CN112703201A - 针对家禽致病原的抗体和其用途 - Google Patents
针对家禽致病原的抗体和其用途 Download PDFInfo
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Abstract
本文描述可用于减少、消除或预防动物的细菌群体感染的方法和抗体。本文还描述可用于由重链抗体和VHH片段靶向以减少动物中的细菌群体的抗原。
Description
交叉引用
本申请要求2018年7月5日提交的美国临时申请号62/694,164的权益，所述申请以引用的方式并入本文。根据35U.S.C.§119要求优先权。上述专利申请以引用的方式并入，就如同本文中充分阐述一般。
发明领域
本发明涉及用于防治与坏死性肠炎相关的微生物的方法和组合物，和其用途。
发明背景
牲畜被病原体污染之后对农业产业造成的损失是全球负担。随着全球人口的增长并且可用于农业的农田数量没有显著增加，需要在不使用更多空间的情况下生产更大量的粮食。用抗生素对动物进行传统治疗是出现多重耐药性生物的主要促成因素，并且被广泛认为是防治牲畜污染的不可持续的解决方案。需要开发抑制病原体与宿主的感染或缔合而不引起抗性的病原体特异性分子。据估计，由于引起坏死性肠炎的病原性生物而对家禽业造成的全球损失为每年$60亿(1)USD。细菌产气荚膜梭菌(Clostridium perfringen)是家禽的坏死性肠炎的病原体，与多种诱病因素(2)联合。
发明内容
参考下文所阐述的定义，本文描述包含重链可变区片段(VHH)的多肽，其预期用途包括但不限于农业或不相关领域中的以下应用：诊断学、体外分析、饲料、治疗学、底物鉴别、营养补充、生物科学和医学研究以及伴随诊断。本文还描述在农业中结合致病原并降低致病原的毒力的包含VHH的多肽。关于这些描述，下文阐述包含VHH的多肽在减少宿主动物的疾病传播和严重程度的方法中的用途，包括其作为产品中的成分的用途。为此，进一步描述产生、表征、改进并且修饰VHH的方法。
以引用的方式并入
本说明书中所提及的所有公布、专利和专利申请均以引用的方式并入本文，其并入程度就如同各个别公布、专利或专利申请特定地并且个别地经指示以引用的方式并入一般。
附图说明
本发明的新颖特征具体地阐述于所附权利要求中。参考以下阐述说明性实施方案的具体实施方式将获得对本发明的特征和优点的更好理解，其中使用本发明的原理，并且其中附图为：
图1A至图1B：图A示出仅骆驼科动物重链抗体和其与VHH结构域的关系的示意图。图B说明VHH结构域的框架区(FR)和互补决定区(CDR)。
图2A至图2F：示出针对本公开的VHH抗体的噬菌体ELISA结合数据。
图3：示出未标记的CnaA可胜过标记的CnaA进行胶原蛋白结合
定义
在描述本发明时，根据以下定义使用以下术语。
在以下描述中，阐述某些特定细节以便提供对多个实施方案的透彻理解。然而，本领域技术人员应理解所提供的实施方案可以在没有这些细节的情况下实施。除非上下文另外要求，否则在整个说明书和以下权利要求中，措词“包含(comprise)”和其变化形式，如“包含(comprises)”和“包含(comprising)”将以开放、包括含义来解释，也就是说解释为“包括但不限于”。除非本文另外明确规定，否则如本说明书和所附权利要求中所用，单数形式“一(a)”、“一(an)”和“所述(the)”包括复数指示物。还应注意，除非本文另外明确规定，否则术语“或”通常以其包括“和/或”的含义使用。此外，本文所提供的标题仅是为了方便起见，并且不解释要求保护的实施方案的范围或含义。
1)宿主
如本文所提及，当产品构成饲料时，“宿主”、“宿主生物”、“接受动物”、“宿主动物”和其变化形式是指产品的预期接受者。在某些实施方案中，宿主是来自总目鸡雁小纲(Galloanserae)。在某些实施方案中，宿主是家禽动物。在某些实施方案中，家禽动物是鸡、火鸡、鸭、鹌鹑、鸽子、雏鸽或鹅。在某些实施方案中，家禽动物是鸡。
2)病原体
如本文所提及，“病原体”、“病原性”和其变化形式是指有毒微生物，其可与宿主生物相关，其在那种生物中引起未感染的宿主生物中不存在的症状或症状集合，包括生存、茁壮成长和繁殖的能力的下降。病原体包括但不限于寄生虫、细菌、病毒、朊病毒、原生生物、真菌和藻类。在某些实施方案中，病原体是属于梭状芽孢杆菌(Clostridium)属的细菌。
“毒力”、“有毒”和其变化形式是指病原体在宿主生物中引起症状的能力。“毒力因子”是指在感染中具有经过证明或假定的作用的核酸、质粒、基因组岛、基因、肽、蛋白质、毒素、脂质、大分子机械或其复合物。
“致病原”是指在感染中具有经过证明或假定的作用的微生物、病原体或毒力因子。
3)细菌
如本文所提及，“细菌(bacteria)”、“细菌(bacterial)”和其变化形式是指但不限于梭状芽孢杆菌菌种或与宿主生物相关的任何其他细菌菌种。在某些实施方案中，细菌可能在与其相关的所有宿主生物中都无毒。
4)抗体
仅骆驼科动物重链抗体和其与VHH结构域和互补决定区(CDR)的关系的示意图在图1中示出。(图A)。仅骆驼科动物重链抗体由通过二硫桥连接的两条重链组成。每条重链含有通过铰链区连接于可变免疫球蛋白结构域(VHH)的两个恒定免疫球蛋白结构域(CH2和CH3)。(图B)是源于单个VHH结构域。每个VHH结构域含有大约110-130个氨基酸的氨基酸序列。VHH结构域由从N端(N)开始的以下区域组成：框架区1(FR1)、互补决定区1(CDR1),、框架区2(FR2)、互补决定区2(CDR2)、框架区3(FR3)、互补决定区3(CDR3)和框架区4(FR4)。所述结构域在C端(C)结束。互补决定区是高度可变的，决定抗体的抗原结合，并且通过VHH结构域的框架区在骨架中保持在一起。所述框架区由更保守的氨基酸序列组成；然而，这些区域中存在一些变异型。
如本文所提及，“VHH”是指包含单个重链可变区的抗体或抗体片段，所述单个重链可变区可以源于天然或合成来源。本文中所提及的NBX是VHH的实例。在某一方面，VHH可以缺乏一部分重链恒定区(CH2或CH3)或整个重链恒定区。
如本文所提及，“重链抗体”是指包含两条重链并且缺乏常规抗体中通常存在的两条轻链的抗体。重链抗体可以起源于骆驼科或软骨鱼纲的物种。在不存在任何轻链的情况下，重链抗体保留与抗原的特异性结合。
如本文所提及，“特异性结合”、“特异性地结合”或其变化形式是指在抗体与其靶分子之间发生的结合，所述结合是由抗体的可变区的至少一个互补决定区(CDR)介导。恒定区与另一分子(例如蛋白质A或G)之间的结合不构成特异性结合。
如本文所提及，“抗体片段”是指常规或重链抗体中保留特异性地结合靶抗原的能力的任何部分，并且可以包括单链抗体、重链抗体的可变区片段、纳米抗体、多肽或免疫球蛋白新抗原受体(IgNAR)。
如本文所提及，当抗体的任何CDR区在一种物种的动物中产生时，“所述抗体起源于所述物种”。在某一物种中产生并且随后通过体外方法(例如，噬菌体展示)优化的抗体被认为已经起源于那个物种。
如本文所提及，“常规抗体”是指任何全长免疫球蛋白，其包含通过二硫键接合在一起的两个重链分子和两个轻链分子。在某些实施方案中，本文所述的抗体、组合物、饲料、产品和方法不使用常规抗体。
5)产生系统
如本文所提及，“产生系统”和其变化形式是指可用于产生本发明的任何物理实施方案或本发明的修改形式的任何系统。非限制性地，这包括但不限于由以下任一者进行的生物产生：细菌、酵母、藻类、节肢动物、节肢动物细胞、植物、哺乳动物细胞。非限制性地，生物产生可生成可以是细胞内、周质、膜相关、分泌或噬菌体相关的抗体。非限制性地，“产生系统”和其变化形式还包括但不限于任何合成产生系统。这包括但不限于从头蛋白质合成、在细胞提取物存在下的蛋白质合成、在纯化酶存在下的蛋白质合成以及任何其他替代性蛋白质合成系统。
6)产品
如本文所提及，“产品”是指本发明的任何物理实施方案或本发明的修改形式，其中VHH与包括自身在内的任何分子的结合规定其用途。这包括但不限于饲料、饲料添加剂、营养补充剂、预混料、药品、治疗剂、药物、诊断工具、体外分析的组分或整体、诊断分析(包括伴随诊断分析)的组分或整体。
7)饲料产品
如本文所提及，“饲料产品”是指本发明的任何物理实施方案或本发明的修改形式，其中VHH与包括自身在内的任何分子的结合规定其作为由宿主生物吸收的产品的预期用途。这包括但不限于饲料、压缩饲料、饲料添加剂、营养补充剂、预混料、药品、治疗剂或药物。
具体实施方式
所提供的本发明描述将联合本文所提供的定义和警告加以解释。
多年来，农业产业已经使用抗生素来防治病原菌。这些抗生素也充当生长促进剂。这种方法已经极大地促进了病原性生物中抗生素抗性的传播。为了逐步淘汰用于非医学目的的抗生素并且限制抗微生物抗性，欧洲已禁止在动物饲料中使用抗生素作为生长促进剂(从2006年起生效)。由于许多在农业上重要的动物的短寿命、对工业规模的畜群进行疫苗接种所带来的后勤挑战以及高昂的成本，无法通过疫苗接种广泛保护饲养动物。动物饲料中预防性抗生素的撤出以及疫苗接种无法提供广泛保护支持以下需求，即开发非抗生素产品以施用于农业动物来预防感染并且促进生长。
影响家禽动物的重要病原体包括细菌(尤其如梭状芽孢杆菌和沙门氏菌(Salmonella)属的成员)以及寄生虫(如艾美球虫(Eimeria)属的成员)。
据估计，由于坏死性肠炎的病原体产气荚膜梭菌而造成的损失为每年$60亿(1)USD。坏死性肠炎可导致鸡群的显著死亡率(3)。在亚临床水平上，由产气荚膜梭菌引起的肠粘膜损害导致降低的消化和吸收、减少的体重增加和增加的饲料转化率(3)。通常，坏死性肠炎发生在一些其他诱病因素对鸡的粘膜损害之后(2)与坏死性肠炎相关的产气荚膜梭菌毒力因子已经显示出包括毒素的产生和对胶原蛋白的粘附(4)。
艾美球虫寄生虫的亚临床感染是坏死性肠炎的最常见诱病因素之一(2)。这些寄生虫可在物理上损害上皮层并且诱导粘液生成(5)。另外，艾美球虫寄生虫也是鸡的球虫病的病原体，据估计所述疾病引起€100亿全球家禽损失(6)。球虫病的特征是减少的体重增加和饲料转化、吸收不良、关联细胞的细胞溶解以及腹泻(7)。
胃肠道微生物群的变化也可用于诱导坏死性肠炎。例如，肠道沙门氏菌(Salmonella enterica)对雏鸡造成的早期感染早期可在实验模型中导致坏死性肠炎的发展，可能是由于宿主免疫反应的改变所致(8)。
针对坏死性肠炎的发展提出的其他诱病因素包括由病毒感染引起的免疫抑制、由饮食改变引起的肠道物理变化以及不良动物管理(2)。
本发明领域中的前期工作依赖于宿主生物来产生针对致病原的保护作用。这种方法通常受到受以上列出的病原体影响的宿主生物的短寿命限制，这确实使宿主生物的免疫系统有足够的时间产生持久免疫力。此外，现有技术的有效性受到与大批宿主生物的广泛疫苗接种相关的技术挑战限制。这些问题通过引入外源肽来规避，所述外源肽经由饲料中和致病原的毒力和传播至宿主中，而不会引起宿主免疫反应。此外，本文所述的方法提供中和肽的调适和改进的范围，所述范围提供了超出宿主天然地能够产生的功能的合成功能。
抗体重链可变区片段(VHH)是包含与抗原的特异性结合区的小(12-15kDa)蛋白。当引入至动物中时，VHH原位结合致病原并且中和其效应。由于其较小质量，与常规抗体(如先前记录的IgY)相比，其不太容易由宿主生物中发现的酶裂解，对温度和pH变化更具适应性，更易溶，具有低全身吸收并且更容易大规模地重组产生，从而使其比常规抗体更适合用于动物治疗。
用于预防或减少毒力的抗体(概述)
一方面，本发明提供一种或多种包含VHH或VHH的多肽，所述多肽结合致病原以减少疾病的严重程度以及物种之间和跨物种传播。在某些实施方案中，将所述VHH供应至宿主动物。在某些实施方案中，所述VHH是产品的成分。
结合以减少毒力
另一方面，本发明提供一种或多种包含VHH或VHH的多肽，所述多肽结合致病原，并且在结合致病原时，减少所述致病原发挥病理功能或促成疾病表型的能力。在某些实施方案中，VHH与致病原的结合减少所述致病原的复制速率。在某些实施方案中，VHH与致病原的结合减少所述致病原结合于其同源受体的能力。在某些实施方案中，VHH与致病原的结合减少所述致病原与另外一种或多种分子相互作用的能力。在某些实施方案中，VHH与致病原的结合减少所述致病原的迁移率或运动性。在某些实施方案中，VHH与致病原的结合减少所述致病原到达感染位点的能力。在某些实施方案中，VHH与致病原的结合减少所述致病原引起细胞死亡的能力。
源于美洲驼的抗体
另一方面，本发明提供一种用重组毒力因子接种骆驼科动物或其他物种，从接种生物的淋巴细胞中检索编码VHH结构域的mRNA，反转录编码VHH结构域的mRNA以产生cDNA，将cDNA克隆至合适载体中并且从所述载体重组表达VHH的方法。在某些实施方案中，骆驼科动物可以是但不限于单峰骆驼、骆驼、美洲驼、羊驼、小羊驼或原驼。在某些实施方案中，接种的物种可以是但不限于可以产生单结构域抗体的任何生物，包括软骨鱼，如软骨鱼纲生物的成员，其包括例如鲨鱼、魟鱼、鳐鱼和锯鳐。在某些实施方案中，重链抗体包含阐述于表1中的序列。在某些实施方案中，重链抗体包含与表1中公开的任何序列具有至少80％、90％、95％、97％或99％同一性的氨基酸序列。在某些实施方案中，重链抗体具有阐述于表2中的CDR1。在某些实施方案中，重链抗体具有阐述于表2中的CDR2。在某些实施方案中，重链抗体具有阐述于表2中的CDR3。
重组表达的抗体
另一方面，本发明提供一种用于在合适的产生生物中产生VHH的方法。合适的产生生物包括但不限于细菌、酵母和藻类。在某些实施方案中，产生细菌是大肠杆菌(Escherichia coli)。在某些实施方案中，产生细菌是芽孢杆菌(Bacillus)属的成员。在某些实施方案中，产生细菌是益生菌。在某些实施方案中，酵母是巴斯德毕赤酵母(Pichiapastoris)。在某些实施方案中，酵母是酿酒酵母(Saccharomyces cerevisiae)。在某些实施方案中，藻类是衣藻(Chlamydomonas)属或褐指藻(Phaeodactylum)属的成员。
添加至饲料中的抗体
另一方面，本发明提供一种或多种包含VHH或VHH的多肽，所述多肽结合致病原并且作为饲料产品的一部分经由任何合适途径施用于宿主动物。在某些实施方案中，所述动物是选自所描述的宿主动物的列表，所述列表是代表性的而非限制性的。在某些实施方案中，施用于接受动物的途径可以是但不限于：口服或直肠引入消化道、提供至外表面(例如作为喷雾剂或浸没剂)、提供至其中栖息动物的介质(包括基于空气的介质)、通过注射提供、静脉内提供、经由呼吸系统提供、经由扩散提供、经由通过内皮或上皮吸收提供或经由第二生物(如酵母、细菌、藻类、噬菌体、植物和昆虫)提供。在某些实施方案中，宿主是来自总目鸡雁小纲(Galloanserae)。在某些实施方案中，宿主是家禽动物。在某些实施方案中，家禽动物是鸡、火鸡、鸭、鹌鹑、鸽子、雏鸽或鹅。在某些实施方案中，家禽动物是鸡。
饲料产品
另一方面，本发明提供一种或多种包含VHH或VHH的多肽，所述多肽结合致病原并且呈产品形式施用于宿主动物。所述产品的形式不受限制，只要其呈所需形式保持与致病原的结合。在某些实施方案中，所述产品是饲料、压缩饲料、营养补充剂、预混料、治疗剂、药品或饲料添加剂，但不限于这些形式。
进料剂量
另一方面，本发明提供一种或多种包含VHH或VHH的多肽，所述多肽结合致病原并且作为产品的一部分以任何合适的给药方案施用于宿主动物。实际上，合适的剂量是产品提供任何程度的针对致病原的保护作用的剂量，并且取决于递送方法、递送时间表、接受动物的环境、接受动物的体格、接受动物的年龄和接受动物的健康状况以及其他因素。在某些实施方案中，VHH以超过1mg/kg体重的浓度施用于接受动物。在某些实施方案中，VHH以超过5mg/kg体重的浓度施用于接受动物。在某些实施方案中，VHH以超过10mg/kg体重的浓度施用于接受动物。在某些实施方案中，VHH以超过50mg/kg体重的浓度施用于接受动物。在某些实施方案中，VHH以超过100mg/kg体重的浓度施用于接受动物。在某些实施方案中，VHH以小于1mg/kg体重的浓度施用于接受动物。在某些实施方案中，VHH以小于500mg/kg体重的浓度施用于接受动物。在某些实施方案中，VHH以小于100mg/kg体重的浓度施用于接受动物。在某些实施方案中，VHH以小于50mg/kg体重的浓度施用于接受动物。在某些实施方案中，VHH以小于10mg/kg体重的浓度施用于接受动物。
进料频率
另一方面，本发明提供一种或多种包含VHH或VHH的多肽，所述多肽结合致病原并且作为产品的一部分以任何合适的给药频率施用于宿主动物。实际上，合适的给药频率是产品提供针对致病原的任何保护作用的频率，并且取决于递送方法、递送时间表、接受动物的环境、接受动物的体格、接受动物的年龄和接受动物的健康状况以及其他因素。在某些实施方案中，给药频率可以是但不限于：恒定地、在一小时内以一致的规定频率(每小时)、在24小时周期内以规定频率(每天)、在一周内以规定频率(每周)、在一个月内以规定频率(每月)、在一年内以规定频率(每年)以及超过1年以任何其他规定频率。
饲料添加剂
另一方面，本发明提供一种或多种包含VHH或VHH的多肽，所述多肽结合致病原并且作为另外包含其他添加剂或涂料的产品的一部分施用于宿主动物。实际上，最合适的涂料或添加剂取决于递送方法、接受动物、接受者的环境、接受动物的饮食要求、递送频率、接受动物的年龄、接受动物的体格、接受动物的健康状况在某些实施方案中，这些添加剂和涂料可以包括但不限于以下列表和其混合物：维生素、抗生素、激素、抗微生物肽、类固醇、益生菌、益生菌、噬菌体、甲壳质、壳聚糖、B-1,3-葡聚糖、蔬菜提取物、胨、虾粉、磷虾、藻类、B-环糊精、褐藻酸盐、胶、黄蓍胶、果胶、明胶、添加剂喷雾、毒素结合剂、短链脂肪酸、中链脂肪酸、酵母、酵母提取物、糖、消化酶、消化化合物、必需矿物、必需盐或纤维。
非饲料用途
另一方面，本发明提供一种或多种包含VHH或VHH的多肽，所述多肽结合致病原，并且可用于非饲料用途，如但不限于：诊断试剂盒、酶联免疫吸附剂分析(ELISA)、western印迹分析、免疫荧光分析或荧光共振能量转移(FRET)分析，呈其现有形式及/或作为结合于另一分子的多肽。在某些实施方案中，所述结合分子可以是但不限于：荧光团、化学发光底物、抗微生物肽、核酸或脂质。
抗原
另一方面，本发明提供一种或多种包含VHH或VHH的多肽，所述多肽结合致病原，包括由梭状芽孢杆菌菌种产生的毒素。在某些实施方案中，所述菌种不属于梭状芽孢杆菌属，但能够携带由梭状芽孢杆菌菌种共享的致病原。在某些实施方案中，梭状芽孢杆菌菌种是指现有和重新分类的生物。在某些实施方案中，梭状芽孢杆菌菌种是产气荚膜梭菌。
在某些实施方案中，所述一种或多种VHH能够结合于起源于相同或不同菌种的一种或多种致病原。在某些实施方案中，所述致病原是与NetB(SEQ ID 207)具有80％或更大的氨基酸序列同一性的多肽。在某些实施方案中，所述致病原是与Cpa(SEQ ID 208)具有80％或更大的氨基酸序列同一性的多肽。在某些实施方案中，所述致病原是与Cpb2(SEQ ID209)具有80％或更大的氨基酸序列同一性的多肽。在某些实施方案中，所述致病原是与CnaA(SEQ ID 210)具有80％或更大的氨基酸序列同一性的多肽。在某些实施方案中，所述致病原是与CnaA的胶原蛋白结合结构域(SEQ ID 211)具有80％或更大的氨基酸序列同一性的多肽。在某些实施方案中，所述致病原是缔合至梭状芽孢杆菌细菌的表面的暴露的肽、蛋白质、蛋白质复合物、核酸、脂质或其组合。在某些实施方案中，所述致病原是菌毛、伞毛、鞭毛、分泌系统或孔蛋白。在某些实施方案中，所述致病原是梭状芽孢杆菌细菌。
在某些实施方案中，所述致病原或其衍生物可以过量提供并且胜过病原体表达的致病原的活性。在某些实施方案中，与CnaA(SEQ ID 210)或CnaA的胶原蛋白结合结构域(SEQ ID 211)具有80％或更大的氨基酸序列同一性的多肽可以过量提供以胜过由产气荚膜梭菌细菌表达的CnaA的活性。
抗原序列
NetB(SEQ ID 207)
>ABW71134.1坏死性肠炎毒素B前体[产气荚膜梭菌]
MKRLKIISITLVLTSVISTSLFSTQTQVFASELNDINKIELKNLSGEIIKENGKEAIKYTSSDTASHKGWKATLSGTFIEDPHSDKKTALLNLEGFIPSDKQIFGSKYYGKMKWPETYRINVKSADVNNNIKIANSIPKNTIDKKDVSNSIGYSIGGNISVEGKTAGAGINASYNVQNTISYEQPDFRTIQRKDDANLASWDIKFVETKDGYNIDSYHAIYGNQLFMKSRLYNNGDKNFTDDRDLSTLISGGFSPNMALALTAPKNAKESVIIVEYQRFDNDYILNWETTQWRGTNKLSSTSEYNEFMFKINWQDHKIEYYL
Cpa(SEQ ID 208)
>WP_057230321.1磷脂酶[产气荚膜梭菌]
MKRKICKALICAALATSLWAGASTKVYAWDGKIDGTGTHAMIVTQGVSILENDLSKNEPESVRKNLEILKENMHELQLGSTYPDYDKNAYDLYQDHFWDPDTDNNFSKDNSWYLAYSIPDTGESQIRKFSALARYEWQRGNYKQATFYLGEAMHYFGDIDTPYHPANVTAVDSAGHVKFETFAEERKEQYKINTAGCKTNEDFYADILKNKDFNAWSKEYARGFAKTGKSIYYSHASMSHSWDDWDYAAKVTLANSQKGTAGYIYRFLHDVSEGNDPSVGKNVKELVAYISTSGEKDAGTDDYMYFGIKTKDGKTQEWEMDNPGNDFMTGSKDTYTFKLKDENLKIDDIQNMWIRKRKYTAFPDAYKPENIKIIANGKVVVDKDINEWISGNSTYNIK
Cpb2(SEQ ID 209)
>AEP94971.1β2-毒素(质粒)[产气荚膜梭菌]
MKKLIVKSTMMLLFSCLLCLGIQLPNTVKANEVNKYQSVMVQYLEAFKNYDIDTIVDISKDSRTVTKEEYKNMLMEFKYDPNQKLKSYEITGSRKIDNGEIFSVKTEFLNGAIYNMEFTVSYIDNKLMVSNMNRISIVNEGKCIPTPSFRTQVCTWDDELSQYIGDAVSFTRSSKFQYSSNTITLNFRQYATSGSRSLKVKYSVVDHWMWGDDIRASQWVYGENPDYARQIKLYLGSGETFKNYRIKVENYTPASIKVFGEGYCY
CnaA(SEQ ID 210)
>ALJ54440.1假定的胶原蛋白粘附素[产气荚膜梭菌]
MKINKKIFSMLFMVIVLFTCISSNFSVSASSIQRGRDISNEVVTSLVATPNSINDGGNVQVRLEFKENHQRNIQSGDTITVKWTNSGEVFFEGYEKTIPLYIKDQNVGQAVIEKTGATLTFNDKIDKLDDVGGWATFTLQGRNITSGNHEHTGIAYIISGSKRADVNITKPESGTTSVFYYKTGSMYTNDTNHVNWWLLVNPSKVYSEKNVYIQDEIQGGQTLEPDSFEIVVTWYDGYVEKFKGKEAIREFHNKYPNSNISVSENKITVNISQEDSTQKFINIFYKTKITNPKQKEFVNNTKAWFKEYNKPAVNGESFNHSVQNINADAGVNGTVKGELKIIKTLKDKSIPIKDVQFKMRRVDNTVIKDGKKELLLTTDDKGIANVKGLPVGKYEVKEISAPEWIAFNPLIAPKLEFTISDQDTEGKLWAVENELKTISIPVEKVWVGQTSERAEIKLFADGIEVDKVILNADNNWKHTFENKPEYNSETKQKINYSVSETTISGYESNITGDAKNGFIVTNTELPDLTIGKEVIGELGDKTKVFNFELTLKQADGKPINGKFNYIGSVDDRYKKESIKPSDGEITFIEGKATITLSHGQEITIKDLPYGVTYKVMEKEANENGYLTTYNGNNEVTTGELKQDTKVQVVNNKEFVPTTGISTTTEQGTMVGMVIFSIGILMVMIVVLLQLNKGLKR
CnaA胶原蛋白结合结构域(SEQ ID 211)
GRDISNEVVTSLVATPNSINDGGNVQVRLEFKENHQRNIQSGDTITVKWTNSGEVFFEGYEKTIPLYIKDQNVGQAVIEKTGATLTFNDKIDKLDDVGGWATFTLQGRNITSGNHEHTGIAYIISGSKRADVNITKPESGTTSVFYYKTGSMYTNDTNHVNWWLLVNPSKVYSEKNVYIQDEIQGGQTLEPDSFEIVVTWYDGYVEKFKGKEAIREFHNKYPNSNISVSENKITVNISQEDSTQKFINIFYKTKITNPKQKEFVNNTKAWFKEYNKPAVNGESFNHSVQNINADAGVNGTVK
实施例
以下说明性实施例代表本文所述的应用、系统和方法的实施方案并且不打算以任何方式进行限制。
虽然本文已经显示并且描述本发明的优选实施方案，但本领域技术人员应显而易知，此类实施方案仅以举例的方式提供。在不偏离本发明的情况下，本领域技术人员现将进行多种变异、变化和取代。应理解，本文所述的发明的实施方案的多种替代方案可以用于实施本发明。
1.抗原的产生
重组抗原可以从大肠杆菌表达系统中纯化。例如，抗原可以在18℃下在自动诱导培养基(Formedium)中生长过夜的大肠杆菌BL21(DE3)细胞中表达。细胞接着在具有12.5μg/ml DNase I和1X蛋白酶抑制剂混合液(Bioshop)的缓冲液A(250mM NaCl、50mM CaCl2、20mM咪唑和10mM HEPES，pH 7.4)中通过声波处理来溶解。溶解产物通过在4℃下以22000xg离心持续30分钟而变得澄清，应用于用缓冲液A预平衡的5ml HisTrap HP柱(GEHealthcare)，用十倍柱体积的缓冲液A洗涤并且用0％至60％(vol/vol)缓冲液B(250mMNaCl、50mM CaCl2、500mM咪唑和10mM HEPES，pH7.4)的梯度洗脱。所述蛋白质接着在4℃下在TEV存在下针对缓冲液C(250mM NaCl、10mM HEPES pH 7.4和5mMβ-巯基乙醇)透析过夜。透析的蛋白质应用于用缓冲液C预平衡的HisTrap HP柱(GE Biosciences)。使6xHis标记的TEV和6xHis-标签结合于所述柱并且在流通液中收集抗原。样品针对缓冲液D(5mM NaCl和10mM Tris pH 8.8)透析过夜并且接着应用于5ml HiTrap Q HP柱(GE Healthcare)。所述蛋白质用0％至50％(vol/vol)缓冲液E(1.0M NaCl和10mM Tris pH8.8)的梯度洗脱。最后，使用缓冲液F(400mM NaCl和20mM HEPES pH 7.4)将洗脱液装载至Superdex 75Increase10/300GL凝胶过滤柱(GE Healthcare)上。所述蛋白质样品接着使用具有适当分子量截断值的Amicon浓缩器(MWCO；Millipore)浓缩至1mg/mL。纯化的蛋白质存储于-80℃下。
2.NBX的产生和淘选
美洲驼免疫
用纯化的致病原(如所列出的抗原)使单个美洲驼免疫，所述致病原可能伴有佐剂。使用100μg每种抗原执行美洲鸵免疫，所述抗原经过汇集并进行注射，共计四次注射。在注射时，使抗原解冻，并用PBS将体积增加至1ml。然后使1ml抗原-PBS混合物与1ml完全弗氏佐剂(CFA)或不完全弗氏佐剂(IFA)混合，共计2ml。每次注射使共计2ml免疫。然后在第0、28、49、70天从免疫动物中收集美洲鸵全血和血清。来自第28、49和70天的血清然后进行分馏以从常规抗体中分离VHH。ELISA可用于测量针对多克隆和富含VHH的馏分中的靶抗原的反应性。从第28、49和70天采集的血清中收集淋巴细胞。
淘选
使用从纯化的美洲驼淋巴细胞中分离的RNA来生成cDNA，以克隆至噬菌粒中。使用所得噬菌粒来转化大肠杆菌TG-1细胞以产生表达的VHH基因的库。噬菌粒库大小可以是约2.5×107个总转化体并且据估计，含有VHH插入物的噬菌粒的估计数目可以是约100％。然后通过针对用于美洲驼免疫的抗原进行淘选来选择高亲和力抗体。执行两轮淘选并且使用噬菌体ELISA来鉴别从第2轮中产生的抗原结合克隆。对抗原结合克隆进行测序，根据其CDR区进行分组，并且针对大肠杆菌中的可溶性表达和抗体纯化进行优先排序。
图2示出本公开的抗体的噬菌体ELISA结果。黑条显示与用表1和表2中规定的抗原涂布的孔结合，所述抗原溶解于磷酸盐缓冲生理盐水(PBS)中。灰色条是阴性对照，其显示仅与用PBS涂布的孔结合。在所有情况下，与抗原靶的结合比与PBS涂布的孔的结合高至少两倍。关于NBX0301至NBX0332的数据显示于图A中。关于NBX0333-NBX0360的数据显示于图B中。关于NBX0501-NBX0515和NBX0517-NBX0528的数据显示于图C中。关于NBX0529-NBX0553的数据显示于图D中。关于NBX0561、NBX0801-NBX0812、NBX0847和NBX0866-NBX0880的数据显示于图E中。关于NBX0881和NBX0883-NBX08108的数据显示于图F中。
从大肠杆菌中纯化VHH
TEV蛋白酶可裂解、6xHis-硫氧还蛋白-NBX融合蛋白在30℃下在自动诱导培养基(Formedium)中生长的大肠杆菌的细胞质中表达持续24小时。通过离心收集细菌，再悬浮于缓冲液A(10mM HEPES pH7.5、250mM NaCl、20mM咪唑)中且使用声波处理来溶解。通过离心去除不溶性材料并且将剩余的可溶性部分应用于用缓冲液A预平衡的HisTrap柱(GEBiosciences)上。所述蛋白质使用FPLC从柱中洗脱，在缓冲液A与缓冲液B(10mM HEPES pH7.5、500mM NaCl、500mM咪唑)之间存在线性梯度。洗脱的蛋白质在TEV蛋白酶存在下透析至缓冲液C(10mM HEPES pH 7.5、500mM NaCl)中过夜。透析的蛋白质应用于用缓冲液C预平衡的HisTrap柱(GE Biosciences)。使6xHis标记的TEV和6xHis-标记的硫氧还蛋白结合于所述柱并且在流通液中收集高度纯化的NBX。NBX蛋白透析至PBS中过夜并且浓缩至约10mg/ml。
具有用于6xHis标记的VHH的表达和分泌的构建体的巴斯德毕赤酵母菌株GS115在30℃下生长持续5天，每天用0.5％(vol/vol)甲醇诱导。通过离心去除酵母细胞并且使含NBX的上清液掺加10mM咪唑。上清液应用于用缓冲液A(10mM HEPES pH 7.5、500mM NaCl)预平衡的HisTrap柱(GE Biosciences)上。所述蛋白质使用FPLC从柱中洗脱，在缓冲液A与缓冲液B(10mM HEPES pH 7.5、500mM NaCl、500mM咪唑)之间存在线性梯度。NBX蛋白透析至PBS中过夜并且浓缩至约10mg/ml。
3.NetB细胞毒性的NBX中和
来自原鸡(Gallus gallus)菌株Leghorn的肝细胞癌源性上皮细胞(LMH细胞)在37℃和5％CO2下以64,000个细胞/孔粘附至组织培养物处理并且涂布有明胶的96孔微量滴定板的表面过夜。重组表达的NetB在37℃和5％CO2下用一定浓度范围内的NBX或其中溶解有NBX的缓冲液(20mM HEPES pH 7.4、150mM NaCl)预孵育持续15分钟。15分钟后，毒素/NBX混合物添加至LMH细胞的一式三份孔中。NetB的最终浓度为5nM。NBX的最终浓度为1、3、9、27、81、243、729和2187nM。具有毒素/NBX混合物的LMH细胞在37℃和5％CO2下孵育持续5小时。根据制造商的说明书，使用Pierce LDH细胞毒性分析试剂盒(Thermo Scientific)测量NetB诱导的细胞毒性。相对于在NBX不存在的情况下的NetB细胞毒性，测定在NBX存在下的NetB细胞毒性百分比。使用GraphPad Prism 8测定抑制剂浓度对反应的非线性拟合，其生成50％抑制浓度(IC50)，所述浓度接近阻断5nM NetB的50％细胞毒性所需的NBX浓度。
表3指示关于所测试的所有NBX，NBX是否可以小于1μM和/或小于50nM的IC50-值中和NetB针对LMH细胞的活性。
4.CnaA胶原蛋白结合的NBX减少
在96孔微量滴定板中，2μg胶原蛋白在4℃下在每孔100μl PBS中孵育过夜。所述板用200μl PBS洗涤且接着在37℃下用200μl含5％脱脂乳的PBS阻断持续2小时。在阻断步骤中，200nM或2μM个别NBX在37℃下与100nM或0nM 6X-组氨酸和麦芽糖结合蛋白(MBP)标记的CnaA在PBS中混合持续30分钟。所述板用200μl PBS洗涤三次，并且将100μl NBX或NBX/MBP-CnaA混合物添加至每个孔中，在37℃下孵育2小时。在用200μl PBS洗涤三次之后，将100μl0.125μg/ml与HRP结合的抗His添加至每个孔中并且在室温下孵育持续1小时。所述板接着用200μl PBS洗涤三次，并将100μl TMB底物添加至每个孔中并且使其显影持续30分钟。为了停止反应，向每个孔中添加50μl 1M HCl。读取所述板在450nm下的吸光度以定量结合。为了定量在NBX存在下CnaA与胶原蛋白的结合的减少，相对于在NBX不存在的情况下的CnaA结合(100％结合)计算减少百分比。
表4指示关于所测试的所有NBX，当NBX是以2μM和/或以200nM供应时，NBX是否可以减少CnaA与胶原蛋白的结合达50％以上。
5.Cpa卵磷脂酶活性的NBX中和
通过从蛋清中分离使Cpa与NBX或PBS混合以在全部商店购买、散养鸡蛋中达到100nM(Cpa)和1uM(NBX)的最终浓度。小心地刺破蛋黄，然后取出5ml，并且与45ml PBS充分地混合以生成10％溶液。所述溶液在500g下离心以去除大的聚集物并且接着传递通过0.45um GD/X针筒过滤器。将60ul过滤的蛋黄溶液添加至Cpa或Cpa/NBX孔中以达到5％v/v蛋黄的最终浓度。板在37℃下孵育持续1h，之后在620nm下测量所述板的光学密度。相对于在NBX不存在的情况下的Cpa卵磷脂酶活性(100％)，测定Cpa卵磷脂酶活性的NBX中和。
表5指示关于所测试的所有NBX，当NBX是以1μM供应时，NBX是否可以减少Cpa卵磷脂酶活性达40％以上。
6.关于胶原蛋白结合，过量提供的未标记的CnaA胜过标记的CnaA
在96孔微量滴定板中，2μg胶原蛋白在4℃下在每孔100μl PBS中孵育过夜。所述板用200μl PBS洗涤且接着在37℃下用200μl含5％脱脂乳的PBS阻断持续2小时。在阻断步骤中，100nM 6X-组氨酸和麦芽糖结合蛋白(MBP)标记的CnaA在37℃下与0与2000nM之间的未标记的CnaA在PBS中混合持续30分钟。所述板用200μl PBS洗涤三次，并且将100μl MBP-CnaA或MBP-CnaA/未标记的CnaA混合物添加至每个孔中，在37℃下孵育2小时。在用200μlPBS洗涤三次之后，将100μl 0.125μg/ml与HRP结合的抗His添加至每个孔中并且在室温下孵育持续1小时。所述板接着用200μl PBS洗涤三次，并将100μl TMB底物添加至每个孔中并且使其显影持续30分钟。为了停止反应，向每个孔中添加50μl 1M HCl。读取所述板在450nm下的吸光度以定量结合。
图3示出在增加浓度的未标记的CnaA存在下MBP-CnaA与胶原蛋白的结合的减少。
本说明书中所提及的所有公布、专利申请、授权专利和其他文献均以引用的方式并入本文，其并入程度就如同各个别公布、专利申请、授权专利或其他文献特定地并且个别地经指示以引用的方式整体并入一般。在与本公开中的定义相抵触的情况下，排除以引用的方式并入的文本中含有的定义。
以下参考文献以引用的方式整体并入。
1.Wade,B.&Keyburn,A.(2015).The true cost of necrotic enteritis.WorldPoultry,31,pp.16-17
2.Moore,R.J.(2016).Necrotic enteritis predisposing factors in broilerchickens.Avian Pathology,45(3),pp.275-281.
3.Abid,S.A.et al.(2016).Emerging threat of necrotic enteritis inpoultry and its control without use of antibiotics:a review.The Journal ofAnimal and Plant Sciences,26(6),pp.1556-1567.
4.Prescott,J.F.et al.(2011).The pathogenesis of necrotic enteritis inchickens:what we know and what we need to know:a review.Avian Pathology,45(3),pp.288-294.
5.Collier,C.T.et al.(2008)Coccidia-induced mucogenesis promotes theonset of necrotic enteritis by supporting Clostridium perfringensgrowth.Veterinary Immunology and Immunopathology,122(1-2),pp.104-115.
6.Van Meirhaeghe,H.&De Gussem,M.(2014).Coccidiosis a major threat tothe chicken gut.Retrieved on May 25,2018from:https://www.poultryworld.net/Home/General/2014/9/Coccidiosis-a-major-threat-to-the-chicken-gut-1568808W/？dossier＝35765&widgetid＝1.
7.Chapman,H.D.(2014).Milestones in avian coccidiosis research:areview.Poultry Science,93(3),pp.501-511.
8.Shivaramaiah,S.et al.(2011).The role of an early SalmonellaTyphimurium infection as a predisposing factor for necrotic enteritis in alaboratory challenge model.Avian Diseases,55(2),pp.319-323.
虽然本文已经显示并且描述本发明的优选实施方案，但本领域技术人员应显而易知，此类实施方案仅以举例的方式提供。在不偏离本发明的情况下，本领域技术人员现将进行多种变异、变化和取代。应理解，本文所述的发明的实施方案的多种替代方案可以用于实施本发明。预期以下权利要求限定本发明的范围并且由此涵盖这些权利要求和其相等物的范围内的方法和结构。
序列表
<110> 诺沃班德畜牧业治疗公司(NOVOBIND LIVESTOCK THERAPEUTICS INC.)
<120> 针对家禽致病原的抗体和其用途
<130> 48647-706.601
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<141> 2019-07-03
<150> 62/694,164
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20 25 30
Met Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val
35 40 45
Ala Thr Ile Ser Gly Ser Gly Ala Gly Thr Phe Tyr Ala Asp Ser Val
50 55 60
Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Leu Glu Asp Thr Ala Gly Tyr Tyr Cys
85 90 95
Ala Arg Arg Met Ser Arg Ser Gly Ile Phe Gly Leu Arg Asp Tyr Asp
100 105 110
Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120
<210> 10
<211> 125
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 10
Gln Val Gln Leu Gln Gln Ser Gly Gly Gly Val Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Ser Leu Ser Cys Ser Pro Tyr Gln Arg Ala Ser Ser Leu Phe
20 25 30
Ala Met Gly Trp Phe Arg Gln Ser Pro Gly Lys Glu Arg Glu Phe Val
35 40 45
Ala Gly Ile Ser Trp Asn Gly Asp Lys Ser Gln Tyr Ala Asp Ser Val
50 55 60
Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Asp Lys Asn Thr Val Phe
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Ala His Arg Ala Ser Phe Glu Leu Gly Phe Ala Thr His Asp Tyr
100 105 110
Asp Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120 125
<210> 11
<211> 121
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 11
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Asn Ala
20 25 30
Asp Met Ala Trp Phe Arg Gln Ser Pro Gly Lys Glu Arg Glu Ser Val
35 40 45
Ala Ala Ile Ser Trp Ser Gly Gly Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Ala Thr Ile Ser Arg Asp Ile Ala Lys Asp Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Ala Gly Gly Tyr Ser Asn Leu Pro Thr Ser Tyr Gly Tyr Trp Gly
100 105 110
Gln Gly Thr Gln Val Thr Val Ser Ser
115 120
<210> 12
<211> 122
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 12
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ala Phe Ser Thr Tyr
20 25 30
Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val
35 40 45
Ala Gly Ile Ser Ser Ser Gly Ala Gly Ser Ala Tyr Val Asp Ser Val
50 55 60
Lys His Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Thr Met Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Ala Ser Thr Thr Ser Trp Gly Lys Phe Ala His Tyr Ile Tyr Trp
100 105 110
Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120
<210> 13
<211> 126
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 13
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Ser Tyr
20 25 30
Ile Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Asp Arg Glu Phe Val
35 40 45
Gly Ala Ile Ser Trp Ser Gly Gly Val Thr His Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Ala Asp Ser Arg Ile Ser Ala Gly Gly Ser Tyr Tyr Glu Ala Asp
100 105 110
Phe Gly Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120 125
<210> 14
<211> 114
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 14
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Val Val Ser Gly Ser Ile Met Ser Ile Arg
20 25 30
Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val
35 40 45
Ala Thr Met Ser Arg Gly Asn Thr Ile Asn Tyr Ala Asp Ser Val Arg
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Val Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Asp Val Tyr Tyr Cys Ala
85 90 95
Ala Leu Leu Asp Ser Tyr Tyr Trp Gly Gln Gly Thr Gln Val Thr Val
100 105 110
Ser Ser
<210> 15
<211> 114
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 15
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Ala Ser Ile Ile Ser Ile Arg
20 25 30
Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val
35 40 45
Ala Thr Met Ser Arg Gly Gly Thr Ile Asn Tyr Ala Asp Ser Val Arg
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Val Phe Leu
65 70 75 80
Glu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr
85 90 95
Ala Leu Leu Asp Ser Tyr Tyr Trp Gly Gln Gly Thr Gln Val Thr Val
100 105 110
Ser Ser
<210> 16
<211> 114
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 16
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Ser Ile Arg
20 25 30
Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val
35 40 45
Ala Thr Met Ser Arg Gly Gly Thr Ile Asn Tyr Ala Asp Ser Val Arg
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ile Thr Val Tyr Leu
65 70 75 80
Gln Met Thr Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Ala Leu Leu Asp Ser Tyr Tyr Trp Gly Gln Gly Thr Gln Val Thr Val
100 105 110
Ser Ser
<210> 17
<211> 131
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 17
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Leu Asp Lys Tyr
20 25 30
Ala Val Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val
35 40 45
Ser Cys Ile Ser Ser Ile Asp Asp Ser Thr Asp Tyr Val Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ala Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Asp Cys
85 90 95
Met Thr Ile Pro Leu Pro Tyr Gly Ser Thr Cys Arg Ile Pro Ser Arg
100 105 110
Ser Asp Leu Leu Ala Ile Asn Tyr Trp Gly Lys Gly Thr Leu Val Thr
115 120 125
Val Ser Ser
130
<210> 18
<211> 120
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 18
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Gln Gly Ser Gly Arg Thr Phe Ser Thr Tyr
20 25 30
Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val
35 40 45
Ala Ala Ile Thr Arg Gly Gly Asn Thr Ile Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Val Ser Asp Lys Asn Thr Val Tyr Leu
65 70 75 80
Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Ala Asp Arg Ile Ile Val Pro Arg Asp Pro Met Asp Tyr Trp Gly Lys
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 19
<211> 124
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 19
Gln Val Gln Leu Gln Gln Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Arg Thr Leu Ser Tyr Trp
20 25 30
Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val
35 40 45
Ala Ala Ile Asn Trp Ser Ser Gly Thr Arg Tyr Ser Asp Ser Val Arg
50 55 60
Asp Arg Phe Thr Ile Asp Gly Asp Thr Asp Lys Thr Thr Val Tyr Leu
65 70 75 80
Glu Met Asn Lys Met Asn Leu Asp Asp Ser Ala Val Tyr Tyr Cys Ala
85 90 95
