BR112015027192A2 - - Google Patents

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Publication number
BR112015027192A2
BR112015027192A2 BR112015027192A BR112015027192A BR112015027192A2 BR 112015027192 A2 BR112015027192 A2 BR 112015027192A2 BR 112015027192 A BR112015027192 A BR 112015027192A BR 112015027192 A BR112015027192 A BR 112015027192A BR 112015027192 A2 BR112015027192 A2 BR 112015027192A2
Authority
BR
Brazil
Application number
BR112015027192A
Other languages
Portuguese (pt)
Other versions
BR112015027192B1 (pt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of BR112015027192A2 publication Critical patent/BR112015027192A2/pt
Publication of BR112015027192B1 publication Critical patent/BR112015027192B1/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/14—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from fungi, algea or lichens
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
    • A01N37/46—N-acyl derivatives
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
    • A01N63/10—Animals; Substances produced thereby or obtained therefrom
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
    • A01N63/50—Isolated enzymes; Isolated proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
    • C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
    • C12N15/8279—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Plant Pathology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Pest Control & Pesticides (AREA)
  • Environmental Sciences (AREA)
  • Dentistry (AREA)
  • Agronomy & Crop Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
BR112015027192-8A 2013-04-29 2014-04-29 Métodos para proteger ou tratar uma planta ou uma parte da referida planta, e tratar pós-colheita para proteger ou tratar uma planta colhida ou uma parte colhida da referida planta, e uso de uma composição farmacêutica BR112015027192B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361817170P 2013-04-29 2013-04-29
US61/817,170 2013-04-29
PCT/EP2014/058771 WO2014177595A1 (en) 2013-04-29 2014-04-29 Agrochemical compositions comprising antibodies binding to sphingolipids

Publications (2)

Publication Number Publication Date
BR112015027192A2 true BR112015027192A2 (enExample) 2017-07-25
BR112015027192B1 BR112015027192B1 (pt) 2022-05-10

Family

ID=50736046

Family Applications (2)

Application Number Title Priority Date Filing Date
BR112015027430-7A BR112015027430B1 (pt) 2013-04-29 2014-04-29 Composição compreendendo pelo menos um polipeptídeo que se liga especificamente a uma glicosilceramida de uma praga de fungos
BR112015027192-8A BR112015027192B1 (pt) 2013-04-29 2014-04-29 Métodos para proteger ou tratar uma planta ou uma parte da referida planta, e tratar pós-colheita para proteger ou tratar uma planta colhida ou uma parte colhida da referida planta, e uso de uma composição farmacêutica

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BR112015027430-7A BR112015027430B1 (pt) 2013-04-29 2014-04-29 Composição compreendendo pelo menos um polipeptídeo que se liga especificamente a uma glicosilceramida de uma praga de fungos

Country Status (16)

