EA201270650A1 - Транскрипционная сигнатура крови активной инфекции mycobacterium tuberculosis по сравнению с латентной - Google Patents

Транскрипционная сигнатура крови активной инфекции mycobacterium tuberculosis по сравнению с латентной

Info

Publication number
EA201270650A1
EA201270650A1 EA201270650A EA201270650A EA201270650A1 EA 201270650 A1 EA201270650 A1 EA 201270650A1 EA 201270650 A EA201270650 A EA 201270650A EA 201270650 A EA201270650 A EA 201270650A EA 201270650 A1 EA201270650 A1 EA 201270650A1
Authority
EA
Eurasian Patent Office
Prior art keywords
mycobacterium tuberculosis
patient
gene expression
latent
blood
Prior art date
Application number
EA201270650A
Other languages
English (en)
Inventor
Жак Ф. Баншеро
Дамьен Шоссабель
Анне О'Гарра
Мэтью Берри
Онн Мин Кон
Original Assignee
Бейлор Рисёч Инститьют
Медикал Рисёч Кансил
Империал Колидж Хэлскэа Энэйчэс Траст
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Бейлор Рисёч Инститьют, Медикал Рисёч Кансил, Империал Колидж Хэлскэа Энэйчэс Траст filed Critical Бейлор Рисёч Инститьют
Publication of EA201270650A1 publication Critical patent/EA201270650A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

Настоящее изобретение включает способы, системы и комплекты для проведения различия между активной и латентной инфекцией Mycobacterium tuberculosis у пациента с подозрением на инфекцию Mycobacterium tuberculosis, способ, включающий этапы получения набора данных экспрессии генов у пациента с подозрением на инфекцию Mycobacterium tuberculosis; упорядочение набора данных экспрессии генов пациентов в один или несколько модулей генов, связанных с инфекцией Mycobacterium tuberculosis; и сравнение набора данных экспрессии генов пациентов относительно каждого одного или нескольких модулей генов с набором данных экспрессии генов лиц, не являющихся пациентами, где увеличение или уменьшение в совокупности экспрессии генов в наборе данных экспрессии генов пациентов относительно одного или нескольких модулей генов является показателем активной инфекции Mycobacterium tuberculosis.
EA201270650A 2009-11-30 2010-08-19 Транскрипционная сигнатура крови активной инфекции mycobacterium tuberculosis по сравнению с латентной EA201270650A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12/628,148 US20110129817A1 (en) 2009-11-30 2009-11-30 Blood transcriptional signature of active versus latent mycobacterium tuberculosis infection
PCT/US2010/046042 WO2011066008A2 (en) 2009-11-30 2010-08-19 Blood transcriptional signature of active versus latent mycobacterium tuberculosis infection

Publications (1)

Publication Number Publication Date
EA201270650A1 true EA201270650A1 (ru) 2013-06-28

Family

ID=44067161

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201270650A EA201270650A1 (ru) 2009-11-30 2010-08-19 Транскрипционная сигнатура крови активной инфекции mycobacterium tuberculosis по сравнению с латентной

Country Status (19)

