UA115254C2 - Похідні 5-фтор-n-(піридин-2-іл)піридин-2-аміну, що містять сульфоксімінову групу - Google Patents

Похідні 5-фтор-n-(піридин-2-іл)піридин-2-аміну, що містять сульфоксімінову групу

Info

Publication number
UA115254C2
UA115254C2 UAA201505911A UAA201505911A UA115254C2 UA 115254 C2 UA115254 C2 UA 115254C2 UA A201505911 A UAA201505911 A UA A201505911A UA A201505911 A UAA201505911 A UA A201505911A UA 115254 C2 UA115254 C2 UA 115254C2
Authority
UA
Ukraine
Prior art keywords
pyridin
fluoro
amine derivatives
derivatives containing
sulfoximine group
Prior art date
Application number
UAA201505911A
Other languages
English (en)
Inventor
Ульріх Лукінг
Нільс Бонке
Арне Шольц
Філіп Ліенау
Герхард Сіемеістер
Ульф Бомер
Дірк Коземунд
Рольф Болманн
Людвіг Цорн
Original Assignee
Баєр Фарма Акціенгезельшафт
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Баєр Фарма Акціенгезельшафт filed Critical Баєр Фарма Акціенгезельшафт
Publication of UA115254C2 publication Critical patent/UA115254C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Даний винахід стосується похідних 5-фтор-N-(піридин-2-іл)піридин-2-аміну, що містять сульфоксімінову групу, загальної формули (І) EMBED MDLDrawOLE.MDLDrawObject.1 , як описано та визначено в даній заявці, та способів їх одержання, їх застосування для лікування та/або профілактики розладів, зокрема гіперпроліферативних захворювань та/або інфекційних хвороб, викликаних вірусами, та/або серцево-судинних захворювань. Винахід також стосується проміжних сполук, корисних при одержанні зазначених сполук загальної формули (І).
UAA201505911A 2012-11-15 2013-11-12 Похідні 5-фтор-n-(піридин-2-іл)піридин-2-аміну, що містять сульфоксімінову групу UA115254C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12192852 2012-11-15
PCT/EP2013/073637 WO2014076091A1 (en) 2012-11-15 2013-11-12 5-fluoro-n-(pyridin-2-yl)pyridin-2-amine derivatives containing a sulfoximine group

Publications (1)

Publication Number Publication Date
UA115254C2 true UA115254C2 (uk) 2017-10-10

Family

ID=47148672

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201505911A UA115254C2 (uk) 2012-11-15 2013-11-12 Похідні 5-фтор-n-(піридин-2-іл)піридин-2-аміну, що містять сульфоксімінову групу

Country Status (43)

