CY1118441T1 - Παραγωγα 5-φθορο-ν-(πυριδιν-2-υλ)πυριδιν-2-αμινης που περιεχουν μια ομαδα σουλφοξιμινης - Google Patents

Παραγωγα 5-φθορο-ν-(πυριδιν-2-υλ)πυριδιν-2-αμινης που περιεχουν μια ομαδα σουλφοξιμινης

Info

Publication number
CY1118441T1
CY1118441T1 CY20171100053T CY171100053T CY1118441T1 CY 1118441 T1 CY1118441 T1 CY 1118441T1 CY 20171100053 T CY20171100053 T CY 20171100053T CY 171100053 T CY171100053 T CY 171100053T CY 1118441 T1 CY1118441 T1 CY 1118441T1
Authority
CY
Cyprus
Prior art keywords
pyridin
fluoro
products containing
amine products
group
Prior art date
Application number
CY20171100053T
Other languages
English (en)
Inventor
Ulrich Lücking
Niels Böhnke
Arne Scholz
Philip Lienau
Gerhard Siemeister
Ulf Bömer
Dirk Kosemund
Rolf Bohlmann
Ludwig Zorn
Original Assignee
Bayer Pharma Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Pharma Aktiengesellschaft filed Critical Bayer Pharma Aktiengesellschaft
Publication of CY1118441T1 publication Critical patent/CY1118441T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Η παρούσα εφεύρεση σχετίζεται με παράγωγα 5-φθορο-Ν-(πυριδιν-2-υλ) πυριδιν-2-αμίνης που περιέχουν μία ομάδα σουλφοξιμίνης του γενικού τύπου (I) όπως περιγράφεται και ορίζεται εδώ, και μεθόδους για την παρασκευή τους, τη χρήση τους για την προφύλαξη από και/ή θεραπεία διαταραχών, ειδικότερα υπερπλαστικών διαταραχών και/ή προκαλούμενων από ιούς μολυσματικών νόσων και/ή καρδιαγγειακών νόσων. Η εφεύρεση σχετίζεται περαιτέρω με ενδιάμεσες ενώσεις χρήσιμες στην παρασκευή των εν λόγω ενώσεων του γενικού τύπου (I).
CY20171100053T 2012-11-15 2017-01-17 Παραγωγα 5-φθορο-ν-(πυριδιν-2-υλ)πυριδιν-2-αμινης που περιεχουν μια ομαδα σουλφοξιμινης CY1118441T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12192852 2012-11-15
PCT/EP2013/073637 WO2014076091A1 (en) 2012-11-15 2013-11-12 5-fluoro-n-(pyridin-2-yl)pyridin-2-amine derivatives containing a sulfoximine group
EP13792885.9A EP2928878B1 (en) 2012-11-15 2013-11-12 5-fluoro-n-(pyridin-2-yl)pyridin-2-amine derivatives containing a sulfoximine group

Publications (1)

Publication Number Publication Date
CY1118441T1 true CY1118441T1 (el) 2017-06-28

Family

ID=47148672

Family Applications (1)

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CY20171100053T CY1118441T1 (el) 2012-11-15 2017-01-17 Παραγωγα 5-φθορο-ν-(πυριδιν-2-υλ)πυριδιν-2-αμινης που περιεχουν μια ομαδα σουλφοξιμινης

Country Status (43)