Ala His Arg Ala Ser Phe Gly Leu Gly Tyr Gln Thr His Glu Tyr Asp
100 105 110
Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120
<210> 20
<211> 124
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 20
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Thr Cys Thr Ala Ser Gly Arg Thr Leu Ser Tyr Trp
20 25 30
Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val
35 40 45
Ala Ala Ile Asn Trp Ser Ser Gly Thr Arg Tyr Ser Asp Ser Val Lys
50 55 60
Asp Arg Phe Thr Ile Asp Gly Asp Ser Asp Lys Thr Thr Val Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Asn Leu Asp Asp Ser Ala Val Tyr Tyr Cys Ala
85 90 95
Ala His Arg Ala Ser Phe Gly Leu Gly Tyr Gln Thr His Glu Tyr Asp
100 105 110
Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120
<210> 21
<211> 126
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 21
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp
1 5 10 15
Ser Leu Arg Leu Ser Cys Leu Ala Ser Gly Gly Thr Phe Ser Ser Tyr
20 25 30
Ile Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Asp Arg Glu Phe Val
35 40 45
Gly Ala Ile Ser Trp Ser Gly Gly Val Thr His Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Ala Asp Ser Arg Ile Ser Ala Gly Gly Ser Tyr Tyr Glu Ala Asp
100 105 110
Phe Gly Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120 125
<210> 22
<211> 122
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 22
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Thr Cys Ala Val Ser Gly Arg Thr Phe Ser Ala Ile
20 25 30
His Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val
35 40 45
Ala Gly Ile Ser Trp Ser Gly Gly Gly Thr Ala Tyr Gly Gly Thr Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Ser
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Ala Ser Asp Thr Asp Trp Gly Arg Ser Ala Ser Tyr Asp Tyr Trp
100 105 110
Gly Gln Gly Thr Gln Val Thr Val Ser Ala
115 120
<210> 23
<211> 126
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 23
Gln Val Gln Leu Gln Gln Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Ser Tyr
20 25 30
Val Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Asp Arg Glu Phe Val
35 40 45
Gly Ala Ile Ser Trp Ser Gly Gly Val Thr His Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Ala Asp Ser Arg Ile Ser Ala Gly Gly Ser Tyr Tyr Glu Ala Asp
100 105 110
Phe Gly Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120 125
<210> 24
<211> 120
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 24
Gln Val Gln Leu Gln Gln Ser Gly Gly Gly Leu Val Gln Ala Gly Asp
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Arg Thr Phe Ser Ser Tyr
20 25 30
Thr Met Gly Trp Phe Arg Gln Thr Pro Gly Lys Glu Arg Glu Phe Val
35 40 45
Ala Ala Ile Ser Trp Ser Gly Thr Tyr Tyr Thr Asp Ser Val Lys Gly
50 55 60
Arg Phe Thr Ile Ser Arg Asp Thr Ala Lys Asn Thr Val Tyr Leu Gln
65 70 75 80
Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Val
85 90 95
Gly Ser Arg Arg Leu Tyr Tyr Ser Ser Asp Ile Asn Tyr Trp Gly Gln
100 105 110
Gly Thr Gln Val Thr Val Ser Ser
115 120
<210> 25
<211> 120
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 25
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Leu Thr Val Ser Arg Tyr
20 25 30
Thr Met Gly Trp Phe Arg Gln Thr Pro Gly Lys Asp Arg Glu Phe Val
35 40 45
Ala Ala Ile Ser Trp Ser Gly Thr Tyr Tyr Thr Asp Ser Val Lys Gly
50 55 60
Arg Phe Thr Ile Ser Val Asp Asn Ala Lys Asn Met Val Tyr Leu Gln
65 70 75 80
Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala
85 90 95
Gly Ser Arg Arg Leu Tyr Tyr Ser Asn Asp Ile Asn Tyr Trp Gly Gln
100 105 110
Gly Thr Gln Val Thr Val Ser Ser
115 120
<210> 26
<211> 123
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 26
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Ser Arg Thr Phe Ser Asn Tyr
20 25 30
Ala Met Ala Trp Phe Arg Gln Thr Pro Gly Lys Glu Arg Glu Phe Leu
35 40 45
Ala Thr Ile Asn Gly Asp Thr Thr Phe Thr Ile Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Ala Arg Gln Trp Asn Pro Thr Met Arg Glu Arg Asp Tyr Gly Tyr
100 105 110
Trp Gly Gln Gly Thr Glu Val Thr Val Ser Ser
115 120
<210> 27
<211> 126
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 27
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Val Phe Glu Asn Tyr
20 25 30
Phe Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val
35 40 45
Ala Ala Thr Asn Trp Asn Thr Ala Thr Asn Trp Asn Thr Tyr Tyr Ala
50 55 60
Ala Phe Val Lys Ala Arg Phe Thr Ile Ser Arg Asp Lys Ala Lys Asn
65 70 75 80
Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val
85 90 95
Tyr Tyr Cys Ala Ala Thr Gly Ser Arg Thr Tyr Asp Val Val Asp Tyr
100 105 110
Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120 125
<210> 28
<211> 124
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 28
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr
20 25 30
Ser Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ser Val
35 40 45
Ala Ala Ile Thr Tyr Ser Gly Ile Thr Thr Ala Tyr Thr Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Trp Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Ala Ser Tyr Ser Ala Ser Arg Ser Tyr Pro Phe Gly Glu Tyr Asp
100 105 110
Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120
<210> 29
<211> 124
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 29
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr
20 25 30
Ser Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ser Val
35 40 45
Ala Ala Ile Thr Tyr Ser Gly Ile Ser Thr Ala Tyr Thr Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Tyr Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Ala Ser Tyr Ser Ala Ser Arg Ser Tyr Pro Phe Gly Glu Tyr Asp
100 105 110
Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120
<210> 30
<211> 115
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 30
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ser
20 25 30
Ala Met Ser Trp Met Arg Gln Ala Pro Gly Lys Ala Val Glu Trp Val
35 40 45
Ser Ser Ile Asn Ile Gly Gly Asp Ser Arg Arg Tyr Ala Glu Ser Val
50 55 60
Ala Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Gly Leu Ala Ser Thr Ile Arg Gly Gln Gly Thr Gln Val Thr
100 105 110
Val Ser Ser
115
<210> 31
<211> 114
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 31
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ser
20 25 30
Ala Met Ser Trp Met Arg Gln Ala Pro Gly Lys Gly Val Glu Trp Val
35 40 45
Ser Ser Ile Glu Val Gly Gly Gly Arg Arg Tyr Ala Glu Ser Val Ala
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ser
85 90 95
Lys Gly Leu Ala Ser Thr Ile Arg Gly Gln Gly Thr Gln Val Thr Val
100 105 110
Ser Ser
<210> 32
<211> 114
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 32
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ser
20 25 30
Ala Met Ser Trp Met Arg Gln Ala Pro Gly Lys Gly Val Glu Trp Val
35 40 45
Ser Ser Ile Gly Ile Asp Gly Gly Arg Arg Tyr Ala Glu Ala Val Ala
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Lys Gly Leu Ala Ser Thr Ile Arg Gly Gln Gly Thr Gln Val Thr Val
100 105 110
Ser Ser
<210> 33
<211> 115
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 33
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ser
20 25 30
Ala Met Ser Trp Met Arg Gln Ala Pro Gly Lys Gly Val Glu Trp Val
35 40 45
Ser Ser Ile Gly Ile Gly Gly Gly Thr Thr Arg Tyr Ala Asp Ser Val
50 55 60
Ala Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Gly Leu Ala Ser Thr Ile Arg Gly Gln Gly Thr Gln Val Thr
100 105 110
Val Ser Ser
115
<210> 34
<211> 120
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 34
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Arg Ser Phe Ser Ser Tyr
20 25 30
Thr Met Gly Trp Phe Arg Gln Thr Pro Gly Lys Glu Arg Glu Phe Val
35 40 45
Ala Ala Ile Ser Trp Ser Gly Thr Tyr Tyr Thr Asp Ser Val Lys Gly
50 55 60
Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln
65 70 75 80
Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Val
85 90 95
Gly Ser Arg Arg Leu Tyr Tyr Ser Ser Asp Ile Asn Tyr Trp Gly Gln
100 105 110
Gly Thr Gln Val Thr Val Ser Ser
115 120
<210> 35
<211> 120
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 35
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Leu Thr Val Ser Arg Tyr
20 25 30
Thr Met Gly Trp Phe Arg Gln Thr Pro Gly Lys Glu Arg Glu Phe Val
35 40 45
Ala Ala Ile Ser Trp Ser Gly Thr Tyr Tyr Thr Asp Ser Val Lys Gly
50 55 60
Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Met Val Tyr Leu Gln
65 70 75 80
Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala
85 90 95
Gly Ser Arg Arg Leu His Tyr Ser Ser Asp Ile Asn Tyr Trp Gly Gln
100 105 110
Gly Thr Gln Val Thr Val Ser Ser
115 120
<210> 36
<211> 128
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 36
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Glu
1 5 10 15
Ser Leu Arg Leu Ser Cys Leu Ala Ala Gly Arg Thr Phe Ser Thr Ser
20 25 30
Thr Leu Gly Trp Phe Arg Gln Ala Pro Gly Leu Glu Arg Glu Phe Val
35 40 45
Ala Ala Ile Arg Tyr Thr Ser Asp Tyr Thr Ala Arg Thr Thr Asp Tyr
50 55 60
Ala Asp Ser Val Lys Gly Arg Phe Ala Ile Ser Arg Asp Tyr Ile Lys
65 70 75 80
Gln Ala Val Tyr Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala
85 90 95
Val Tyr Tyr Cys Ala Ala Ala Lys Tyr Gly Met Gly Tyr Ser Asp Pro
100 105 110
Ser Gly Tyr Thr Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120 125
<210> 37
<211> 123
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 37
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Ser Arg Thr Phe Ser Asn Tyr
20 25 30
Ala Met Ala Trp Phe Arg Gln Thr Pro Gly Lys Glu Arg Glu Phe Leu
35 40 45
Ala Ala Ile Thr Gly Asp Thr Ala Phe Thr Ile Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Pro Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Ala Arg Gln Trp Asn Pro Thr Met Arg Glu Arg Asp Tyr Gly Tyr
100 105 110
Trp Gly Gln Gly Thr Glu Val Thr Val Ser Ser
115 120
<210> 38
<211> 127
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 38
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Arg Phe Arg Leu Tyr
20 25 30
His Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val
35 40 45
Ala Val Ile Ser Trp Ser Gly Gly Thr Thr Val Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Glu Lys Asn Ala Gly Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Val Asp Arg Leu Ile Glu Ser Phe Ser Asp Pro Thr Ala Trp Pro
100 105 110
Arg Met Asp Tyr Trp Gly Lys Gly Ala Leu Val Thr Val Ser Ser
115 120 125
<210> 39
<211> 115
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 39
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ser
20 25 30
Ala Met Ser Trp Met Arg Gln Ala Pro Gly Lys Gly Val Glu Trp Val
35 40 45
Ser Ser Ile Asn Ile Gly Gly Gly Thr Thr Ser Tyr Ala Asp Ser Val
50 55 60
Ala Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Gly Leu Ala Ser Thr Ile Arg Gly Gln Gly Thr Gln Val Thr
100 105 110
Val Ser Ser
115
<210> 40
<211> 115
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 40
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ser
20 25 30
Ala Met Ser Trp Met Arg Gln Ala Pro Gly Lys Gly Val Glu Trp Val
35 40 45
Ser Ser Ile Asn Ile Gly Gly Gly Thr Arg Arg Tyr Ala Glu Ser Val
50 55 60
Ala Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Gly Leu Ala Ser Thr Ile Arg Gly Gln Gly Thr Gln Val Thr
100 105 110
Val Ser Ser
115
<210> 41
<211> 127
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 41
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Lys Phe Arg Leu Tyr
20 25 30
His Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val
35 40 45
Ala Val Ile Ser Trp Ser Gly Gly Ser Thr Val Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Glu Lys Asn Ala Gly Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Val Asp Arg Leu Ile Glu Ser Phe Ser Asp Pro Thr Ala Trp Pro
100 105 110
Arg Met Asp Tyr Trp Gly Lys Gly Ala Leu Val Thr Val Ser Ser
115 120 125
<210> 42
<211> 114
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 42
Gln Val Gln Leu Gln Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ser
20 25 30
Ala Met Ser Trp Met Arg Gln Ala Pro Gly Lys Gly Val Glu Trp Val
35 40 45
Ser Ser Ile Asn Ile Gly Gly Gly Thr Arg Tyr Ala Asp Ser Val Ala
50 55 60
Gly Arg Phe Thr Ile Tyr Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Lys Gly Leu Ala Ser Thr Ile Arg Gly Gln Gly Thr Gln Val Thr Val
100 105 110
Ser Ser
<210> 43
<211> 123
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 43
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr
20 25 30
Asp Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ser Ile Ser Tyr Asn Ile Tyr Tyr Ala Asp Phe Val Lys Gly Arg
50 55 60
Phe Thr Ile Ser Lys Asp Asn Ala Lys Asn Thr Val Ser Leu Gln Met
65 70 75 80
Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Val
85 90 95
Gln Arg Arg Gly Ser Tyr Ser Tyr Asp Arg Ala Gln Ser Tyr Asp Tyr
100 105 110
Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120
<210> 44
<211> 114
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 44
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ser
20 25 30
Ala Met Ser Trp Met Arg Gln Ala Pro Gly Lys Gly Val Glu Trp Val
35 40 45
Ser Ser Ile Glu Ile Gly Gly Thr Arg Arg Tyr Ala Glu Ser Val Ala
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Lys Gly Leu Ala Ser Thr Ile Arg Gly Gln Gly Thr Gln Val Thr Val
100 105 110
Ser Ser
<210> 45
<211> 115
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 45
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ser
20 25 30
Pro Met Ser Trp Met Arg Gln Ala Pro Gly Lys Gly Val Glu Trp Val
35 40 45
Ser Ser Ile Asn Ile Gly Ala Gly Thr Thr Arg Tyr Ala Glu Ser Val
50 55 60
Ala Gly Arg Phe Thr Ile Ala Arg Asp Asn Ala Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Gly Leu Ala Ser Thr Ile Arg Gly Gln Gly Thr Gln Val Ile
100 105 110
Val Ser Ser
115
<210> 46
<211> 115
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 46
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ser
20 25 30
Ala Met Ser Trp Met Arg Gln Ala Pro Gly Lys Gly Val Glu Trp Val
35 40 45
Ser Ser Ile Asn Ile Gly Gly Gly Asp Lys Arg Tyr Ala Glu Ser Val
50 55 60
Ala Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Phe Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Gly Leu Ala Ser Thr Ile Arg Gly Gln Gly Thr Gln Val Thr
100 105 110
Val Ser Ser
115
<210> 47
<211> 114
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 47
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ser
20 25 30
Ala Met Ser Trp Met Arg Gln Ala Pro Gly Lys Gly Val Glu Trp Val
35 40 45
Ser Ser Ile Glu Thr Gly Gly Thr Lys Arg Tyr Ala Glu Ser Val Ala
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Asn Leu
65 70 75 80
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Lys Gly Leu Ala Ser Thr Ile Arg Gly Gln Gly Thr Gln Val Thr Val
100 105 110
Ser Ser
<210> 48
<211> 115
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 48
Gln Val Gln Leu Gln Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ser
20 25 30
Pro Met Ser Trp Met Arg Gln Ala Pro Gly Lys Gly Val Glu Trp Val
35 40 45
Ser Ser Ile Asn Ile Gly Glu Gly Thr Thr Arg Tyr Ala Glu Ser Val
50 55 60
Ala Gly Arg Phe Thr Ile Ser Arg Asp Asn Val Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Gly Leu Ala Ser Thr Ile Arg Gly Gln Gly Thr Gln Val Thr
100 105 110
Val Ser Ser
115
<210> 49
<211> 115
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 49
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ser
20 25 30
Pro Met Ser Trp Met Arg Gln Ala Pro Gly Lys Gly Val Glu Trp Val
35 40 45
Ser Ser Ile Asn Ile Gly Gly Asp Thr Arg Arg Tyr Ala Glu Ser Val
50 55 60
Ala Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Gly Leu Ala Ser Thr Ile Arg Gly Gln Gly Thr Gln Val Thr
100 105 110
Val Ser Ser
115
<210> 50
<211> 114
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 50
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ser
20 25 30
Ala Met Ser Trp Met Arg Gln Ala Pro Gly Asn Gly Val Glu Trp Val
35 40 45
Ser Ser Val Asn Ile Asp Gly Gly Arg Arg Tyr Ala Glu Ala Val Ala
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Lys Gly Leu Ala Ser Thr Ile Arg Gly Gln Gly Thr Gln Val Thr Val
100 105 110
Ser Ser
<210> 51
<211> 114
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 51
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ser
20 25 30
Ala Met Ala Trp Met Arg Gln Ala Pro Gly Lys Gly Val Glu Trp Val
35 40 45
Ser Ser Ile Ser Ile Asp Gly Gly Arg Arg Tyr Ala Glu Ala Val Ala
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Lys Gly Leu Ala Ser Thr Ile Arg Gly Gln Gly Thr Gln Val Thr Val
100 105 110
Ser Ser
<210> 52
<211> 127
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 52
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Lys Phe Thr Leu Tyr
20 25 30
His Met Gly Trp Phe Arg Gln Thr Pro Gly Lys Glu Arg Glu Phe Val
35 40 45
Ala Val Ile Ser Trp Ser Gly Arg Ser Thr Val Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Asp Lys Asn Ala Gly Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys
85 90 95
Ala Val Asp Arg Leu Ile Glu Lys Phe Ser Asp Pro Thr Ala Trp Pro
100 105 110
Arg Met Asp Ser Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser
115 120 125
<210> 53
<211> 122
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 53
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ala Ser Met Gly
20 25 30
Trp Phe Arg Gln Ala Pro Gly Thr Gln Arg Glu Phe Val Ala Thr Ile
35 40 45
Thr Arg Ser Ser Ile Tyr Thr Asp Tyr Ser Asp Ser Val Lys Gly Arg
50 55 60
Phe Ala Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met
65 70 75 80
Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Asp
85 90 95
Ser Thr Met Ser Gly Ser Ser Arg Tyr Ser Ser Asp Tyr Ala Tyr Trp
100 105 110
Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120
<210> 54
<211> 114
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 54
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ser
20 25 30
Pro Met Ser Trp Met Arg Gln Ala Pro Gly Lys Gly Val Glu Trp Val
35 40 45
Ser Ser Ile Asp Ile Gly Gly Asn Arg Arg Tyr Ala Glu Ala Val Ala
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Lys Gly Leu Ala Ser Thr Ile Arg Gly Gln Gly Thr Gln Val Thr Val
100 105 110
Ser Ser
<210> 55
<211> 127
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 55
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Arg Arg Phe Thr Leu Tyr
20 25 30
His Met Gly Trp Phe Arg Gln Arg Pro Gly Lys Glu Arg Glu Phe Val
35 40 45
Ala Val Ile Ser Trp Ser Gly Gly Ser Thr Val Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Glu Lys Asn Ala Gly Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Val Asp Arg Leu Ile Glu Ser Phe Ser Asp Pro Thr Ala Trp Pro
100 105 110
Arg Met Asp Tyr Trp Gly Lys Gly Ala Leu Val Thr Val Ser Ser
115 120 125
<210> 56
<211> 127
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 56
Gln Val Gln Leu Gln Gln Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Arg Phe Ser Leu Tyr
20 25 30
His Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val
35 40 45
Ala Val Ile Ser Trp Ser Gly Gly Thr Thr Val Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Glu Lys Asn Ala Gly Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Val Asp Arg Leu Ile Glu Ser Phe Ser Asp Pro Thr Ala Trp Pro
100 105 110
Arg Met Asp Tyr Trp Gly Lys Gly Ala Leu Val Thr Val Ser Ser
115 120 125
<210> 57
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 57
Gln Arg Ala Ser Ser Leu Phe Ala Met
1 5
<210> 58
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 58
Gly Ser Ile Phe Ser Ile Ser Ser Ala
1 5
<210> 59
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 59
Gly Arg Thr Leu Ser Tyr Trp Thr Met
1 5
<210> 60
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 60
Gly Gly Thr Phe Ser Ser Tyr Thr Met
1 5
<210> 61
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 61
Gly Phe Thr Leu Asp Lys Tyr Ala Val
1 5
<210> 62
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 62
Gly Phe Thr Val Pro Tyr Tyr Tyr Ile
1 5
<210> 63
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 63
Gly Ser Thr Phe Asn Asn Tyr Met Ile
1 5
<210> 64
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 64
Gly Arg Thr Phe Ser Asn Ala Asp Met
1 5
<210> 65
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 65
Gly Arg Ala Phe Ser Thr Tyr Gly Met
1 5
<210> 66
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 66
Gly Gly Thr Phe Ser Ser Tyr Ile Met
1 5
<210> 67
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 67
Gly Ser Ile Met Ser Ile Arg Val Met
1 5
<210> 68
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 68
Ala Ser Ile Ile Ser Ile Arg Val Met
1 5
<210> 69
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 69
Gly Ser Ile Phe Ser Ile Arg Val Met
1 5
<210> 70
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 70
Gly Phe Thr Leu Asp Lys Tyr Ala Val
1 5
<210> 71
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 71
Gly Arg Thr Phe Ser Thr Tyr Ala Met
1 5
<210> 72
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 72
Gly Arg Thr Phe Ser Ala Ile His Met
1 5
<210> 73
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 73
Gly Gly Thr Phe Ser Ser Tyr Val Met
1 5
<210> 74
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 74
Gly Arg Thr Phe Ser Ser Tyr Thr Met
1 5
<210> 75
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 75
Gly Leu Thr Val Ser Arg Tyr Thr Met
1 5
<210> 76
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 76
Ser Arg Thr Phe Ser Asn Tyr Ala Met
1 5
<210> 77
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 77
Gly Arg Val Phe Glu Asn Tyr Phe Met
1 5
<210> 78
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 78
Gly Arg Thr Phe Ser Ser Tyr Ser Met
1 5
<210> 79
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 79
Gly Arg Thr Phe Ser Ser Tyr Ser Met
1 5
<210> 80
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 80
Gly Phe Thr Phe Ser Asn Ser Ala Met
1 5
<210> 81
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 81
Gly Phe Thr Phe Ser Asn Ser Ala Met
1 5
<210> 82
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 82
Gly Phe Thr Phe Ser Asn Ser Ala Met
1 5
<210> 83
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 83
Gly Phe Thr Phe Ser Asn Ser Ala Met
1 5
<210> 84
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 84
Gly Arg Ser Phe Ser Ser Tyr Thr Met
1 5
<210> 85
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 85
Gly Leu Thr Val Ser Arg Tyr Thr Met
1 5
<210> 86
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 86
Gly Arg Thr Phe Ser Thr Ser Thr Leu
1 5
<210> 87
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 87
Ser Arg Thr Phe Ser Asn Tyr Ala Met
1 5
<210> 88
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 88
Gly Arg Arg Phe Arg Leu Tyr His Met
1 5
<210> 89
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 89
Gly Phe Thr Phe Ser Asn Ser Ala Met
1 5
<210> 90
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 90
Gly Phe Thr Phe Ser Asn Ser Ala Met
1 5
<210> 91
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 91
Gly Arg Lys Phe Arg Leu Tyr His Met
1 5
<210> 92
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 92
Gly Phe Thr Phe Ser Asn Ser Ala Met
1 5
<210> 93
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 93
Gly Arg Thr Phe Ser Ser Tyr Asp Met
1 5
<210> 94
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 94
Gly Phe Thr Phe Ser Asn Ser Ala Met
1 5
<210> 95
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 95
Gly Phe Thr Phe Ser Asn Ser Pro Met
