23 2020-08-27 Merial Inc تركيبات موضعية تحتوي على فيبرونيل و بيرميثرين و طرق استخدامها
DK2898064T3 (en) * 2012-09-19 2019-03-04 Microvascular Tissues Inc COMPOSITIONS FOR TREATMENT AND PREVENTION OF TISSUE DAMAGE AND DISEASE
EP3171860A4 (en) * 2014-07-25 2017-08-09 Laurent Pharmaceuticals Solid oral formulation of fenretinide

Also Published As

Publication number Publication date
CN115737649A (zh) 2023-03-07
JP2019516793A (ja) 2019-06-20
US20190070158A1 (en) 2019-03-07
JP2022052770A (ja) 2022-04-04
ES2954856T3 (es) 2023-11-27
AR104691A1 (es) 2017-08-09
EP3458051C0 (en) 2023-06-07
WO2017201010A1 (en) 2017-11-23
US10695331B2 (en) 2020-06-30
EP3458051A4 (en) 2020-01-08
JP7255043B2 (ja) 2023-04-11
CN108883092A (zh) 2018-11-23
MX2018013630A (es) 2019-06-17
EP3458051B1 (en) 2023-06-07
CN115645412A (zh) 2023-01-31
EP3458051A1 (en) 2019-03-27

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B06W Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]