BR112015010707B1 - Derivados de 5-flúor-n-(piridin-2-il)piridin-2-amina contendo um grupo sulfoximina, seus usos, processos de preparação, combinação e composição farmacêutica - Google Patents

Derivados de 5-flúor-n-(piridin-2-il)piridin-2-amina contendo um grupo sulfoximina, seus usos, processos de preparação, combinação e composição farmacêutica Download PDF

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Publication number
BR112015010707B1
BR112015010707B1 BR112015010707-9A BR112015010707A BR112015010707B1 BR 112015010707 B1 BR112015010707 B1 BR 112015010707B1 BR 112015010707 A BR112015010707 A BR 112015010707A BR 112015010707 B1 BR112015010707 B1 BR 112015010707B1
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group
alkyl
formula
compounds
compound
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BR112015010707-9A
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English (en)
Portuguese (pt)
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BR112015010707A2 (pt
BR112015010707A8 (pt
Inventor
Rolf Bohlmann
Ludwig Zorn
Gerhard Siemeister
Ulrich Lücking
Niels Böhnke
Arne Scholz
Philip Lienau
Ulf Bömer
Dirk Kosemund
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Bayer Pharma Aktiengesellschaft
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Publication of BR112015010707A2 publication Critical patent/BR112015010707A2/pt
Publication of BR112015010707A8 publication Critical patent/BR112015010707A8/pt
Publication of BR112015010707B1 publication Critical patent/BR112015010707B1/pt

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72Nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
BR112015010707-9A 2012-11-15 2013-11-12 Derivados de 5-flúor-n-(piridin-2-il)piridin-2-amina contendo um grupo sulfoximina, seus usos, processos de preparação, combinação e composição farmacêutica BR112015010707B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12192852.7 2012-11-15
EP12192852 2012-11-15
PCT/EP2013/073637 WO2014076091A1 (en) 2012-11-15 2013-11-12 5-fluoro-n-(pyridin-2-yl)pyridin-2-amine derivatives containing a sulfoximine group

Publications (3)

Publication Number Publication Date
BR112015010707A2 BR112015010707A2 (pt) 2017-07-11
BR112015010707A8 BR112015010707A8 (pt) 2019-10-01
BR112015010707B1 true BR112015010707B1 (pt) 2022-05-17

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BR112015010707-9A BR112015010707B1 (pt) 2012-11-15 2013-11-12 Derivados de 5-flúor-n-(piridin-2-il)piridin-2-amina contendo um grupo sulfoximina, seus usos, processos de preparação, combinação e composição farmacêutica

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US (2) US9650340B2 (OSRAM)
EP (1) EP2928878B1 (OSRAM)
JP (1) JP6263193B2 (OSRAM)
KR (1) KR102242871B1 (OSRAM)
CN (1) CN105102444B (OSRAM)
AP (1) AP3872A (OSRAM)
AR (1) AR093505A1 (OSRAM)
AU (1) AU2013346939B2 (OSRAM)
BR (1) BR112015010707B1 (OSRAM)
CA (1) CA2891358C (OSRAM)
CL (1) CL2015001304A1 (OSRAM)
CR (1) CR20150256A (OSRAM)
CU (1) CU20150052A7 (OSRAM)
CY (1) CY1118441T1 (OSRAM)
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DO (1) DOP2015000118A (OSRAM)
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ME (1) ME02880B (OSRAM)
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PE (1) PE20151071A1 (OSRAM)
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PL (1) PL2928878T3 (OSRAM)
PT (1) PT2928878T (OSRAM)
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SG (1) SG11201503079PA (OSRAM)
SI (1) SI2928878T1 (OSRAM)
SV (1) SV2015004979A (OSRAM)
TN (1) TN2015000185A1 (OSRAM)
TW (1) TWI613193B (OSRAM)
UA (1) UA115254C2 (OSRAM)
UY (1) UY35141A (OSRAM)
WO (1) WO2014076091A1 (OSRAM)

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HK1215246A1 (zh) 2012-10-18 2016-08-19 Bayer Pharma Aktiengesellschaft 含碸基的n-(吡啶-2-基)嘧啶-4-胺衍生物
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CA3090843A1 (en) * 2018-02-13 2019-08-22 Bayer Aktiengesellschaft Use of 5-fluoro-4-(4-fluoro-2-methoxyphenyl)-n-{4-[(s-methylsulfonimidoyl)methyl]pyridin-2-yl}pyridin-2-amine for treating diffuse large b-cell lymphoma
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HK1218296A1 (zh) 2013-07-04 2017-02-10 Bayer Pharma Aktiengesellschaft 磺亚胺取代的5-氟-n-(吡啶-2-基)吡啶-2-胺衍生物以及其作爲cdk9激酶抑制剂的用途
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WO2014076091A1 (en) 2014-05-22
PH12015501003B1 (en) 2017-10-20
IL238322A (en) 2017-08-31
SV2015004979A (es) 2017-01-30
ES2612978T3 (es) 2017-05-19
US9650340B2 (en) 2017-05-16
HK1213255A1 (zh) 2016-06-30
MA38090B1 (fr) 2018-09-28
CA2891358A1 (en) 2014-05-22
PL2928878T3 (pl) 2017-04-28
AP2015008432A0 (en) 2015-05-31
IL238322A0 (en) 2015-06-30
CN105102444A (zh) 2015-11-25
DOP2015000118A (es) 2015-06-15
PH12015501003A1 (en) 2015-07-27
TN2015000185A1 (en) 2016-10-03
JO3332B1 (ar) 2019-03-13
SG11201503079PA (en) 2015-06-29
SI2928878T1 (sl) 2016-12-30
MX374333B (es) 2025-03-06
AU2013346939B2 (en) 2017-06-08
BR112015010707A2 (pt) 2017-07-11
EA201590890A1 (ru) 2015-11-30
AR093505A1 (es) 2015-06-10
PE20151071A1 (es) 2015-08-19
MA38090A1 (fr) 2018-02-28
KR20150084968A (ko) 2015-07-22
US20170202815A1 (en) 2017-07-20
NZ707084A (en) 2019-09-27
JP6263193B2 (ja) 2018-01-17
EP2928878A1 (en) 2015-10-14
KR102242871B1 (ko) 2021-04-20
UY35141A (es) 2014-06-30
ECSP15019323A (es) 2016-01-29
TWI613193B (zh) 2018-02-01
AP3872A (en) 2016-10-31
US9877954B2 (en) 2018-01-30
BR112015010707A8 (pt) 2019-10-01
TW201420569A (zh) 2014-06-01
JP2015537015A (ja) 2015-12-24
UA115254C2 (uk) 2017-10-10
CA2891358C (en) 2021-05-18
CY1118441T1 (el) 2017-06-28
LT2928878T (lt) 2016-11-25
US20150291528A1 (en) 2015-10-15
DK2928878T3 (en) 2016-12-19
EP2928878B1 (en) 2016-11-02
HRP20161547T1 (hr) 2016-12-30
ME02880B (me) 2018-04-20
MX2015006169A (es) 2015-08-10
PT2928878T (pt) 2017-02-08
CN105102444B (zh) 2017-08-01
HUE032868T2 (en) 2017-11-28
RS55580B1 (sr) 2017-06-30
CR20150256A (es) 2015-07-01
CU20150052A7 (es) 2015-09-29
MY170609A (en) 2019-08-20
AU2013346939A1 (en) 2015-05-14
EA027226B1 (ru) 2017-07-31
CL2015001304A1 (es) 2015-07-17

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