1 5
<210> 96
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 96
Gly Phe Thr Phe Ser Asn Ser Ala Met
1 5
<210> 97
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 97
Gly Phe Thr Phe Ser Asn Ser Ala Met
1 5
<210> 98
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 98
Gly Phe Thr Phe Ser Asn Ser Pro Met
1 5
<210> 99
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 99
Gly Phe Thr Phe Ser Asn Ser Pro Met
1 5
<210> 100
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 100
Gly Phe Thr Phe Ser Asn Ser Ala Met
1 5
<210> 101
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 101
Gly Phe Thr Phe Ser Asn Ser Ala Met
1 5
<210> 102
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 102
Gly Gly Lys Phe Thr Leu Tyr His Met
1 5
<210> 103
<211> 6
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 103
Gly Arg Thr Ala Ser Met
1 5
<210> 104
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 104
Gly Phe Thr Phe Ser Asn Ser Pro Met
1 5
<210> 105
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 105
Gly Arg Arg Phe Thr Leu Tyr His Met
1 5
<210> 106
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 106
Gly Arg Arg Phe Ser Leu Tyr His Met
1 5
<210> 107
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 107
Ile Ser Trp Asn Gly Asp Lys Ser
1 5
<210> 108
<211> 7
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 108
Ile Phe Ser Asp Gly Ser Thr
1 5
<210> 109
<211> 7
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 109
Ile Asn Trp Ser Ser Gly Thr
1 5
<210> 110
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 110
Ile Thr Trp Asn Ser Glu Val Thr
1 5
<210> 111
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 111
Ile Ser Ser Ile Asp Asp Ser Thr
1 5
<210> 112
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 112
Ile Ala Ser Ser Ser Gly Lys Ala
1 5
<210> 113
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 113
Ile Ser Gly Ser Gly Ala Gly Thr
1 5
<210> 114
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 114
Ile Ser Trp Ser Gly Gly Arg Thr
1 5
<210> 115
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 115
Ile Ser Ser Ser Gly Ala Gly Ser
1 5
<210> 116
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 116
Ile Ser Trp Ser Gly Gly Val Thr
1 5
<210> 117
<211> 7
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 117
Met Ser Arg Gly Asn Thr Ile
1 5
<210> 118
<211> 7
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 118
Met Ser Arg Gly Gly Thr Ile
1 5
<210> 119
<211> 7
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 119
Met Ser Arg Gly Gly Thr Ile
1 5
<210> 120
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 120
Ile Ser Ser Ile Asp Asp Ser Thr
1 5
<210> 121
<211> 7
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 121
Ile Thr Arg Gly Gly Asn Thr
1 5
<210> 122
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 122
Ile Ser Trp Ser Gly Gly Gly Thr
1 5
<210> 123
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 123
Ile Ser Trp Ser Gly Gly Val Thr
1 5
<210> 124
<211> 6
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 124
Ile Ser Trp Ser Gly Thr
1 5
<210> 125
<211> 6
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 125
Ile Ser Trp Ser Gly Thr
1 5
<210> 126
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 126
Ile Asn Gly Asp Thr Thr Phe Thr
1 5
<210> 127
<211> 11
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 127
Thr Asn Trp Asn Thr Ala Thr Asn Trp Asn Thr
1 5 10
<210> 128
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 128
Ile Thr Tyr Ser Gly Ile Thr Thr
1 5
<210> 129
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 129
Ile Thr Tyr Ser Gly Ile Ser Thr
1 5
<210> 130
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 130
Ile Asn Ile Gly Gly Asp Ser Arg
1 5
<210> 131
<211> 7
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 131
Ile Glu Val Gly Gly Gly Arg
1 5
<210> 132
<211> 7
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 132
Ile Gly Ile Asp Gly Gly Arg
1 5
<210> 133
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 133
Ile Gly Ile Gly Gly Gly Thr Thr
1 5
<210> 134
<211> 6
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 134
Ile Ser Trp Ser Gly Thr
1 5
<210> 135
<211> 6
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 135
Ile Ser Trp Ser Gly Thr
1 5
<210> 136
<211> 12
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 136
Ile Arg Tyr Thr Ser Asp Tyr Thr Ala Arg Thr Thr
1 5 10
<210> 137
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 137
Ile Thr Gly Asp Thr Ala Phe Thr
1 5
<210> 138
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 138
Ile Ser Trp Ser Gly Gly Thr Thr
1 5
<210> 139
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 139
Ile Asn Ile Gly Gly Gly Thr Thr
1 5
<210> 140
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 140
Ile Asn Ile Gly Gly Gly Thr Arg
1 5
<210> 141
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 141
Ile Ser Trp Ser Gly Gly Ser Thr
1 5
<210> 142
<211> 7
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 142
Ile Asn Ile Gly Gly Gly Thr
1 5
<210> 143
<211> 5
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 143
Ile Ser Tyr Asn Ile
1 5
<210> 144
<211> 7
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 144
Ile Glu Ile Gly Gly Thr Arg
1 5
<210> 145
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 145
Ile Asn Ile Gly Ala Gly Thr Thr
1 5
<210> 146
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 146
Ile Asn Ile Gly Gly Gly Asp Lys
1 5
<210> 147
<211> 7
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 147
Ile Glu Thr Gly Gly Thr Lys
1 5
<210> 148
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 148
Ile Asn Ile Gly Glu Gly Thr Thr
1 5
<210> 149
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 149
Ile Asn Ile Gly Gly Asp Thr Arg
1 5
<210> 150
<211> 7
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 150
Val Asn Ile Asp Gly Gly Arg
1 5
<210> 151
<211> 7
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 151
Ile Ser Ile Asp Gly Gly Arg
1 5
<210> 152
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 152
Ile Ser Trp Ser Gly Arg Ser Thr
1 5
<210> 153
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 153
Ile Thr Arg Ser Ser Ile Tyr Thr
1 5
<210> 154
<211> 7
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 154
Ile Asp Ile Gly Gly Asn Arg
1 5
<210> 155
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 155
Ile Ser Trp Ser Gly Gly Ser Thr
1 5
<210> 156
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 156
Ile Ser Trp Ser Gly Gly Thr Thr
1 5
<210> 157
<211> 18
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 157
Ala Ala His Arg Ala Ser Phe Glu Leu Gly Phe Ala Thr His Asp Tyr
1 5 10 15
Asp Phe
<210> 158
<211> 5
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 158
Ala Val Asp Gly Tyr
1 5
<210> 159
<211> 18
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 159
Ala Ala His Arg Ala Ser Phe Gly Leu Gly Tyr Gln Thr His Glu Tyr
1 5 10 15
Asp Phe
<210> 160
<211> 11
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 160
Ala Ala Gly Arg Ala Gly Ser Gly Phe Thr Ser
1 5 10
<210> 161
<211> 24
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 161
Met Thr Ile Pro Leu Pro Tyr Gly Ser Thr Cys Asp Ile Pro Ser Arg
1 5 10 15
Ser Asp Leu Leu Ala Ile Asn Tyr
20
<210> 162
<211> 19
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 162
Ala Ala Leu Arg Lys Tyr Gly Ser Thr Cys Tyr Leu His Val Leu Glu
1 5 10 15
Tyr Asp Tyr
<210> 163
<211> 17
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 163
Ala Arg Arg Met Ser Arg Ser Gly Ile Phe Gly Leu Arg Asp Tyr Asp
1 5 10 15
Ser
<210> 164
<211> 14
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 164
Ala Ala Gly Gly Tyr Ser Asn Leu Pro Thr Ser Tyr Gly Tyr
1 5 10
<210> 165
<211> 15
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 165
Ala Ala Ser Thr Thr Ser Trp Gly Lys Phe Ala His Tyr Ile Tyr
1 5 10 15
<210> 166
<211> 19
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 166
Ala Ala Asp Ser Arg Ile Ser Ala Gly Gly Ser Tyr Tyr Glu Ala Asp
1 5 10 15
Phe Gly Ser
<210> 167
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 167
Ala Ala Leu Leu Asp Ser Tyr Tyr
1 5
<210> 168
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 168
Thr Ala Leu Leu Asp Ser Tyr Tyr
1 5
<210> 169
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 169
Ala Ala Leu Leu Asp Ser Tyr Tyr
1 5
<210> 170
<211> 24
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 170
Met Thr Ile Pro Leu Pro Tyr Gly Ser Thr Cys Arg Ile Pro Ser Arg
1 5 10 15
Ser Asp Leu Leu Ala Ile Asn Tyr
20
<210> 171
<211> 14
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 171
Ala Ala Asp Arg Ile Ile Val Pro Arg Asp Pro Met Asp Tyr
1 5 10
<210> 172
<211> 15
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 172
Ala Ala Ser Asp Thr Asp Trp Gly Arg Ser Ala Ser Tyr Asp Tyr
1 5 10 15
<210> 173
<211> 19
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 173
Ala Ala Asp Ser Arg Ile Ser Ala Gly Gly Ser Tyr Tyr Glu Ala Asp
1 5 10 15
Phe Gly Ser
<210> 174
<211> 15
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 174
Ala Val Gly Ser Arg Arg Leu Tyr Tyr Ser Ser Asp Ile Asn Tyr
1 5 10 15
<210> 175
<211> 15
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 175
Ala Ala Gly Ser Arg Arg Leu Tyr Tyr Ser Asn Asp Ile Asn Tyr
1 5 10 15
<210> 176
<211> 16
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 176
Ala Ala Arg Gln Trp Asn Pro Thr Met Arg Glu Arg Asp Tyr Gly Tyr
1 5 10 15
<210> 177
<211> 16
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 177
Ala Ala Thr Gly Ser Arg Thr Tyr Asp Val Val Asp Tyr Tyr Asp Tyr
1 5 10 15
<210> 178
<211> 17
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 178
Ala Ala Ser Tyr Ser Ala Ser Arg Ser Tyr Pro Phe Gly Glu Tyr Asp
1 5 10 15
Tyr
<210> 179
<211> 17
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 179
Ala Ala Ser Tyr Ser Ala Ser Arg Ser Tyr Pro Phe Gly Glu Tyr Asp
1 5 10 15
Tyr
<210> 180
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 180
Ala Lys Gly Leu Ala Ser Thr Ile
1 5
<210> 181
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 181
Ser Lys Gly Leu Ala Ser Thr Ile
1 5
<210> 182
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 182
Ala Lys Gly Leu Ala Ser Thr Ile
1 5
<210> 183
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 183
Ala Lys Gly Leu Ala Ser Thr Ile
1 5
<210> 184
<211> 15
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 184
Ala Val Gly Ser Arg Arg Leu Tyr Tyr Ser Ser Asp Ile Asn Tyr
1 5 10 15
<210> 185
<211> 15
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 185
Ala Ala Gly Ser Arg Arg Leu His Tyr Ser Ser Asp Ile Asn Tyr
1 5 10 15
<210> 186
<211> 17
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 186
Ala Ala Ala Lys Tyr Gly Met Gly Tyr Ser Asp Pro Ser Gly Tyr Thr
1 5 10 15
Tyr
<210> 187
<211> 16
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 187
Ala Ala Arg Gln Trp Asn Pro Thr Met Arg Glu Arg Asp Tyr Gly Tyr
1 5 10 15
<210> 188
<211> 18
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 188
Ala Val Asp Arg Leu Ile Glu Ser Phe Ser Asp Pro Thr Ala Trp Pro
1 5 10 15
Arg Met
<210> 189
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 189
Ala Lys Gly Leu Ala Ser Thr Ile
1 5
<210> 190
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 190
Ala Lys Gly Leu Ala Ser Thr Ile
1 5
<210> 191
<211> 18
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 191
Ala Val Asp Arg Leu Ile Glu Ser Phe Ser Asp Pro Thr Ala Trp Pro
1 5 10 15
Arg Met
<210> 192
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 192
Ala Lys Gly Leu Ala Ser Thr Ile
1 5
<210> 193
<211> 19
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 193
Ala Ala Val Gln Arg Arg Gly Ser Tyr Ser Tyr Asp Arg Ala Gln Ser
1 5 10 15
Tyr Asp Tyr
<210> 194
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 194
Ala Lys Gly Leu Ala Ser Thr Ile
1 5
<210> 195
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 195
Ala Lys Gly Leu Ala Ser Thr Ile
1 5
<210> 196
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 196
Ala Lys Gly Leu Ala Ser Thr Ile
1 5
<210> 197
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 197
Ala Lys Gly Leu Ala Ser Thr Ile
1 5
<210> 198
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 198
Ala Lys Gly Leu Ala Ser Thr Ile
1 5
<210> 199
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 199
Ala Lys Gly Leu Ala Ser Thr Ile
1 5
<210> 200
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 200
Ala Lys Gly Leu Ala Ser Thr Ile
1 5
<210> 201
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 201
Ala Lys Gly Leu Ala Ser Thr Ile
1 5
<210> 202
<211> 20
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 202
Ala Val Asp Arg Leu Ile Glu Lys Phe Ser Asp Pro Thr Ala Trp Pro
1 5 10 15
Arg Met Asp Ser
20
<210> 203
<211> 18
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 203
Ala Ala Asp Ser Thr Met Ser Gly Ser Ser Arg Tyr Ser Ser Asp Tyr
1 5 10 15
Ala Tyr
<210> 204
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 204
Ala Lys Gly Leu Ala Ser Thr Ile
1 5
<210> 205
<211> 20
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 205
Ala Val Asp Arg Leu Ile Glu Ser Phe Ser Asp Pro Thr Ala Trp Pro
1 5 10 15
Arg Met Asp Tyr
20
<210> 206
<211> 20
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 206
Ala Val Asp Arg Leu Ile Glu Ser Phe Ser Asp Pro Thr Ala Trp Pro
1 5 10 15
Arg Met Asp Tyr
20
<210> 207
<211> 322
<212> PRT
<213> 产气荚膜梭菌(Clostridium perfringens)
<400> 207
Met Lys Arg Leu Lys Ile Ile Ser Ile Thr Leu Val Leu Thr Ser Val
1 5 10 15
Ile Ser Thr Ser Leu Phe Ser Thr Gln Thr Gln Val Phe Ala Ser Glu
20 25 30
Leu Asn Asp Ile Asn Lys Ile Glu Leu Lys Asn Leu Ser Gly Glu Ile
35 40 45
Ile Lys Glu Asn Gly Lys Glu Ala Ile Lys Tyr Thr Ser Ser Asp Thr
50 55 60
Ala Ser His Lys Gly Trp Lys Ala Thr Leu Ser Gly Thr Phe Ile Glu
65 70 75 80
Asp Pro His Ser Asp Lys Lys Thr Ala Leu Leu Asn Leu Glu Gly Phe
85 90 95
Ile Pro Ser Asp Lys Gln Ile Phe Gly Ser Lys Tyr Tyr Gly Lys Met
100 105 110
Lys Trp Pro Glu Thr Tyr Arg Ile Asn Val Lys Ser Ala Asp Val Asn
115 120 125
Asn Asn Ile Lys Ile Ala Asn Ser Ile Pro Lys Asn Thr Ile Asp Lys
130 135 140
Lys Asp Val Ser Asn Ser Ile Gly Tyr Ser Ile Gly Gly Asn Ile Ser
145 150 155 160
Val Glu Gly Lys Thr Ala Gly Ala Gly Ile Asn Ala Ser Tyr Asn Val
165 170 175
Gln Asn Thr Ile Ser Tyr Glu Gln Pro Asp Phe Arg Thr Ile Gln Arg
180 185 190
Lys Asp Asp Ala Asn Leu Ala Ser Trp Asp Ile Lys Phe Val Glu Thr
195 200 205
Lys Asp Gly Tyr Asn Ile Asp Ser Tyr His Ala Ile Tyr Gly Asn Gln
210 215 220
Leu Phe Met Lys Ser Arg Leu Tyr Asn Asn Gly Asp Lys Asn Phe Thr
225 230 235 240
Asp Asp Arg Asp Leu Ser Thr Leu Ile Ser Gly Gly Phe Ser Pro Asn
245 250 255
Met Ala Leu Ala Leu Thr Ala Pro Lys Asn Ala Lys Glu Ser Val Ile
260 265 270
Ile Val Glu Tyr Gln Arg Phe Asp Asn Asp Tyr Ile Leu Asn Trp Glu
275 280 285
Thr Thr Gln Trp Arg Gly Thr Asn Lys Leu Ser Ser Thr Ser Glu Tyr
290 295 300
Asn Glu Phe Met Phe Lys Ile Asn Trp Gln Asp His Lys Ile Glu Tyr
305 310 315 320
Tyr Leu
<210> 208
<211> 398
<212> PRT
<213> 产气荚膜梭菌(Clostridium perfringens)
<400> 208
Met Lys Arg Lys Ile Cys Lys Ala Leu Ile Cys Ala Ala Leu Ala Thr
1 5 10 15
Ser Leu Trp Ala Gly Ala Ser Thr Lys Val Tyr Ala Trp Asp Gly Lys
20 25 30
Ile Asp Gly Thr Gly Thr His Ala Met Ile Val Thr Gln Gly Val Ser
35 40 45
Ile Leu Glu Asn Asp Leu Ser Lys Asn Glu Pro Glu Ser Val Arg Lys
50 55 60
Asn Leu Glu Ile Leu Lys Glu Asn Met His Glu Leu Gln Leu Gly Ser
65 70 75 80
Thr Tyr Pro Asp Tyr Asp Lys Asn Ala Tyr Asp Leu Tyr Gln Asp His
85 90 95
Phe Trp Asp Pro Asp Thr Asp Asn Asn Phe Ser Lys Asp Asn Ser Trp
100 105 110
Tyr Leu Ala Tyr Ser Ile Pro Asp Thr Gly Glu Ser Gln Ile Arg Lys
115 120 125
Phe Ser Ala Leu Ala Arg Tyr Glu Trp Gln Arg Gly Asn Tyr Lys Gln
130 135 140
Ala Thr Phe Tyr Leu Gly Glu Ala Met His Tyr Phe Gly Asp Ile Asp
145 150 155 160
Thr Pro Tyr His Pro Ala Asn Val Thr Ala Val Asp Ser Ala Gly His
165 170 175
Val Lys Phe Glu Thr Phe Ala Glu Glu Arg Lys Glu Gln Tyr Lys Ile
180 185 190
Asn Thr Ala Gly Cys Lys Thr Asn Glu Asp Phe Tyr Ala Asp Ile Leu
195 200 205
Lys Asn Lys Asp Phe Asn Ala Trp Ser Lys Glu Tyr Ala Arg Gly Phe
210 215 220
Ala Lys Thr Gly Lys Ser Ile Tyr Tyr Ser His Ala Ser Met Ser His
225 230 235 240
Ser Trp Asp Asp Trp Asp Tyr Ala Ala Lys Val Thr Leu Ala Asn Ser
245 250 255
Gln Lys Gly Thr Ala Gly Tyr Ile Tyr Arg Phe Leu His Asp Val Ser
260 265 270
Glu Gly Asn Asp Pro Ser Val Gly Lys Asn Val Lys Glu Leu Val Ala
275 280 285
Tyr Ile Ser Thr Ser Gly Glu Lys Asp Ala Gly Thr Asp Asp Tyr Met
290 295 300
Tyr Phe Gly Ile Lys Thr Lys Asp Gly Lys Thr Gln Glu Trp Glu Met
305 310 315 320
Asp Asn Pro Gly Asn Asp Phe Met Thr Gly Ser Lys Asp Thr Tyr Thr
325 330 335
Phe Lys Leu Lys Asp Glu Asn Leu Lys Ile Asp Asp Ile Gln Asn Met
340 345 350
Trp Ile Arg Lys Arg Lys Tyr Thr Ala Phe Pro Asp Ala Tyr Lys Pro
355 360 365
Glu Asn Ile Lys Ile Ile Ala Asn Gly Lys Val Val Val Asp Lys Asp
370 375 380
Ile Asn Glu Trp Ile Ser Gly Asn Ser Thr Tyr Asn Ile Lys
385 390 395
<210> 209
<211> 265
<212> PRT
<213> 产气荚膜梭菌(Clostridium perfringens)
<400> 209
Met Lys Lys Leu Ile Val Lys Ser Thr Met Met Leu Leu Phe Ser Cys
1 5 10 15
Leu Leu Cys Leu Gly Ile Gln Leu Pro Asn Thr Val Lys Ala Asn Glu
20 25 30
Val Asn Lys Tyr Gln Ser Val Met Val Gln Tyr Leu Glu Ala Phe Lys
35 40 45
Asn Tyr Asp Ile Asp Thr Ile Val Asp Ile Ser Lys Asp Ser Arg Thr
50 55 60
Val Thr Lys Glu Glu Tyr Lys Asn Met Leu Met Glu Phe Lys Tyr Asp
65 70 75 80
Pro Asn Gln Lys Leu Lys Ser Tyr Glu Ile Thr Gly Ser Arg Lys Ile
85 90 95
Asp Asn Gly Glu Ile Phe Ser Val Lys Thr Glu Phe Leu Asn Gly Ala
100 105 110
Ile Tyr Asn Met Glu Phe Thr Val Ser Tyr Ile Asp Asn Lys Leu Met
115 120 125
Val Ser Asn Met Asn Arg Ile Ser Ile Val Asn Glu Gly Lys Cys Ile
130 135 140
Pro Thr Pro Ser Phe Arg Thr Gln Val Cys Thr Trp Asp Asp Glu Leu
145 150 155 160
Ser Gln Tyr Ile Gly Asp Ala Val Ser Phe Thr Arg Ser Ser Lys Phe
165 170 175
Gln Tyr Ser Ser Asn Thr Ile Thr Leu Asn Phe Arg Gln Tyr Ala Thr
180 185 190
Ser Gly Ser Arg Ser Leu Lys Val Lys Tyr Ser Val Val Asp His Trp
195 200 205
Met Trp Gly Asp Asp Ile Arg Ala Ser Gln Trp Val Tyr Gly Glu Asn
210 215 220
Pro Asp Tyr Ala Arg Gln Ile Lys Leu Tyr Leu Gly Ser Gly Glu Thr
225 230 235 240
Phe Lys Asn Tyr Arg Ile Lys Val Glu Asn Tyr Thr Pro Ala Ser Ile
245 250 255
Lys Val Phe Gly Glu Gly Tyr Cys Tyr
260 265
<210> 210
<211> 696
<212> PRT
<213> 产气荚膜梭菌(Clostridium perfringens)
<400> 210
Met Lys Ile Asn Lys Lys Ile Phe Ser Met Leu Phe Met Val Ile Val
1 5 10 15
Leu Phe Thr Cys Ile Ser Ser Asn Phe Ser Val Ser Ala Ser Ser Ile
20 25 30
Gln Arg Gly Arg Asp Ile Ser Asn Glu Val Val Thr Ser Leu Val Ala
35 40 45
Thr Pro Asn Ser Ile Asn Asp Gly Gly Asn Val Gln Val Arg Leu Glu
50 55 60
Phe Lys Glu Asn His Gln Arg Asn Ile Gln Ser Gly Asp Thr Ile Thr
65 70 75 80
Val Lys Trp Thr Asn Ser Gly Glu Val Phe Phe Glu Gly Tyr Glu Lys
85 90 95
Thr Ile Pro Leu Tyr Ile Lys Asp Gln Asn Val Gly Gln Ala Val Ile
100 105 110
Glu Lys Thr Gly Ala Thr Leu Thr Phe Asn Asp Lys Ile Asp Lys Leu
115 120 125
Asp Asp Val Gly Gly Trp Ala Thr Phe Thr Leu Gln Gly Arg Asn Ile
130 135 140
Thr Ser Gly Asn His Glu His Thr Gly Ile Ala Tyr Ile Ile Ser Gly
145 150 155 160
Ser Lys Arg Ala Asp Val Asn Ile Thr Lys Pro Glu Ser Gly Thr Thr
165 170 175
Ser Val Phe Tyr Tyr Lys Thr Gly Ser Met Tyr Thr Asn Asp Thr Asn
180 185 190
His Val Asn Trp Trp Leu Leu Val Asn Pro Ser Lys Val Tyr Ser Glu
195 200 205
Lys Asn Val Tyr Ile Gln Asp Glu Ile Gln Gly Gly Gln Thr Leu Glu
210 215 220
Pro Asp Ser Phe Glu Ile Val Val Thr Trp Tyr Asp Gly Tyr Val Glu
225 230 235 240
Lys Phe Lys Gly Lys Glu Ala Ile Arg Glu Phe His Asn Lys Tyr Pro
245 250 255
Asn Ser Asn Ile Ser Val Ser Glu Asn Lys Ile Thr Val Asn Ile Ser
260 265 270
Gln Glu Asp Ser Thr Gln Lys Phe Ile Asn Ile Phe Tyr Lys Thr Lys
275 280 285
Ile Thr Asn Pro Lys Gln Lys Glu Phe Val Asn Asn Thr Lys Ala Trp
290 295 300
Phe Lys Glu Tyr Asn Lys Pro Ala Val Asn Gly Glu Ser Phe Asn His
305 310 315 320
Ser Val Gln Asn Ile Asn Ala Asp Ala Gly Val Asn Gly Thr Val Lys
325 330 335
Gly Glu Leu Lys Ile Ile Lys Thr Leu Lys Asp Lys Ser Ile Pro Ile
340 345 350
Lys Asp Val Gln Phe Lys Met Arg Arg Val Asp Asn Thr Val Ile Lys
355 360 365
Asp Gly Lys Lys Glu Leu Leu Leu Thr Thr Asp Asp Lys Gly Ile Ala
370 375 380
Asn Val Lys Gly Leu Pro Val Gly Lys Tyr Glu Val Lys Glu Ile Ser
385 390 395 400
Ala Pro Glu Trp Ile Ala Phe Asn Pro Leu Ile Ala Pro Lys Leu Glu
405 410 415
Phe Thr Ile Ser Asp Gln Asp Thr Glu Gly Lys Leu Trp Ala Val Glu
420 425 430
Asn Glu Leu Lys Thr Ile Ser Ile Pro Val Glu Lys Val Trp Val Gly
435 440 445
Gln Thr Ser Glu Arg Ala Glu Ile Lys Leu Phe Ala Asp Gly Ile Glu
450 455 460
Val Asp Lys Val Ile Leu Asn Ala Asp Asn Asn Trp Lys His Thr Phe
465 470 475 480
Glu Asn Lys Pro Glu Tyr Asn Ser Glu Thr Lys Gln Lys Ile Asn Tyr
485 490 495
Ser Val Ser Glu Thr Thr Ile Ser Gly Tyr Glu Ser Asn Ile Thr Gly
500 505 510
Asp Ala Lys Asn Gly Phe Ile Val Thr Asn Thr Glu Leu Pro Asp Leu
515 520 525
Thr Ile Gly Lys Glu Val Ile Gly Glu Leu Gly Asp Lys Thr Lys Val
530 535 540
Phe Asn Phe Glu Leu Thr Leu Lys Gln Ala Asp Gly Lys Pro Ile Asn
545 550 555 560
Gly Lys Phe Asn Tyr Ile Gly Ser Val Asp Asp Arg Tyr Lys Lys Glu
565 570 575
Ser Ile Lys Pro Ser Asp Gly Glu Ile Thr Phe Ile Glu Gly Lys Ala
580 585 590
Thr Ile Thr Leu Ser His Gly Gln Glu Ile Thr Ile Lys Asp Leu Pro
595 600 605
Tyr Gly Val Thr Tyr Lys Val Met Glu Lys Glu Ala Asn Glu Asn Gly
610 615 620
Tyr Leu Thr Thr Tyr Asn Gly Asn Asn Glu Val Thr Thr Gly Glu Leu
625 630 635 640
Lys Gln Asp Thr Lys Val Gln Val Val Asn Asn Lys Glu Phe Val Pro
645 650 655
Thr Thr Gly Ile Ser Thr Thr Thr Glu Gln Gly Thr Met Val Gly Met
660 665 670
Val Ile Phe Ser Ile Gly Ile Leu Met Val Met Ile Val Val Leu Leu
675 680 685
Gln Leu Asn Lys Gly Leu Lys Arg
690 695
<210> 211
<211> 302
<212> PRT
<213> 产气荚膜梭菌(Clostridium perfringens)
<400> 211
Gly Arg Asp Ile Ser Asn Glu Val Val Thr Ser Leu Val Ala Thr Pro
1 5 10 15
Asn Ser Ile Asn Asp Gly Gly Asn Val Gln Val Arg Leu Glu Phe Lys
20 25 30
Glu Asn His Gln Arg Asn Ile Gln Ser Gly Asp Thr Ile Thr Val Lys
35 40 45
Trp Thr Asn Ser Gly Glu Val Phe Phe Glu Gly Tyr Glu Lys Thr Ile
50 55 60
Pro Leu Tyr Ile Lys Asp Gln Asn Val Gly Gln Ala Val Ile Glu Lys
65 70 75 80
Thr Gly Ala Thr Leu Thr Phe Asn Asp Lys Ile Asp Lys Leu Asp Asp
85 90 95
Val Gly Gly Trp Ala Thr Phe Thr Leu Gln Gly Arg Asn Ile Thr Ser
100 105 110
Gly Asn His Glu His Thr Gly Ile Ala Tyr Ile Ile Ser Gly Ser Lys
115 120 125
Arg Ala Asp Val Asn Ile Thr Lys Pro Glu Ser Gly Thr Thr Ser Val
130 135 140
Phe Tyr Tyr Lys Thr Gly Ser Met Tyr Thr Asn Asp Thr Asn His Val
145 150 155 160
Asn Trp Trp Leu Leu Val Asn Pro Ser Lys Val Tyr Ser Glu Lys Asn
165 170 175
Val Tyr Ile Gln Asp Glu Ile Gln Gly Gly Gln Thr Leu Glu Pro Asp
180 185 190
Ser Phe Glu Ile Val Val Thr Trp Tyr Asp Gly Tyr Val Glu Lys Phe
195 200 205
Lys Gly Lys Glu Ala Ile Arg Glu Phe His Asn Lys Tyr Pro Asn Ser
210 215 220
Asn Ile Ser Val Ser Glu Asn Lys Ile Thr Val Asn Ile Ser Gln Glu
225 230 235 240
Asp Ser Thr Gln Lys Phe Ile Asn Ile Phe Tyr Lys Thr Lys Ile Thr
245 250 255
Asn Pro Lys Gln Lys Glu Phe Val Asn Asn Thr Lys Ala Trp Phe Lys
