BR112013027123A2 - método e sistema para analisar características de tecido, e, método de análise de características de agrupamento de células - Google Patents

método e sistema para analisar características de tecido, e, método de análise de características de agrupamento de células

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Publication number
BR112013027123A2
BR112013027123A2 BR112013027123A BR112013027123A BR112013027123A2 BR 112013027123 A2 BR112013027123 A2 BR 112013027123A2 BR 112013027123 A BR112013027123 A BR 112013027123A BR 112013027123 A BR112013027123 A BR 112013027123A BR 112013027123 A2 BR112013027123 A2 BR 112013027123A2
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BR
Brazil
Prior art keywords
cluster
cell
profile data
analysis method
analyzing tissue
Prior art date
Application number
BR112013027123A
Other languages
English (en)
Inventor
Colin Craig Mcculloch
Original Assignee
Gen Electric
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gen Electric filed Critical Gen Electric
Publication of BR112013027123A2 publication Critical patent/BR112013027123A2/pt

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57434—Specifically defined cancers of prostate
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F18/00—Pattern recognition
    • G06F18/20—Analysing
    • G06F18/21—Design or setup of recognition systems or techniques; Extraction of features in feature space; Blind source separation
    • G06F18/211—Selection of the most significant subset of features
    • G06F18/2115—Selection of the most significant subset of features by evaluating different subsets according to an optimisation criterion, e.g. class separability, forward selection or backward elimination
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V10/00—Arrangements for image or video recognition or understanding
    • G06V10/70—Arrangements for image or video recognition or understanding using pattern recognition or machine learning
    • G06V10/77—Processing image or video features in feature spaces; using data integration or data reduction, e.g. principal component analysis [PCA] or independent component analysis [ICA] or self-organising maps [SOM]; Blind source separation
    • G06V10/771—Feature selection, e.g. selecting representative features from a multi-dimensional feature space
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00—Scenes; Scene-specific elements
    • G06V20/60—Type of objects
    • G06V20/69—Microscopic objects, e.g. biological cells or cellular parts
    • G06V20/698—Matching; Classification
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/56—Staging of a disease; Further complications associated with the disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/60—Complex ways of combining multiple protein biomarkers for diagnosis

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  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Theoretical Computer Science (AREA)
  • Immunology (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Chemical & Material Sciences (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Data Mining & Analysis (AREA)
  • Evolutionary Computation (AREA)
  • Multimedia (AREA)
  • Artificial Intelligence (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Medical Informatics (AREA)
  • Evolutionary Biology (AREA)
  • Computing Systems (AREA)
  • Oncology (AREA)
  • Software Systems (AREA)
  • Databases & Information Systems (AREA)
  • Hospice & Palliative Care (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Physiology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Image Processing (AREA)

Abstract

método e sistema para analisar características de tecido, e, método de análise de características de agrupamento de células um conjunto de dados de dados de perfil celular é armazenado. os dados de perfil celular incluem dados de imagem biométrica multiplexada descrevendo a expressão de uma pluralidade de biomarcadores. dados do perfil celular são gerados a partir de amostras de tecidos retiradas de uma coorte de pacientes tendo uma avaliação relativa aos comuns. múltiplos conjuntos de agrupamentos de células similares são gerados a partir do conjunto de dados; a proporção de células em cada agrupamento é examinada para uma associação com um diagnóstico, um prognóstico, ou uma resposta; e uma conjunto preditivo de agrupamento é selecionado com base no desempenho do modelo. um conjunto preditivo de agrupamento é selecionado com base em uma comparação entre o desempenho de, pelo menos, um modelo de um da pluralidade de conjuntos de agrupamentos. as técnicas de exibição que auxiliam na compreensão das características de um agrupamento são descritas.
BR112013027123A 2011-04-22 2012-04-23 método e sistema para analisar características de tecido, e, método de análise de características de agrupamento de células BR112013027123A2 (pt)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201161478224P 2011-04-22 2011-04-22
US13/252,080 US20120271553A1 (en) 2011-04-22 2011-10-03 Analyzing the expression of biomarkers in cells with clusters
US13/252,072 US20120269418A1 (en) 2011-04-22 2011-10-03 Analyzing the expression of biomarkers in cells with clusters
US13/252,078 US20120269419A1 (en) 2011-04-22 2011-10-03 Analyzing the expression of biomarkers in cells with moments
US13/252,069 US20120270752A1 (en) 2011-04-22 2011-10-03 Analyzing the expression of biomarkers in cells with moments
PCT/EP2012/057395 WO2012143562A2 (en) 2011-04-22 2012-04-23 Analyzing the expression of biomarkers in cells with clusters

Publications (1)

Publication Number Publication Date
BR112013027123A2 true BR112013027123A2 (pt) 2017-01-10

Family

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Family Applications (4)

Application Number Title Priority Date Filing Date
BR112013027125A BR112013027125A2 (pt) 2011-04-22 2012-04-23 método e sistema para analisar características de tecido, e, kit
BR112013027122A BR112013027122A2 (pt) 2011-04-22 2012-04-23 método e sistema para analisar características de tecido, e, kit
BR112013027123A BR112013027123A2 (pt) 2011-04-22 2012-04-23 método e sistema para analisar características de tecido, e, método de análise de características de agrupamento de células
BR112013027124A BR112013027124A2 (pt) 2011-04-22 2012-04-23 método e sistema para analisar características de tecido

Family Applications Before (2)

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BR112013027125A BR112013027125A2 (pt) 2011-04-22 2012-04-23 método e sistema para analisar características de tecido, e, kit
BR112013027122A BR112013027122A2 (pt) 2011-04-22 2012-04-23 método e sistema para analisar características de tecido, e, kit

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BR112013027124A BR112013027124A2 (pt) 2011-04-22 2012-04-23 método e sistema para analisar características de tecido

Country Status (8)

Country Link
US (5) US20120269419A1 (pt)
EP (4) EP2700036A2 (pt)
JP (4) JP6063446B2 (pt)
BR (4) BR112013027125A2 (pt)
CA (4) CA2833428A1 (pt)
RU (3) RU2013145154A (pt)
SG (4) SG194592A1 (pt)
WO (4) WO2012143561A2 (pt)

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Also Published As

Publication number Publication date
CA2833497A1 (en) 2012-10-26
WO2012143556A3 (en) 2013-05-30
JP2014521926A (ja) 2014-08-28
EP2700036A2 (en) 2014-02-26
EP2700037A2 (en) 2014-02-26
JP2014516413A (ja) 2014-07-10
JP6163152B2 (ja) 2017-07-12
SG194590A1 (en) 2013-12-30
WO2012143556A2 (en) 2012-10-26
JP2014521925A (ja) 2014-08-28
WO2012143562A3 (en) 2013-02-28
BR112013027122A2 (pt) 2017-01-10
CA2833804A1 (en) 2012-10-26
SG194592A1 (en) 2013-12-30
JP6063447B2 (ja) 2017-01-18
JP2014517954A (ja) 2014-07-24
JP6143743B2 (ja) 2017-06-07
US20120269419A1 (en) 2012-10-25
EP2700042A2 (en) 2014-02-26
BR112013027124A2 (pt) 2017-01-10
EP2700042B1 (en) 2021-03-17
WO2012143558A2 (en) 2012-10-26
BR112013027125A2 (pt) 2017-01-10
SG194588A1 (en) 2013-12-30
EP2700038A2 (en) 2014-02-26
US20140185905A1 (en) 2014-07-03
JP6063446B2 (ja) 2017-01-18
WO2012143562A2 (en) 2012-10-26
WO2012143561A2 (en) 2012-10-26
WO2012143561A3 (en) 2013-05-23
US20120270752A1 (en) 2012-10-25
WO2012143558A3 (en) 2012-12-20
US20120269418A1 (en) 2012-10-25
SG194594A1 (en) 2013-12-30
US20120271553A1 (en) 2012-10-25
CA2833428A1 (en) 2012-10-26
RU2013145151A (ru) 2015-05-27
RU2013145162A (ru) 2015-05-27
RU2013145154A (ru) 2015-05-27
CA2833295A1 (en) 2012-10-26
EP2700038B1 (en) 2021-04-21

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