Country Link
US (2) US9650340B2 (uk)
EP (1) EP2928878B1 (uk)
JP (1) JP6263193B2 (uk)
KR (1) KR102242871B1 (uk)
CN (1) CN105102444B (uk)
AP (1) AP3872A (uk)
AR (1) AR093505A1 (uk)
AU (1) AU2013346939B2 (uk)
BR (1) BR112015010707B1 (uk)
CA (1) CA2891358C (uk)
CL (1) CL2015001304A1 (uk)
CR (1) CR20150256A (uk)
CU (1) CU20150052A7 (uk)
CY (1) CY1118441T1 (uk)
DK (1) DK2928878T3 (uk)
DO (1) DOP2015000118A (uk)
EA (1) EA027226B1 (uk)
EC (1) ECSP15019323A (uk)
ES (1) ES2612978T3 (uk)
HK (1) HK1213255A1 (uk)
HR (1) HRP20161547T1 (uk)
HU (1) HUE032868T2 (uk)
IL (1) IL238322A (uk)
JO (1) JO3332B1 (uk)
LT (1) LT2928878T (uk)
MA (1) MA38090B1 (uk)
ME (1) ME02880B (uk)
MX (1) MX2015006169A (uk)
MY (1) MY170609A (uk)
NZ (1) NZ707084A (uk)
PE (1) PE20151071A1 (uk)
PH (1) PH12015501003B1 (uk)
PL (1) PL2928878T3 (uk)
PT (1) PT2928878T (uk)
RS (1) RS55580B1 (uk)
SG (1) SG11201503079PA (uk)
SI (1) SI2928878T1 (uk)
SV (1) SV2015004979A (uk)
TN (1) TN2015000185A1 (uk)
TW (1) TWI613193B (uk)
UA (1) UA115254C2 (uk)
UY (1) UY35141A (uk)
WO (1) WO2014076091A1 (uk)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6858615B2 (en) 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenyl guanidine sodium channel blockers
TWI555737B (zh) 2011-05-24 2016-11-01 拜耳知識產權公司 含有硫醯亞胺基團之４－芳基－ｎ－苯基－１，３，５－三氮雜苯－２－胺
AR086745A1 (es) 2011-06-27 2014-01-22 Parion Sciences Inc 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida
US9708293B2 (en) 2012-10-18 2017-07-18 Bayer Pharma Aktiengesellschaft N-(pyridin-2-yl)pyrimidin-4-amine derivatives containing a sulfone group
EP2909176B1 (en) 2012-10-18 2016-07-20 Bayer Pharma Aktiengesellschaft 5-fluoro-n-(pyridin-2-yl)pyridin-2-amine derivatives containing a sulfone group
RS55580B1 (sr) 2012-11-15 2017-06-30 Bayer Pharma AG Derivati 5-fluoro-n-(piridin-2-il)piridin-2-amina koji sadrže sulfoksiminsku grupu
TW201418243A (zh) 2012-11-15 2014-05-16 Bayer Pharma AG 含有磺醯亞胺基團之ｎ－（吡啶－２－基）嘧啶－４－胺衍生物
KR20150095870A (ko) 2012-12-17 2015-08-21 패리온 사이언스 인코퍼레이티드 3,5-디아미노-6-클로로-n-(n-(4-페닐부틸)카르밤이미도일)피라진-2-카르복스아미드 화합물
HUE032891T2 (hu) 2012-12-17 2017-11-28 Parion Sciences Inc Klórpirazin-karboxamid-származékok nem kielégítõ nyálkahártya-hidratáció által elõsegített megbetegedések kezelésére