260 265 270
Glu Tyr Asn Lys Pro Ala Val Asn Gly Glu Ser Phe Asn His Ser Val
275 280 285
Gln Asn Ile Asn Ala Asp Ala Gly Val Asn Gly Thr Val Lys
290 295 300
<210> 212
<211> 114
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 212
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Ser Ile Arg
20 25 30
Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val
35 40 45
Ala Thr Met Ser Arg Gly Gly Thr Ile Asn Tyr Ala Asp Ser Val Arg
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Val Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Ala Leu Leu Asp Ser Tyr Tyr Trp Gly Gln Gly Thr Gln Val Thr Val
100 105 110
Ser Ser
<210> 213
<211> 114
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 213
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Val Val Ser Gly Ser Ile Met Ser Ile Arg
20 25 30
Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val
35 40 45
Ala Thr Met Ser Arg Gly Asn Thr Ile Asn Tyr Ala Asp Ser Val Arg
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Val Phe Leu
65 70 75 80
Glu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Ala Leu Leu Asp Ser Tyr Tyr Trp Gly Gln Gly Thr Gln Val Thr Val
100 105 110
Ser Ser
<210> 214
<211> 114
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 214
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Ala Ser Ile Ile Ser Ile Arg
20 25 30
Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val
35 40 45
Ala Thr Met Ser Arg Gly Gly Thr Ile Asn Tyr Ala Asp Ser Val Arg
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Val Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Asp Val Tyr Tyr Cys Ala
85 90 95
Ala Leu Leu Asp Ser Tyr Tyr Trp Gly Gln Gly Thr Gln Val Thr Val
100 105 110
Ser Ser
<210> 215
<211> 114
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 215
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Val Val Ser Gly Ser Ile Met Ser Ile Arg
20 25 30
Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val
35 40 45
Ala Thr Met Ser Arg Gly Gly Thr Ile Asn Tyr Ala Asp Ser Val Arg
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Val Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr
85 90 95
Ala Leu Leu Asp Ser Tyr Tyr Trp Gly Gln Gly Thr Gln Val Thr Val
100 105 110
Ser Ser
<210> 216
<211> 114
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 216
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Ser Ile Arg
20 25 30
Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val
35 40 45
Ala Thr Met Ser Arg Gly Gly Thr Ile Asn Tyr Ala Asp Ser Val Arg
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Val Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr
85 90 95
Ala Leu Leu Asp Ser Tyr Tyr Trp Gly Gln Gly Thr Gln Val Thr Val
100 105 110
Ser Ser
<210> 217
<211> 114
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 217
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Val Val Ser Gly Ser Ile Met Ser Ile Arg
20 25 30
Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val
35 40 45
Ala Thr Met Ser Arg Gly Gly Thr Ile Asn Tyr Ala Asp Ser Val Arg
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu
65 70 75 80
Gln Met Thr Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr
85 90 95
Ala Leu Leu Asp Ser Tyr Tyr Trp Gly Gln Gly Thr Gln Val Thr Val
100 105 110
Ser Ser
<210> 218
<211> 114
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 218
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Ser Ile Arg
20 25 30
Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val
35 40 45
Ala Thr Met Ser Arg Gly Gly Thr Ile Asn Tyr Ala Asp Ser Val Arg
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Val Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Asp Val Tyr Tyr Cys Ala
85 90 95
Ala Leu Leu Asp Ser Tyr Tyr Trp Gly Gln Gly Thr Gln Val Thr Val
100 105 110
Ser Ser
<210> 219
<211> 114
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 219
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Val Val Ser Gly Ser Ile Met Ser Ile Arg
20 25 30
Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val
35 40 45
Ala Thr Met Ser Arg Gly Asn Thr Ile Asn Tyr Ala Asp Ser Val Arg
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu
65 70 75 80
Gln Met Thr Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Ala Leu Leu Asp Ser Tyr Tyr Trp Gly Gln Gly Thr Gln Val Thr Val
100 105 110
Ser Ser
<210> 220
<211> 114
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 220
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Ala Ser Ile Phe Ser Ile Arg
20 25 30
Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val
35 40 45
Ala Thr Met Ser Arg Gly Asn Thr Ile Asn Tyr Ala Asp Ser Val Arg
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Val Tyr Leu
65 70 75 80
Gln Met Thr Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Ala Leu Leu Asp Ser Tyr Tyr Trp Gly Gln Gly Thr Gln Val Thr Val
100 105 110
Ser Ser
<210> 221
<211> 114
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 221
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Val Val Ser Gly Ser Ile Met Ser Ile Arg
20 25 30
Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val
35 40 45
Ala Thr Met Ser Arg Gly Gly Thr Ile Asn Tyr Ala Asp Ser Val Arg
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Val Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Ala Leu Leu Asp Ser Tyr Tyr Trp Gly Gln Gly Thr Gln Val Thr Val
100 105 110
Ser Ser
<210> 222
<211> 114
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 222
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Ala Ser Ile Ile Ser Ile Arg
20 25 30
Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val
35 40 45
Ala Thr Met Ser Arg Gly Gly Thr Ile Asn Tyr Ala Asp Ser Val Arg
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Val Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr
85 90 95
Ala Leu Leu Asp Ser Tyr Tyr Trp Gly Gln Gly Thr Gln Val Thr Val
100 105 110
Ser Ser
<210> 223
<211> 114
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 223
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Ala Ser Ile Ile Ser Ile Arg
20 25 30
Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val
35 40 45
Ala Thr Met Ser Arg Gly Gly Thr Ile Asn Tyr Ala Asp Ser Val Arg
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Val Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Ala Leu Leu Asp Ser Tyr Tyr Trp Gly Gln Gly Thr Gln Val Thr Val
100 105 110
Ser Ser
<210> 224
<211> 114
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 224
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Ala Ser Ile Met Ser Ile Arg
20 25 30
Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val
35 40 45
Ala Thr Met Ser Arg Gly Asn Thr Ile Asn Tyr Ala Asp Ser Val Arg
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Val Phe Leu
65 70 75 80
Glu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Ala Leu Leu Asp Ser Tyr Tyr Trp Gly Gln Gly Thr Gln Val Thr Val
100 105 110
Ser Ser
<210> 225
<211> 114
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 225
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Ala Ser Ile Met Ser Ile Arg
20 25 30
Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val
35 40 45
Ala Thr Met Ser Arg Gly Gly Thr Ile Asn Tyr Ala Asp Ser Val Arg
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Val Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Asp Val Tyr Tyr Cys Ala
85 90 95
Ala Leu Leu Asp Ser Tyr Tyr Trp Gly Gln Gly Thr Gln Val Thr Val
100 105 110
Ser Ser
<210> 226
<211> 114
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 226
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Val Val Ser Gly Ser Ile Met Ser Ile Arg
20 25 30
Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val
35 40 45
Ala Thr Met Ser Arg Gly Gly Thr Ile Asn Tyr Ala Asp Ser Val Arg
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Val Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Asp Val Tyr Tyr Cys Ala
85 90 95
Ala Leu Leu Asp Ser Tyr Tyr Trp Gly Gln Gly Thr Gln Val Thr Val
100 105 110
Ser Ser
<210> 227
<211> 114
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 227
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Ala Ser Ile Ile Ser Ile Arg
20 25 30
Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val
35 40 45
Ala Thr Met Ser Arg Gly Gly Thr Ile Asn Tyr Ala Asp Ser Val Arg
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Val Tyr Leu
65 70 75 80
Gln Met Thr Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Ala Leu Leu Asp Ser Tyr Tyr Trp Gly Gln Gly Thr Gln Val Thr Val
100 105 110
Ser Ser
<210> 228
<211> 114
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 228
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Val Val Ser Gly Ser Ile Met Ser Ile Arg
20 25 30
Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val
35 40 45
Ala Thr Met Ser Arg Gly Asn Thr Ile Asn Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Val Phe Leu
65 70 75 80
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Asp Val Tyr Tyr Cys Ala
85 90 95
Ala Leu Leu Asp Ser Tyr Tyr Trp Gly Gln Gly Thr Gln Val Thr Val
100 105 110
Ser Ser
<210> 229
<211> 114
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 229
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Ala Ser Ile Met Ser Ile Arg
20 25 30
Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val
35 40 45
Ala Thr Met Ser Arg Gly Asn Thr Ile Asn Tyr Ala Asp Ser Val Arg
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Val Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Ala Leu Leu Asp Ser Tyr Tyr Trp Gly Gln Gly Thr Gln Val Thr Val
100 105 110
Ser Ser
<210> 230
<211> 114
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 230
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Val Val Ser Gly Ser Ile Met Ser Ile Arg
20 25 30
Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val
35 40 45
Ala Thr Met Ser Arg Gly Asn Thr Ile Asn Tyr Ala Asp Ser Val Arg
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Val Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Ala Leu Leu Asp Ser Tyr Tyr Trp Gly Gln Gly Thr Gln Val Thr Val
100 105 110
Ser Ser
<210> 231
<211> 114
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 231
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Val Val Ser Gly Ser Ile Ile Ser Ile Arg
20 25 30
Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val
35 40 45
Ala Thr Met Ser Arg Gly Gly Thr Ile Asn Tyr Ala Asp Ser Val Arg
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Val Phe Leu
65 70 75 80
Glu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Ala Leu Leu Asp Ser Tyr Tyr Trp Gly Gln Gly Thr Gln Val Thr Val
100 105 110
Ser Ser
<210> 232
<211> 114
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 232
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Ala Ser Ile Ile Ser Ile Arg
20 25 30
Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val
35 40 45
Ala Thr Met Ser Arg Gly Asn Thr Ile Asn Tyr Ala Asp Ser Val Arg
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr Val Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Arg Pro Asp Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Ala Leu Leu Asp Ser Tyr Tyr Trp Gly Gln Gly Thr Gln Val Thr Val
100 105 110
Ser Ser
<210> 233
<211> 123
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 233
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Ser Ile Asn
20 25 30
Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Asp Leu Val
35 40 45
Ala Leu Ile Thr Ser Gly Gly Ser Thr Thr Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn
85 90 95
Ala Ala Gln Ser Arg Thr Ser Trp Leu Phe Pro Asp Glu Tyr Asp Tyr
100 105 110
Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120
<210> 234
<211> 126
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 234
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ile Tyr
20 25 30
Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val
35 40 45
Ala Val Ile Asn Arg Gly Gly Gly Thr Thr Thr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Val Ser
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Ala Asp Arg Val Thr Asp Thr Tyr Tyr Tyr Leu Asn Pro Glu Ser
100 105 110
Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120 125
<210> 235
<211> 116
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 235
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Gly Arg Arg Val Gly
20 25 30
Tyr Met Ala Trp Tyr Arg Gln Thr Pro Gly Lys Gln Arg Glu Ser Val
35 40 45
Ala Thr Ile Ser Arg Ala Gly Ala Thr Lys Tyr Ala Asp Ser Val Lys
50 55 60
Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asp Thr Val Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys Phe
85 90 95
Ala Ser Leu Ile Asp Ala Gly Thr Tyr Trp Gly Gln Gly Thr Gln Val
100 105 110
Thr Val Ser Ser
115
<210> 236
<211> 126
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 236
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ile Tyr
20 25 30
Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val
35 40 45
Ala Val Ile Asn Arg Ser Gly Gly Thr Thr Thr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Val Ser
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Ala Asp Arg Val Thr Asp Thr Tyr Tyr Tyr Leu Asn Pro Glu Ser
100 105 110
Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120 125
<210> 237
<211> 111
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 237
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Met Ser Phe Ser Leu Gly
20 25 30
Thr Ile Tyr Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val
35 40 45
Ala Phe Ile Thr Asn Ala Asp Thr Thr Met Tyr Ala Asn Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Gly Lys Asn Thr Val Phe Leu
65 70 75 80
Leu Met Asn Asn Leu Lys Pro Glu Asp Ser Ala Val Tyr Tyr Cys Asn
85 90 95
Thr Ala Thr Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
100 105 110
<210> 238
<211> 116
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 238
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Ser Gly Arg Arg Val Gly
20 25 30
Tyr Met Ala Trp Tyr Arg Gln Thr Pro Gly Lys Gln Arg Glu Leu Val
35 40 45
Ala Thr Ile Ser Arg Ala Gly Ala Thr Asn Tyr Ala Asp Ser Val Lys
50 55 60
Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys Phe
85 90 95
Ala Ser Val Phe Asp Ala Gly Thr Tyr Trp Gly Gln Gly Thr Gln Val
100 105 110
Thr Val Ser Ser
115
<210> 239
<211> 116
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 239
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Gly Arg Arg Val Gly
20 25 30
Tyr Met Ala Trp Tyr Arg Gln Thr Pro Gly Lys Gln Arg Glu Leu Val
35 40 45
Ala Thr Ile Ser Arg Ala Gly Ala Thr Asn Tyr Ala Asp Ser Val Lys
50 55 60
Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys Phe
85 90 95
Ala Ser Ile Phe Asp Ala Gly Thr Tyr Trp Gly Gln Gly Thr Gln Val
100 105 110
Thr Val Ser Ser
115
<210> 240
<211> 116
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 240
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ser Gly Ser Arg Ile Asn
20 25 30
Tyr Met Ala Trp His Arg Gln Thr Pro Gly Arg Gln Arg Glu Leu Val
35 40 45
Ala Val Ile Asn Arg Thr Gly Ala Ala Asn Tyr Ala Arg Ser Val Lys
50 55 60
Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu
65 70 75 80
Gln Met Asn Asp Leu Lys Pro Asp Asp Thr Ala Ile Tyr Tyr Cys Phe
85 90 95
Ala Ser Tyr Leu Gly Ala Gly Ala Tyr Trp Gly Gln Gly Thr Gln Val
100 105 110
Thr Val Ser Ser
115
<210> 241
<211> 118
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 241
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Thr Tyr
20 25 30
Thr Val Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val
35 40 45
Ala Ser Ile Thr Trp Asn Gly Gly Thr Ile Leu Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Leu
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Val Met Gly Ala Ala Gly Gln Gly Trp Arg Tyr Trp Gly Gln Gly Thr
100 105 110
Gln Val Thr Val Ser Ser
115
<210> 242
<211> 116
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 242
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ser Gly Ser Arg Ile Asn
20 25 30
Tyr Met Ala Trp His Arg Gln Thr Pro Gly Arg Gln Arg Glu Leu Val
35 40 45
Ala Val Ile Asn Arg Thr Gly Ala Ala Lys Tyr Ala Asp Ser Val Lys
50 55 60
Asp Arg Phe Thr Val Ser Arg Asp Asn Ala Glu Asn Thr Val Tyr Leu
65 70 75 80
Gln Met Asn Asp Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys Trp
85 90 95
Ala Ser Tyr Leu Gly Ala Gly Thr Tyr Trp Gly Gln Gly Ile Gln Val
100 105 110
Thr Val Ser Ser
115
<210> 243
<211> 112
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 243
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Asn
20 25 30
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Gly Ser Ile Tyr Ser Asp Asp Ser Thr Asn Tyr Ala Pro Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Ala Asn Thr Leu Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ser
85 90 95
Lys Glu Gly Gly Leu Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser
100 105 110
<210> 244
<211> 116
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 244
Gln Val Gln Leu Gln Gln Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Gly Arg Arg Val Gly
20 25 30
Tyr Met Ala Trp Tyr Arg Gln Thr Pro Gly Lys Gln Arg Glu Leu Val
35 40 45
Ala Thr Ile Ser Arg Ala Gly Ala Thr Asn Tyr Ala Asp Ser Val Lys
50 55 60
Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys Phe
85 90 95
Ala Ser Val Phe Asp Ala Gly Thr Tyr Trp Gly Gln Gly Thr Gln Val
100 105 110
Thr Val Ser Ser
115
<210> 245
<211> 116
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 245
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Gly Arg Arg Val Gly
20 25 30
Tyr Met Ala Trp Tyr Arg Gln Thr Pro Gly Lys Gln Arg Glu Leu Val
35 40 45
Ala Thr Ile Ser Arg Ala Gly Ala Thr Asn Tyr Ala Asp Ser Val Lys
50 55 60
Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys Phe
85 90 95
Ala Ser Leu Phe Asp Ala Gly Thr Tyr Trp Gly Gln Gly Thr Gln Val
100 105 110
Thr Val Ser Ser
115
<210> 246
<211> 123
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 246
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Gly Arg
20 25 30
Thr Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val
35 40 45
Ala Ala Ile Thr Trp Ser Gly Gly Thr Thr Tyr Tyr Pro Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Ile Pro Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Ser Asp Gly Pro Trp Arg Ala Thr Thr Pro Asp Ala Tyr Asp Tyr
100 105 110
Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120
<210> 247
<211> 111
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 247
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Gly Thr Ile Asp
20 25 30
Ser Met Gly Trp Tyr Arg Glu Ala Pro Gly Lys Arg Arg Glu Leu Val
35 40 45
Ala Phe Ile Met Phe Ser Gly Arg Thr Ile Tyr Gln Asp Ser Val Lys
50 55 60
Gly Arg Phe Ser Ile Ser Gly Asp Asn Ala Lys Lys Thr Val Ser Leu
65 70 75 80
Gln Met Thr Ser Leu Lys Pro Glu Asp Thr Gly Val Tyr Tyr Cys Tyr
85 90 95
Ser Asn Gln Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
100 105 110
<210> 248
<211> 118
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 248
Gln Val Gln Leu Gln Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Phe Ser Leu Leu Phe Gly
20 25 30
Thr Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val
35 40 45
Ser Cys Val Ser Ser Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Lys Ala Lys Asn Thr Trp Tyr
65 70 75 80
Leu Gln Met His Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Thr Arg Cys Thr Val Val Pro Gly Ile Thr Trp Gly Gln Gly Thr
100 105 110
Gln Val Thr Val Ser Ser
115
<210> 249
<211> 112
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 249
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Val Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Val Ala Pro Gly Ser Ile Thr Arg Val Gly
20 25 30
Gly Met Gly Trp Tyr Arg Gln Pro Pro Gly Lys Glu Arg Glu Leu Val
35 40 45
Ala Leu Ile Asn Glu Val Gly Asn Thr Asn Tyr Gly Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Thr Val Tyr Leu
65 70 75 80
Glu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Trp
85 90 95
Ile Pro Pro Ile Pro Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
100 105 110
<210> 250
<211> 118
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 250
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Thr Ser Pro Phe Ser Leu Arg Leu Gly
20 25 30
Val Val Gly Trp Phe Arg Gln Ala Pro Gly Arg Glu Arg Glu Gly Val
35 40 45
Ser Cys Ile Ser Ser Ser Glu Gly Ser Thr His Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Thr Arg Cys Thr Val Val Pro Gly Ile Thr Trp Gly Gln Gly Thr
100 105 110
Gln Val Thr Val Ser Ser
115
<210> 251
<211> 127
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 251
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Ala Arg Thr Ser Ser Ser Arg
20 25 30
Ala Met Gly Trp Phe Arg Gln Thr Pro Val Arg Glu Arg Glu Phe Val
35 40 45
Ala Ala Ile Ser Trp Ser Gly Gly Arg Thr Ala Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Leu Ser Lys Tyr Asp Lys Asp Thr Val Ser Leu
65 70 75 80
Thr Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Ala Arg Arg Ser Asp Phe Thr Gly Asp Tyr Ala Tyr Ser Gly Arg Ser
100 105 110
Ala Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120 125
<210> 252
<211> 115
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 252
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Phe Ile Phe Asp
20 25 30
Lys Met Asp Trp Tyr Arg Gln Thr Pro Glu Lys Ser Arg Glu Leu Val
35 40 45
Ala Thr Leu Met Ser Arg Gly Asp Pro Tyr Tyr Leu Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Thr Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Val Cys Arg
85 90 95
Gly Arg Ala Gly Glu Arg Val Tyr Trp Gly Gln Gly Thr Gln Val Thr
100 105 110
Val Ser Ser
115
<210> 253
<211> 125
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 253
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Gly Val
20 25 30
Ile Val Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Leu
35 40 45
Ala Thr Thr Leu Trp Ser Gly Gly Ser Thr Tyr Tyr Thr Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Val Ala Lys Asn Met Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Ala Ala Ile Tyr Tyr Cys
85 90 95
Ala Ala Lys Tyr Gly Gly Ser Leu Ser Tyr Met His Pro Thr Gly Tyr
100 105 110
Thr Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120 125
<210> 254
<211> 123
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 254
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Ile Val Phe Thr Ile Ser
20 25 30
Thr Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val
35 40 45
Ala Ser Ile Asn Arg Ser Gly Ala Leu Thr Ser His Ala Asn Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Ala Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Asp Glu Asp Thr Ala Ile Tyr Tyr Cys
85 90 95
Ala Ala Ser Lys Ala Asn Met Pro Ala Leu Pro Ala Asn Tyr Asp Tyr
100 105 110
Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120
<210> 255
<211> 112
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 255
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Val Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Val Ala Pro Gly Ser Ile Thr Arg Leu Gly
20 25 30
Ser Met Gly Trp Tyr Arg Gln Pro Pro Gly Lys Gln Arg Glu Leu Val
35 40 45
Ala Leu Ile Thr Ala Val Gly Asn Thr Asn Tyr Gly Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Met Val Tyr Leu
65 70 75 80
Glu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Trp
85 90 95
Ile Pro Pro Ile Pro Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