Country Link
US (2) US9650340B2 (el)
EP (1) EP2928878B1 (el)
JP (1) JP6263193B2 (el)
KR (1) KR102242871B1 (el)
CN (1) CN105102444B (el)
AP (1) AP3872A (el)
AR (1) AR093505A1 (el)
AU (1) AU2013346939B2 (el)
BR (1) BR112015010707B1 (el)
CA (1) CA2891358C (el)
CL (1) CL2015001304A1 (el)
CR (1) CR20150256A (el)
CU (1) CU20150052A7 (el)
CY (1) CY1118441T1 (el)
DK (1) DK2928878T3 (el)
DO (1) DOP2015000118A (el)
EA (1) EA027226B1 (el)
EC (1) ECSP15019323A (el)
ES (1) ES2612978T3 (el)
HK (1) HK1213255A1 (el)
HR (1) HRP20161547T1 (el)
HU (1) HUE032868T2 (el)
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LT (1) LT2928878T (el)
MA (1) MA38090B1 (el)
ME (1) ME02880B (el)
MX (1) MX2015006169A (el)
MY (1) MY170609A (el)
NZ (1) NZ707084A (el)
PE (1) PE20151071A1 (el)
PH (1) PH12015501003B1 (el)
PL (1) PL2928878T3 (el)
PT (1) PT2928878T (el)
RS (1) RS55580B1 (el)
SG (1) SG11201503079PA (el)
SI (1) SI2928878T1 (el)
SV (1) SV2015004979A (el)
TN (1) TN2015000185A1 (el)
TW (1) TWI613193B (el)
UA (1) UA115254C2 (el)
UY (1) UY35141A (el)
WO (1) WO2014076091A1 (el)

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Publication number Publication date
CR20150256A (es) 2015-07-01
ME02880B (me) 2018-04-20
DK2928878T3 (en) 2016-12-19
JO3332B1 (ar) 2019-03-13
PT2928878T (pt) 2017-02-08
UY35141A (es) 2014-06-30
UA115254C2 (uk) 2017-10-10
HUE032868T2 (en) 2017-11-28
US9877954B2 (en) 2018-01-30
ECSP15019323A (es) 2016-01-29
TWI613193B (zh) 2018-02-01
PH12015501003A1 (en) 2015-07-27
KR102242871B1 (ko) 2021-04-20
RS55580B1 (sr) 2017-06-30
KR20150084968A (ko) 2015-07-22
BR112015010707A8 (pt) 2019-10-01
CA2891358A1 (en) 2014-05-22
CL2015001304A1 (es) 2015-07-17
IL238322A (en) 2017-08-31
DOP2015000118A (es) 2015-06-15
BR112015010707A2 (pt) 2017-07-11
MY170609A (en) 2019-08-20
SV2015004979A (es) 2017-01-30
EA027226B1 (ru) 2017-07-31
CU20150052A7 (es) 2015-09-29
HK1213255A1 (zh) 2016-06-30
AP3872A (en) 2016-10-31
TW201420569A (zh) 2014-06-01
CN105102444A (zh) 2015-11-25
PH12015501003B1 (en) 2015-07-27
EP2928878A1 (en) 2015-10-14
PE20151071A1 (es) 2015-08-19
CA2891358C (en) 2021-05-18
US20170202815A1 (en) 2017-07-20
HRP20161547T1 (hr) 2016-12-30
AR093505A1 (es) 2015-06-10
CN105102444B (zh) 2017-08-01
MX2015006169A (es) 2015-08-10
BR112015010707B1 (pt) 2022-05-17
MA38090B1 (fr) 2018-09-28
LT2928878T (lt) 2016-11-25
US9650340B2 (en) 2017-05-16
PL2928878T3 (pl) 2017-04-28
US20150291528A1 (en) 2015-10-15
AP2015008432A0 (en) 2015-05-31
EA201590890A1 (ru) 2015-11-30
AU2013346939A1 (en) 2015-05-14
TN2015000185A1 (en) 2016-10-03
ES2612978T3 (es) 2017-05-19
JP6263193B2 (ja) 2018-01-17
WO2014076091A1 (en) 2014-05-22
NZ707084A (en) 2019-09-27
JP2015537015A (ja) 2015-12-24
MA38090A1 (fr) 2018-02-28
SI2928878T1 (sl) 2016-12-30
SG11201503079PA (en) 2015-06-29
IL238322A0 (en) 2015-06-30
AU2013346939B2 (en) 2017-06-08
EP2928878B1 (en) 2016-11-02

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