CA2917096C (en) 2013-07-04 2021-05-18 Bayer Pharma Aktiengesellschaft Sulfoximine substituted 5-fluoro-n-(pyridin-2-yl)pyridin-2-amine derivatives and their use as cdk9 kinase inhibitors
US9102633B2 (en) 2013-12-13 2015-08-11 Parion Sciences, Inc. Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds
CN106232596A (zh) 2014-03-13 2016-12-14 拜耳医药股份有限公司 含有砜基团的5‑氟‑n‑(吡啶‑2‑基)吡啶‑2‑胺衍生物
EP3126338B1 (en) 2014-04-01 2019-09-04 Bayer Pharma Aktiengesellschaft Disubstituted 5-fluoro pyrimidine derivatives containing a sulfondiimine group
ES2743799T3 (es) 2014-04-11 2020-02-20 Bayer Pharma AG Nuevos compuestos macrocíclicos
WO2016059086A1 (en) 2014-10-16 2016-04-21 Bayer Pharma Aktiengesellschaft Fluorinated benzofuranyl-pyrimidine derivatives containing a sulfoximine group
CA2964683A1 (en) 2014-10-16 2016-04-21 Bayer Pharma Aktiengesellschaft Fluorinated benzofuranyl-pyrimidine derivatives containing a sulfone group
CA2999931A1 (en) 2015-09-29 2017-04-06 Bayer Pharma Aktiengesellschaft Novel macrocyclic sulfondiimine compounds
US10214542B2 (en) 2015-10-08 2019-02-26 Bayer Pharma Aktiengesellschaft Modified macrocyclic compounds
WO2017060322A2 (en) 2015-10-10 2017-04-13 Bayer Pharma Aktiengesellschaft Ptefb-inhibitor-adc
US11254690B2 (en) 2017-03-28 2022-02-22 Bayer Pharma Aktiengesellschaft PTEFb inhibiting macrocyclic compounds
WO2018177889A1 (en) 2017-03-28 2018-10-04 Bayer Aktiengesellschaft Novel ptefb inhibiting macrocyclic compounds
AU2019221019A1 (en) * 2018-02-13 2020-07-23 Bayer Aktiengesellschaft Use of 5-Fluoro-4-(4-fluoro-2-methoxyphenyl)-N-{4-[(S-methylsulfonimidoyl)methyl]pyridin-2-yl}pyridin-2-amine for treating diffuse large B-cell lymphoma
JP2023505850A (ja) 2019-12-09 2023-02-13 石薬集団中奇制薬技術（石家庄）有限公司 サイクリン依存性キナーゼ９阻害剤としての化合物及びその用途
US20230106032A1 (en) * 2020-03-06 2023-04-06 Bayer Aktiengesellschaft Imidazotriazines acting on cancer via inhibition of cdk12
CN116249701A (zh) * 2020-10-12 2023-06-09 上海海雁医药科技有限公司 取代的二（吡啶-2-基）胺衍生物、其组合物及医药上的用途
CN117015539A (zh) * 2022-03-25 2023-11-07 成都苑东生物制药股份有限公司 一种氨基吡啶类衍生物、其制备方法及用途
WO2024044757A1 (en) * 2022-08-26 2024-02-29 Sanford Burnham Prebys Medical Discovery Institute Aminopyrimidine and aminotriazine derivatives as myc protein modulators