100 105 110
<210> 256
<211> 112
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 256
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Val Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Val Ala Pro Gly Ser Ile Thr Arg Leu Gly
20 25 30
Gly Met Gly Trp Tyr Arg Gln Thr Pro Gly Lys Gln Arg Glu Leu Val
35 40 45
Ala Leu Ile Asp Thr Val Gly Asn Thr Asn Tyr Gly Glu Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Met Val Tyr Leu
65 70 75 80
Glu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Trp
85 90 95
Ile Pro Pro Ile Pro Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
100 105 110
<210> 257
<211> 123
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 257
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp
1 5 10 15
Ser Leu Thr Leu Ser Cys Val Ala Ser Glu Arg Ala Phe Met Tyr Asn
20 25 30
Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Asp Phe Val Ala
35 40 45
Val Arg Asn Trp Asn Val Glu Arg Thr Asn Tyr Ala Asp Phe Ala Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Ala Ala Lys Lys Val Met Tyr Leu
65 70 75 80
Lys Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Thr Thr Arg Val Trp Pro Thr Gln His Gln Met Gly Gln Ile Glu Tyr
100 105 110
Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120
<210> 258
<211> 115
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 258
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Ser Ser Phe Asn Thr Met Gly
20 25 30
Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val Ala Gly Ile
35 40 45
Thr Ser Gly Gly Thr Ile Lys Tyr Gly Asp Ser Val Lys Gly Arg Phe
50 55 60
Thr Ile Ser Gly Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asp
65 70 75 80
Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Val Ala Asp Trp
85 90 95
Gln Tyr Gly Ser Thr Trp Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr
100 105 110
Val Ser Ser
115
<210> 259
<211> 124
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 259
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Asn Phe Asp Tyr Tyr
20 25 30
Ser Met Gly Trp Phe Arg Gln Ala Pro Gly Asn Glu Arg Ile Phe Val
35 40 45
Ala Ala Ile Asn Trp Arg Gly Ala Val Ile Asp Tyr Pro Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Arg Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Ala Ala Ser Ser Ser Ser Arg Leu Leu Glu Pro Ile Gly Tyr Asn
100 105 110
Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120
<210> 260
<211> 120
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 260
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Met Phe Ser Ile Asn
20 25 30
Asp Met Thr Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Met Val
35 40 45
Ala Thr Ile Ser Ser Gly Gly Thr Thr Asp Tyr Thr Glu Ser Val Lys
50 55 60
Gly Arg Phe Phe Val Ile Arg Asp Asn Ala Lys Ile Thr Val Tyr Leu
65 70 75 80
Gln Met Asn Lys Leu Arg Pro Glu Asp Ser Gly Val Tyr Tyr Cys Ala
85 90 95
Gly Asn Leu Lys Arg Ser Glu Thr Ser Tyr Tyr Trp Lys Thr Gly Gln
100 105 110
Gly Ile Gln Val Thr Val Ser Ser
115 120
<210> 261
<211> 122
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 261
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Gly
1 5 10 15
Ser Leu Lys Leu Ser Cys Ala Thr Ser Gly Arg Thr Phe Ser Arg Tyr
20 25 30
His Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val
35 40 45
Ala Ala Ile Ser Leu Ser Gly Gly Gly Thr Ala Phe Ala Asn Phe Val
50 55 60
Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Thr Ala Asp Arg His Glu Trp Gly Arg Leu Met Lys Gly Asp Tyr Trp
100 105 110
Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120
<210> 262
<211> 127
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 262
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Thr Val Ser Cys Ser Ala Ser Gly Arg Thr Ser Asn Ser Tyr
20 25 30
Asn Met Ala Trp Phe Arg Gln Gly Pro Gly Lys Glu Arg Glu Leu Val
35 40 45
Ala Ala Ile Ser Trp Thr Gly Gly Phe Thr Ser Tyr Thr Asn Ser Val
50 55 60
Lys Asp Arg Phe Thr Ile Ser Arg Glu Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Ala Thr Ser Arg Ser Leu Thr Ser Ala Met Thr Arg Glu Ile Arg
100 105 110
Ala Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120 125
<210> 263
<211> 115
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 263
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Phe Ser Phe Asn
20 25 30
Lys Met Asp Trp Tyr Arg Gln Ala Pro Glu Lys Gln Arg Glu Leu Val
35 40 45
Ala Thr Phe Met Asn Asp Gly Asn Thr Tyr Tyr Val Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Lys Phe Glu Asp Thr Ala Val Tyr Tyr Cys Arg
85 90 95
Gly Arg Ala Gly Met Glu Val Tyr Trp Gly Gln Gly Thr Gln Val Thr
100 105 110
Val Ser Ser
115
<210> 264
<211> 117
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 264
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Thr Leu Ser Cys Ala Thr Ser Pro Leu Thr Leu Arg Leu Gly
20 25 30
Pro Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val
35 40 45
Ser Cys Ile Ser Ser Arg Asp Asp Lys Asn Tyr Ala Glu Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Met Val Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Thr Arg Cys Thr Val Val Pro Gly Ile Ser Trp Gly Gln Gly Thr Gln
100 105 110
Val Thr Val Ser Ser
115
<210> 265
<211> 123
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 265
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Asn Phe Gly Tyr Tyr
20 25 30
Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Asn Glu Arg Ile Phe Val
35 40 45
Ala Ala Ile Thr Trp Arg Gly Val Ile His His Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Ala Ala Ser Ser Ser Ser Arg Pro Leu Glu Pro Ile Gly Tyr Asn Tyr
100 105 110
Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120
<210> 266
<211> 126
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 266
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Asp Ile Phe Ser Ala Ala
20 25 30
Gly Met Ala Trp Phe Arg Gln Thr Pro Gly Lys Glu Arg Asp Leu Val
35 40 45
Ala Tyr Val Thr Trp Asp Gly Gly Thr Thr Arg Tyr Lys Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Leu
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Ala Gly Asn Thr Gly Pro Phe Asn Leu Leu His Ser Ser Ala Gln
100 105 110
Tyr Ala Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120 125
<210> 267
<211> 117
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 267
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Thr Ser Pro Leu Thr Leu Arg Leu Gly
20 25 30
Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Met Val
35 40 45
Ser Cys Ile Thr Ser Thr Glu Asp Lys Asn Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Met Val Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Lys Leu Glu Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Thr Arg Cys Thr Val Val Pro Gly Ile Ser Trp Gly Gln Gly Thr Gln
100 105 110
Val Thr Val Ser Ser
115
<210> 268
<211> 112
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 268
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Val Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Val Ala Pro Gly Ser Ile Thr Arg Ile Gly
20 25 30
Gly Met Gly Trp Tyr Arg Gln Pro Pro Gly Lys Gln Arg Glu Leu Val
35 40 45
Ala Leu Ile Asn Thr Val Gly Asn Thr Asn Tyr Gly Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Thr Val Tyr Leu
65 70 75 80
Glu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Trp
85 90 95
Ile Pro Pro Leu Pro Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
100 105 110
<210> 269
<211> 119
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 269
Gln Val Gln Leu Gln Gln Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Arg Ser Phe Ser Arg Tyr
20 25 30
Ile Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ser Val
35 40 45
Ala Arg Ile Ala Pro Ser Gly Gly Ser Ala Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Asn Leu Lys Ser Glu Asp Thr Ala Val Tyr His Cys
85 90 95
Ala Ala Arg Tyr Asp Met Asp Tyr Glu Tyr Lys Thr Trp Gly Pro Gly
100 105 110
Thr Gln Val Thr Val Ser Ser
115
<210> 270
<211> 116
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 270
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ser Gly Ser Arg Ile Gly
20 25 30
Phe Met Ala Trp His Arg Gln Thr Pro Gly Arg Gln Arg Glu Leu Val
35 40 45
Ala Val Ile Asn Arg Thr Gly Ala Thr Arg Tyr Ala Asp Ser Val Lys
50 55 60
Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu
65 70 75 80
Gln Met Asn Asp Leu Lys Pro Asp Asp Thr Ala Leu Tyr Tyr Cys Phe
85 90 95
Ala Ser Val Val Asp Ala Gly Thr Tyr Trp Gly Gln Gly Thr Gln Val
100 105 110
Thr Val Ser Ser
115
<210> 271
<211> 127
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 271
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Leu Thr Phe Ser Asp Tyr
20 25 30
Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Gln Glu Arg Glu Phe Val
35 40 45
Ala Arg Ile Ser Leu Thr Ala Ala Ser Thr Leu Tyr Ala Asp Ser Val
50 55 60
Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Pro Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Ala Gln Gly Arg Ile Leu Arg Gly Arg Gly Leu Phe Lys Ala Ser
100 105 110
Asp Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120 125
<210> 272
<211> 116
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 272
Gln Val Gln Leu Gln Gln Ser Gly Gly Gly Ser Val Gln Thr Gly Gly
1 5 10 15
Ser Leu Ala Leu Ser Cys Ala Ala Ser Gly Thr Ile Ser Ile Phe Asp
20 25 30
Pro Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val
35 40 45
Ala Ser Ile Ser Glu Gly Ser Thr Asn Tyr Ala Asn Ser Val Lys Gly
50 55 60
Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Thr Val Ser Leu Gln
65 70 75 80
Met Asn Ser Leu Glu Pro Ala Asp Thr Ala Val Tyr Tyr Cys Arg Leu
85 90 95
Ser Arg Tyr Tyr Asn Ser Asn Ile Tyr Trp Gly Gln Gly Thr Gln Val
100 105 110
Thr Val Ser Ser
115
<210> 273
<211> 119
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 273
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Asn Ile Tyr Gly Ile Asn
20 25 30
Val Ile Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Met Val
35 40 45
Ala Arg Ser Ala Asn Gly Gly Thr Thr Arg Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Val Lys Asn Ile Val Tyr Leu
65 70 75 80
Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Ala Tyr Tyr Cys Lys
85 90 95
Ala Glu Leu Tyr Thr Leu Gln His Asn Tyr Glu Tyr Trp Gly Gln Gly
100 105 110
Thr Gln Val Thr Val Ser Ser
115
<210> 274
<211> 116
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 274
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly
1 5 10 15
Ser Leu Ala Leu Ser Cys Val Ala Ser Gly Thr Leu Ser Leu Phe Asp
20 25 30
Pro Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val
35 40 45
Ala Ser Ile Ser Gly Leu Ser Thr Asn Tyr Ala Asn Ser Val Lys Gly
50 55 60
Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Lys Thr Val Ser Leu Gln
65 70 75 80
Met Asn Ser Leu Glu Pro Ala Asp Thr Ala Val Tyr Tyr Cys His Leu
85 90 95
Ser Arg Tyr Tyr Asn Ser Asn Ile Tyr Trp Gly Gln Gly Thr Gln Val
100 105 110
Thr Val Ser Ser
115
<210> 275
<211> 120
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 275
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Val Leu Ser Ile Asn
20 25 30
Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Arg Arg Glu Met Val
35 40 45
Ala Arg Ile Thr Asn Gly Gly Ser Thr Asn Tyr Ala Gly Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Glu Asn Thr Lys Asn Thr Met Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Leu
85 90 95
Ala Glu Glu Arg Pro Tyr Tyr Gly Gly Pro Leu Glu Tyr Trp Gly Gln
100 105 110
Gly Thr Gln Val Thr Val Ser Gln
115 120
<210> 276
<211> 116
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 276
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Thr Thr Phe Arg Val Gly
20 25 30
Thr Met Ala Trp Phe Arg Gln Asp Pro Gly Lys Gln Arg Glu Leu Val
35 40 45
Ala Gly Ile Thr Ser Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Ile Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Ile Tyr Val Cys Phe
85 90 95
Ala Asn Ile Val Asp Arg Pro Val Ser Trp Gly Gln Gly Thr Gln Val
100 105 110
Thr Val Ser Ser
115
<210> 277
<211> 116
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 277
Gln Val Gln Leu Gln Gln Ser Gly Gly Gly Ala Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Thr Leu Ser Cys Val Ala Ser Gly Ser Gly Ser Arg Ile Gly
20 25 30
Leu Met Ala Trp Tyr Arg Gln Thr Pro Gly Arg Gln Arg Glu Leu Val
35 40 45
Ala Val Ile Lys Gly Thr Gly Thr Thr Arg Tyr Ala Asp Ser Val Lys
50 55 60
Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Met Tyr Leu
65 70 75 80
Gln Met Asn Asp Leu Lys Pro Asp Asp Thr Ala Leu Tyr Tyr Cys Phe
85 90 95
Ala Ser Val Leu Gly Ala Gly Thr Tyr Trp Gly Gln Gly Thr Gln Val
100 105 110
Thr Val Ser Ser
115
<210> 278
<211> 116
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 278
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly
1 5 10 15
Ser Leu Ala Leu Ser Cys Ala Ala Ser Gly Thr Ile Ser Leu Phe Asp
20 25 30
Ser Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val
35 40 45
Ala Ser Ile Thr Glu Gly Ser Thr Asn Tyr Ala Asn Ser Val Lys Gly
50 55 60
Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Thr Val Ser Leu Gln
65 70 75 80
Met Asn Ser Leu Glu Pro Ala Asp Thr Ala Val Tyr Tyr Cys Arg Leu
85 90 95
Ser Arg Tyr Tyr Asn Ser Asn Ile Tyr Trp Gly Gln Gly Thr Gln Val
100 105 110
Thr Val Ser Ser
115
<210> 279
<211> 114
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 279
Gln Val Gln Leu Gln Gln Ser Gly Gly Gly Leu Val Gln Ser Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Thr Ser Leu Asn Phe Asp
20 25 30
Asp Met Arg Trp Tyr Arg Gln Thr Pro Gly Lys Arg Arg Glu Trp Val
35 40 45
Ala Ile Ile Asn Thr Phe Pro Ala Gly Thr Thr Ala Ser Tyr Ala Asp
50 55 60
Ser Val Lys Gly Arg Phe Thr Ile Ser Lys Val Asn Gly Glu Asn Thr
65 70 75 80
Val His Leu Gln Met Asn Arg Leu Lys Pro Glu Asp Thr Ala Val Tyr
85 90 95
Tyr Cys Asn Ala Gly Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val
100 105 110
Ser Ser
<210> 280
<211> 116
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 280
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Ser Asp Ser Ser Ile Asn
20 25 30
Tyr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Val Leu Leu
35 40 45
Ala Ala Ile Ser Arg Asp Gly Arg Ser Asn Tyr Ala Asp Ser Val Arg
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp Leu
65 70 75 80
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Tyr
85 90 95
Val Asp Pro Leu Gly Arg Val Pro Arg Trp Gly Gln Gly Thr Gln Val
100 105 110
Thr Val Ser Ser
115
<210> 281
<211> 113
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 281
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ala Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Thr Leu Ser Cys Val Ala Ser Gly Thr Val Asn Leu Met Ala
20 25 30
Trp Tyr Arg Gln Thr Pro Gly Arg Gln Arg Glu Leu Val Ala Val Ile
35 40 45
Lys Gly Thr Gly Thr Thr Arg Tyr Ala Asp Ser Val Lys Asp Arg Phe
50 55 60
Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Met Tyr Leu Gln Met Asn
65 70 75 80
Asp Leu Lys Pro Asp Asp Thr Ala Leu Tyr Tyr Cys Phe Ala Ser Val
85 90 95
Leu Gly Ala Gly Thr Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser
100 105 110
Ser
<210> 282
<211> 113
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 282
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Ser Arg Asn
20 25 30
Ile Ile Leu Trp His Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val
35 40 45
Gly Gly Ile Asn Thr Gly Gly Arg Thr Asn Tyr Glu Ser Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu
65 70 75 80
Gln Met Asp Arg Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn
85 90 95
Ala Pro Ser Leu Gly Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser
100 105 110
Ser
<210> 283
<211> 115
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 283
Gln Val Gln Leu Gln Gln Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ser Gly Ser Ile Asn Tyr
20 25 30
Met Ala Trp His Arg Gln Thr Pro Gly Arg Gln Arg Glu Leu Val Ala
35 40 45
Val Ile Asn Arg Thr Gly Ala Ala Arg Tyr Ala Asp Ser Val Lys Asp
50 55 60
Arg Phe Thr Ile Ser Arg Asp Asn Ala Glu Asn Thr Met Tyr Leu Gln
65 70 75 80
Met Asn Asp Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys Phe Ala
85 90 95
Ser Ala Leu Gly Ala Gly Val Tyr Trp Gly Gln Gly Thr Gln Val Thr
100 105 110
Val Ser Ser
115
<210> 284
<211> 116
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 284
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Gly Trp Arg Val Gly
20 25 30
Tyr Met Ala Trp Tyr Arg Gln Thr Pro Gly Lys Gln Arg Glu Leu Val
35 40 45
Ala Thr Ile Ser Arg Ala Gly Ala Thr Arg Tyr Glu Asp Ser Val Lys
50 55 60
Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys Phe
85 90 95
Ala Ser Ile Ile Asp Ala Gly Thr Tyr Trp Gly Gln Gly Thr Pro Val
100 105 110
Thr Val Ser Ser
115
<210> 285
<211> 123
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 285
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Glu Asn Phe Ser Thr Tyr
20 25 30
Val Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val
35 40 45
Ala Ala His Asn Trp Arg Gly Gly Gly Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp His Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Glu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Ala Arg Ser Gly Gly Ser Tyr Thr Tyr Thr Gly Ser Tyr His Tyr
100 105 110
Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120
<210> 286
<211> 123
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 286
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ala Gly Arg Thr Phe Ser Ser Tyr
20 25 30
Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val
35 40 45
Ala Thr Ile Ser Arg Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Ala Asn Arg Tyr Gly Ser Ser Ser Tyr Gln Gly Gln Tyr Ala Ser
100 105 110
Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120
<210> 287
<211> 123
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 287
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr
20 25 30
His Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val
35 40 45
Ala Thr Ile Ser Arg Ser Gly Gly Phe Thr Ser Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Trp
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Ala Gln Gln Trp Pro Asp Pro Arg Asn Pro Asn Gly Tyr Asp Tyr
100 105 110
Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120
<210> 288
<211> 123
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 288
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ala Cys Ala Ala Ser Gly Arg Thr Phe Ile Asn Tyr
20 25 30
Gly Met Ala Trp Phe Arg Gln Ser Pro Gly Lys Glu Arg Glu Phe Val
35 40 45
Ala Ala Val Ser Ile Ser Gly Ala Gly Thr Ala Tyr Val Glu Pro Val
50 55 60
Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Thr Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Ala Ala Lys Ala Gly His Trp Gly Arg Asp Ala Asn Tyr Asp Tyr
100 105 110
Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120
<210> 289
<211> 123
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 289
Gln Val Gln Leu Gln Gln Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr Leu Thr Ala Tyr
20 25 30
Gly Met Ala Trp Phe Arg Gln Ser Pro Gly Lys Glu Arg Glu Phe Val
35 40 45
Ala Ala Val Ser Leu Ser Gly Ala Ser Thr Ala Tyr Val Glu Pro Val
50 55 60
Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Thr Gln Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Ala Ala Lys Ala Gly Gln Trp Gly Arg Asp Ala Lys Tyr Asp Tyr
100 105 110
Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120
<210> 290
<211> 128
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 290
Gln Val Gln Leu Gln Gln Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Thr Tyr
20 25 30
Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val
35 40 45
Ala Gly Ile Ser Trp Ser Gly Gly Arg Ile Ser Tyr Thr Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Thr Ala Asp Leu Lys Gly Leu Trp Ala Leu Gly Leu Pro Gly His Tyr
100 105 110
Ala Ser Trp Asp Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120 125
<210> 291
<211> 115
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 291
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Gly Ser Ile Asn
20 25 30
Ile Met Asp Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Asp Leu Val
35 40 45
Ala Thr Phe Thr Ser Gly Gly Ser Thr Val Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asp Thr Val Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Arg
85 90 95
Ala Arg Arg Gly Trp Ala Ile Tyr Trp Gly Gln Gly Thr Gln Val Thr
100 105 110
Val Ser Ser
115
<210> 292
<211> 123
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 292
Gln Val Gln Leu Gln Gln Ser Gly Gly Gly Leu Val Gln Ala Gly Asp
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr
20 25 30
Gly Met Gly Trp Phe Arg Gln Ala Thr Gly Lys Glu Arg Glu Phe Val
35 40 45
Ala Gly Ile Ser Arg Thr Gly Ser Gly Thr Ala Tyr Ala Asp Ser Val
50 55 60
Lys Ser Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Ala Asp Ser Gly Gly Ser Trp Gly Arg Gly Thr Thr Tyr Asp Tyr
100 105 110
Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120
<210> 293
<211> 124
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 293
Gln Val Gln Leu Gln Gln Ser Gly Gly Gly Ser Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Arg Ala Ser Ala Arg Ala Ser Ser Ile Gly
20 25 30
Ala Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Asp Arg Glu Leu Val
35 40 45
Ala Ala Val Thr Ala Gly Ala Asp Thr Thr Tyr Tyr Arg Asp Phe Val
50 55 60
Lys Gly Arg Phe Thr Leu Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Leu Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Ala Tyr Asn Thr Ala Gly Trp Gly Glu Pro His Gln Ser Tyr Arg
100 105 110
Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120
<210> 294
<211> 122
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 294
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Lys Leu Ser Cys Val Ala Ser Gly Leu Thr Phe Gly Asn Tyr
20 25 30
Asp Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val
35 40 45
Thr His Ile Ser Ser Ser Gly Ala Tyr Thr Ser Tyr Ala Tyr Phe Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Ile Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys
85 90 95
Ala Gly Arg Arg Ser Val Val Val Arg Ser Phe Asp Tyr Asp Tyr Trp
100 105 110
Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120
<210> 295
<211> 115
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 295
Gln Val Gln Leu Gln Gln Ser Gly Gly Gly Leu Val His Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ile Phe Asn Ala Asn
20 25 30
Gly Met Tyr Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val
35 40 45
Ala Ser Leu Tyr Arg Ser Gly Ser Thr Asn Tyr Leu Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn
85 90 95
Val Asn Trp Ala Leu His Asp Ser Trp Gly Gln Gly Thr Gln Val Thr
100 105 110
Val Ser Ser
115
<210> 296
<211> 123
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 296
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Arg Thr Phe Ser Ser Asp
20 25 30
Gly Met Ala Trp Phe Arg Gln Ala Thr Gly Lys Glu Arg Glu Phe Val
35 40 45
Ala Gly Ile Ser Arg Thr Gly Ser Ala Thr Ala Tyr Ala Glu Phe Val
50 55 60
Lys Ser Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Ala Asn Ser Gly Gly His Trp Trp Arg Gly Ala Thr Tyr Asp Tyr
100 105 110
Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120
<210> 297
<211> 115
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 297
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Thr Ile Phe Ser Ala Asn
20 25 30
Gly Met Tyr Trp Tyr Arg Gln Ala Leu Gly Gln Arg Arg Glu Leu Val
