BR112015006305B1 - composições farmacêuticas para prevenir e/ou tratar dislipidemia e para aumentar o colesterol de hdl - Google Patents

composições farmacêuticas para prevenir e/ou tratar dislipidemia e para aumentar o colesterol de hdl Download PDF

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Publication number
BR112015006305B1
BR112015006305B1 BR112015006305-5A BR112015006305A BR112015006305B1 BR 112015006305 B1 BR112015006305 B1 BR 112015006305B1 BR 112015006305 A BR112015006305 A BR 112015006305A BR 112015006305 B1 BR112015006305 B1 BR 112015006305B1
Authority
BR
Brazil
Prior art keywords
group
compound
hdl
cholesterol
ezetimibe
Prior art date
Application number
BR112015006305-5A
Other languages
English (en)
Portuguese (pt)
Other versions
BR112015006305A2 (pt
Inventor
Toshiaki Takizawa
Yasunobu Yoshinaka
Original Assignee
Kowa Company, Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kowa Company, Ltd. filed Critical Kowa Company, Ltd.
Publication of BR112015006305A2 publication Critical patent/BR112015006305A2/pt
Publication of BR112015006305B1 publication Critical patent/BR112015006305B1/pt

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42Oxazoles
    • A61K31/423Oxazoles condensed with carbocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
BR112015006305-5A 2012-09-27 2013-09-27 composições farmacêuticas para prevenir e/ou tratar dislipidemia e para aumentar o colesterol de hdl BR112015006305B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2012-214635 2012-09-27
JP2012214635 2012-09-27
PCT/JP2013/005756 WO2014050134A1 (ja) 2012-09-27 2013-09-27 脂質異常症治療剤

Publications (2)

Publication Number Publication Date
BR112015006305A2 BR112015006305A2 (pt) 2017-07-04
BR112015006305B1 true BR112015006305B1 (pt) 2020-11-17

Family

ID=50387566

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015006305-5A BR112015006305B1 (pt) 2012-09-27 2013-09-27 composições farmacêuticas para prevenir e/ou tratar dislipidemia e para aumentar o colesterol de hdl

Country Status (20)

Country Link
US (4) US9572798B2 (https=)
EP (1) EP2902025B1 (https=)
JP (1) JP6238460B2 (https=)
KR (1) KR102098032B1 (https=)
CN (1) CN104640544B (https=)
AU (1) AU2013321918B2 (https=)
BR (1) BR112015006305B1 (https=)
CA (1) CA2901650C (https=)
EA (1) EA024873B1 (https=)
ES (1) ES2752039T3 (https=)
IL (1) IL237981B (https=)
IN (1) IN2015DN02966A (https=)
MX (1) MX357446B (https=)
MY (1) MY177686A (https=)
PH (1) PH12015500471A1 (https=)
PL (1) PL2902025T3 (https=)
PT (1) PT2902025T (https=)
SG (1) SG11201501740XA (https=)
TW (1) TWI598098B (https=)
WO (1) WO2014050134A1 (https=)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI691331B (zh) * 2014-09-26 2020-04-21 日商興和股份有限公司 脂質異常症治療劑
KR20200024165A (ko) * 2017-06-30 2020-03-06 교와 가부시키가이샤 의약 조성물
WO2019004448A1 (ja) * 2017-06-30 2019-01-03 興和株式会社 医薬組成物
JPWO2019004452A1 (ja) * 2017-06-30 2020-04-30 興和株式会社 医薬組成物
US11344535B2 (en) 2017-06-30 2022-05-31 Kowa Company, Ltd. Pharmaceutical composition
JPWO2019004453A1 (ja) * 2017-06-30 2020-04-30 興和株式会社 医薬品
HUE069648T2 (hu) * 2017-06-30 2025-03-28 Kowa Co Gyógyszerészeti készítmény
EP3646864B1 (en) 2017-06-30 2026-04-08 Kowa Company, Ltd. Pharmaceutical containing pemafibrate
JP7425603B2 (ja) * 2017-06-30 2024-01-31 興和株式会社 医薬組成物
US11446282B2 (en) 2017-12-21 2022-09-20 Kowa Company, Ltd. Methods of treating mixed dyslipidemia and hypertriglycertdemia
US20190224169A1 (en) * 2017-12-21 2019-07-25 Kowa Company, Ltd. Methods of Treatment of Hypertriglyceridemia
EP3903781A4 (en) * 2018-12-27 2023-01-25 Kowa Company, Ltd. PHARMACEUTICAL PREPARATION
US20220096443A1 (en) * 2018-12-27 2022-03-31 Kowa Company, Ltd. Pharmaceutical composition
JP2020105174A (ja) * 2018-12-27 2020-07-09 興和株式会社 医薬組成物