Country Link
US (5) US20160145325A1 (enExample)
EP (3) EP2992101B1 (enExample)
JP (4) JP6967347B2 (enExample)
CN (4) CN116076508A (enExample)
AU (3) AU2014273418B2 (enExample)
BR (2) BR112015027430B1 (enExample)
CA (2) CA2910874C (enExample)
DK (1) DK2992100T3 (enExample)
ES (2) ES2762151T3 (enExample)
HR (1) HRP20192182T1 (enExample)
HU (1) HUE047580T2 (enExample)
PL (2) PL2992100T3 (enExample)
PT (1) PT2992100T (enExample)
TR (1) TR201819577T4 (enExample)
WO (2) WO2014177595A1 (enExample)
ZA (2) ZA201507757B (enExample)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2795480C (en) 2010-04-06 2021-10-26 Vrije Universiteit Brussel Specific delivery of agrochemicals
CN116076508A (zh) 2013-04-29 2023-05-09 鲁汶天主教大学 包含结合至鞘脂的抗体的农用化学组合物
WO2016071438A2 (en) * 2014-11-05 2016-05-12 Agrosavfe Nv Transgenic plant comprising a polynucleotide encoding a variable domain of heavy-chain antibody
US20180222966A1 (en) * 2013-04-29 2018-08-09 Agrosavfe N.V. Transgenic plant comprising a polynucleotide encoding a variable domain of heavy-chain antibody
JP6376798B2 (ja) * 2014-03-27 2018-08-22 三菱重工業株式会社 洗濯排水生物処理製剤を用いた洗濯排水処理装置及び方法
EP3415010A1 (en) * 2017-06-13 2018-12-19 Agrosavfe Nv Insect-controlling polypeptides and methods
JP7327885B2 (ja) * 2017-08-09 2023-08-16 オリオンズ バイオサイエンス インコーポレイテッド Ｃｌｅｃ９ａ結合物質およびその使用
US10017560B1 (en) 2017-11-16 2018-07-10 King Saud University Nanobody against begomoviruses
AU2019215440B2 (en) 2018-02-05 2025-12-04 Orionis Biosciences, Inc. Fibroblast binding agents and use thereof
CN112703201A (zh) * 2018-07-05 2021-04-23 诺沃班德畜牧业治疗公司 针对家禽致病原的抗体和其用途
CN109081870B (zh) * 2018-09-21 2021-12-03 成都阿帕克生物科技有限公司 一种抗人促绒毛膜促性腺激素β亚单位的纳米抗体及核酸分子和应用
CA3118892A1 (en) 2018-11-08 2020-05-14 Orionis Biosciences, Inc. Modulation of dendritic cell lineages
WO2020144164A1 (en) 2019-01-07 2020-07-16 Bactolife Aps Pathogen binding proteins
JP7773371B2 (ja) 2019-03-28 2025-11-19 オリオニス バイオサイエンシズ，インコーポレイテッド Ｃｌｅｃ９ａベースキメラタンパク質複合体
MY206450A (en) * 2019-04-08 2024-12-17 Dna Twopointo Inc Transposition of nucleic acid constructs into eukaryotic genomes with a transposase from amyelois
BR112021020437A2 (pt) * 2019-04-13 2022-02-15 Flagship Pioneering Innovations Vi Llc Pacotes de mensageiros de plantas encapsulando polipeptídeos e seus usos
CN110205252A (zh) * 2019-06-20 2019-09-06 江苏大学 喷雾干燥制备拮抗酵母固体制剂的方法
