BR112017021970A2 - bioconjugados e usos dos mesmos - Google Patents

bioconjugados e usos dos mesmos

Info

Publication number
BR112017021970A2
BR112017021970A2 BR112017021970A BR112017021970A BR112017021970A2 BR 112017021970 A2 BR112017021970 A2 BR 112017021970A2 BR 112017021970 A BR112017021970 A BR 112017021970A BR 112017021970 A BR112017021970 A BR 112017021970A BR 112017021970 A2 BR112017021970 A2 BR 112017021970A2
Authority
BR
Brazil
Prior art keywords
binding unit
bioconjugates
peptides
glycan
vcam
Prior art date
Application number
BR112017021970A
Other languages
English (en)
Inventor
Prestwich Glenn
Eric Paderi John
Chen Julia
lloyd bartlett ii Rush
Original Assignee
Symic Ip Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Symic Ip Llc filed Critical Symic Ip Llc
Publication of BR112017021970A2 publication Critical patent/BR112017021970A2/pt

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
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    • A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
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    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
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    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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    • A61L27/54—Biologically active materials, e.g. therapeutic substances
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    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
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    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Obesity (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)

Abstract

são aqui fornecidos bioconjugados compreendendo um glicano e de 1 a cerca de 50 peptídeos ligados, em que os peptídeos compreendem uma unidade de ligação ao colágeno, uma unidade de ligação ao ácido hialurônico, uma unidade de ligação a icam, uma unidade de ligação a vcam e/ou uma unidade de ligação à selectina, composições contendo-os e suas utilizações.
BR112017021970A 2015-04-17 2016-04-15 bioconjugados e usos dos mesmos BR112017021970A2 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562149428P 2015-04-17 2015-04-17
US201562241057P 2015-10-13 2015-10-13
US201562244665P 2015-10-21 2015-10-21
PCT/US2016/027953 WO2016168743A1 (en) 2015-04-17 2016-04-15 Bioconjugates and uses thereof

Publications (1)

Publication Number Publication Date
BR112017021970A2 true BR112017021970A2 (pt) 2018-07-10

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ID=55809257

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112017021970A BR112017021970A2 (pt) 2015-04-17 2016-04-15 bioconjugados e usos dos mesmos

Country Status (17)

Country Link
US (3) US20160331841A1 (pt)
EP (1) EP3283124B1 (pt)
JP (2) JP2018513879A (pt)
KR (1) KR20180016988A (pt)
CN (1) CN107771085A (pt)
AU (1) AU2016248341B2 (pt)
BR (1) BR112017021970A2 (pt)
CA (1) CA2982680A1 (pt)
EA (1) EA201792245A1 (pt)
HK (1) HK1251183A1 (pt)
IL (1) IL254977B (pt)
MA (1) MA44262A (pt)
MX (1) MX2017013196A (pt)
PH (1) PH12017501863A1 (pt)
SG (2) SG11201708357QA (pt)
TW (1) TW201718019A (pt)
WO (1) WO2016168743A1 (pt)

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US8846003B2 (en) 2008-03-27 2014-09-30 Symic Biomedical, Inc. Collagen-binding synthetic peptidoglycans, preparation, and methods of use
EA201591454A1 (ru) 2013-03-15 2015-12-30 Симик Биомедикал, Инк. Связывающие внеклеточный матрикс синтетические пептидогликаны
CN110403730A (zh) 2013-12-10 2019-11-05 诺瓦普拉斯玛有限公司 用于操作植入物的容器、仪器和方法
US10772931B2 (en) 2014-04-25 2020-09-15 Purdue Research Foundation Collagen binding synthetic peptidoglycans for treatment of endothelial dysfunction
AU2015259298A1 (en) 2014-05-12 2017-01-05 Purdue Research Foundation Selectin and ICAM/VCAM peptide ligand conjugates
BR112017024018A2 (pt) * 2015-05-11 2018-07-17 Nova Plasma Ltd aparelho e método para manipulação de um implante
JP6876217B2 (ja) * 2017-05-19 2021-05-26 二村　芳弘 抗炎症作用を呈するペプチドグリカン誘導体
WO2019010490A1 (en) * 2017-07-07 2019-01-10 Symic Ip, Llc BIOCONJUGATES WITH CHEMICALLY MODIFIED SKELETONS
CN110809478A (zh) * 2017-07-07 2020-02-18 斯米克Ip有限公司 合成的生物缀合物
US11495438B2 (en) 2017-08-16 2022-11-08 Nova Plasma Ltd. Plasma treating an implant
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