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU230253B1 (hu) 2001-01-26 2015-11-30 Merck Sharp & Dohme Corp Peroxiszóma proliferátor-aktivált receptor (PPAR) aktivátor(ok) és szterin-abszorpció inhibitor(ok) kombinációi és alkalmazásuk vaszkuláris indikációk kezelésére
US7205321B2 (en) 2001-11-15 2007-04-17 Eli Lilly And Company Peroxisome proliferator activated receptor alpha agonists
US6987118B2 (en) 2003-05-21 2006-01-17 Pfizer Inc. Tetrahydroisoquinoline derivatives as PPAR-alpha activators
WO2005009942A1 (ja) 2003-07-28 2005-02-03 Kyorin Pharmaceutical Co., Ltd. 光学活性置換フェニルプロピオン酸誘導体
EA009374B1 (ru) 2003-09-03 2007-12-28 Кова Ко., Лтд. Активирующее ppar соединение и содержащая его фармацевтическая композиция
CN100425594C (zh) * 2003-09-03 2008-10-15 兴和株式会社 Ppar活性化化合物及含该化合物的医药组合物
DE102004016845A1 (de) 2004-04-07 2005-10-27 Bayer Healthcare Ag Phenylthioessigsäure-Derivate und ihre Verwendung
US7629372B2 (en) 2004-09-16 2009-12-08 Merck & Co., Inc. Compounds for the treatment of dyslipidemia and other lipid disorders
TWI359810B (en) 2004-11-04 2012-03-11 Mitsubishi Tanabe Pharma Corp Carboxylic acid derivative containing thiazole rin
WO2007008529A2 (en) 2005-07-08 2007-01-18 Kalypsys, Inc Celullar cholesterol absorption modifiers
WO2007008541A2 (en) 2005-07-08 2007-01-18 Kalypsys, Inc. Cellular cholesterol absorption modifiers
US7795291B2 (en) 2006-07-07 2010-09-14 Bristol-Myers Squibb Company Substituted acid derivatives useful as anti-atherosclerotic, anti-dyslipidemic, anti-diabetic and anti-obesity agents and method
CA2663502A1 (en) 2006-09-15 2008-03-20 Schering Corporation Azetidinone derivatives and methods of use thereof
WO2008104875A1 (en) 2007-03-01 2008-09-04 Pfizer Products Inc. Oxazolidinones as cholesterol absorption inhibitors
TWI407955B (zh) * 2007-03-29 2013-09-11 Kowa Co 高脂血症之預防及/或治療劑
WO2009047240A1 (en) 2007-10-09 2009-04-16 Smithkline Beecham Corporation Indole derivatives useful as ppar activators
DE102007061757A1 (de) 2007-12-20 2009-06-25 Bayer Healthcare Ag Substituierte 2-Phenylpyrimidin-5-carbonsäuren und ihre Verwendung

Also Published As

Publication number Publication date
KR20150063035A (ko) 2015-06-08
AU2013321918B2 (en) 2018-05-10
PH12015500471B1 (en) 2015-04-20
EP2902025B1 (en) 2019-08-07
HK1206620A1 (zh) 2016-01-15
JP6238460B2 (ja) 2017-11-29
US9572798B2 (en) 2017-02-21
US20190167645A1 (en) 2019-06-06
EP2902025A4 (en) 2016-03-02
MX357446B (es) 2018-07-10
MX2015003705A (es) 2015-06-10
IL237981A0 (en) 2015-05-31
US20180185337A1 (en) 2018-07-05
EA024873B1 (ru) 2016-10-31
CA2901650C (en) 2021-05-04
CN104640544A (zh) 2015-05-20
US10258609B2 (en) 2019-04-16
CN104640544B (zh) 2017-05-03
US20150196538A1 (en) 2015-07-16
BR112015006305A2 (pt) 2017-07-04
TW201417811A (zh) 2014-05-16
IL237981B (en) 2020-05-31
ES2752039T3 (es) 2020-04-02
EP2902025A1 (en) 2015-08-05
PL2902025T3 (pl) 2020-03-31
IN2015DN02966A (https=) 2015-09-18
PH12015500471A1 (en) 2015-04-20
WO2014050134A1 (ja) 2014-04-03
US9931321B2 (en) 2018-04-03
TWI598098B (zh) 2017-09-11
KR102098032B1 (ko) 2020-04-07
US20170112811A1 (en) 2017-04-27
AU2013321918A1 (en) 2015-04-23
EA201590653A1 (ru) 2015-07-30
CA2901650A1 (en) 2014-04-03
SG11201501740XA (en) 2015-04-29
US11013722B2 (en) 2021-05-25
PT2902025T (pt) 2019-11-04
JPWO2014050134A1 (ja) 2016-08-22
MY177686A (en) 2020-09-23

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06I Publication of requirement cancelled [chapter 6.9 patent gazette]

Free format text: ANULADA A PUBLICACAO CODIGO 6.6.1 NA RPI NO 2462 DE 13/03/2018 POR TER SIDO INDEVIDA.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B06T Formal requirements before examination [chapter 6.20 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 27/09/2013, OBSERVADAS AS CONDICOES LEGAIS.