WO2021072312A1 (en) * 2019-10-11 2021-04-15 The Trustees Of The University Of Pennsylvania Compositions and methods for targeting cd13 and tim-3 with car t cells to treat acute myeloid leukemia
BR112022009087A2 (pt) 2019-11-11 2022-07-26 Ibi Ag Innovative Bio Insecticides Ltd Nanocorpos para controle de insetos e usos dos mesmos
ES2992601T3 (en) 2020-03-31 2024-12-16 Biotalys NV Anti-fungal polypeptides
WO2021226204A2 (en) * 2020-05-05 2021-11-11 Oncorus, Inc. Anti-dll3 antibodies and methods of use
CN115867350A (zh) * 2020-05-15 2023-03-28 智利南方大学 针对SARS-CoV-2病毒的单域VHH抗体
US20230265478A1 (en) 2020-07-31 2023-08-24 Biotalys NV Methods of increasing recombinant protein yields
EP4015041A1 (en) * 2020-12-15 2022-06-22 Universidad De Zaragoza Treatment of fungal infections or diseases
CN113121692B (zh) * 2021-04-29 2022-12-06 中国科学技术大学 结合人rage胞外域的羊驼源抗体
WO2023148301A1 (en) 2022-02-02 2023-08-10 Biotalys NV Modified microbial cells and uses thereof
EP4473108A1 (en) 2022-02-02 2024-12-11 Biotalys NV Methods for genome editing
WO2023172983A1 (en) * 2022-03-08 2023-09-14 Molecular Templates, Inc. Ctla-4 binding molecules comprising shiga toxin a subunit scaffolds and uses thereof
CN115043935B (zh) * 2022-03-31 2023-06-27 深圳市人民医院 靶向新冠病毒的纳米抗体及其制备方法和应用
US20250382652A1 (en) 2022-12-22 2025-12-18 Biotalys NV Methods for genome editing
US20260026500A1 (en) 2022-12-29 2026-01-29 Biotalys NV Agrochemical compositions
EP4642233A1 (en) 2022-12-30 2025-11-05 Biotalys NV Agglomerate
EP4642232A1 (en) 2022-12-30 2025-11-05 Biotalys NV Self-emulsifiable concentrate
EP4642916A2 (en) 2022-12-30 2025-11-05 Biotalys NV Secretion signals
CN116267297B (zh) * 2023-02-21 2024-09-06 广西壮族自治区农业科学院 一种通过水分管理预防甘蔗白条病的方法
CN117659194B (zh) * 2023-11-30 2024-08-13 科弈(浙江)药业科技有限公司 靶向egfr的纳米抗体、药物偶联物及其用途
WO2025133390A1 (en) 2023-12-22 2025-06-26 Biotalys NV Anti-fungal vhh antibodies
WO2025154058A1 (en) 2024-01-21 2025-07-24 Ibi-Ag Innovative Bio Insecticides Ltd. Anti-insect hsp70 nanobodies and uses thereof
WO2025154056A1 (en) 2024-01-21 2025-07-24 Ibi-Ag Innovative Bio Insecticides Ltd. Anti-insect cda nanobodies and uses thereof
CN117866903B (zh) * 2024-03-12 2024-06-04 北京贝来药业有限公司 单域抗体修饰的干细胞及其在疾病治疗中用途
WO2026008785A1 (en) 2024-07-03 2026-01-08 Biotalys NV Agrochemical compositions
CN120623329A (zh) * 2025-01-15 2025-09-12 中国人民解放军军事科学院军事医学研究院 抗埃博拉病毒vp40蛋白的纳米抗体3e07及在病毒检测中的应用
CN119661667B (zh) * 2025-02-21 2025-05-13 南京农业大学三亚研究院 一种药物靶标蛋白MoFrd1及其在农业病害防治中的应用

