BR112013027122A2 - método e sistema para analisar características de tecido, e, kit - Google Patents
método e sistema para analisar características de tecido, e, kitInfo
- Publication number
- BR112013027122A2 BR112013027122A2 BR112013027122A BR112013027122A BR112013027122A2 BR 112013027122 A2 BR112013027122 A2 BR 112013027122A2 BR 112013027122 A BR112013027122 A BR 112013027122A BR 112013027122 A BR112013027122 A BR 112013027122A BR 112013027122 A2 BR112013027122 A2 BR 112013027122A2
- Authority
- BR
- Brazil
- Prior art keywords
- cell
- field
- tissue characteristics
- assessment
- observed
- Prior art date
Links
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57434—Specifically defined cancers of prostate
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06F—ELECTRIC DIGITAL DATA PROCESSING
- G06F18/00—Pattern recognition
- G06F18/20—Analysing
- G06F18/21—Design or setup of recognition systems or techniques; Extraction of features in feature space; Blind source separation
- G06F18/211—Selection of the most significant subset of features
- G06F18/2115—Selection of the most significant subset of features by evaluating different subsets according to an optimisation criterion, e.g. class separability, forward selection or backward elimination
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
- G06V10/00—Arrangements for image or video recognition or understanding
- G06V10/70—Arrangements for image or video recognition or understanding using pattern recognition or machine learning
- G06V10/77—Processing image or video features in feature spaces; using data integration or data reduction, e.g. principal component analysis [PCA] or independent component analysis [ICA] or self-organising maps [SOM]; Blind source separation
- G06V10/771—Feature selection, e.g. selecting representative features from a multi-dimensional feature space
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- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
- G06V20/00—Scenes; Scene-specific elements
- G06V20/60—Type of objects
- G06V20/69—Microscopic objects, e.g. biological cells or cellular parts
- G06V20/698—Matching; Classification
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/56—Staging of a disease; Further complications associated with the disease
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/60—Complex ways of combining multiple protein biomarkers for diagnosis
Abstract
método e sistema para analisar características de tecido, e, kit um conjunto de dados de dados de perfil celular é armazenado. os dados de perfil celular incluem dados de imagem biométrica multiplexada descrevendo a expressão de uma pluralidade de biomarcadores com relação a um campo de visão em que células individuais são delineadas e segmentar em compartimentos. cada célula no campo é atribuída a um único agrupamento em conjunto selecionado de agrupamentos com base em similaridade celular; similaridade celular é determinada com base na pluralidade de atributos de células selecionadas. a proporção de células em cada agrupamento é observada. as proporções observadas são examinadas para uma associação com um diagnóstico, um prognóstico, ou uma resposta derivada de uma associação conhecida do conjunto selecionado de agrupamentos com o, pelo menos, um fragmento de metainformação incluindo a avaliação do nível de campo de visão ou uma avaliação do nível de paciente.
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161478224P | 2011-04-22 | 2011-04-22 | |
US13/252,078 US20120269419A1 (en) | 2011-04-22 | 2011-10-03 | Analyzing the expression of biomarkers in cells with moments |
US13/252,080 US20120271553A1 (en) | 2011-04-22 | 2011-10-03 | Analyzing the expression of biomarkers in cells with clusters |
US13/252,072 US20120269418A1 (en) | 2011-04-22 | 2011-10-03 | Analyzing the expression of biomarkers in cells with clusters |
US13/252,069 US20120270752A1 (en) | 2011-04-22 | 2011-10-03 | Analyzing the expression of biomarkers in cells with moments |
