BR112018071347A2 - moduladores de nlrp3 - Google Patents
moduladores de nlrp3Info
- Publication number
- BR112018071347A2 BR112018071347A2 BR112018071347A BR112018071347A BR112018071347A2 BR 112018071347 A2 BR112018071347 A2 BR 112018071347A2 BR 112018071347 A BR112018071347 A BR 112018071347A BR 112018071347 A BR112018071347 A BR 112018071347A BR 112018071347 A2 BR112018071347 A2 BR 112018071347A2
- Authority
- BR
- Brazil
- Prior art keywords
- nlrp3
- disease
- condition
- disorder
- compound
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
a presente invenção refere-se a entidades químicas (por exemplo, um composto ou um sal farmaceuticamente aceitável, e/ou hidrato, e/ou cocristal, e/ou combinação de fármaco do composto) que modulam (por exemplo, agonizam ou agonizam parcialmente) nlrp3 que é útil, por exemplo, para tratar uma condição, doença ou distúrbio em que uma diminuição em atividade de nlrp3 (por exemplo, uma condição, doença ou distúrbio associado com sinalização de nlrp3 reprimida ou prejudicada) contribui para a patologia e/ou sintomas e/ou progressão da condição, doença ou distúrbio (por exemplo, câncer) em um indivíduo (por exemplo, um humano). esta invenção também apresenta composições, bem como, outros métodos de usar e preparar as mesmas.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662324626P | 2016-04-19 | 2016-04-19 | |
US201762460519P | 2017-02-17 | 2017-02-17 | |
PCT/US2017/028384 WO2017184746A1 (en) | 2016-04-19 | 2017-04-19 | Nlrp3 modulators |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112018071347A2 true BR112018071347A2 (pt) | 2019-02-05 |
Family
ID=58672702
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112018071347A BR112018071347A2 (pt) | 2016-04-19 | 2017-04-19 | moduladores de nlrp3 |
Country Status (12)
Country | Link |
---|---|
US (2) | US10556903B2 (pt) |
EP (1) | EP3445761A1 (pt) |
JP (1) | JP7104633B6 (pt) |
KR (1) | KR20180134395A (pt) |
CN (1) | CN109071535B (pt) |
AU (1) | AU2017252640A1 (pt) |
BR (1) | BR112018071347A2 (pt) |
CA (1) | CA3021349A1 (pt) |
IL (1) | IL262303A (pt) |
MX (1) | MX2018012249A (pt) |
SG (1) | SG11201809082WA (pt) |
WO (1) | WO2017184746A1 (pt) |
Families Citing this family (59)
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WO2019123340A1 (en) | 2017-12-20 | 2019-06-27 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 3'3' cyclic dinucleotides with phosphonate bond activating the sting adaptor protein |
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2017
- 2017-04-19 AU AU2017252640A patent/AU2017252640A1/en not_active Abandoned
- 2017-04-19 JP JP2018554782A patent/JP7104633B6/ja active Active
- 2017-04-19 MX MX2018012249A patent/MX2018012249A/es unknown
- 2017-04-19 EP EP17722231.2A patent/EP3445761A1/en active Pending
- 2017-04-19 US US16/093,990 patent/US10556903B2/en active Active
- 2017-04-19 KR KR1020187032949A patent/KR20180134395A/ko not_active Application Discontinuation
- 2017-04-19 CA CA3021349A patent/CA3021349A1/en not_active Abandoned
- 2017-04-19 SG SG11201809082WA patent/SG11201809082WA/en unknown
- 2017-04-19 CN CN201780024285.4A patent/CN109071535B/zh active Active
- 2017-04-19 WO PCT/US2017/028384 patent/WO2017184746A1/en active Application Filing
- 2017-04-19 BR BR112018071347A patent/BR112018071347A2/pt not_active Application Discontinuation
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US11072612B2 (en) | 2021-07-27 |
CN109071535A (zh) | 2018-12-21 |
KR20180134395A (ko) | 2018-12-18 |
US10556903B2 (en) | 2020-02-11 |
CN109071535B (zh) | 2021-10-08 |
JP2019513809A (ja) | 2019-05-30 |
JP7104633B2 (ja) | 2022-07-21 |
MX2018012249A (es) | 2019-02-07 |
JP7104633B6 (ja) | 2023-12-22 |
US20190127367A1 (en) | 2019-05-02 |
US20200157097A1 (en) | 2020-05-21 |
AU2017252640A1 (en) | 2018-12-06 |
CA3021349A1 (en) | 2017-10-26 |
SG11201809082WA (en) | 2018-11-29 |
IL262303A (en) | 2018-12-31 |
EP3445761A1 (en) | 2019-02-27 |
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