35 40 45
Ala Ser Leu Tyr Arg Asp Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn
85 90 95
Val Asn Trp Ala Leu His Asp Ser Trp Gly Gln Gly Thr Gln Val Thr
100 105 110
Val Ser Ser
115
<210> 298
<211> 125
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 298
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Val Val Gln Ala Gly Asp
1 5 10 15
Ser Leu Arg Leu Ser Cys Thr Ala Ser Thr Arg Ala Ser Ile Val Gly
20 25 30
Ala Met Ala Trp Phe Arg Gln Ala Pro Gly Arg Asn Arg Asp Ile Val
35 40 45
Ala Ala Ile Ala Ala Gly Ser Pro Ser Thr Pro Tyr Tyr Ala Asp Ser
50 55 60
Val Lys Gly Arg Phe Ala Ile Ser Arg Asp Asn Ala Lys Asn Thr Val
65 70 75 80
Tyr Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Ile Tyr Tyr
85 90 95
Cys Ala Ala Tyr Asn Thr Ala Asn Trp Gly Gln Pro His Gln Ser Tyr
100 105 110
Arg His Trp Gly Gln Gly Ile Gln Val Thr Val Ser Ser
115 120 125
<210> 299
<211> 118
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 299
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Ala Ala Ala Ser Gly Ser Ile Leu Asn Ile Asn
20 25 30
Val Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Gln Arg Glu Trp Val
35 40 45
Ala Ser Ile Tyr Arg Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn
85 90 95
Val Val Thr Tyr Gly Ser Asn Arg Arg Asp Phe Trp Gly Gln Gly Thr
100 105 110
Gln Val Thr Val Ser Thr
115
<210> 300
<211> 123
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 300
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr
20 25 30
Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Asp Arg Glu Phe Val
35 40 45
Ser Thr Ile Ser Arg Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Ala Asn Arg Tyr Gly Ser Ser Ser Tyr Gln Gly Gln Tyr Gly Ser
100 105 110
Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120
<210> 301
<211> 123
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 301
Gln Val Gln Leu Gln Gln Ser Gly Gly Gly Leu Val Gln Ala Gly Asp
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr
20 25 30
Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val
35 40 45
Ala Ser Ile Ser Arg Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Val Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Ala Asn Arg Tyr Gly Ser Ser Ser Tyr Gln Gly Gln Tyr Asp Tyr
100 105 110
Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120
<210> 302
<211> 115
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 302
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Thr Ile Phe Ser Ile Asn
20 25 30
Gly Met Tyr Trp Tyr Arg Gln Ala Leu Gly Lys Arg Arg Glu Leu Val
35 40 45
Ala Ser Leu Tyr Arg Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn
85 90 95
Val Asn Trp Ala Leu Gln Asp Ser Trp Gly Gln Gly Thr Gln Val Thr
100 105 110
Val Ser Ser
115
<210> 303
<211> 115
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 303
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Thr Ser Asp Gly Ser Ile Asn
20 25 30
Val Met Asp Trp Tyr Arg Gln Thr Pro Gly Lys Gln Arg Asp Leu Val
35 40 45
Ala Thr Ile Thr Ser Leu Gly Ser Gln Val Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asp Thr Val Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Arg
85 90 95
Ala Arg Arg Gly Trp Ala Ile Tyr Trp Gly Gln Gly Thr Gln Val Thr
100 105 110
Val Ser Ser
115
<210> 304
<211> 128
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 304
Gln Val Gln Leu Gln Gln Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Asn Ile Tyr
20 25 30
Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val
35 40 45
Ala Gly Ile Ser Asp Ser Gly Gly Ser Ala Asn Tyr Ala Asp Ser Val
50 55 60
Lys Asp Arg Phe Thr Ile Ser Met Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Ala Asp Leu Thr Gly Leu Trp Ala Leu Gly Leu Pro Gly His Tyr
100 105 110
Ala Ser Trp Asp Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120 125
<210> 305
<211> 117
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 305
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Ser
20 25 30
Ala Met Ser Trp Val Arg Gln Val Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ser Ile Gly Ser Asp Gly Glu Asn Ile Tyr Tyr Ala Asp Ala Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Met Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Leu Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Gln Leu Gly Arg Thr Val Leu Asp Tyr Phe Lys Gly Gln Gly Thr Gln
100 105 110
Val Thr Val Ser Ser
115
<210> 306
<211> 123
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 306
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ile Asn Tyr
20 25 30
Gly Met Ala Trp Phe Arg Gln Ser Pro Gly Lys Glu Arg Glu Phe Val
35 40 45
Ala Ala Val Ser Ser Ser Gly Ala Gly Thr Ala Tyr Val Glu Pro Val
50 55 60
Lys Asp Arg Phe Thr Ile Ser Arg Asn Asn Thr Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Ala Ala Lys Ala Gly Gln Trp Gly Arg Tyr Ala Asn Tyr Asp Tyr
100 105 110
Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120
<210> 307
<211> 123
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 307
Gln Val Gln Leu Gln Gln Ser Gly Gly Gly Leu Val Gln Ala Gly Asp
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr
20 25 30
Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val
35 40 45
Ala Ala Ile Ser Arg Ser Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Thr Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Ala Asn Pro Tyr Gly Ser Ser Ser Tyr Gln Gly Gln Tyr Gly Ser
100 105 110
Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120
<210> 308
<211> 123
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 308
Gln Val Gln Leu Gln Gln Ser Gly Gly Gly Leu Val Gln Ala Gly Asp
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ala Phe Ser Gly Tyr
20 25 30
Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Arg Glu Arg Glu Phe Val
35 40 45
Ala Ala Ile Ser Arg Gly Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Ala Asn Arg Tyr Gly Ser Ser Ser Tyr Gln Gly Gln Tyr Gly Ser
100 105 110
Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120
<210> 309
<211> 123
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 309
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ile Asn Tyr
20 25 30
Gly Met Ala Trp Phe Arg Gln Ser Pro Gly Lys Glu Arg Glu Phe Val
35 40 45
Ala Ala Val Ser Ser Ser Gly Ala Gly Thr Ala Tyr Val Glu Pro Val
50 55 60
Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asp Thr Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Ala Ala Lys Ala Gly His Trp Gly Arg Asp Ala Asn Tyr Asp Tyr
100 105 110
Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120
<210> 310
<211> 116
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 310
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Met Val Glu Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ser Ser Ile Thr
20 25 30
Phe Met Gly Trp His Arg Gln Ala Pro Gly Lys Glu Gly Glu Phe Val
35 40 45
Ala Leu Ile Ala Arg Ser Gly Thr Thr Thr Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu
65 70 75 80
Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Tyr
85 90 95
Val Asp Arg Arg Gly Ala Val Pro Thr Trp Gly Gln Gly Thr Gln Val
100 105 110
Thr Val Ser Ser
115
<210> 311
<211> 116
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 311
Gln Val Gln Leu Gln Gln Ser Gly Gly Gly Leu Val Glu Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ser Ser Ile Thr
20 25 30
Phe Met Gly Trp His Arg Gln Ala Pro Gly Glu Gln Gly Glu Leu Val
35 40 45
Ala Leu Ile Ala Arg Ser Gly Thr Thr Thr Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu
65 70 75 80
Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Tyr
85 90 95
Val Asp Arg Arg Asp Val Val Pro Thr Trp Gly Gln Gly Thr Gln Val
100 105 110
Thr Val Ser Ser
115
<210> 312
<211> 117
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 312
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Gly Phe Pro Ile Ile
20 25 30
Thr Phe Met Gly Tyr Tyr Arg Gln Ala Pro Gly Asn Gln Arg Glu Leu
35 40 45
Val Ala Ile Ile Ser Arg Gly Gly Val Ala Lys Tyr Gly Asp Ser Val
50 55 60
Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Glu Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Tyr Ala Asp Arg Phe Ser Gly Ser Pro Thr Trp Gly Gln Gly Thr Gln
100 105 110
Val Thr Val Ser Ser
115
<210> 313
<211> 114
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 313
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Val Ser Ser Ile Gly Thr Met
20 25 30
Gly Trp Phe Arg Gln Ala Pro Gly Lys Gln Pro Glu Leu Val Ala Ser
35 40 45
Ile Ser Arg Val Gly Thr Thr Asn Tyr Ala Asn Ser Val Lys Gly Arg
50 55 60
Phe Thr Val Ser Arg Asp Asn Ala Gln Asn Thr Met Tyr Leu Gln Met
65 70 75 80
Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Leu Cys Phe Ala Asn
85 90 95
Val Ile Ser Gly Pro Val Tyr Trp Gly Gln Gly Thr Gln Val Thr Val
100 105 110
Ser Ser
<210> 314
<211> 123
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 314
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Thr Arg Phe Phe Ser Asn Tyr
20 25 30
Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val
35 40 45
Ala Ala Ile Ser Arg Asp Gly Ala Val Pro Leu Ser Gly Asn Ser Val
50 55 60
Pro Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Ala Ser Arg Gln Gly Asn Pro Tyr Ala Gln Thr Ser Tyr Asp Tyr
100 105 110
Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120
<210> 315
<211> 120
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 315
Gln Val Gln Leu Gln Glu Ser Gly Gly Glu Val Val Ala Pro Gly Gly
1 5 10 15
Ser Leu Ser Leu Ser Cys Val Ala Ser Gly Ser Ala Asp Ser Ile Lys
20 25 30
Ile Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val
35 40 45
Ala Thr Ile Thr Ser Gly Gly Thr Thr Glu Phe Ala Glu Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Met
65 70 75 80
Gln Met Asn Ser Leu Ser Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn
85 90 95
Ala Leu Val Ser Arg Arg Asp Ser Ala Ala Tyr Phe Ala Trp Gly Gln
100 105 110
Gly Thr Gln Val Thr Val Ser Ser
115 120
<210> 316
<211> 115
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 316
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Ser Ile Val Ser Ile Thr
20 25 30
Pro Met Met Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Trp Val
35 40 45
Ala Ile Thr Thr Arg Asp Gly Ala Pro Ala Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Ser Ala Lys Asn Thr Val Tyr Leu
65 70 75 80
Gln Met Asn Tyr Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Lys
85 90 95
Ala Arg Lys Asp Ser His Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr
100 105 110
Val Ser Ser
115
<210> 317
<211> 119
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 317
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Thr Ile Gly Ser Ile Gln
20 25 30
Arg Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val
35 40 45
Ala Thr Arg Thr Asn Gly Gly Thr Thr Asn Tyr Gly Asp Ser Val Arg
50 55 60
Gly Arg Phe Thr Ile Ser Val Asp Val Ala Lys Asn Thr Val Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn
85 90 95
Ala His Ile Arg Glu Tyr Tyr Ser Thr Tyr Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Gln Val Thr Val Ser Ser
115
<210> 318
<211> 120
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 318
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Ser Ile Ser Arg Ile Arg
20 25 30
Asp Met Ala Trp His Arg Gln Val Pro Gly Lys Gln Arg Glu Leu Val
35 40 45
Ala Ser Ile Ser Ser Gly Gly Ser Thr Asn Val Ala Asp Ser Leu Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Gly Lys Asn Thr Met Tyr Leu
65 70 75 80
Gln Met Asp Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys Asn
85 90 95
Ala Leu Phe Asn Pro Ile Asp Gly Pro Ala Arg Tyr Tyr Trp Gly Gln
100 105 110
Gly Thr Gln Val Thr Val Ser Ser
115 120
<210> 319
<211> 120
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 319
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Ser Ile Ser Arg Ile Tyr
20 25 30
Asp Met Ala Trp His Arg Gln Val Pro Gly Lys Gln Arg Glu Leu Val
35 40 45
Ala Gly Ile Ser Arg Gly Gly Ser Thr Asn Val Ala Asp Ser Leu Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Gly Lys Asn Thr Val Tyr Leu
65 70 75 80
Gln Met Asp Asn Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys Thr
85 90 95
Ala Leu Phe Asn Pro Val Asp Gly Thr Ala Arg Tyr Tyr Trp Gly Gln
100 105 110
Gly Thr Gln Val Thr Val Ser Ser
115 120
<210> 320
<211> 120
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 320
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Ile Phe Ser Ile Asn
20 25 30
Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val
35 40 45
Ala Ser Ile Thr Ser Gly Gly Gln Ile Lys Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Thr Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn
85 90 95
Ala Ala Ser Ser Thr Trp Pro Pro Arg Asp Tyr Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Gln Val Thr Val Ser Ser
115 120
<210> 321
<211> 120
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 321
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Ser Ile Ser Ser Ile Ala
20 25 30
Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val
35 40 45
Ala Arg Ile Thr Asn Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn
85 90 95
Ala Asp Glu Arg Pro Tyr Tyr Gly Asp Ser Val Leu Ser Trp Gly Gln
100 105 110
Gly Thr Gln Val Thr Val Ser Ser
115 120
<210> 322
<211> 117
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 322
Gln Val Gln Leu Gln Gln Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Gly Phe Pro Ile Ile
20 25 30
Thr Phe Met Gly Tyr Tyr Arg Gln Thr Pro Gly Asn Gln Arg Glu Glu
35 40 45
Val Ala Leu Ile Asn Arg Gly Gly Val Ala Lys Tyr Gly Asp Ser Val
50 55 60
Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Glu Met Asn Asn Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Tyr Ala Asp Arg Phe Ser Gly Ser Pro Thr Trp Gly Gln Gly Thr Gln
100 105 110
Val Thr Val Ser Ser
115
<210> 323
<211> 125
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 323
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Asn Tyr
20 25 30
His Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val
35 40 45
Ala Ala Ile Ser Arg Gly Thr Ser Thr Thr Phe Tyr Arg Asp Ser Val
50 55 60
Arg Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Ala Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Ala Asp Ala Asp Arg Ser Thr Thr Ile Tyr Ser Arg Asp Ile Tyr
100 105 110
Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120 125
<210> 324
<211> 123
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 324
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Gly Thr Phe Ser Asn Tyr
20 25 30
Arg Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val
35 40 45
Ala Ala Ile Ser Arg Asp Gly Ala Val Pro Leu Ser Gly Asn Ser Pro
50 55 60
Leu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Ala Ser Arg Gln Gly Leu Pro Tyr Val Glu Thr Ser Tyr Asp Tyr
100 105 110
Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120
<210> 325
<211> 116
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 325
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ser Ile Ser Ser Ile Thr
20 25 30
Phe Met Gly Trp Tyr Arg Gln Val Leu Gly Glu Gln Arg Glu Leu Val
35 40 45
Ala Leu Ser Ala Arg Arg Gly Thr Thr Thr Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu
65 70 75 80
Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Tyr
85 90 95
Val Asp Arg Arg Asp Glu Val Pro Thr Trp Gly Gln Gly Thr Gln Val
100 105 110
Thr Val Ser Ser
115
<210> 326
<211> 125
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 326
Gln Val Gln Leu Gln Gln Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Ser Tyr
20 25 30
Val Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Leu
35 40 45
Ala Ala Ile Arg Trp Ser Arg Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Val Phe Arg Asp Thr Val Glu Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Ala Asp Gly Asn Pro Ala Lys Leu Val Leu Asp Gln Tyr Gly Met
100 105 110
Asp Tyr Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser
115 120 125
<210> 327
<211> 116
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 327
Gln Val Gln Leu Gln Gln Ser Gly Gly Gly Leu Val Glu Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ser Glu Ile Thr
20 25 30
Tyr Met Gly Trp His Arg Gln Ala Pro Gly Glu Gln Arg Glu Leu Val
35 40 45
Ala Leu Ile Ala Arg Val Gly Thr Thr Arg Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu
65 70 75 80
Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Tyr
85 90 95
Val Asp Gln Arg Gly Val Val Pro Thr Trp Gly Gln Gly Thr Gln Val
100 105 110
Thr Val Ser Ser
115
<210> 328
<211> 124
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 328
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Arg Ala Ser Ala Arg Ala Ser Ser Ile Gly
20 25 30
Ala Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Asp Arg Glu Leu Val
35 40 45
Ala Ala Val Asn Ala Gly Ala Asp Thr Thr Tyr Tyr Arg Asp Phe Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Leu Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Ala Tyr Asn Thr Ala Gly Trp Gly Glu Pro His Gln Ser Tyr Arg
100 105 110
Tyr Trp Gly Gln Gly Ile Gln Val Thr Val Ser Ser
115 120
<210> 329
<211> 121
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 329
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Ser Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Ile Ile Ser
20 25 30
Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val
35 40 45
Ala Thr Ile Thr Ser Gly Gly Ser Thr Asn Tyr Ala Asp Pro Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Met Val Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn
85 90 95
Ala Glu Val His Val Trp Gly Val Pro Gly Pro Arg Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Gln Val Thr Val Ser Ser
115 120
<210> 330
<211> 123
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 330
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr
20 25 30
Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val
35 40 45
Ala Thr Ile Ser Arg Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Ala Asn Pro Tyr Gly Ser Ser Ser Tyr Gln Gly Gln Tyr Ala Ser
100 105 110
Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120
<210> 331
<211> 115
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 331
Gln Val Gln Leu Gln Gln Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Ser Ser Asn
20 25 30
Gly Met Tyr Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val
35 40 45
Ala Ser Leu Tyr Arg Ser Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn
85 90 95
Val Asn Trp Ala Leu His Asp Ser Trp Gly Gln Gly Thr Gln Val Thr
100 105 110
Val Ser Ser
115
<210> 332
<211> 123
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 332
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ala Tyr
20 25 30
Gly Met Ala Trp Phe Arg Gln Ser Pro Gly Lys Glu Arg Glu Phe Val
35 40 45
Ala Ala Val Ser Gly Gly Gly Gly Gly Thr Ala Tyr Ala Glu Pro Val
50 55 60
Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Thr Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Ala Ala Thr Ala Gly His Trp Gly Arg Asp Ala Asn Tyr Asp Tyr
100 105 110
Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120
<210> 333
<211> 115
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 333
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Ser Ser Asn
20 25 30
Gly Met Tyr Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val
35 40 45
Ala Ser Leu Phe Arg Ser Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Gln Asn Thr Val Tyr Leu
65 70 75 80
Arg Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn
85 90 95
Val Asn Trp Ala Leu His Asp Ser Trp Gly Pro Gly Thr Gln Val Thr
100 105 110
Val Ser Ser
115
<210> 334
<211> 123
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 334
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr
20 25 30
Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val
35 40 45
Ala Ala Ile Ser Arg Ser Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Thr Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Ala Asn Pro Tyr Gly Ser Ser Ser Tyr Gln Gly Gln Tyr Gly Ser
100 105 110
Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120
<210> 335
<211> 115
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 335
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Ile His Ser Ile Asn
20 25 30
Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val
35 40 45
Ala Ile Ile Ser Ser Gly Gly Arg Thr Thr Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Ser Thr Ile Thr Gly Asp Asn Asp Lys Asn Thr Val Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr
85 90 95
Met Val Trp Gly Leu Arg Tyr Tyr Trp Gly Gln Gly Thr Gln Val Thr
100 105 110
Val Ser Ser
115
<210> 336
<211> 115
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 336
Gln Val Gln Leu Gln Gln Ser Gly Gly Gly Phe Val Arg Pro Gly Glu
1 5 10 15
Ser Leu Thr Leu Ser Cys Ala Ala Ser Thr Ser Ile Phe Ser Ser Asn
20 25 30
Gly Met Tyr Trp Tyr Arg Gln Ala Pro Gly Lys Arg Arg Glu Leu Val
35 40 45
Ala Ser Leu Phe Arg Ser Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn
85 90 95
Val Asn Trp Ala Leu His Asp Ser Trp Gly Gln Gly Thr Gln Val Thr
100 105 110
Val Ser Ser
115
<210> 337
<211> 123
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 337
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr
20 25 30
Ala Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val
35 40 45
Ala Ala Ile Ser Arg Gly Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Ala Asn Pro Tyr Gly Ser Ser Ser Tyr Gln Gly Gln Tyr Gly Ser
100 105 110
Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120
<210> 338
<211> 115
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 338
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Ser Ser Asn
20 25 30
Gly Met Tyr Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val
35 40 45
Ala Ser Leu Tyr Arg Ser Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn
85 90 95
Val Asn Trp Ala Leu His Asp Ser Trp Gly Gln Gly Thr Gln Val Thr
100 105 110
Val Ser Ser
115
<210> 339
<211> 115
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 339
Gln Val Gln Leu Gln Gln Ser Gly Gly Gly Glu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Ser Ser Asn
20 25 30
Gly Met Tyr Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val
35 40 45
Ala Ser Leu Tyr Arg Ser Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn
85 90 95
Val Asn Trp Ala Leu His Asp Ser Trp Gly Gln Gly Thr Gln Val Thr
100 105 110
Val Ser Ser
115
<210> 340
<211> 115
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
多肽
<400> 340
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Ser Ile Leu Ser Ala Asn
20 25 30
Gly Met Tyr Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val
35 40 45
Ala Ser Leu Tyr Arg Ser Gly Ser Thr Asp Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Arg Asp Thr Met Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn
85 90 95
Val Asn Trp Ala Leu His Asp Ser Trp Gly Gln Gly Thr Gln Val Thr
100 105 110
Val Ser Ser
115
<210> 341
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 341
Ala Ser Ile Ile Ser Ile Arg Val Met
1 5
<210> 342
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 342
Gly Ser Ile Met Ser Ile Arg Val Met
1 5
<210> 343
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 343
Gly Ser Ile Phe Ser Ile Arg Val Met
1 5
<210> 344
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 344
Ala Ser Ile Phe Ser Ile Arg Val Met
1 5
<210> 345
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 345
