BR112014011563A2 - métodos para detectar o papiloma-vírus humano e fornecer o prognóstico para carci-noma de células escamosas de cabeça e pescoço - Google Patents

métodos para detectar o papiloma-vírus humano e fornecer o prognóstico para carci-noma de células escamosas de cabeça e pescoço

Info

Publication number
BR112014011563A2
BR112014011563A2 BR112014011563A BR112014011563A BR112014011563A2 BR 112014011563 A2 BR112014011563 A2 BR 112014011563A2 BR 112014011563 A BR112014011563 A BR 112014011563A BR 112014011563 A BR112014011563 A BR 112014011563A BR 112014011563 A2 BR112014011563 A2 BR 112014011563A2
Authority
BR
Brazil
Prior art keywords
head
cell carcinoma
squamous cell
neck squamous
hnscc
Prior art date
Application number
BR112014011563A
Other languages
English (en)
Other versions
BR112014011563B1 (pt
Inventor
Franzmann Elizabeth
M Reis Isildinha
Pereira Lutecia
C Duncan Robert
Original Assignee
Univ Miami
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Miami filed Critical Univ Miami
Publication of BR112014011563A2 publication Critical patent/BR112014011563A2/pt
Publication of BR112014011563B1 publication Critical patent/BR112014011563B1/pt

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/5743—Specifically defined cancers of skin, e.g. melanoma
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57488—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds identifable in body fluids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/01—DNA viruses
    • G01N2333/025—Papovaviridae, e.g. papillomavirus, polyomavirus, SV40, BK virus, JC virus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70585—CD44
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/50—Determining the risk of developing a disease

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Oncology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)

Abstract

abstract methods and kits for diagnosing and determining prognosis of head and neck squamous cell carcinoma are described. an exemplary method for diagnosing head and neck squamous cell carcinoma (hnscc) in a subject may comprise assaying a saliva sample from the subject for the presence of total protein, solcd44, and hpv, and using the combination of total protein, hpv, and cd44 levels in a multivariate analysis to determine a combined score, whereby an increase in score above a cut-off point distinguishes subjects with hnscc, or an elevated risk of future occurrence thereof, from subjects without hnscc or at low risk of future occurrence thereof. ----------------------------------------------------------------------------------------------------------- tradução do resumo resumo patente de invenção: "métodos para detectar o papiloma-vírus humano e fornecer o prognóstico para carci-noma de células escamosas de cabeça e pescoço". métodos e kits para o diagnóstico e determinação de prog-nóstico de carcinoma de células escamosas de cabeça e pescoço são descritos. um método exemplar para o diagnóstico de carcinoma de células escamosas (hnscc) de cabeça e pescoço em um indivíduo pode incluir a análise de uma amostra de saliva do indivíduo para a presença de proteínas totais, solcd44 e hpv e usando a combinação de níveis de proteínas totais, hpv, e cd44 em uma análise multivariada para determinar uma pontuação combinada, segundo o qual um aumento na pontuação acima de um ponto de corte distingue os indi-víduos com hnscc, ou um risco elevado de ocorrência futura do mesmo, de indivíduos sem hnscc ou de baixo risco de ocorrência fu-tura do mesmo.
BR112014011563-0A 2011-11-15 2012-11-15 Método para determinar um risco aumentado de carcinoma de células escamosas de cabeça e pescoço (hnscc) em um indivíduo humano infectado com papiloma vírus humano (hpv), e kit BR112014011563B1 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161559974P 2011-11-15 2011-11-15
US61/559,974 2011-11-15
US201261654595P 2012-06-01 2012-06-01
US61/654,595 2012-06-01
PCT/US2012/065282 WO2013074793A1 (en) 2011-11-15 2012-11-15 Methods for detecting human papillomavirus and providing prognosis for head and neck squamous cell carcinoma

Publications (2)

Publication Number Publication Date
BR112014011563A2 true BR112014011563A2 (pt) 2017-05-09
BR112014011563B1 BR112014011563B1 (pt) 2022-05-24

Family

ID=48430146

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014011563-0A BR112014011563B1 (pt) 2011-11-15 2012-11-15 Método para determinar um risco aumentado de carcinoma de células escamosas de cabeça e pescoço (hnscc) em um indivíduo humano infectado com papiloma vírus humano (hpv), e kit

Country Status (13)

