BR112016002435A2 - proteínas biomarcadoras da síndrome urêmica hemolítica atípica - Google Patents

proteínas biomarcadoras da síndrome urêmica hemolítica atípica

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Publication number
BR112016002435A2
BR112016002435A2 BR112016002435A BR112016002435A BR112016002435A2 BR 112016002435 A2 BR112016002435 A2 BR 112016002435A2 BR 112016002435 A BR112016002435 A BR 112016002435A BR 112016002435 A BR112016002435 A BR 112016002435A BR 112016002435 A2 BR112016002435 A2 BR 112016002435A2
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BR
Brazil
Prior art keywords
ahus
biomarker proteins
uremic syndrome
treatment
hemolytic uremic
Prior art date
Application number
BR112016002435A
Other languages
English (en)
Other versions
BR112016002435A8 (pt
Inventor
Kukreja Anjli
A Bedard Krystin (Falecida)
Cofiell Roxanne
Faas Mcknight Susan
Yan Yan
Original Assignee
Alexion Pharmeceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Alexion Pharmeceuticals Inc filed Critical Alexion Pharmeceuticals Inc
Priority to BR122020019190-2A priority Critical patent/BR122020019190B1/pt
Publication of BR112016002435A2 publication Critical patent/BR112016002435A2/pt
Publication of BR112016002435A8 publication Critical patent/BR112016002435A8/pt

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
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    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/54F(ab')2
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55Fab or Fab'
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/60Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622Single chain antibody (scFv)
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
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    • C07K2317/60Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/626Diabody or triabody
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • GPHYSICS
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    • G01N2333/46Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701Details
    • G01N2333/4716Complement proteins, e.g. anaphylatoxin, C3a, C5a
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    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/475Assays involving growth factors
    • G01N2333/485Epidermal growth factor [EGF] (urogastrone)
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    • G01N2333/522Alpha-chemokines, e.g. NAP-2, ENA-78, GRO-alpha/MGSA/NAP-3, GRO-beta/MIP-2alpha, GRO-gamma/MIP-2beta, IP-10, GCP-2, MIG, PBSF, PF-4 or KC
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    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
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    • G01N2333/54Interleukins [IL]
    • G01N2333/5434IL-12
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N2333/52Assays involving cytokines
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    • G01MEASURING; TESTING
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    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
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    • G01N2333/705Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
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    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
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    • G01N2333/70539MHC-molecules, e.g. HLA-molecules
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    • G01N2333/715Assays involving receptors, cell surface antigens or cell surface determinants for cytokines; for lymphokines; for interferons
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    • G01N2333/7452Thrombomodulin
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    • G01N2333/775Apolipopeptides
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    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
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    • G01N2333/8107Endopeptidase (E.C. 3.4.21-99) inhibitors
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    • G01N2333/90Enzymes; Proenzymes
    • G01N2333/914Hydrolases (3)
    • G01N2333/948Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/974Thrombin
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    • G01N2800/22Haematology
    • G01N2800/226Thrombotic disorders, i.e. thrombo-embolism irrespective of location/organ involved, e.g. renal vein thrombosis, venous thrombosis
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    • G01N2800/347Renal failures; Glomerular diseases; Tubulointerstitial diseases, e.g. nephritic syndrome, glomerulonephritis; Renovascular diseases, e.g. renal artery occlusion, nephropathy
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    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
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Abstract

a divulgação fornece proteínas biomarcadoras, uma mudança na concentração ou nível de atividade das quais está associada com a síndrome urêmica hemolítica atípica (ahus) ou tratamento clinicamente significativo de ahus com um inibidor de complemento. também são fornecidos composições e métodos para apurar a concentração e/ou atividade de uma ou mais das proteínas biomarcadoras em um fluído biológico. as composições e métodos são úteis, entre outras coisas, para avaliar o risco de desenvolver ahus, diagnosticar ahus, determinar se um indivíduo está experienciando a primeira apresentação aguda de ahus, monitorar a progressão ou diminuição de ahus, e/ou monitorar a resposta ao tratamento com um inibidor de complemento ou otimizar tal tratamento.
BR112016002435A 2013-08-07 2014-08-06 proteínas biomarcadoras da síndrome urêmica hemolítica atípica BR112016002435A8 (pt)

Priority Applications (1)

Application Number Priority Date Filing Date Title
BR122020019190-2A BR122020019190B1 (pt) 2013-08-07 2014-08-06 Métodos para monitorar a responsividade de um indivíduo ao tratamento com um inibidor do complemento, métodos para diagnosticar um indivíduo tendo ou com risco de desenvolver síndrome urêmica hemolítica atípica (ahus) e uso de um kit de diagnóstico para diagnosticar ahus

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361863299P 2013-08-07 2013-08-07
US201361913180P 2013-12-06 2013-12-06
PCT/US2014/049957 WO2015021166A2 (en) 2013-08-07 2014-08-06 Atypical hemolytic uremic syndrome biomarker proteins

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BR112016002435A2 true BR112016002435A2 (pt) 2017-09-12
BR112016002435A8 BR112016002435A8 (pt) 2020-09-29

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BR112016002435A BR112016002435A8 (pt) 2013-08-07 2014-08-06 proteínas biomarcadoras da síndrome urêmica hemolítica atípica
BR122020019190-2A BR122020019190B1 (pt) 2013-08-07 2014-08-06 Métodos para monitorar a responsividade de um indivíduo ao tratamento com um inibidor do complemento, métodos para diagnosticar um indivíduo tendo ou com risco de desenvolver síndrome urêmica hemolítica atípica (ahus) e uso de um kit de diagnóstico para diagnosticar ahus

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BR122020019190-2A BR122020019190B1 (pt) 2013-08-07 2014-08-06 Métodos para monitorar a responsividade de um indivíduo ao tratamento com um inibidor do complemento, métodos para diagnosticar um indivíduo tendo ou com risco de desenvolver síndrome urêmica hemolítica atípica (ahus) e uso de um kit de diagnóstico para diagnosticar ahus

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US (5) US20150079613A1 (pt)
EP (3) EP3290922A1 (pt)
JP (3) JP6211701B2 (pt)
KR (3) KR102448976B1 (pt)
CN (1) CN105683759B (pt)
AU (1) AU2014306002B2 (pt)
BR (2) BR112016002435A8 (pt)
CA (1) CA2918959C (pt)
EA (1) EA034870B1 (pt)
ES (1) ES2650917T3 (pt)
HK (1) HK1218443A1 (pt)
IL (1) IL243653B (pt)
SI (1) SI3011345T1 (pt)
WO (1) WO2015021166A2 (pt)

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US20150079613A1 (en) 2013-08-07 2015-03-19 Ryan Kitchel Atypical hemolytic uremic syndrome biomarker proteins
JP6654137B2 (ja) 2013-09-16 2020-02-26 チルドレンズ ホスピタル メディカル センター Hsct関連血栓性微小血管症の治療のための組成物及び方法
IL229134A0 (en) * 2013-10-29 2014-03-31 Omrix Biopharmaceuticals Ltd Compounds and methods for stabilizing thrombin activity
ES2898424T3 (es) * 2015-03-29 2022-03-07 Endothel Pharma Aps Una composición que comprende prostaciclina o sus análogos para tratamiento de pacientes críticamente enfermos de modo agudo
WO2016200627A1 (en) 2015-06-09 2016-12-15 Children's Hospital Medical Center Dosing algorithm for complement inhibitor
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