PCT/EP2012/057394 WO2012143561A2 (en) | 2011-04-22 | 2012-04-23 | Analyzing the expression of biomarkers in cells with clusters |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112013027122A2 true BR112013027122A2 (pt) | 2017-01-10 |
Family
ID=47021377
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112013027125A BR112013027125A2 (pt) | 2011-04-22 | 2012-04-23 | método e sistema para analisar características de tecido, e, kit |
BR112013027124A BR112013027124A2 (pt) | 2011-04-22 | 2012-04-23 | método e sistema para analisar características de tecido |
BR112013027122A BR112013027122A2 (pt) | 2011-04-22 | 2012-04-23 | método e sistema para analisar características de tecido, e, kit |
BR112013027123A BR112013027123A2 (pt) | 2011-04-22 | 2012-04-23 | método e sistema para analisar características de tecido, e, método de análise de características de agrupamento de células |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112013027125A BR112013027125A2 (pt) | 2011-04-22 | 2012-04-23 | método e sistema para analisar características de tecido, e, kit |
BR112013027124A BR112013027124A2 (pt) | 2011-04-22 | 2012-04-23 | método e sistema para analisar características de tecido |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112013027123A BR112013027123A2 (pt) | 2011-04-22 | 2012-04-23 | método e sistema para analisar características de tecido, e, método de análise de características de agrupamento de células |
Country Status (8)
Country | Link |
---|---|
US (5) | US20120270752A1 (pt) |
EP (4) | EP2700042B1 (pt) |
JP (4) | JP6063446B2 (pt) |
BR (4) | BR112013027125A2 (pt) |
CA (4) | CA2833428A1 (pt) |
RU (3) | RU2013145151A (pt) |
SG (4) | SG194594A1 (pt) |
WO (4) | WO2012143556A2 (pt) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB201111594D0 (en) * | 2011-07-06 | 2011-08-24 | Equateq Ltd | New improved process |
WO2014089494A1 (en) * | 2012-12-06 | 2014-06-12 | Clarient Diagnostic Services, Inc. | Systems and methods for split screen display of a biological specimen and for capturing records thereof |
US9488639B2 (en) * | 2013-02-25 | 2016-11-08 | Flagship Biosciences, Inc. | Cell-based tissue analysis |
US8995740B2 (en) | 2013-04-17 | 2015-03-31 | General Electric Company | System and method for multiplexed biomarker quantitation using single cell segmentation on sequentially stained tissue |
WO2015003178A1 (en) * | 2013-07-03 | 2015-01-08 | Coyne Scientific, Llc | Methods for predicting responses to chemical or biologic substances |
US9322051B2 (en) | 2013-10-07 | 2016-04-26 | General Electric Company | Probing of biological samples |
US9298968B1 (en) * | 2014-09-12 | 2016-03-29 | Flagship Biosciences, Inc. | Digital image analysis of inflammatory cells and mediators of inflammation |
CA2971129A1 (en) | 2015-01-22 | 2016-07-28 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and systems for determining proportions of distinct cell subsets |
US10672505B2 (en) | 2015-06-03 | 2020-06-02 | General Electric Company | Biological data annotation and visualization |
US9953133B2 (en) | 2015-06-03 | 2018-04-24 | General Electric Company | Biological data annotation and visualization |
EP3395937A4 (en) * | 2015-12-22 | 2019-08-21 | Nikon Corporation | IMAGE PROCESSING APPARATUS |
US20180032681A1 (en) * | 2016-07-29 | 2018-02-01 | General Electric Company | Biological feature analysis technique |
WO2018151223A1 (ja) * | 2017-02-16 | 2018-08-23 | 国立大学法人京都大学 | 細胞評価方法、細胞評価装置、及び細胞評価プログラム |
US10127696B2 (en) * | 2017-03-22 | 2018-11-13 | Sas Institute Inc. | Computer system to generate scalable plots using clustering |
WO2018201072A2 (en) * | 2017-04-28 | 2018-11-01 | 4D Path Inc. | Apparatus, systems, and methods for rapid cancer detection |
KR101990430B1 (ko) * | 2017-06-22 | 2019-06-18 | 한국과학기술원 | 암의 재발 예후 예측을 위한 바이오마커 발굴 시스템 및 방법 |
US10706328B2 (en) | 2018-05-07 | 2020-07-07 | Google Llc | Focus-weighted, machine learning disease classifier error prediction for microscope slide images |