Gly Ser Ile Met Ser Ile Arg Val Met
1 5
<210> 346
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 346
Ala Ser Ile Met Ser Ile Arg Val Met
1 5
<210> 347
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 347
Ala Ser Ile Met Ser Ile Arg Val Met
1 5
<210> 348
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 348
Gly Ser Ile Met Ser Ile Arg Val Met
1 5
<210> 349
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 349
Gly Ser Ile Ile Ser Ile Arg Val Met
1 5
<210> 350
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 350
Ala Ser Ile Ile Ser Ile Arg Val Met
1 5
<210> 351
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 351
Gly Ser Ile Phe Ser Ile Asn Val Met
1 5
<210> 352
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 352
Gly Arg Thr Phe Ser Ile Tyr Ala Met
1 5
<210> 353
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 353
Gly Ser Gly Arg Arg Val Gly Tyr Met
1 5
<210> 354
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 354
Gly Arg Thr Phe Ser Ile Tyr Ala Met
1 5
<210> 355
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 355
Gly Met Ser Phe Ser Leu Gly Thr Ile
1 5
<210> 356
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 356
Gly Ser Gly Arg Arg Val Gly Tyr Met
1 5
<210> 357
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 357
Gly Ser Gly Arg Arg Val Gly Tyr Met
1 5
<210> 358
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 358
Gly Ser Gly Ser Arg Ile Asn Tyr Met
1 5
<210> 359
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 359
Gly Arg Thr Phe Ser Thr Tyr Thr Val
1 5
<210> 360
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 360
Gly Ser Gly Ser Arg Ile Asn Tyr Met
1 5
<210> 361
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 361
Gly Phe Thr Phe Ser Arg Asn Tyr Met
1 5
<210> 362
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 362
Gly Ser Gly Arg Arg Val Gly Tyr Met
1 5
<210> 363
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 363
Gly Ser Gly Arg Arg Val Gly Tyr Met
1 5
<210> 364
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 364
Gly Arg Thr Phe Ser Gly Arg Thr Met
1 5
<210> 365
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 365
Gly Ser Ile Gly Thr Ile Asp Ser Met
1 5
<210> 366
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 366
Glu Phe Ser Leu Leu Phe Gly Thr Ile
1 5
<210> 367
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 367
Gly Ser Ile Thr Arg Val Gly Gly Met
1 5
<210> 368
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 368
Pro Phe Ser Leu Arg Leu Gly Val Val
1 5
<210> 369
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 369
Ala Arg Thr Ser Ser Ser Arg Ala Met
1 5
<210> 370
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 370
Gly Ser Thr Phe Ile Phe Asp Lys Met
1 5
<210> 371
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 371
Gly Arg Thr Phe Ser Gly Val Ile Val
1 5
<210> 372
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 372
Arg Ile Val Phe Thr Ile Ser Thr Met
1 5
<210> 373
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 373
Gly Ser Ile Thr Arg Leu Gly Ser Met
1 5
<210> 374
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 374
Gly Ser Ile Thr Arg Leu Gly Gly Met
1 5
<210> 375
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 375
Glu Arg Ala Phe Met Tyr Asn Met
1 5
<210> 376
<211> 6
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 376
Ser Ser Phe Asn Thr Met
1 5
<210> 377
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 377
Gly Arg Asn Phe Asp Tyr Tyr Ser Met
1 5
<210> 378
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 378
Gly Ser Met Phe Ser Ile Asn Asp Met
1 5
<210> 379
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 379
Gly Arg Thr Phe Ser Arg Tyr His Met
1 5
<210> 380
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 380
Gly Arg Thr Ser Asn Ser Tyr Asn Met
1 5
<210> 381
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 381
Gly Ser Thr Phe Ser Phe Asn Lys Met
1 5
<210> 382
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 382
Pro Leu Thr Leu Arg Leu Gly Pro Ile
1 5
<210> 383
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 383
Gly Arg Asn Phe Gly Tyr Tyr Thr Met
1 5
<210> 384
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 384
Gly Asp Ile Phe Ser Ala Ala Gly Met
1 5
<210> 385
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 385
Pro Leu Thr Leu Arg Leu Gly Ala Ile
1 5
<210> 386
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 386
Gly Ser Ile Thr Arg Ile Gly Gly Met
1 5
<210> 387
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 387
Gly Arg Ser Phe Ser Arg Tyr Ile Met
1 5
<210> 388
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 388
Gly Ser Gly Ser Arg Ile Gly Phe Met
1 5
<210> 389
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 389
Gly Leu Thr Phe Ser Asp Tyr Ala Met
1 5
<210> 390
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 390
Gly Thr Ile Ser Ile Phe Asp Pro Met
1 5
<210> 391
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 391
Arg Asn Ile Tyr Gly Ile Asn Val Ile
1 5
<210> 392
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 392
Gly Thr Leu Ser Leu Phe Asp Pro Met
1 5
<210> 393
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 393
Gly Arg Val Leu Ser Ile Asn Ala Met
1 5
<210> 394
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 394
Arg Thr Thr Phe Arg Val Gly Thr Met
1 5
<210> 395
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 395
Gly Ser Gly Ser Arg Ile Gly Leu Met
1 5
<210> 396
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 396
Gly Thr Ile Ser Leu Phe Asp Ser Met
1 5
<210> 397
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 397
Glu Thr Ser Leu Asn Phe Asp Asp Met
1 5
<210> 398
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 398
Gly Ser Asp Ser Ser Ile Asn Tyr Met
1 5
<210> 399
<211> 6
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 399
Gly Thr Val Asn Leu Met
1 5
<210> 400
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 400
Gly Ser Ile Phe Ser Arg Asn Ile Ile
1 5
<210> 401
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 401
Gly Ser Gly Ser Ile Asn Tyr Met
1 5
<210> 402
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 402
Gly Ser Gly Trp Arg Val Gly Tyr Met
1 5
<210> 403
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 403
Gly Glu Asn Phe Ser Thr Tyr Val Met
1 5
<210> 404
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 404
Gly Arg Thr Phe Ser Ser Tyr Ala Met
1 5
<210> 405
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 405
Gly Arg Thr Phe Ser Ser Tyr His Met
1 5
<210> 406
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 406
Gly Arg Thr Phe Ile Asn Tyr Gly Met
1 5
<210> 407
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 407
Gly Arg Thr Leu Thr Ala Tyr Gly Met
1 5
<210> 408
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 408
Gly Arg Thr Phe Ser Thr Tyr Ala Met
1 5
<210> 409
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 409
Gly Ser Ile Gly Ser Ile Asn Ile Met
1 5
<210> 410
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 410
Gly Arg Thr Phe Ser Ser Tyr Gly Met
1 5
<210> 411
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 411
Ala Arg Ala Ser Ser Ile Gly Ala Met
1 5
<210> 412
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 412
Gly Leu Thr Phe Gly Asn Tyr Asp Met
1 5
<210> 413
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 413
Gly Arg Ile Phe Asn Ala Asn Gly Met
1 5
<210> 414
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 414
Glu Arg Thr Phe Ser Ser Asp Gly Met
1 5
<210> 415
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 415
Gly Thr Ile Phe Ser Ala Asn Gly Met
1 5
<210> 416
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 416
Thr Arg Ala Ser Ile Val Gly Ala Met
1 5
<210> 417
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 417
Gly Ser Ile Leu Asn Ile Asn Val Met
1 5
<210> 418
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 418
Gly Arg Thr Phe Ser Ser Tyr Ala Met
1 5
<210> 419
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 419
Gly Arg Thr Phe Ser Ser Tyr Ala Met
1 5
<210> 420
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 420
Gly Thr Ile Phe Ser Ile Asn Gly Met
1 5
<210> 421
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 421
Thr Ser Asp Gly Ser Ile Asn Val Met
1 5
<210> 422
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 422
Gly Arg Thr Phe Asn Ile Tyr Ala Met
1 5
<210> 423
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 423
Gly Phe Thr Phe Arg Ser Ser Ala Met
1 5
<210> 424
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 424
Gly Arg Thr Phe Ile Asn Tyr Gly Met
1 5
<210> 425
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 425
Gly Arg Thr Phe Ser Ser Tyr Ala Met
1 5
<210> 426
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 426
Gly Arg Ala Phe Ser Gly Tyr Ala Met
1 5
<210> 427
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 427
Gly Arg Thr Phe Ile Asn Tyr Gly Met
1 5
<210> 428
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 428
Gly Ser Ile Ser Ser Ile Thr Phe Met
1 5
<210> 429
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 429
Gly Ser Ile Ser Ser Ile Thr Phe Met
1 5
<210> 430
<211> 10
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 430
Gly Thr Gly Phe Pro Ile Ile Thr Phe Met
1 5 10
<210> 431
<211> 7
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 431
Val Ser Ser Ile Gly Thr Met
1 5
<210> 432
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 432
Thr Arg Phe Phe Ser Asn Tyr Ala Met
1 5
<210> 433
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 433
Gly Ser Ala Asp Ser Ile Lys Ile Met
1 5
<210> 434
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 434
Glu Ser Ile Val Ser Ile Thr Pro Met
1 5
<210> 435
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 435
Glu Thr Ile Gly Ser Ile Gln Arg Met
1 5
<210> 436
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 436
Gly Ser Ile Ser Arg Ile Arg Asp Met
1 5
<210> 437
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 437
Gly Ser Ile Ser Arg Ile Tyr Asp Met
1 5
<210> 438
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 438
Gly Thr Ile Phe Ser Ile Asn Val Met
1 5
<210> 439
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 439
Arg Ser Ile Ser Ser Ile Ala Ala Met
1 5
<210> 440
<211> 10
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 440
Gly Thr Gly Phe Pro Ile Ile Thr Phe Met
1 5 10
<210> 441
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 441
Gly Arg Thr Phe Ser Asn Tyr His Met
1 5
<210> 442
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 442
Glu Gly Thr Phe Ser Asn Tyr Arg Met
1 5
<210> 443
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 443
Gly Ser Ile Ser Ser Ile Thr Phe Met
1 5
<210> 444
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 444
Gly Gly Thr Phe Ser Ser Tyr Val Met
1 5
<210> 445
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 445
Gly Ser Ile Ser Glu Ile Thr Tyr Met
1 5
<210> 446
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 446
Ala Arg Ala Ser Ser Ile Gly Ala Met
1 5
<210> 447
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 447
Gly Ser Ile Phe Ile Ile Ser Thr Met
1 5
<210> 448
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 448
Gly Arg Thr Phe Ser Ser Tyr Ala Met
1 5
<210> 449
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 449
Gly Ser Ile Phe Ser Ser Asn Gly Met
1 5
<210> 450
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 450
Gly Arg Thr Phe Ser Ala Tyr Gly Met
1 5
<210> 451
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 451
Gly Ser Ile Phe Ser Ser Asn Gly Met
1 5
<210> 452
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 452
Gly Arg Thr Phe Ser Ser Tyr Ala Met
1 5
<210> 453
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 453
Gly Ile Ile His Ser Ile Asn Val Met
1 5
<210> 454
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 454
Thr Ser Ile Phe Ser Ser Asn Gly Met
1 5
<210> 455
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 455
Gly Arg Thr Phe Ser Ser Tyr Ala Met
1 5
<210> 456
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 456
Gly Ser Ile Phe Ser Ser Asn Gly Met
1 5
<210> 457
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 457
Gly Ser Ile Phe Ser Ser Asn Gly Met
1 5
<210> 458
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 458
Arg Ser Ile Leu Ser Ala Asn Gly Met
1 5
<210> 459
<211> 7
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 459
Met Ser Arg Gly Gly Thr Ile
1 5
<210> 460
<211> 7
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 460
Met Ser Arg Gly Gly Thr Ile
1 5
<210> 461
<211> 7
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 461
Met Ser Arg Gly Gly Thr Ile
1 5
<210> 462
<211> 7
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 462
Met Ser Arg Gly Asn Thr Ile
1 5
<210> 463
<211> 7
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 463
Met Ser Arg Gly Gly Thr Ile
1 5
<210> 464
<211> 7
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 464
Met Ser Arg Gly Asn Thr Ile
1 5
<210> 465
<211> 7
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 465
Met Ser Arg Gly Gly Thr Ile
1 5
<210> 466
<211> 7
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 466
Met Ser Arg Gly Asn Thr Ile
1 5
<210> 467
<211> 7
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 467
Met Ser Arg Gly Gly Thr Ile
1 5
<210> 468
<211> 7
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 468
Met Ser Arg Gly Asn Thr Ile
1 5
<210> 469
<211> 7
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 469
Ile Thr Ser Gly Gly Ser Thr
1 5
<210> 470
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 470
Ile Asn Arg Gly Gly Gly Thr Thr
1 5
<210> 471
<211> 7
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 471
Ile Ser Arg Ala Gly Ala Thr
1 5
<210> 472
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 472
Ile Asn Arg Ser Gly Gly Thr Thr
1 5
<210> 473
<211> 7
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 473
Ile Thr Asn Ala Asp Thr Thr
1 5
<210> 474
<211> 7
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 474
Ile Ser Arg Ala Gly Ala Thr
1 5
<210> 475
<211> 7
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 475
Ile Ser Arg Ala Gly Ala Thr
1 5
<210> 476
<211> 7
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 476
Ile Asn Arg Thr Gly Ala Ala
1 5
<210> 477
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 477
Ile Thr Trp Asn Gly Gly Thr Ile
1 5
<210> 478
<211> 7
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 478
Ile Asn Arg Thr Gly Ala Ala
1 5
<210> 479
<211> 7
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 479
Ile Tyr Ser Asp Asp Ser Thr
1 5
<210> 480
<211> 7
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 480
Ile Ser Arg Ala Gly Ala Thr
1 5
<210> 481
<211> 7
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 481
Ile Ser Arg Ala Gly Ala Thr
1 5
<210> 482
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 482
Ile Thr Trp Ser Gly Gly Thr Thr
1 5
<210> 483
<211> 7
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 483
Ile Met Phe Ser Gly Arg Thr
1 5
<210> 484
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 484
Val Ser Ser Ser Asp Gly Ser Thr
1 5
<210> 485
<211> 7
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 485
Ile Asn Glu Val Gly Asn Thr
1 5
<210> 486
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 486
Ile Ser Ser Ser Glu Gly Ser Thr
1 5
<210> 487
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 487
Ile Ser Trp Ser Gly Gly Arg Thr
1 5
<210> 488
<211> 7
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 488
Leu Met Ser Arg Gly Asp Pro
1 5
<210> 489
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 489
Thr Leu Trp Ser Gly Gly Ser Thr
1 5
<210> 490
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 490
Ile Asn Arg Ser Gly Ala Leu Thr
1 5
<210> 491
<211> 7
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 491
Ile Thr Ala Val Gly Asn Thr
1 5
<210> 492
<211> 7
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 492
Ile Asp Thr Val Gly Asn Thr
1 5
<210> 493
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 493
Arg Asn Trp Asn Val Glu Arg Thr
1 5
<210> 494
<211> 7
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 494
Ile Thr Ser Gly Gly Thr Ile
1 5
<210> 495
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 495
Ile Asn Trp Arg Gly Ala Val Ile
1 5
<210> 496
<211> 7
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 496
Ile Ser Ser Gly Gly Thr Thr
1 5
<210> 497
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 497
Ile Ser Leu Ser Gly Gly Gly Thr
1 5
<210> 498
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 498
Ile Ser Trp Thr Gly Gly Phe Thr
1 5
<210> 499
<211> 7
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 499
Phe Met Asn Asp Gly Asn Thr
1 5
<210> 500
<211> 7
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 500
Ile Ser Ser Arg Asp Asp Lys
1 5
<210> 501
<211> 7
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 501
Ile Thr Trp Arg Gly Val Ile
1 5
<210> 502
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 502
Val Thr Trp Asp Gly Gly Thr Thr
1 5
<210> 503
<211> 7
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 503
Ile Thr Ser Thr Glu Asp Lys
1 5
<210> 504
<211> 7
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 504
Ile Asn Thr Val Gly Asn Thr
1 5
<210> 505
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 505
Ile Ala Pro Ser Gly Gly Ser Ala
1 5
<210> 506
<211> 7
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 506
Ile Asn Arg Thr Gly Ala Thr
1 5
<210> 507
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 507
Ile Ser Leu Thr Ala Ala Ser Thr
1 5
<210> 508
<211> 6
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 508
Ile Ser Glu Gly Ser Thr
1 5
<210> 509
<211> 7
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 509
Ser Ala Asn Gly Gly Thr Thr
1 5
<210> 510
<211> 6
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 510
Ile Ser Gly Leu Ser Thr
1 5
<210> 511
<211> 7
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 511
Ile Thr Asn Gly Gly Ser Thr
1 5
<210> 512
<211> 7
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 512
Ile Thr Ser Gly Gly Ser Thr
1 5
<210> 513
<211> 7
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 513
Ile Lys Gly Thr Gly Thr Thr
1 5
<210> 514
<211> 6
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 514
Ile Thr Glu Gly Ser Thr
1 5
<210> 515
<211> 10
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 515
Ile Asn Thr Phe Pro Ala Gly Thr Thr Ala
1 5 10
<210> 516
<211> 7
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 516
Ile Ser Arg Asp Gly Arg Ser
1 5
<210> 517
<211> 7
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 517
Ile Lys Gly Thr Gly Thr Thr
1 5
<210> 518
<211> 7
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 518
Ile Asn Thr Gly Gly Arg Thr
1 5
<210> 519
<211> 7
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 519
Ile Asn Arg Thr Gly Ala Ala
1 5
<210> 520
<211> 7
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 520
Ile Ser Arg Ala Gly Ala Thr
1 5
<210> 521
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 521
His Asn Trp Arg Gly Gly Gly Thr
1 5
<210> 522
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 522
Ile Ser Arg Ser Gly Gly Ser Thr
1 5
<210> 523
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 523
Ile Ser Arg Ser Gly Gly Phe Thr
1 5
<210> 524
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 524
Val Ser Ile Ser Gly Ala Gly Thr
1 5
<210> 525
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 525
Val Ser Leu Ser Gly Ala Ser Thr
1 5
<210> 526
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 526
Ile Ser Trp Ser Gly Gly Arg Ile
1 5
<210> 527
<211> 7
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 527
Phe Thr Ser Gly Gly Ser Thr
1 5
<210> 528
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 528
Ile Ser Arg Thr Gly Ser Gly Thr
1 5
<210> 529
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 529
Val Thr Ala Gly Ala Asp Thr Thr
1 5
<210> 530
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 530
Ile Ser Ser Ser Gly Ala Tyr Thr
1 5
<210> 531
<211> 7
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 531
Leu Tyr Arg Ser Gly Ser Thr
1 5
<210> 532
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 532
Ile Ser Arg Thr Gly Ser Ala Thr
1 5
<210> 533
<211> 7
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 533
Leu Tyr Arg Asp Gly Ser Thr
1 5
<210> 534
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 534
Ile Ala Ala Gly Ser Pro Ser Thr Pro
1 5
<210> 535
<211> 7
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 535
Ile Tyr Arg Asp Gly Ser Thr
1 5
<210> 536
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 536
Ile Ser Arg Ser Gly Gly Ser Thr
1 5
<210> 537
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 537
Ile Ser Arg Ser Gly Gly Ser Thr
1 5
<210> 538
<211> 7
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 538
Leu Tyr Arg Gly Gly Ser Thr
1 5
<210> 539
<211> 7
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 539
Ile Thr Ser Leu Gly Ser Gln
1 5
<210> 540
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 540
Ile Ser Asp Ser Gly Gly Ser Ala
1 5
<210> 541
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 541
Ile Gly Ser Asp Gly Glu Asn Ile
1 5
<210> 542
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 542
Val Ser Ser Ser Gly Ala Gly Thr
1 5
<210> 543
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 543
Ile Ser Arg Ser Gly Gly Thr Thr
1 5
<210> 544
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 544
Ile Ser Arg Gly Gly Gly Thr Thr
1 5
<210> 545
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 545
Val Ser Ser Ser Gly Ala Gly Thr
1 5
<210> 546
<211> 7
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 546
Ile Ala Arg Ser Gly Thr Thr
1 5
<210> 547
<211> 7
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 547
Ile Ala Arg Ser Gly Thr Thr
1 5
<210> 548
<211> 7
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 548
Ile Ser Arg Gly Gly Val Ala
1 5
<210> 549
<211> 7
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 549
Ile Ser Arg Val Gly Thr Thr
1 5
<210> 550
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 550
Ile Ser Arg Asp Gly Ala Val Pro
1 5
<210> 551
<211> 7
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 551
Ile Thr Ser Gly Gly Thr Thr
1 5
<210> 552
<211> 7
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 552
Thr Thr Arg Asp Gly Ala Pro
1 5
<210> 553
<211> 7
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 553
Arg Thr Asn Gly Gly Thr Thr
1 5
<210> 554
<211> 7
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 554
Ile Ser Ser Gly Gly Ser Thr
1 5
<210> 555
<211> 7
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 555
Ile Ser Arg Gly Gly Ser Thr
1 5
<210> 556
<211> 7
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 556
Ile Thr Ser Gly Gly Gln Ile
1 5
<210> 557
<211> 7
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 557
Ile Thr Asn Gly Gly Ser Thr
1 5
<210> 558
<211> 7
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 558
Ile Asn Arg Gly Gly Val Ala