Country Link
US (2) US20110129817A1 (ru)
EP (1) EP2519652A4 (ru)
JP (1) JP2013511981A (ru)
KR (2) KR20140078768A (ru)
CN (1) CN102844444A (ru)
AP (1) AP2012006346A0 (ru)
AR (1) AR080570A1 (ru)
AU (1) AU2010325179B2 (ru)
BR (1) BR112012013029A2 (ru)
CA (1) CA2782211A1 (ru)
CL (1) CL2012001400A1 (ru)
EA (1) EA201270650A1 (ru)
IL (1) IL220016A0 (ru)
MX (1) MX2012006031A (ru)
PE (1) PE20121690A1 (ru)
SG (1) SG10201407855WA (ru)
TW (1) TW201131032A (ru)
WO (1) WO2011066008A2 (ru)
ZA (1) ZA201204806B (ru)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2524966A1 (en) * 2011-05-18 2012-11-21 Rheinische Friedrich-Wilhelms-Universität Bonn Molecular analysis of tuberculosis
TWI458978B (zh) * 2011-12-27 2014-11-01 Chengchung Chou 判別開放性或潛伏性結核菌感染之方法
CA2867118A1 (en) * 2012-03-13 2013-09-19 Baylor Research Institute Early detection of tuberculosis treatment response
CA2867481A1 (en) * 2012-04-13 2013-10-17 Somalogic, Inc. Tuberculosis biomarkers and uses thereof
GB201211158D0 (en) * 2012-06-22 2012-08-08 Univ Nottingham Trent Biomarkers and uses thereof
US20150284780A1 (en) * 2012-10-30 2015-10-08 Imperial Innovations Limited Method of detecting active tuberculosis in children in the presence of a co-morbidity
EP2931923A1 (en) * 2012-12-13 2015-10-21 Baylor Research Institute Blood transcriptional signatures of active pulmonary tuberculosis and sarcoidosis
AU2014223824B2 (en) * 2013-02-28 2020-02-27 Albert Einstein College Of Medicine, Inc. Tuberculosis biomarkers and uses thereof
GB201315748D0 (en) 2013-09-04 2013-10-16 Imp Innovations Ltd Biological methods and materials for use therein
WO2015048098A1 (en) 2013-09-24 2015-04-02 Washington University Diagnostic methods for infectious disease using endogenous gene expression
CN106461674A (zh) * 2014-04-15 2017-02-22 斯坦陵布什大学 一种用于诊断结核性脑膜炎的方法
CN103954755B (zh) * 2014-04-30 2017-04-05 广东省结核病控制中心 一种结核分枝杆菌潜伏感染的诊断试剂盒
EP3139922B1 (en) 2014-05-05 2019-08-14 Emory University Methods of diagnosing and treating tuberculosis
US10920275B2 (en) * 2015-10-14 2021-02-16 The Board Of Trustees Of The Leland Stanford Junior University Methods for diagnosis of tuberculosis
GB201519872D0 (en) 2015-11-11 2015-12-23 Univ Cape Town And Ct For Infectious Disease Res Biomarkers for prospective determination of risk for development of active tuberculosis
GB2547034A (en) * 2016-02-05 2017-08-09 Imp Innovations Ltd Biological methods and materials for use therein
KR101888101B1 (ko) * 2016-09-19 2018-08-14 충남대학교산학협력단 Scotin 단백질의 과발현에 의하여 결핵균 생존 및 증식을 억제하는 방법
JP6306124B2 (ja) * 2016-11-01 2018-04-04 国立大学法人高知大学 結核検査用バイオマーカー
CN107653313B (zh) * 2017-09-12 2021-07-09 首都医科大学附属北京胸科医院 Retn和klk1在作为结核病检测标志物中的应用
US11443433B2 (en) * 2018-02-10 2022-09-13 The Trustees Of The University Of Pennsylvania Quantification and staging of body-wide tissue composition and of abnormal states on medical images via automatic anatomy recognition
GB201804019D0 (en) * 2018-03-13 2018-04-25 Univ Cape Town Method for predicting progression to active tuberculosis disease
US11036779B2 (en) * 2018-04-23 2021-06-15 Verso Biosciences, Inc. Data analytics systems and methods
CN109061191B (zh) * 2018-08-23 2021-08-24 中国人民解放军第三〇九医院 S100p蛋白作为标志物在诊断活动性结核病中的应用
CN108828235A (zh) * 2018-08-23 2018-11-16 中国人民解放军第三〇九医院 Pglyrp1蛋白作为标志物在诊断活动性结核病中的应用
CN110286231A (zh) * 2019-06-19 2019-09-27 中国人民解放军总医院第八医学中心 用于检测cd160蛋白的物质在制备用于诊断活动性结核病的产品中的应用
CN111304313A (zh) * 2019-12-13 2020-06-19 南方医科大学 一种检测fpr1基因表达水平的试剂的应用
EP3868894A1 (en) * 2020-02-21 2021-08-25 Forschungszentrum Borstel, Leibniz Lungenzentrum Method for diagnosis and treatment monitoring and individual therapy end decision in tuberculosis infection
WO2024119057A2 (en) * 2022-12-02 2024-06-06 Cornell University Plasma cell-free rna signatures of tuberculosis
CN116994646B (zh) * 2023-08-01 2024-06-11 东莞市滨海湾中心医院(东莞市太平人民医院、东莞市第五人民医院) 一种菌阳活动性肺结核风险评估模型的构建方法与应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6627198B2 (en) * 1997-03-13 2003-09-30 Corixa Corporation Fusion proteins of Mycobacterium tuberculosis antigens and their uses
US6713257B2 (en) * 2000-08-25 2004-03-30 Rosetta Inpharmatics Llc Gene discovery using microarrays
WO2003008647A2 (en) * 2000-11-28 2003-01-30 University Of Cincinnati Blood assessment of injury
US7393540B2 (en) * 2001-07-04 2008-07-01 Health Protection Agency Mycobacterial antigens expressed during latency
AU2003241055A1 (en) * 2002-06-20 2004-01-06 Glaxo Group Limited Surrogate markers for the determination of the disease status of an individual infected by mycobacterium tuberculosis
SG182951A1 (en) * 2008-06-25 2012-08-30 Baylor Res Inst Blood transcriptional signature of mycobacterium tuberculosis infection