Family Cites Families (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02128697A (ja) * 1988-11-09 1990-05-17 Hoechst Japan Ltd 抗フコシルセラミドモノクローナル抗体
FI903489A0 (fi) 1988-11-11 1990-07-10 Medical Res Council Ligander med en enda sektion, receptorer innehaollande naemnda ligander, foerfaranden foer deras framstaellning samt anvaendning av liganderna och receptorerna.
EP1498427B1 (en) 1992-08-21 2009-12-16 Vrije Universiteit Brussel Immunoglobulins devoid of light chains
DK0698097T3 (da) 1993-04-29 2001-10-08 Unilever Nv Produktion af antistoffer eller (funktionaliserede) fragmenter deraf afledt af Camelidae-immunoglobuliner med tung kæde
FR2708622B1 (fr) 1993-08-02 1997-04-18 Raymond Hamers Vecteur recombinant contenant une séquence d'un gène de lipoprotéine de structure pour l'expression de séquences de nucléotides.
JPH10506274A (ja) * 1994-09-19 1998-06-23 リークスラントボウユニフエルジタイト・ワゲニンゲン 農作物保護剤をコードする遺伝子構築物、ならびにそうした構築物を含有しかつ発現する形質転換された植物、ならびに農作物における病害生物体（ｐｌａｇｕｅ ｏｒｇａｎｉｓｍｓ）および病原体の調節方法
EP0739981A1 (en) 1995-04-25 1996-10-30 Vrije Universiteit Brussel Variable fragments of immunoglobulins - use for therapeutic or veterinary purposes
AU740043B2 (en) 1996-06-27 2001-10-25 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw Recognition molecules interacting specifically with the active site or cleft of a target molecule
BR9907241A (pt) 1998-01-26 2000-10-17 Unilever Nv Biblioteca de expressão, processo para preparar a mesma, uso de uma fonte não imunizada de sequências de ácido nucleico, e, processos para preparar fragmentos de anticorpos e, para preparar um anticorpo
WO2000002996A2 (en) 1998-07-10 2000-01-20 Cornell Research Foundation, Inc. Recombinant constructs and systems for secretion of proteins via type iii secretion systems
BR9915543A (pt) 1998-10-16 2001-08-14 Fraunhofer Ges Forschung Resistência a doenças por plantas mediada por patogenicidas moleculares
WO2000040968A1 (en) 1999-01-05 2000-07-13 Unilever Plc Binding of antibody fragments to solid supports
WO2000043507A1 (en) 1999-01-19 2000-07-27 Unilever Plc Method for producing antibody fragments
ID30380A (id) 1999-04-22 2001-11-29 Unilever Nv Penghambatan infeksi virus menggunakan protein pengikat antigen bervalensi tunggal
KR100455617B1 (ko) 1999-07-22 2004-11-06 독립행정법인농업생물자원연구소 단자엽 식물의 초신속 형질전환 방법
US6479280B1 (en) 1999-09-24 2002-11-12 Vlaams Interuniversitair Institutuut Voor Biotechnologie Vzw Recombinant phages capable of entering host cells via specific interaction with an artificial receptor
DK1233987T3 (da) 1999-11-29 2009-09-28 Bac Ip B V Immobiliserede enkelt-domæne antigenbindende molekyler
EP1242460B1 (en) 1999-11-29 2006-10-18 Unilever Plc Immobilisation of proteins using a polypeptide segment
EP1118669A3 (en) 1999-12-17 2001-08-29 Unilever Plc Production of camelid antibodies in plants
EP1134231B1 (en) 2000-03-14 2009-04-15 Unilever N.V. Antibody heavy chain variable domains against human dietary lipases, and their uses
CA2380443C (en) 2000-05-26 2013-03-12 Ginette Dubuc Single-domain antigen-binding antibody fragments derived from llama antibodies
US20040053340A1 (en) 2000-12-13 2004-03-18 De Haard Johannes Joseph Protein arrays
GB0110029D0 (en) * 2001-04-24 2001-06-13 Grosveld Frank Transgenic animal
US20060073141A1 (en) 2001-06-28 2006-04-06 Domantis Limited Compositions and methods for treating inflammatory disorders
EP1433793A4 (en) * 2001-09-13 2006-01-25 Inst Antibodies Co Ltd METHOD FOR CREATING A CAMEL ANTIBODY LIBRARY
JP2005289809A (ja) 2001-10-24 2005-10-20 Vlaams Interuniversitair Inst Voor Biotechnologie Vzw (Vib Vzw) 突然変異重鎖抗体
AU2002351896A1 (en) 2001-12-11 2003-06-23 Ablynx N.V. Method for displaying loops from immunoglobulin domains in different contexts
AU2002360068B2 (en) 2001-12-21 2009-09-03 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw Method for cloning of variable domain sequences