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI2311825T1 (sl) 2000-12-21 2016-02-29 Novartis Ag Pirimidinamini kot angiogenetski modulatorji
DE10239042A1 (de) 2002-08-21 2004-03-04 Schering Ag Makrozyclische Pyrimidine, deren Herstellung und Verwendung als Arzneimittel
DE10349423A1 (de) * 2003-10-16 2005-06-16 Schering Ag Sulfoximinsubstituierte Parimidine als CDK- und/oder VEGF-Inhibitoren, deren Herstellung und Verwendung als Arzneimittel
MX2007007272A (es) 2004-12-17 2007-07-11 Astrazeneca Ab 4-(4-imidazol-4-il)pirimidin-2-ilamino)benzamidas como inhibidores de cdk.
DE102006041382A1 (de) * 2006-08-29 2008-03-20 Bayer Schering Pharma Ag Carbamoyl-Sulfoximide als Proteinkinaseinhibitoren
DE102006042143A1 (de) 2006-09-08 2008-03-27 Bayer Healthcare Aktiengesellschaft Neue substituierte Bipyridin-Derivate und ihre Verwendung
WO2008060248A1 (en) 2006-11-15 2008-05-22 S*Bio Pte Ltd. Indole sustituted pyrimidines and use thereof in the treatment of cancer
EP2094681A1 (en) 2006-12-22 2009-09-02 Novartis AG Indol-4-yl-pyrimidinyl-2-yl-amine derivatives and use thereof as cyclin dependant kinase inhibitors
JP2010514689A (ja) 2006-12-22 2010-05-06 ノバルティス アーゲー 癌、炎症およびウイルス感染症の処置のためのｃｄｋ阻害剤としてのヘテロアリール−ヘテロアリール化合物
US8507498B2 (en) 2007-04-24 2013-08-13 Ingenium Pharmaceuticals Gmbh 4, 6-disubstituted aminopyrimidine derivatives as inhibitors of protein kinases
JP5693951B2 (ja) 2007-04-24 2015-04-01 アストラゼネカ エービー プロテインキナーゼの阻害剤
JP5379787B2 (ja) 2007-04-24 2013-12-25 インゲニウム ファーマシューティカルズ ジーエムビーエイチ プロテインキナーゼの阻害剤
WO2008132138A1 (en) 2007-04-25 2008-11-06 Ingenium Pharmaceuticals Gmbh Derivatives of 4,6-disubstituted aminopyrimidines
WO2009029998A1 (en) 2007-09-06 2009-03-12 Cytopia Research Pty Ltd Retrometabolic compounds
GB0805477D0 (en) 2008-03-26 2008-04-30 Univ Nottingham Pyrimidines triazines and their use as pharmaceutical agents
US8415381B2 (en) 2009-07-30 2013-04-09 Novartis Ag Heteroaryl compounds and their uses
EP2550257B1 (en) 2010-03-22 2016-12-21 Lead Discovery Center GmbH Pharmaceutically active disubstituted triazine derivatives
WO2012101063A1 (en) * 2011-01-28 2012-08-02 Novartis Ag N-acyl pyridine biaryl compounds and their uses
US9242937B2 (en) * 2011-03-02 2016-01-26 Bayer Intellectual Property Gmbh Pharmaceutically active disubstituted pyridine derivatives
EP2527332A1 (en) * 2011-05-24 2012-11-28 Bayer Intellectual Property GmbH 4-Aryl-N-phenyl-1,3,5-triazin-2-amines containing a sulfoximine group as CDK9 inhibitors
JP5982490B2 (ja) 2011-09-16 2016-08-31 バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ 二置換５−フルオロ−ピリミジン
CA2848615C (en) 2011-09-16 2020-02-25 Bayer Intellectual Property Gmbh Disubstituted 5-fluoro pyrimidine derivatives containing a sulfoximine group
ES2597232T3 (es) 2012-10-18 2017-01-17 Bayer Pharma Aktiengesellschaft 4-(orto)-fluorofenil-5-fluoropirimidin-2-il aminas que contienen un grupo sulfona
EP2909176B1 (en) * 2012-10-18 2016-07-20 Bayer Pharma Aktiengesellschaft 5-fluoro-n-(pyridin-2-yl)pyridin-2-amine derivatives containing a sulfone group
RS55580B1 (sr) 2012-11-15 2017-06-30 Bayer Pharma AG Derivati 5-fluoro-n-(piridin-2-il)piridin-2-amina koji sadrže sulfoksiminsku grupu
ES2622583T3 (es) 2012-11-15 2017-07-06 Bayer Pharma Aktiengesellschaft 4-(Orto)-fluorofenil-5-fluoropirimidin-2-ilaminas que contienen un grupo sulfoximina
CA2917096C (en) 2013-07-04 2021-05-18 Bayer Pharma Aktiengesellschaft Sulfoximine substituted 5-fluoro-n-(pyridin-2-yl)pyridin-2-amine derivatives and their use as cdk9 kinase inhibitors
CN106232596A (zh) 2014-03-13 2016-12-14 拜耳医药股份有限公司 含有砜基团的5‑氟‑n‑(吡啶‑2‑基)吡啶‑2‑胺衍生物

