BR112015010203A8 - composição para a prevenção ou tratamento de diabetes, complicações diabéticas ou diabesidade, uso de um conjugado análogo da oxintomodulina, e, método para a preparação de um conjugado análogo da oxintomodulina - Google Patents

composição para a prevenção ou tratamento de diabetes, complicações diabéticas ou diabesidade, uso de um conjugado análogo da oxintomodulina, e, método para a preparação de um conjugado análogo da oxintomodulina Download PDF

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Publication number
BR112015010203A8
BR112015010203A8 BR112015010203A BR112015010203A BR112015010203A8 BR 112015010203 A8 BR112015010203 A8 BR 112015010203A8 BR 112015010203 A BR112015010203 A BR 112015010203A BR 112015010203 A BR112015010203 A BR 112015010203A BR 112015010203 A8 BR112015010203 A8 BR 112015010203A8
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Brazil
Prior art keywords
diabetes
oxytomodulin
analog
treatment
oxintomodulin
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BR112015010203A
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English (en)
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BR112015010203B1 (pt
BR112015010203A2 (pt
Inventor
Jin Kim Dae
Sun Kim Jin
Hyun Lee Sang
Chang Kwon Se
Youb Jung Sung
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Hanmi Pharm Ind Co Ltd
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Application filed by Hanmi Pharm Ind Co Ltd filed Critical Hanmi Pharm Ind Co Ltd
Priority to BR122019024272-0A priority Critical patent/BR122019024272B1/pt
Publication of BR112015010203A2 publication Critical patent/BR112015010203A2/pt
Publication of BR112015010203A8 publication Critical patent/BR112015010203A8/pt
Publication of BR112015010203B1 publication Critical patent/BR112015010203B1/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/643—Albumins, e.g. HSA, BSA, ovalbumin or a Keyhole Limpet Hemocyanin [KHL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/6435—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a connective tissue peptide, e.g. collagen, fibronectin or gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3046—Stomach, Intestines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Diabetes (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

composição para o tratamento de diabetes ou diabesidade compreendendo um análogo da oxintomodulina". a presente invenção se refere a uma composição para a prevenção ou tratamento de diabetes, complicações diabéticas ou diabesidade, compreendendo um análogo da oxintomodulina como um ingrediente ativo. a invenção também se refere a um método para o tratamento de diabetes, complicações diabéticas ou diabesidade, compreendendo administrar uma quantidade farmaceuticamente eficaz de um análogo da oxintomodulina a um paciente. o análogo da oxintomodulina tem uma alta capacidade de ativar o receptor de glp-1 e o receptor de glucagon, comparado com a oxintomodulina nativa. o análogo de oxintomodulina induz a expansão das células beta e aumenta a secreção de insulina, reduzindo assim os níveis de glicose no sangue que foram aumentados devido a uma dieta com alto teor calórico e rica em gordura. o análogo de oxintomodulina induz a diminuição do peso corporal e da ingestão da dieta para aumentar a sensibilidade à insulina e permitir que níveis de glicose no sangue, os quais não são controlados devido à resistência à insulina, sejam mantidos em níveis normais. assim, o análogo oxintomodulina pode ser eficazmente usado para prevenir ou tratar a diabetes e doenças afins
BR112015010203-4A 2012-11-06 2013-11-06 uso de uma composição para a preparação de um medicamento para a prevenção ou o tratamento de diabetes, complicações diabéticas ou diabesidade compreendendo um conjugado analogo da oxintomodulina BR112015010203B1 (pt)

Priority Applications (1)

Application Number Priority Date Filing Date Title
BR122019024272-0A BR122019024272B1 (pt) 2012-11-06 2013-11-06 composição para a prevenção ou tratamento de diabetes complicações diabéticas ou diabesidade e uso de composição para a preparação de um medicamento para a prevenção ou tratamento de diabetes, complicações diabéticas ou diabesidade

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR10-2012-0124724 2012-11-06
KR1020120124724A KR101993393B1 (ko) 2012-11-06 2012-11-06 옥신토모듈린 유도체를 포함하는 당뇨병 또는 비만성 당뇨병 치료용 조성물
PCT/KR2013/009990 WO2014073845A1 (en) 2012-11-06 2013-11-06 A composition for treating diabetes or diabesity comprising oxyntomodulin analog

Publications (3)

Publication Number Publication Date
BR112015010203A2 BR112015010203A2 (pt) 2017-08-22
BR112015010203A8 true BR112015010203A8 (pt) 2019-11-26
BR112015010203B1 BR112015010203B1 (pt) 2021-05-18

Family

ID=50684885

Family Applications (3)

Application Number Title Priority Date Filing Date
BR112015010203-4A BR112015010203B1 (pt) 2012-11-06 2013-11-06 uso de uma composição para a preparação de um medicamento para a prevenção ou o tratamento de diabetes, complicações diabéticas ou diabesidade compreendendo um conjugado analogo da oxintomodulina
BR122021003984-4A BR122021003984B1 (pt) 2012-11-06 2013-11-06 Composição para a prevenção ou tratamento de diabetes, complicações diabéticas ou diabesidade, uso da composição para a preparação de um medicamento para a prevenção ou tratamento de diabetes, complicações diabéticas ou diabesidade
BR122019024272-0A BR122019024272B1 (pt) 2012-11-06 2013-11-06 composição para a prevenção ou tratamento de diabetes complicações diabéticas ou diabesidade e uso de composição para a preparação de um medicamento para a prevenção ou tratamento de diabetes, complicações diabéticas ou diabesidade

Family Applications After (2)

Application Number Title Priority Date Filing Date
BR122021003984-4A BR122021003984B1 (pt) 2012-11-06 2013-11-06 Composição para a prevenção ou tratamento de diabetes, complicações diabéticas ou diabesidade, uso da composição para a preparação de um medicamento para a prevenção ou tratamento de diabetes, complicações diabéticas ou diabesidade
BR122019024272-0A BR122019024272B1 (pt) 2012-11-06 2013-11-06 composição para a prevenção ou tratamento de diabetes complicações diabéticas ou diabesidade e uso de composição para a preparação de um medicamento para a prevenção ou tratamento de diabetes, complicações diabéticas ou diabesidade

Country Status (30)

Country Link
US (2) US20150299282A1 (pt)
EP (2) EP3679944B1 (pt)
JP (4) JP6363613B2 (pt)
KR (1) KR101993393B1 (pt)
CN (1) CN104918632B (pt)
AR (2) AR093386A1 (pt)
AU (3) AU2013342324B2 (pt)
BR (3) BR112015010203B1 (pt)
CA (1) CA2890329C (pt)
CL (1) CL2015001207A1 (pt)
DK (1) DK2916860T3 (pt)
EA (2) EA031928B1 (pt)
ES (1) ES2802099T3 (pt)
HK (1) HK1211856A1 (pt)
HR (1) HRP20200925T1 (pt)
HU (1) HUE049240T2 (pt)
IL (2) IL238631B (pt)
LT (1) LT2916860T (pt)
MX (1) MX360335B (pt)
MY (1) MY173828A (pt)
NZ (2) NZ708105A (pt)
PE (1) PE20151420A1 (pt)
PH (2) PH12018501424A1 (pt)
PL (1) PL2916860T3 (pt)
PT (1) PT2916860T (pt)
SG (3) SG10202110636WA (pt)
TW (4) TWI645856B (pt)
UA (1) UA117570C2 (pt)
WO (1) WO2014073845A1 (pt)
ZA (1) ZA201503999B (pt)

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