Also Published As

Publication number Publication date
AU2010325179A1 (en) 2012-07-05
KR20140078768A (ko) 2014-06-25
CL2012001400A1 (es) 2014-05-09
AR080570A1 (es) 2012-04-18
WO2011066008A2 (en) 2011-06-03
EP2519652A4 (en) 2013-05-01
US20140080732A1 (en) 2014-03-20
US20110129817A1 (en) 2011-06-02
MX2012006031A (es) 2012-10-03
BR112012013029A2 (pt) 2016-10-04
ZA201204806B (en) 2013-02-27
PE20121690A1 (es) 2012-12-16
JP2013511981A (ja) 2013-04-11
AU2010325179B2 (en) 2015-03-12
CA2782211A1 (en) 2011-06-03
AP2012006346A0 (en) 2012-06-30
SG10201407855WA (en) 2015-01-29
WO2011066008A3 (en) 2011-07-21
TW201131032A (en) 2011-09-16
IL220016A0 (en) 2012-07-31
KR20120107979A (ko) 2012-10-04
CN102844444A (zh) 2012-12-26
EP2519652A2 (en) 2012-11-07

Similar Documents

Publication Publication Date Title
EA201270650A1 (ru) Транскрипционная сигнатура крови активной инфекции mycobacterium tuberculosis по сравнению с латентной
EA201170088A1 (ru) Транскрипционная сигнатура крови инфекции mycobacterium tuberculosis
BR112013027122A2 (pt) método e sistema para analisar características de tecido, e, kit
EP4335932A3 (en) Methods of monitoring conditions by sequence analysis
BR112014031715A2 (pt) métodos e aparatos para usar dados de vibração para determinar uma condição de um dispositivo de controle de processo
Camargo et al. Peritoneal dialysis–related peritonitis due to coagulase-negative Staphylococcus: A review of 115 cases in a Brazilian center
EA201100803A1 (ru) Квалификация данных и ассоциированных метаданных во время процесса сбора данных
EA201100389A1 (ru) Генератор пакетов данных, способ определения положения и передачи пароля
WO2013175314A3 (en) System and method for detecting preeclampsia
WO2012104764A3 (en) Method for estimation of information flow in biological networks
BR112015017767A2 (pt) sistema para detectar estágios do sono de um indivíduo, método para detectar estágios do sono de um indivíduo, e, sistema configurado para detectar estágios do sono de um indivíduo
GB201319170D0 (en) Malware detection
BR112013003751A2 (pt) sistema e método para estimar características direcionais com base nas medidas do momento de flexão
BR112014003877A2 (pt) biomarcadores de micro-rna e métodos de uso dos mesmos
BR112018008905A2 (pt) método, e sistema
GB201201766D0 (en) Method
EP4390940A3 (en) Methods for detecting variants in next-generation sequencing genomic data
Thomas et al. Translational research: A patient-centered approach to bridge the valley of death
MX2014011045A (es) Metodo para seleccionar o identificar un sujeto para la terapia antagonista vib.
ITMI20121513A1 (it) Processo di analisi oftalmologica
WO2014011608A3 (en) Kinetic-based tool for biometric identification, verification, validation and profiling
Bosia Pragmatic abilities across symptoms dimensions in schizophrenia Marta Bosia, Giorgio Arcara, Andrea Moro, Roberto Cavallaro, Valentina Bambini Studi italiani di linguistica teorica e applicata XLIV, 3 (2015)
CR20130018A (es) Mètodo para diagnosticar una respuesta al tratamiento en sujetos con esclerosis mùltiple
WO2010064016A3 (en) Methods for determining a prognosis in multiple myeloma
Yun et al. A diagnosis model for amnestic mild cognitive impairment based on structural network characteristics of the brain