Also Published As

Publication number Publication date
CU20150052A7 (es) 2015-09-29
BR112015010707A8 (pt) 2019-10-01
HUE032868T2 (en) 2017-11-28
AP3872A (en) 2016-10-31
SG11201503079PA (en) 2015-06-29
CR20150256A (es) 2015-07-01
ME02880B (me) 2018-04-20
AU2013346939B2 (en) 2017-06-08
BR112015010707A2 (pt) 2017-07-11
PE20151071A1 (es) 2015-08-19
CY1118441T1 (el) 2017-06-28
ECSP15019323A (es) 2016-01-29
PL2928878T3 (pl) 2017-04-28
PH12015501003A1 (en) 2015-07-27
MY170609A (en) 2019-08-20
HRP20161547T1 (hr) 2016-12-30
PH12015501003B1 (en) 2015-07-27
IL238322A (en) 2017-08-31
WO2014076091A1 (en) 2014-05-22
MA38090A1 (fr) 2018-02-28
BR112015010707B1 (pt) 2022-05-17
AR093505A1 (es) 2015-06-10
LT2928878T (lt) 2016-11-25
US20150291528A1 (en) 2015-10-15
TW201420569A (zh) 2014-06-01
EA027226B1 (ru) 2017-07-31
NZ707084A (en) 2019-09-27
HK1213255A1 (zh) 2016-06-30
JO3332B1 (ar) 2019-03-13
AU2013346939A1 (en) 2015-05-14
CN105102444A (zh) 2015-11-25
DOP2015000118A (es) 2015-06-15
KR20150084968A (ko) 2015-07-22
US20170202815A1 (en) 2017-07-20
CL2015001304A1 (es) 2015-07-17
EA201590890A1 (ru) 2015-11-30
ES2612978T3 (es) 2017-05-19
IL238322A0 (en) 2015-06-30
JP6263193B2 (ja) 2018-01-17
MX2015006169A (es) 2015-08-10
JP2015537015A (ja) 2015-12-24
AP2015008432A0 (en) 2015-05-31
KR102242871B1 (ko) 2021-04-20
TWI613193B (zh) 2018-02-01
EP2928878A1 (en) 2015-10-14
RS55580B1 (sr) 2017-06-30
CA2891358A1 (en) 2014-05-22
MA38090B1 (fr) 2018-09-28
CN105102444B (zh) 2017-08-01
DK2928878T3 (en) 2016-12-19
PT2928878T (pt) 2017-02-08
CA2891358C (en) 2021-05-18
SV2015004979A (es) 2017-01-30
TN2015000185A1 (en) 2016-10-03
US9650340B2 (en) 2017-05-16
UY35141A (es) 2014-06-30
EP2928878B1 (en) 2016-11-02
SI2928878T1 (sl) 2016-12-30
US9877954B2 (en) 2018-01-30

Similar Documents

Publication Publication Date Title
TN2015000185A1 (en) 5-fluoro-n-(pyridin-2-yl)pyridin-2-amine derivatives containing a sulfoximine group
TN2013000485A1 (en) 4-aryl-n-phenyl-1,3,5-triazin-2-amines containing a sulfoximine group
WO2014060375A3 (en) 5-fluoro-n-(pyridin-2-yl)pyridin-2-amine derivatives containing a sulfone group
CA2917096C (en) Sulfoximine substituted 5-fluoro-n-(pyridin-2-yl)pyridin-2-amine derivatives and their use as cdk9 kinase inhibitors
TN2015000186A1 (en) N-(pyridin-2-yl)pyrimidin-4-amine derivatives containing a sulfoximine group
MX2013012233A (es) 4-aril-n-fenil-1,3,5-triazin-2-aminas sustituidas.
PH12016501968A1 (en) Novel macrocyclic compounds
NZ629996A (en) 2’- substituted carba-nucleoside analogs for antiviral treatment
MY173877A (en) Branched 3-phenylpropionic acid derivatives and the use thereof
WO2014060493A3 (en) N-(pyridin-2-yl)pyrimidin-4-amine derivatives containing a sulfone group
MX2015007916A (es) Peri-carbinoles.
EA030383B9 (ru) Бициклически замещённые урацилы, способы их получения, их применение, лекарственное средство и способ лечения с их применением
PH12014501967B1 (en) Benzodioxanes in combination with other actives for inhibiting leukotriene production
CA2878796C (en) Derivatives of pyridinone as inhibitors for tissue transglutaminase
IN2015DN00085A (uk)
TN2015000095A1 (en) Macrolide derivatives, preparation thereof and therapeutic use thereof
PH12015502703A1 (en) Pharmaceutical compositions
NZ622558A (en) Hiv replication inhibitors