WO2020056372A1 (en) * | 2018-09-14 | 2020-03-19 | Krishnan Ramanathan | Multimodal learning framework for analysis of clinical trials |
WO2020068684A2 (en) | 2018-09-24 | 2020-04-02 | Krishnan Ramanathan | Hybrid analysis framework for prediction of outcomes in clinical trials |
US11128667B2 (en) * | 2018-11-29 | 2021-09-21 | Rapid7, Inc. | Cluster detection and elimination in security environments |
WO2020112478A1 (en) * | 2018-11-29 | 2020-06-04 | Somalogic, Inc. | Methods for determining disease risk combining downsampling of class-imbalanced sets with survival analysis |
CN113158982A (zh) * | 2021-05-17 | 2021-07-23 | 广东中卡云计算有限公司 | 一种半介入式的目标关键点标注方法 |
WO2023033056A1 (ja) * | 2021-09-01 | 2023-03-09 | イミュニティリサーチ株式会社 | 細胞集団同定システム、方法、およびプログラム |
EP4224488A1 (en) | 2022-02-02 | 2023-08-09 | Aizoon S.r.l. | Method for the prognosis of a disease following upon a therapeutic treatment, and corresponding system and computer program product |
EP4250301A1 (en) | 2022-03-24 | 2023-09-27 | Aizoon S.r.l. | Method for estimating a variable of interest associated to a given disease as a function of a plurality of different omics data, corresponding device, and computer program product |
US20240028964A1 (en) | 2022-07-25 | 2024-01-25 | Aizoon S.r.l. | Method for providing a clinical decision support, corresponding system for providing a clinical decision support, and computer program product |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6463438B1 (en) * | 1994-06-03 | 2002-10-08 | Urocor, Inc. | Neural network for cell image analysis for identification of abnormal cells |
US5740269A (en) * | 1994-09-20 | 1998-04-14 | Neopath, Inc. | Method and apparatus for robust biological specimen classification |
US6996549B2 (en) * | 1998-05-01 | 2006-02-07 | Health Discovery Corporation | Computer-aided image analysis |
US6282305B1 (en) * | 1998-06-05 | 2001-08-28 | Arch Development Corporation | Method and system for the computerized assessment of breast cancer risk |
US6337472B1 (en) * | 1998-10-19 | 2002-01-08 | The University Of Texas System Board Of Regents | Light imaging microscope having spatially resolved images |
EP1425302A2 (en) * | 2001-01-24 | 2004-06-09 | Protein Design Labs | Methods of diagnosis of breast cancer, compositions and methods of screening for modulators of breast cancer |
AU2003255332A1 (en) * | 2002-07-30 | 2004-02-23 | Steinbeis-Transferzentrum Analytische Elektronenmikroskopie, Biomedizin, Biotechnologie-Heidelberg | Method and apparatus for multiple labeling detection and evaluation of a plurality of particles |
US20040121413A1 (en) * | 2002-12-20 | 2004-06-24 | Aebersold Rudolf H. | Androgen-regulated genes and uses for diagnosis, prognosis and treatment of prostate neoplastic conditions |
US20050265588A1 (en) * | 2004-02-03 | 2005-12-01 | Bioimagene, Inc. | Method and system for digital image based flourescent in situ hybridization (FISH) analysis |
US20060275844A1 (en) * | 2005-04-19 | 2006-12-07 | Linke Steven P | Diagnostic markers of breast cancer treatment and progression and methods of use thereof |
US8041090B2 (en) * | 2005-09-10 | 2011-10-18 | Ge Healthcare Uk Limited | Method of, and apparatus and computer software for, performing image processing |
US7933435B2 (en) * | 2005-11-21 | 2011-04-26 | Vala Sciences, Inc. | System, method, and kit for processing a magnified image of biological material to identify components of a biological object |
CA2652562C (en) * | 2006-05-17 | 2015-05-12 | Cellumen, Inc. | Method for automated tissue analysis |
US8019134B2 (en) * | 2006-11-16 | 2011-09-13 | Definiens Ag | Automatic image analysis and quantification for fluorescence in situ hybridization |
US7741045B2 (en) * | 2006-11-16 | 2010-06-22 | General Electric Company | Sequential analysis of biological samples |
CA2678919A1 (en) * | 2007-03-27 | 2008-10-02 | Ranit Aharonov | Gene expression signature for classification of cancers |