JP2005517674A (ja) 2002-01-03 2005-06-16 フラームス・インテルウニフェルシタイル・インステイチュート・フォール・ビオテヒノロヒー・ヴェーゼットウェー 腫瘍の処置に有用な新規免疫コンジュゲート
AU2003224073C1 (en) 2002-04-22 2010-03-11 AgroProtect GmbH Antibodies, recombinant antibodies, recombinant antibody fragments and fusions mediated plant disease resistance against fungi
DE10234116A1 (de) * 2002-07-26 2004-02-12 Land Rheinland-Pfalz vertreten durch die Staatliche Lehr- und Forschungsanstalt für Landwirtschaft, Weinbau und Gartenbau (SLFA) Verfahren zur Expression von gegen virale Proteine gerichtete scFv-Fragmenten in Pflanzen und deren Verwendung
EP1558647B1 (en) 2002-11-08 2015-06-10 Ablynx N.V. Single domain antibodies directed against tumour necrosis factor-alpha and uses therefor
WO2004041862A2 (en) 2002-11-08 2004-05-21 Ablynx N.V. Single domain antibodies directed against tumour necrosis factor-alpha and uses therefor
RU2357974C2 (ru) 2003-01-10 2009-06-10 Аблинкс Н.В. Терапевтические полипептиды, их гомологи, их фрагменты и их применение для модуляции агрегации, опосредованной тромбоцитами
JP4283127B2 (ja) * 2003-06-20 2009-06-24 独立行政法人科学技術振興機構 転写因子を転写抑制因子に変換するペプチド及びこれをコードするポリヌクレオチド、並びにその利用
US7563443B2 (en) 2004-09-17 2009-07-21 Domantis Limited Monovalent anti-CD40L antibody polypeptides and compositions thereof
US20080014192A1 (en) * 2006-05-23 2008-01-17 Poeta Maurizio D Methods For The Diagnosis And Treatment of Fungal Infections Caused By Microorganisms Producing Glucosylceramide
AU2008241364B2 (en) 2007-04-20 2013-03-21 Hexima Limited Modified plant defensin
NZ580505A (en) 2007-04-20 2011-03-31 Hexima Ltd Modified plant defensin comprising a signal peptide, a mature domain from a Class I defensin and a C-terminal propeptide tail from a Class II plant defensin
CU23688A1 (es) 2008-03-28 2011-07-11 Ct Ingenieria Genetica Biotech Secuencias de ácido nucleico y aminoácidos para el control de agentes patógenos
EP2143735A1 (en) * 2008-07-10 2010-01-13 Institut Pasteur Variable domains of camelid heavy-chain antibodies directed against glial fibrillary acidic proteins
CN102149283A (zh) 2008-08-12 2011-08-10 植物保健公司 稳定的液体harpin蛋白制剂的制备、制剂及用途
DK2367840T3 (en) 2008-12-08 2015-10-12 Complix N V SINGLE CHAIN ​​antiparallel coiled-coil PROTEINS
TW201106971A (en) * 2009-05-28 2011-03-01 Glaxo Group Ltd Antigen-binding proteins
AU2010288743A1 (en) 2009-08-24 2011-09-01 Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung E.V. Antibody fusion-mediated plant resistance against Oomycota
WO2011085070A2 (en) 2010-01-06 2011-07-14 Virginia Tech Intellectual Properties, Inc. Methods and compositions to improve the health of plants, animals and microbes by manipulating protein entry into symbionts and their hosts
CA2795480C (en) 2010-04-06 2021-10-26 Vrije Universiteit Brussel Specific delivery of agrochemicals
WO2012011396A1 (ja) * 2010-07-20 2012-01-26 国立大学法人東京大学 ナノ抗体を発現するトランスジェニックイネ
EP2609116A1 (en) 2010-08-26 2013-07-03 Agrosavfe N.V. Insect binding antibodies
EP2609119B1 (en) 2010-08-26 2017-10-18 Agrosavfe N.V. Chitinous polysaccharide antigen binding proteins
CN103153044B (zh) 2010-10-08 2015-06-17 韩国生命工学研究院 源自巴西橡胶树的乳胶分泌组织特异性srpp启动子及其用途
JP2012157315A (ja) * 2011-02-02 2012-08-23 Gekkeikan Sake Co Ltd ラクダ科動物抗体の重鎖可変ドメイン（ｖｈｈ）の生産方法
WO2013050594A1 (en) 2011-10-06 2013-04-11 Agrosavfe N.V. Manufacturing of specifically targeting microcapsules
US20180222966A1 (en) 2013-04-29 2018-08-09 Agrosavfe N.V. Transgenic plant comprising a polynucleotide encoding a variable domain of heavy-chain antibody
CN116076508A (zh) 2013-04-29 2023-05-09 鲁汶天主教大学 包含结合至鞘脂的抗体的农用化学组合物
WO2016071438A2 (en) 2014-11-05 2016-05-12 Agrosavfe Nv Transgenic plant comprising a polynucleotide encoding a variable domain of heavy-chain antibody

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