1 5
<210> 559
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 559
Ile Ser Arg Gly Thr Ser Thr Thr
1 5
<210> 560
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 560
Ile Ser Arg Asp Gly Ala Val Pro
1 5
<210> 561
<211> 7
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 561
Ser Ala Arg Arg Gly Thr Thr
1 5
<210> 562
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 562
Ile Arg Trp Ser Arg Gly Ser Thr
1 5
<210> 563
<211> 7
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 563
Ile Ala Arg Val Gly Thr Thr
1 5
<210> 564
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 564
Val Asn Ala Gly Ala Asp Thr Thr
1 5
<210> 565
<211> 7
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 565
Ile Thr Ser Gly Gly Ser Thr
1 5
<210> 566
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 566
Ile Ser Arg Ser Gly Gly Ser Thr
1 5
<210> 567
<211> 7
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 567
Leu Tyr Arg Ser Gly Ser Thr
1 5
<210> 568
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 568
Val Ser Gly Gly Gly Gly Gly Thr
1 5
<210> 569
<211> 7
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 569
Leu Phe Arg Ser Gly Ser Thr
1 5
<210> 570
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 570
Ile Ser Arg Ser Gly Gly Thr Thr
1 5
<210> 571
<211> 7
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 571
Ile Ser Ser Gly Gly Arg Thr
1 5
<210> 572
<211> 7
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 572
Leu Phe Arg Ser Gly Ser Thr
1 5
<210> 573
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 573
Ile Ser Arg Gly Gly Gly Thr Thr
1 5
<210> 574
<211> 7
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 574
Leu Tyr Arg Ser Gly Ser Thr
1 5
<210> 575
<211> 7
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 575
Leu Tyr Arg Ser Gly Ser Thr
1 5
<210> 576
<211> 7
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 576
Leu Tyr Arg Ser Gly Ser Thr
1 5
<210> 577
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 577
Ala Ala Leu Leu Asp Ser Tyr Tyr
1 5
<210> 578
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 578
Thr Ala Leu Leu Asp Ser Tyr Tyr
1 5
<210> 579
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 579
Thr Ala Leu Leu Asp Ser Tyr Tyr
1 5
<210> 580
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 580
Ala Ala Leu Leu Asp Ser Tyr Tyr
1 5
<210> 581
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 581
Ala Ala Leu Leu Asp Ser Tyr Tyr
1 5
<210> 582
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 582
Ala Ala Leu Leu Asp Ser Tyr Tyr
1 5
<210> 583
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 583
Ala Ala Leu Leu Asp Ser Tyr Tyr
1 5
<210> 584
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 584
Ala Ala Leu Leu Asp Ser Tyr Tyr
1 5
<210> 585
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 585
Ala Ala Leu Leu Asp Ser Tyr Tyr
1 5
<210> 586
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 586
Ala Ala Leu Leu Asp Ser Tyr Tyr
1 5
<210> 587
<211> 17
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 587
Asn Ala Ala Gln Ser Arg Thr Ser Trp Leu Phe Pro Asp Glu Tyr Asp
1 5 10 15
Tyr
<210> 588
<211> 19
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 588
Ala Ala Asp Arg Val Thr Asp Thr Tyr Tyr Tyr Leu Asn Pro Glu Ser
1 5 10 15
Tyr Asp Tyr
<210> 589
<211> 10
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 589
Phe Ala Ser Leu Ile Asp Ala Gly Thr Tyr
1 5 10
<210> 590
<211> 19
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 590
Ala Ala Asp Arg Val Thr Asp Thr Tyr Tyr Tyr Leu Asn Pro Glu Ser
1 5 10 15
Tyr Asp Tyr
<210> 591
<211> 5
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 591
Asn Thr Ala Thr Ser
1 5
<210> 592
<211> 10
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 592
Phe Ala Ser Val Phe Asp Ala Gly Thr Tyr
1 5 10
<210> 593
<211> 10
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 593
Phe Ala Ser Ile Phe Asp Ala Gly Thr Tyr
1 5 10
<210> 594
<211> 10
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 594
Phe Ala Ser Tyr Leu Gly Ala Gly Ala Tyr
1 5 10
<210> 595
<211> 11
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 595
Val Met Gly Ala Ala Gly Gln Gly Trp Arg Tyr
1 5 10
<210> 596
<211> 10
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 596
Trp Ala Ser Tyr Leu Gly Ala Gly Thr Tyr
1 5 10
<210> 597
<211> 6
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 597
Ser Lys Glu Gly Gly Leu
1 5
<210> 598
<211> 10
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 598
Phe Ala Ser Val Phe Asp Ala Gly Thr Tyr
1 5 10
<210> 599
<211> 10
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 599
Phe Ala Ser Leu Phe Asp Ala Gly Thr Tyr
1 5 10
<210> 600
<211> 16
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 600
Ala Ser Asp Gly Pro Trp Arg Ala Thr Thr Pro Asp Ala Tyr Asp Tyr
1 5 10 15
<210> 601
<211> 5
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 601
Tyr Ser Asn Gln Tyr
1 5
<210> 602
<211> 11
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 602
Ala Thr Arg Cys Thr Val Val Pro Gly Ile Thr
1 5 10
<210> 603
<211> 6
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 603
Trp Ile Pro Pro Ile Pro
1 5
<210> 604
<211> 11
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 604
Ala Thr Arg Cys Thr Val Val Pro Gly Ile Thr
1 5 10
<210> 605
<211> 21
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 605
Ala Ala Arg Arg Ser Asp Phe Thr Gly Asp Tyr Ala Tyr Ser Gly Arg
1 5 10 15
Ser Ala Tyr Asp Tyr
20
<210> 606
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 606
Arg Gly Arg Ala Gly Glu Arg Val Tyr
1 5
<210> 607
<211> 18
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 607
Ala Ala Lys Tyr Gly Gly Ser Leu Ser Tyr Met His Pro Thr Gly Tyr
1 5 10 15
Thr Tyr
<210> 608
<211> 16
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 608
Ala Ala Ser Lys Ala Asn Met Pro Ala Leu Pro Ala Asn Tyr Asp Tyr
1 5 10 15
<210> 609
<211> 6
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 609
Trp Ile Pro Pro Ile Pro
1 5
<210> 610
<211> 6
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 610
Trp Ile Pro Pro Ile Pro
1 5
<210> 611
<211> 17
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 611
Ala Thr Thr Arg Val Trp Pro Thr Gln His Gln Met Gly Gln Ile Glu
1 5 10 15
Tyr
<210> 612
<211> 12
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 612
Val Ala Asp Trp Gln Tyr Gly Ser Thr Trp Asn Tyr
1 5 10
<210> 613
<211> 17
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 613
Ala Ala Ala Ser Ser Ser Ser Arg Leu Leu Glu Pro Ile Gly Tyr Asn
1 5 10 15
Tyr
<210> 614
<211> 14
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 614
Ala Gly Asn Leu Lys Arg Ser Glu Thr Ser Tyr Tyr Trp Lys
1 5 10
<210> 615
<211> 15
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 615
Thr Ala Asp Arg His Glu Trp Gly Arg Leu Met Lys Gly Asp Tyr
1 5 10 15
<210> 616
<211> 20
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 616
Ala Ala Thr Ser Arg Ser Leu Thr Ser Ala Met Thr Arg Glu Ile Arg
1 5 10 15
Ala Tyr Asp Tyr
20
<210> 617
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 617
Arg Gly Arg Ala Gly Met Glu Val Tyr
1 5
<210> 618
<211> 11
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 618
Ala Thr Arg Cys Thr Val Val Pro Gly Ile Ser
1 5 10
<210> 619
<211> 17
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 619
Ala Ala Ala Ser Ser Ser Ser Arg Pro Leu Glu Pro Ile Gly Tyr Asn
1 5 10 15
Tyr
<210> 620
<211> 19
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 620
Ala Ala Gly Asn Thr Gly Pro Phe Asn Leu Leu His Ser Ser Ala Gln
1 5 10 15
Tyr Ala Tyr
<210> 621
<211> 11
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 621
Ala Thr Arg Cys Thr Val Val Pro Gly Ile Ser
1 5 10
<210> 622
<211> 6
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 622
Trp Ile Pro Pro Leu Pro
1 5
<210> 623
<211> 12
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 623
Ala Ala Arg Tyr Asp Met Asp Tyr Glu Tyr Lys Thr
1 5 10
<210> 624
<211> 10
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 624
Phe Ala Ser Val Val Asp Ala Gly Thr Tyr
1 5 10
<210> 625
<211> 20
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 625
Ala Ala Gln Gly Arg Ile Leu Arg Gly Arg Gly Leu Phe Lys Ala Ser
1 5 10 15
Asp Tyr Asp Tyr
20
<210> 626
<211> 11
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 626
Arg Leu Ser Arg Tyr Tyr Asn Ser Asn Ile Tyr
1 5 10
<210> 627
<211> 13
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 627
Lys Ala Glu Leu Tyr Thr Leu Gln His Asn Tyr Glu Tyr
1 5 10
<210> 628
<211> 11
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 628
His Leu Ser Arg Tyr Tyr Asn Ser Asn Ile Tyr
1 5 10
<210> 629
<211> 14
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 629
Leu Ala Glu Glu Arg Pro Tyr Tyr Gly Gly Pro Leu Glu Tyr
1 5 10
<210> 630
<211> 10
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 630
Phe Ala Asn Ile Val Asp Arg Pro Val Ser
1 5 10
<210> 631
<211> 10
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 631
Phe Ala Ser Val Leu Gly Ala Gly Thr Tyr
1 5 10
<210> 632
<211> 11
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 632
Arg Leu Ser Arg Tyr Tyr Asn Ser Asn Ile Tyr
1 5 10
<210> 633
<211> 5
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 633
Asn Ala Gly Asp Tyr
1 5
<210> 634
<211> 10
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 634
Tyr Val Asp Pro Leu Gly Arg Val Pro Arg
1 5 10
<210> 635
<211> 10
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 635
Phe Ala Ser Val Leu Gly Ala Gly Thr Tyr
1 5 10
<210> 636
<211> 7
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 636
Asn Ala Pro Ser Leu Gly Tyr
1 5
<210> 637
<211> 10
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 637
Phe Ala Ser Ala Leu Gly Ala Gly Val Tyr
1 5 10
<210> 638
<211> 10
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 638
Phe Ala Ser Ile Ile Asp Ala Gly Thr Tyr
1 5 10
<210> 639
<211> 16
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 639
Ala Ala Arg Ser Gly Gly Ser Tyr Thr Tyr Thr Gly Ser Tyr His Tyr
1 5 10 15
<210> 640
<211> 16
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 640
Ala Ala Asn Arg Tyr Gly Ser Ser Ser Tyr Gln Gly Gln Tyr Ala Ser
1 5 10 15
<210> 641
<211> 16
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 641
Ala Ala Gln Gln Trp Pro Asp Pro Arg Asn Pro Asn Gly Tyr Asp Tyr
1 5 10 15
<210> 642
<211> 16
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 642
Ala Ala Ala Lys Ala Gly His Trp Gly Arg Asp Ala Asn Tyr Asp Tyr
1 5 10 15
<210> 643
<211> 16
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 643
Ala Ala Ala Lys Ala Gly Gln Trp Gly Arg Asp Ala Lys Tyr Asp Tyr
1 5 10 15
<210> 644
<211> 21
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 644
Thr Ala Asp Leu Lys Gly Leu Trp Ala Leu Gly Leu Pro Gly His Tyr
1 5 10 15
Ala Ser Trp Asp Ser
20
<210> 645
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 645
Arg Ala Arg Arg Gly Trp Ala Ile Tyr
1 5
<210> 646
<211> 16
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 646
Ala Ala Asp Ser Gly Gly Ser Trp Gly Arg Gly Thr Thr Tyr Asp Tyr
1 5 10 15
<210> 647
<211> 17
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 647
Ala Ala Tyr Asn Thr Ala Gly Trp Gly Glu Pro His Gln Ser Tyr Arg
1 5 10 15
Tyr
<210> 648
<211> 15
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 648
Ala Gly Arg Arg Ser Val Val Val Arg Ser Phe Asp Tyr Asp Tyr
1 5 10 15
<210> 649
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 649
Asn Val Asn Trp Ala Leu His Asp Ser
1 5
<210> 650
<211> 16
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 650
Ala Ala Asn Ser Gly Gly His Trp Trp Arg Gly Ala Thr Tyr Asp Tyr
1 5 10 15
<210> 651
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 651
Asn Val Asn Trp Ala Leu His Asp Ser
1 5
<210> 652
<211> 17
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 652
Ala Ala Tyr Asn Thr Ala Asn Trp Gly Gln Pro His Gln Ser Tyr Arg
1 5 10 15
His
<210> 653
<211> 12
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 653
Asn Val Val Thr Tyr Gly Ser Asn Arg Arg Asp Phe
1 5 10
<210> 654
<211> 16
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 654
Ala Ala Asn Arg Tyr Gly Ser Ser Ser Tyr Gln Gly Gln Tyr Gly Ser
1 5 10 15
<210> 655
<211> 16
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 655
Ala Ala Asn Arg Tyr Gly Ser Ser Ser Tyr Gln Gly Gln Tyr Asp Tyr
1 5 10 15
<210> 656
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 656
Asn Val Asn Trp Ala Leu Gln Asp Ser
1 5
<210> 657
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 657
Arg Ala Arg Arg Gly Trp Ala Ile Tyr
1 5
<210> 658
<211> 21
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 658
Ala Ala Asp Leu Thr Gly Leu Trp Ala Leu Gly Leu Pro Gly His Tyr
1 5 10 15
Ala Ser Trp Asp Ser
20
<210> 659
<211> 10
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 659
Gln Leu Gly Arg Thr Val Leu Asp Tyr Phe
1 5 10
<210> 660
<211> 16
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 660
Ala Ala Ala Lys Ala Gly Gln Trp Gly Arg Tyr Ala Asn Tyr Asp Tyr
1 5 10 15
<210> 661
<211> 16
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 661
Ala Ala Asn Pro Tyr Gly Ser Ser Ser Tyr Gln Gly Gln Tyr Gly Ser
1 5 10 15
<210> 662
<211> 16
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 662
Ala Ala Asn Arg Tyr Gly Ser Ser Ser Tyr Gln Gly Gln Tyr Gly Ser
1 5 10 15
<210> 663
<211> 16
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 663
Ala Ala Ala Lys Ala Gly His Trp Gly Arg Asp Ala Asn Tyr Asp Tyr
1 5 10 15
<210> 664
<211> 10
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 664
Tyr Val Asp Arg Arg Gly Ala Val Pro Thr
1 5 10
<210> 665
<211> 10
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 665
Tyr Val Asp Arg Arg Asp Val Val Pro Thr
1 5 10
<210> 666
<211> 10
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 666
Tyr Ala Asp Arg Phe Ser Gly Ser Pro Thr
1 5 10
<210> 667
<211> 10
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 667
Phe Ala Asn Val Ile Ser Gly Pro Val Tyr
1 5 10
<210> 668
<211> 16
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 668
Ala Ala Ser Arg Gln Gly Asn Pro Tyr Ala Gln Thr Ser Tyr Asp Tyr
1 5 10 15
<210> 669
<211> 14
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 669
Asn Ala Leu Val Ser Arg Arg Asp Ser Ala Ala Tyr Phe Ala
1 5 10
<210> 670
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 670
Lys Ala Arg Lys Asp Ser His Asp Tyr
1 5
<210> 671
<211> 13
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 671
Asn Ala His Ile Arg Glu Tyr Tyr Ser Thr Tyr Asp Tyr
1 5 10
<210> 672
<211> 14
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 672
Asn Ala Leu Phe Asn Pro Ile Asp Gly Pro Ala Arg Tyr Tyr
1 5 10
<210> 673
<211> 14
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 673
Thr Ala Leu Phe Asn Pro Val Asp Gly Thr Ala Arg Tyr Tyr
1 5 10
<210> 674
<211> 14
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 674
Asn Ala Ala Ser Ser Thr Trp Pro Pro Arg Asp Tyr Asp Tyr
1 5 10
<210> 675
<211> 14
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 675
Asn Ala Asp Glu Arg Pro Tyr Tyr Gly Asp Ser Val Leu Ser
1 5 10
<210> 676
<211> 10
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 676
Tyr Ala Asp Arg Phe Ser Gly Ser Pro Thr
1 5 10
<210> 677
<211> 18
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 677
Ala Ala Asp Ala Asp Arg Ser Thr Thr Ile Tyr Ser Arg Asp Ile Tyr
1 5 10 15
Asp Tyr
<210> 678
<211> 16
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 678
Ala Ala Ser Arg Gln Gly Leu Pro Tyr Val Glu Thr Ser Tyr Asp Tyr
1 5 10 15
<210> 679
<211> 10
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 679
Tyr Val Asp Arg Arg Asp Glu Val Pro Thr
1 5 10
<210> 680
<211> 18
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 680
Ala Ala Asp Gly Asn Pro Ala Lys Leu Val Leu Asp Gln Tyr Gly Met
1 5 10 15
Asp Tyr
<210> 681
<211> 10
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 681
Tyr Val Asp Gln Arg Gly Val Val Pro Thr
1 5 10
<210> 682
<211> 17
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 682
Ala Ala Tyr Asn Thr Ala Gly Trp Gly Glu Pro His Gln Ser Tyr Arg
1 5 10 15
Tyr
<210> 683
<211> 15
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 683
Asn Ala Glu Val His Val Trp Gly Val Pro Gly Pro Arg Asp Tyr
1 5 10 15
<210> 684
<211> 16
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 684
Ala Ala Asn Pro Tyr Gly Ser Ser Ser Tyr Gln Gly Gln Tyr Ala Ser
1 5 10 15
<210> 685
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 685
Asn Val Asn Trp Ala Leu His Asp Ser
1 5
<210> 686
<211> 16
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 686
Ala Ala Ala Thr Ala Gly His Trp Gly Arg Asp Ala Asn Tyr Asp Tyr
1 5 10 15
<210> 687
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 687
Asn Val Asn Trp Ala Leu His Asp Ser
1 5
<210> 688
<211> 16
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 688
Ala Ala Asn Pro Tyr Gly Ser Ser Ser Tyr Gln Gly Gln Tyr Gly Ser
1 5 10 15
<210> 689
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 689
Thr Met Val Trp Gly Leu Arg Tyr Tyr
1 5
<210> 690
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 690
Asn Val Asn Trp Ala Leu His Asp Ser
1 5
<210> 691
<211> 16
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 691
Ala Ala Asn Pro Tyr Gly Ser Ser Ser Tyr Gln Gly Gln Tyr Gly Ser
1 5 10 15
<210> 692
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 692
Asn Val Asn Trp Ala Leu His Asp Ser
1 5
<210> 693
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 693
Asn Val Asn Trp Ala Leu His Asp Ser
1 5
<210> 694
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
肽
<400> 694
Asn Val Asn Trp Ala Leu His Asp Ser
1 5
<210> 695
<211> 6
<212> PRT
<213> 人工序列(Artificial Sequence)
<220>
<223> 人工序列的描述：合成
6xHis标签
<400> 695
His His His His His His
1 5
Claims (44)
1.一种能够以小于50nM的IC50值减少NetB针对LMH细胞的细胞毒性的多肽。
2.一种能够以小于1mM的IC50值减少NetB针对LMH细胞的细胞毒性的多肽。
3.一种能够在200nM下减少nM CnaA与胶原蛋白的结合达50％以上的多肽。
4.一种能够在2μM下减少nM CnaA与胶原蛋白的结合达50％以上的多肽。
5.一种能够在1μM下减少Cpa卵磷脂酶活性达40％以上的多肽。
6.一种包含重链抗体的至少一个可变区片段(VHH)的多肽，其中所述至少一个VHH特异性地结合致病原。
7.如权利要求1至6中任一项所述的多肽，其中所述多肽包含多个VHH。
8.如权利要求7所述的多肽，其中所述多肽包含至少三个VHH。
9.如权利要求7或8所述的多肽，其中所述多个VHH中的任一者与所述多个VHH的另一VHH同一。
10.如权利要求7至9中任一项所述的多肽，其中所述多个VHH通过接头彼此共价偶联，所述接头包含一个或多个氨基酸。
11.如权利要求1至10中任一项所述的多肽，其中所述重链抗体的所述可变区片段包含与SEQ ID No:1至56或212至340中的任一者至少80％、90％、95％、97％、98％、99％或100％同一的氨基酸序列。
12.如权利要求1至10中任一项所述的多肽，其中所述重链抗体的所述可变区片段包含如SEQ ID No:57至106或341至458中的任一者所阐述的互补决定区1(CDR1)、如SEQ ID No:107至156或459至576中的任一者所阐述的互补决定区2(CDR2)和如SEQ ID No:157至206或577至694中的任一者所阐述的互补决定区3(CDR3)。
13.一种多肽复合物，其中所述多肽包含第一组分多肽和第二组分多肽，其中所述第一组分多肽和所述第二组分多肽未共价连接在一起，并且通过蛋白质-蛋白质相互作用、小分子-蛋白质相互作用或小分子-小分子相互作用偶联在一起，其中所述第一和所述第二组分多肽中的每一者都包含特异性地结合病原体的VHH。
14.如权利要求1至12中任一项所述的多肽或如权利要求13所述的多肽复合物，其中所述病原体是家禽相关细菌。
15.如权利要求1至12中任一项所述的多肽或如权利要求13所述的多肽复合物，其中所述家禽相关细菌包含梭状芽孢杆菌菌种。
16.如权利要求1至12中任一项所述的多肽或如权利要求13所述的多肽复合物，其中所述梭状芽孢杆菌菌种是产气荚膜梭菌。
17.如权利要求16所述的多肽或多肽复合物，其中所述VHH特异性地结合梭状芽孢杆菌毒力因子。
18.如权利要求16所述的多肽或多肽复合物，其中所述VHH特异性地结合与SEQ ID No:207至211或其组合至少60％、70％、80％、90％、95％、98％、99％或100％同一的抗原或多肽。
19.如权利要求18所述的多肽或多肽复合物，其中所述梭状芽孢杆菌毒力因子是NetB多肽、NetB样毒素多肽、Cpa多肽、Cpa样毒素多肽、Cpb2多肽、Cpb2样毒素多肽、CnaA多肽、CnaA样多肽、CnaA胶原蛋白结合结构域多肽或CnaA胶原蛋白结合结构域样多肽。
20.如权利要求1至12中任一项所述的多肽或如权利要求13所述的多肽复合物，其中所述VHH可以中和NetB细胞毒性达10％、20％、30％、40％、50％、60％、70％、80％、90％、95％、99％或100％。
21.如权利要求1至12中任一项所述的多肽或如权利要求13所述的多肽复合物，其中所述VHH可以抑制CnaA的胶原蛋白结合达10％、20％、30％、40％、50％、60％、70％、80％、90％、95％、99％或100％。
22.如权利要求1至12中任一项所述的多肽或如权利要求13所述的多肽复合物，其中所述VHH可以中和Cpa细胞毒性达10％、20％、30％、40％、50％、60％、70％、80％、90％、95％、99％或100％。
23.如权利要求1至12中任一项所述的多肽或如权利要求13所述的多肽复合物，其中所述VHH可以中和Cpb2细胞毒性达10％、20％、30％、40％、50％、60％、70％、80％、90％、95％、99％或100％。
24.与SEQ ID No:207至211或其组合至少60％、70％、80％、90％、95％、98％、99％或100％同一的多肽用于减少产气荚膜梭菌毒力因子的活性的用途。
25.SEQ ID 210或211的多肽，其中所述多肽可以胜过产气荚膜梭菌表面表达的CnaA与胶原蛋白的结合达10％、20％、30％、40％、50％、60％、70％、80％、90％、95％、99％或100％。
26.一种编码如权利要求1至12或14至25中任一项所述的多肽或如权利要求13至23中任一项所述的多肽复合物的核酸。
27.多种核酸，其编码如权利要求13至23中任一项所述的多肽复合物。
28.一种包含如权利要求26所述的核酸或如权利要求27所述的多种核酸的载体，其可以用于在任何产生系统中产生如权利要求1至12或14至25中任一项所述的多肽或如权利要求13至23中任一项所述的多肽复合物。
29.一种包含如权利要求26所述的核酸或如权利要求27所述的多种核酸的细胞。
30.如权利要求29所述的细胞，其中所述细胞是酵母细胞。
31.如权利要求30所述的细胞，其中所述酵母属于毕赤酵母属。
32.如权利要求30所述的细胞，其中所述酵母属于酵母(Saccharomyces)属。
33.如权利要求29所述的细胞，其中所述细胞是细菌细胞。
34.如权利要求33所述的细胞，其中所述细菌属于埃希氏菌(Escherichia)属。
35.如权利要求33所述的细胞，其中所述细菌是益生菌。
36.如权利要求35所述的细胞，其中所述益生菌是选自由芽孢杆菌(Bacillus)属、乳酸杆菌(Lactobacillus)属、双歧杆菌(Bifidobacterium)属组成的组。
37.如权利要求1至12或14至25中任一项所述的多肽或如权利要求13至23中任一项所述的多肽复合物，在任何从头蛋白质合成系统中合成。
38.如权利要求1至12或14至25中任一项所述的多肽或如权利要求13至23中任一项所述的多肽复合物，其还包含维生素、抗生素、激素、抗微生物肽、类固醇、益生菌、益生菌、噬菌体、甲壳质、壳聚糖、B-1,3-葡聚糖、蔬菜提取物、胨、虾粉、磷虾、藻类、B-环糊精、褐藻酸盐、胶、黄蓍胶、果胶、明胶、添加剂喷雾、毒素结合剂、短链脂肪酸、中链脂肪酸、酵母、酵母提取物、糖、消化酶、消化化合物、必需矿物、必需盐或纤维。
39.一种产生如权利要求1至12或14至25中任一项所述的多肽或如权利要求13至23中任一项所述的多肽复合物的方法，其包括(a)在培养基中孵育如权利要求29至36中任一项所述的细胞，所述培养基适用于从所述细胞分泌所述多肽；和(b)从所述培养基中纯化所述多肽。
40.如权利要求1至12或14至25中任一项所述的多肽或如权利要求13至23中任一项所述的多肽复合物，用于减少或预防家禽动物、另一动物物种或人类个体中的家禽相关细菌感染。
41.如权利要求1至12或14至25中任一项所述的多肽或如权利要求13至23中任一项所述的多肽复合物，用于减少家禽相关细菌从家禽物种至另一家禽动物、另一动物物种或人类个体的传播，或预防家禽相关细菌从家禽物种至另一家禽动物、另一动物物种或人类个体的传播。
42.如权利要求40或41所述的用途，其中所述家禽动物是鸡、火鸡、鸭、鹌鹑、鸽子、雏鸽、鸵鸟或鹅物种。
43.如权利要求40或41所述的用途，其中所述非家禽动物物种是猪、绵羊、山羊、马、牛、美洲驼、羊驼、貂、兔、狗、猫或人类。
44.如权利要求40或41所述的用途，其中所述多肽适合于口服或直肠引入消化道、提供至外表面(例如作为喷雾剂或浸没剂)、提供至其中栖息所述动物的介质(包括基于空气的介质)、通过注射提供、静脉内提供、经由呼吸系统提供、经由扩散提供、经由通过内皮或上皮吸收提供或经由第二生物(如酵母、细菌、藻类、噬菌体、植物和昆虫)提供至宿主。
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| WO2016150884A1 (en) | 2015-03-20 | 2016-09-29 | Orbsen Therapeutics Limited | Modulators of syndecan-2 and uses thereof |
| EP3922253A1 (en) | 2016-01-15 | 2021-12-15 | Orbsen Therapeutics Limited | Sdc-2 exosome compositions and methods of isolation and use |
| WO2017199094A1 (en) | 2016-05-20 | 2017-11-23 | Novobind Livestock Therapeutics Inc. | Antibodies against microorganisms and uses thereof |
| BR112019025019A2 (pt) * | 2017-05-31 | 2020-06-30 | Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of Agriculture And Agri-Food | polipeptídeo isolado de pilus de clostridium perfringens, polipeptídeo imunogênico, vetor, vacina, uso de um polipeptídeo imunogênico, método de tratamento, anticorpo, método para detectar infecção e método para detectar um polipeptídeo imunogênico |
| WO2019012334A2 (en) | 2017-07-14 | 2019-01-17 | Orbsen Therapeutics Limited | METHODS OF ISOLATION AND USE OF CD39 STROMAL STEM CELLS |
| GB202207698D0 (en) * | 2022-05-25 | 2022-07-06 | Eco Animal Health Ltd | Antibodies |
| WO2024089627A1 (en) * | 2022-10-26 | 2024-05-02 | Berking Biotechnology Spa | Single domain antibody - sdab/vhh against the nucleoprotein of sars-cov-2 virus |
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| CN116589569A (zh) * | 2023-03-06 | 2023-08-15 | 中国农业科学院兰州兽医研究所 | 一种抗h7n9亚型流感病毒ha蛋白的纳米抗体及其噬菌体展示文库的构建方法和应用 |
| CN116589569B (zh) * | 2023-03-06 | 2024-06-07 | 中国农业科学院兰州兽医研究所 | 一种抗h7n9亚型流感病毒ha蛋白的纳米抗体及其噬菌体展示文库的构建方法和应用 |
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| PH12021550025A1 (en) | 2021-09-27 |
| IL279879A (en) | 2021-03-01 |
| EP3818079A4 (en) | 2022-04-06 |
| CA3103656A1 (en) | 2020-02-20 |
| BR112021000100A2 (pt) | 2021-03-30 |
| MX2021000184A (es) | 2021-05-12 |
| EP3818079A2 (en) | 2021-05-12 |
| WO2020035741A2 (en) | 2020-02-20 |
| WO2020035741A3 (en) | 2020-05-07 |
| US20210269512A1 (en) | 2021-09-02 |
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