CA2683134A1 (en) * | 2007-05-07 | 2008-11-13 | Ge Healthcare Bio-Sciences Corp. | System and method for the automated analysis of cellular assays and tissues |
ES2374686T3 (es) * | 2007-05-14 | 2012-02-21 | Historx, Inc. | Separación en compartimentos por caracterización de píxel usando agrupamiento de datos de imágenes. |
WO2009108215A1 (en) * | 2007-09-06 | 2009-09-03 | Aviaradx, Inc. | Tumor grading and cancer prognosis |
EP2332087B1 (en) * | 2008-07-25 | 2020-04-22 | Fundação D. Anna Sommer Champalimaud E Dr. Carlos Montez Champalimaud | Systems and methods of treating, diagnosing and predicting the occurrence of a medical condition |
US9779213B2 (en) * | 2008-07-25 | 2017-10-03 | Fundacao D. Anna Sommer Champalimaud E Dr. Carlos Montez Champalimaud | System for evaluating a pathological stage of prostate cancer |
US8320655B2 (en) * | 2009-10-16 | 2012-11-27 | General Electric Company | Process and system for analyzing the expression of biomarkers in cells |
US20110091081A1 (en) * | 2009-10-16 | 2011-04-21 | General Electric Company | Method and system for analyzing the expression of biomarkers in cells in situ in their tissue of origin |
WO2011087778A1 (en) * | 2009-12-22 | 2011-07-21 | The Children's Hospital Of Philadelphia | Automated quantitative multidimensional volumetric analysis and visualization |
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2011
- 2011-10-03 US US13/252,069 patent/US20120270752A1/en not_active Abandoned
- 2011-10-03 US US13/252,072 patent/US20120269418A1/en not_active Abandoned
- 2011-10-03 US US13/252,080 patent/US20120271553A1/en not_active Abandoned
- 2011-10-03 US US13/252,078 patent/US20120269419A1/en not_active Abandoned
-
2012
- 2012-04-23 SG SG2013078753A patent/SG194594A1/en unknown
- 2012-04-23 CA CA2833428A patent/CA2833428A1/en not_active Abandoned
- 2012-04-23 CA CA2833804A patent/CA2833804A1/en not_active Abandoned
- 2012-04-23 JP JP2014505669A patent/JP6063446B2/ja active Active
- 2012-04-23 RU RU2013145151/15A patent/RU2013145151A/ru not_active Application Discontinuation
- 2012-04-23 EP EP12719316.7A patent/EP2700042B1/en active Active
- 2012-04-23 WO PCT/EP2012/057387 patent/WO2012143556A2/en unknown
- 2012-04-23 WO PCT/EP2012/057394 patent/WO2012143561A2/en unknown
- 2012-04-23 CA CA2833295A patent/CA2833295A1/en not_active Abandoned
- 2012-04-23 JP JP2014505670A patent/JP6143743B2/ja active Active
- 2012-04-23 SG SG2013078688A patent/SG194588A1/en unknown
- 2012-04-23 BR BR112013027125A patent/BR112013027125A2/pt not_active IP Right Cessation
- 2012-04-23 EP EP12716028.1A patent/EP2700037A2/en not_active Withdrawn
- 2012-04-23 CA CA2833497A patent/CA2833497A1/en not_active Abandoned
- 2012-04-23 EP EP12716027.3A patent/EP2700036A2/en not_active Withdrawn
- 2012-04-23 RU RU2013145162/15A patent/RU2013145162A/ru not_active Application Discontinuation
- 2012-04-23 WO PCT/EP2012/057390 patent/WO2012143558A2/en unknown
- 2012-04-23 SG SG2013078738A patent/SG194592A1/en unknown
- 2012-04-23 SG SG2013078712A patent/SG194590A1/en unknown
- 2012-04-23 BR BR112013027124A patent/BR112013027124A2/pt not_active IP Right Cessation
- 2012-04-23 BR BR112013027122A patent/BR112013027122A2/pt not_active IP Right Cessation
- 2012-04-23 WO PCT/EP2012/057395 patent/WO2012143562A2/en unknown
- 2012-04-23 BR BR112013027123A patent/BR112013027123A2/pt not_active IP Right Cessation
- 2012-04-23 JP JP2014505671A patent/JP6063447B2/ja active Active
- 2012-04-23 EP EP12717662.6A patent/EP2700038B1/en active Active
- 2012-04-23 JP JP2014505668A patent/JP6163152B2/ja active Active
- 2012-04-23 RU RU2013145154/15A patent/RU2013145154A/ru not_active Application Discontinuation
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2014
- 2014-03-05 US US14/197,558 patent/US20140185905A1/en not_active Abandoned
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B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |