BR112015011729A2 - dispositivo de perfusão adesivo de vários dias para administração transdérmica de rotigotina - Google Patents

dispositivo de perfusão adesivo de vários dias para administração transdérmica de rotigotina

Info

Publication number
BR112015011729A2
BR112015011729A2 BR112015011729A BR112015011729A BR112015011729A2 BR 112015011729 A2 BR112015011729 A2 BR 112015011729A2 BR 112015011729 A BR112015011729 A BR 112015011729A BR 112015011729 A BR112015011729 A BR 112015011729A BR 112015011729 A2 BR112015011729 A2 BR 112015011729A2
Authority
BR
Brazil
Prior art keywords
rotigotine
transdermal therapeutic
transdermal
present
therapeutic system
Prior art date
Application number
BR112015011729A
Other languages
English (en)
Other versions
BR112015011729B1 (pt
Inventor
Lappert Aurelia
Wolff Hans-Michael
Josef Leonhard Johannes
Kassner Kristina
Emgenbroich Marco
Müller Walter
Cawello Willi
Original Assignee
Lts Lohmann Therapie Systeme Ag
Ucb Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47215446&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112015011729(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lts Lohmann Therapie Systeme Ag, Ucb Pharma Gmbh filed Critical Lts Lohmann Therapie Systeme Ag
Publication of BR112015011729A2 publication Critical patent/BR112015011729A2/pt
Publication of BR112015011729B1 publication Critical patent/BR112015011729B1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7092—Transdermal patches having multiple drug layers or reservoirs, e.g. for obtaining a specific release pattern, or for combining different drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B37/00—Methods or apparatus for laminating, e.g. by curing or by ultrasonic bonding
    • B32B37/12—Methods or apparatus for laminating, e.g. by curing or by ultrasonic bonding characterised by using adhesives
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2556/00—Patches, e.g. medical patches, repair patches

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1/1 resumo “dispositivo de perfusão adesivo de vários dias para administração transdérmica de rotigotina" a presente invenção refere-se a um sistema terapêutico transdérmico, que compreende (a) uma camada de suporte, (b) uma camada de matriz auto-adesiva à base de solvente contendo rotigotina como o ingrediente ativo, e (c) um revestimento de liberação, em que a camada de matriz auto-adesiva possui um peso de revestimento de cerca de 75 a 400 g/m2 e compreende uma camada de reservatório contendo ao redor de 9 a 25 % em peso de rotigotina com base no peso da camada de reservatório, um kit que compreende dois sistemas terapêuticos transdérmicos da presente invenção assim como um método para a preparação do sistema terapêutico transdérmico da presente invenção. além disso, a presente invenção refere-se a um sistema terapêutico transdérmico que compreende rotigotina como o ingrediente ativo para uso no tratamento de pacientes que sofrem de doença de parkinson, síndrome positiva de parkinson, depressão, fibromialgia e a síndrome das pernas inquietas e para uso no tratamento ou prevenção da perda neuronal dopaminérgica ou distúrbios cognitivos mediante a administração transdérmica de rotigotina uma vez ou duas vezes por semana, em que o sistema terapêutico transdérmico compreende uma camada de suporte, uma camada de matriz autoadesiva contendo rotigotina à base de solvente assim como um revestimento de liberação, e é adaptado a fim de permitir a administração transdérmica de quantidades terapeuticamente eficazes de rotigotina durante pelo menos 3 dias.
BR112015011729-5A 2012-11-22 2013-11-21 Sistema terapêutico transdérmico, kit compreendendo o mesmo e método para a preparação do mesmo BR112015011729B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12193808 2012-11-22
EP12193808.8 2012-11-22
PCT/EP2013/003515 WO2014079573A1 (en) 2012-11-22 2013-11-21 Multi-day patch for the transdermal administration of rotigotine

Publications (2)

Publication Number Publication Date
BR112015011729A2 true BR112015011729A2 (pt) 2017-07-11
BR112015011729B1 BR112015011729B1 (pt) 2022-08-16

Family

ID=47215446

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015011729-5A BR112015011729B1 (pt) 2012-11-22 2013-11-21 Sistema terapêutico transdérmico, kit compreendendo o mesmo e método para a preparação do mesmo

Country Status (15)

Country Link
US (2) US11389410B2 (pt)
EP (1) EP2922533B1 (pt)
JP (1) JP6301356B2 (pt)
KR (1) KR20150094588A (pt)
CN (2) CN110200950B (pt)
AR (1) AR093481A1 (pt)
AU (1) AU2013350037B2 (pt)
BR (1) BR112015011729B1 (pt)
CA (1) CA2887085C (pt)
EA (1) EA201500553A1 (pt)
ES (1) ES2639294T3 (pt)
IN (1) IN2015DN02488A (pt)
MX (1) MX354502B (pt)
TW (1) TW201431570A (pt)
WO (1) WO2014079573A1 (pt)

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US20220151949A1 (en) 2022-05-19
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CN110200950A (zh) 2019-09-06
CA2887085A1 (en) 2014-05-30
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