Country Link
US (3) US20140329230A1 (pt)
EP (1) EP2780714B1 (pt)
JP (1) JP6174035B2 (pt)
CN (1) CN104067126B (pt)
AU (3) AU2012340441A1 (pt)
BR (1) BR112014011563B1 (pt)
CA (1) CA2855971C (pt)
CO (1) CO6980621A2 (pt)
ES (1) ES2640532T3 (pt)
IL (1) IL232556A (pt)
MX (1) MX352642B (pt)
PE (1) PE20141565A1 (pt)
WO (1) WO2013074793A1 (pt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140329230A1 (en) 2011-11-15 2014-11-06 University Of Miami Methods for detecting human papillomavirus and providing prognosis for head and neck squamous cell carcinoma
RU2016104892A (ru) * 2013-07-31 2017-09-04 Юнивёрсити Оф Майями Композиции и способы для идентификации риска развития ракового заболевания у субъекта
EP3036345A2 (en) * 2013-08-19 2016-06-29 Notre Dame Du Lac Method and composition for detection of oncogenic hpv
WO2015179712A1 (en) 2014-05-22 2015-11-26 University Of Notre Dame Du Lac Integrated membrane sensor for rapid molecular detection
US11268153B2 (en) 2015-06-22 2022-03-08 The Johns Hopkins University Head and neck squamous cell carcinoma assays
JP6655243B2 (ja) * 2015-09-01 2020-02-26 国立大学法人 鹿児島大学 口腔前癌病変の検出方法
CN107092854B (zh) * 2016-02-18 2020-05-22 财团法人金属工业研究发展中心 检测细胞受人类乳头瘤病毒(hpv)感染的装置及其检测方法
GB201808839D0 (en) 2018-05-30 2018-07-11 Cancer Research Tech Ltd Method of predicting survival rates for cancer patients
WO2020018954A1 (en) * 2018-07-20 2020-01-23 Predentome, Inc. Methods and systems for oral microbiome analysis
WO2020176569A1 (en) * 2019-02-26 2020-09-03 University Of Miami Device for methods of detecting cancer
WO2022226153A1 (en) * 2021-04-23 2022-10-27 The University Of Chicago Machine learning based histopathological recurrence prediction models for hpv+ head / neck squamous cell carcinoma
WO2024086159A1 (en) * 2022-10-17 2024-04-25 Vigilant Biosciences, Inc. Methods and compositions for oral cancer risk

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5403551A (en) 1993-09-16 1995-04-04 Roche Diagnostic Systems, Inc. Assaying device and container for in field analysis of a specimen and later shipment of the unadulterated specimen
US6235470B1 (en) 1993-11-12 2001-05-22 The Johns Hopkins University School Of Medicine Detection of neoplasia by analysis of saliva
US5990299A (en) * 1995-08-14 1999-11-23 Icn Pharmaceuticals, Inc. Control of CD44 gene expression for therapeutic use
US5976895A (en) 1996-03-11 1999-11-02 American Biomedica Corporation Device for the collection, testing and shipment of body fluid samples
DE19829473C2 (de) * 1998-07-01 2000-08-10 Magnus Von Knebel Doeberitz Ch Verfahren zur frühen Diagnose von Carcinomen
US6379620B1 (en) 1998-11-16 2002-04-30 Barry M. Tydings Assaying device and method for in field urinalysis
US6294349B1 (en) 1999-03-01 2001-09-25 University Of Mississippi Medical Ctr. Method of diagnosing and monitoring malignant breast carcinomas
US7189397B2 (en) 1999-10-08 2007-03-13 Arius Research Inc. Cytotoxicity mediation of cells evidencing surface expression of CD44
US20040029114A1 (en) 2001-01-24 2004-02-12 Eos Technology, Inc. Methods of diagnosis of breast cancer, compositions and methods of screening for modulators of breast cancer
DE60300339T2 (de) * 2003-08-25 2006-04-13 Mtm Laboratories Ag Verfahren zum Nachweis von Karzinomen in solubilisierten zervikalen Körperproben
JP4563186B2 (ja) 2004-02-16 2010-10-13 理研ビタミン株式会社 耐熱性が改善されたアントシアニン色素
WO2005095987A2 (en) * 2004-03-26 2005-10-13 University Of Miami Salivary soluble cd44: a molecular marker for head and neck cancer
EP1898942B1 (en) 2004-07-14 2012-09-05 Biospectrum, Inc. Antiproliferative peptides
WO2007079284A2 (en) 2005-11-10 2007-07-12 University Of Kentucky Lung cancer diagnostic assay
US8088591B2 (en) * 2006-05-12 2012-01-03 University Of Miami Biomarkers for detection and diagnosis of head and neck squamous cell carcinoma
CN101230390A (zh) * 2007-12-07 2008-07-30 湖北大学 一种用于妇科恶性肿瘤早期筛选的基因芯片及其检测方法
US8715926B2 (en) * 2008-11-24 2014-05-06 Loma Linda University Biomarkers for the detection of head and neck tumors
US20140329230A1 (en) 2011-11-15 2014-11-06 University Of Miami Methods for detecting human papillomavirus and providing prognosis for head and neck squamous cell carcinoma

Also Published As

Publication number Publication date
CN104067126A (zh) 2014-09-24
EP2780714B1 (en) 2017-08-16
US20150219656A1 (en) 2015-08-06
US10180431B2 (en) 2019-01-15
US10180430B2 (en) 2019-01-15
MX2014005887A (es) 2014-09-08
IL232556A0 (en) 2014-06-30
BR112014011563B1 (pt) 2022-05-24
CO6980621A2 (es) 2014-06-27
AU2018203361B2 (en) 2020-08-27
CA2855971A1 (en) 2013-05-23
AU2012340441A1 (en) 2014-05-29
CN104067126B (zh) 2017-04-12
ES2640532T3 (es) 2017-11-03
JP2014533372A (ja) 2014-12-11
US20160305942A1 (en) 2016-10-20
CA2855971C (en) 2022-01-04
PE20141565A1 (es) 2014-10-25
AU2018203361A1 (en) 2018-05-31
IL232556A (en) 2017-12-31
MX352642B (es) 2017-12-01
US20140329230A1 (en) 2014-11-06
EP2780714A4 (en) 2015-07-15
JP6174035B2 (ja) 2017-08-02
EP2780714A1 (en) 2014-09-24
WO2013074793A1 (en) 2013-05-23
AU2020277155A1 (en) 2020-12-24

Similar Documents

Publication Publication Date Title
BR112014011563A2 (pt) métodos para detectar o papiloma-vírus humano e fornecer o prognóstico para carci-noma de células escamosas de cabeça e pescoço
BR112019006930A2 (pt) dispositivos e métodos para análise de amostra
MX2018012580A (es) Métodos y kits para el diagnóstico y la estratificación de riesgo en pacientes con isquemia.
GB201209668D0 (en) Methods of monitoring conditions by sequence analysis
EP2566983A4 (en) SERIAL ANALYSIS OF BIOMARKERS FOR THE DIAGNOSIS OF A DISEASE
BR112016004320A2 (pt) biossensor, sistema, kit, métodos de determinação ou de identificação e de quantificação de uma concentração de amônia ou íon amônio, de diagnóstico de uma doença metabólica em um sujeito, de determinação da resposta do paciente a uma terapia, de fabricação de um biossensor, de um sistema ou de qualquer tira de teste e de detecção da presença, ausência, ou quantidade de aminoácidos em uma amostra, e, tira de teste
JP2014533372A5 (pt)
NZ608384A (en) Biomarkers of renal injury
BR112013027123A2 (pt) método e sistema para analisar características de tecido, e, método de análise de características de agrupamento de células
EA200971124A1 (ru) Множественный анализ образцов крови
ATE554389T1 (de) Apex als marker für lungenkrebs
WO2010011357A3 (en) Detection of prostate cancer using psa glycosylation patterns
WO2014074835A8 (en) Antibody compositions and immunoassay methods to detect isoforms of anti-mullerian hormone
WO2020055954A3 (en) Methods for detecting liver diseases
WO2011160015A3 (en) Rotors for immunoassays
EA201370070A1 (ru) СПОСОБ ДЕТЕКЦИИ, ДИФФЕРЕНЦИАЦИИ И КВАНТИФИКАЦИИ ПОПУЛЯЦИЙ Т-КЛЕТОК С ИСПОЛЬЗОВАНИЕМ КОЛИЧЕСТВЕННОЙ ПЦР С ОБРАТНОЙ ТРАНСКРИПЦИЕЙ В РЕАЛЬНОМ ВРЕМЕНИ (ОТ-колПЦР РВ)
BRPI0518405A2 (pt) detecÇço de vÍrus papiloma humano (hpv) utilizando sondas de Ácido nuclÉico, microcontas e separador de cÉlulas ativado fluorescente (facs)
BR112014005651A2 (pt) aparelho de diagnóstico
BR112012024206A2 (pt) método e sistema para analisar uma amostra de sangue
MX354089B (es) Metodos y aparato para la deteccion de sensibilidad al gluten y su diferenciacion de la enfermedad celiaca.
WO2013036754A3 (en) Methods and compositions for diagnosis of ovarian cancer
Fiseha et al. Urinary markers of tubular Injury in HIV‐infected patients
TWI666446B (zh) 皮膚黏彈性的標記物及其利用
US20150204885A1 (en) Method for the direct detection of mycobacterium tuberculosis
ATE475098T1 (de) Verfahren zur messung von plasmaspiegeln von pentraxin ptx3

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B350 Update of information on the portal [chapter 15.35 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B09X Republication of the decision to grant [chapter 9.1.3 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 15/11/2012, OBSERVADAS AS CONDICOES LEGAIS

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 11A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2748 DE 05-09-2023 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.