BR112014017474A8 - dispositivo para uso na detecção de afinidades de ligação - Google Patents
dispositivo para uso na detecção de afinidades de ligaçãoInfo
- Publication number
- BR112014017474A8 BR112014017474A8 BR112014017474A BR112014017474A BR112014017474A8 BR 112014017474 A8 BR112014017474 A8 BR 112014017474A8 BR 112014017474 A BR112014017474 A BR 112014017474A BR 112014017474 A BR112014017474 A BR 112014017474A BR 112014017474 A8 BR112014017474 A8 BR 112014017474A8
- Authority
- BR
- Brazil
- Prior art keywords
- flat waveguide
- binding sites
- binding
- binding affinities
- detecting binding
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/55—Specular reflectivity
- G01N21/552—Attenuated total reflection
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
- G01N21/774—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides the reagent being on a grating or periodic structure
- G01N21/7743—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides the reagent being on a grating or periodic structure the reagent-coated grating coupling light in or out of the waveguide
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plasma & Fusion (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Optical Integrated Circuits (AREA)
Abstract
resumo patente de invenção: "dispositivo para uso na detecção de afinidades de ligação". trata-se de um dispositivo para uso na detecção de afinidades de ligação que compreende um guia de onda plano (2) disposto em um substrato (3) e um acoplador óptico (4) para acoplar luz coerente (1) de um comprimento de onda predeterminado para o interior do guia de onda plano. a luz coerente se propaga através do guia de onda plano (2) com um campo evanescente (6) que se propaga ao longo de uma superfície externa (5) do guia de onda plano. a superfície externa (5) do guia de onda plano compreende sítios de ligação (7) na mesma capazes de ligar amostras-alvo (8) aos sítios de ligação (7) de modo que a luz do campo evanescente (6) seja espalhada pelas amostras-alvo (8) ligadas aos sítios de ligação (7). os sítios de ligação (7) são dispostos ao longo de uma pluralidade de linhas predeterminadas (9) que são dispostas de modo que a luz espalhada interfira de modo construtivo em uma localização de detecção predeterminada com uma diferença em comprimento de trajetória óptica que é um número inteiro múltiplo do comprimento de onda predeterminado. 21817378v1 1/1 21817378v1
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP12151436.8 | 2012-01-17 | ||
EP12151436.8A EP2618130A1 (en) | 2012-01-17 | 2012-01-17 | Device for use in the detection of binding affinities |
PCT/EP2013/050825 WO2013107811A1 (en) | 2012-01-17 | 2013-01-17 | Device for use in the detection of binding affinities |
Publications (3)
Publication Number | Publication Date |
---|---|
BR112014017474A2 BR112014017474A2 (pt) | 2017-06-13 |
BR112014017474A8 true BR112014017474A8 (pt) | 2017-07-04 |
BR112014017474B1 BR112014017474B1 (pt) | 2020-11-10 |
Family
ID=47628121
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112014017474-1A BR112014017474B1 (pt) | 2012-01-17 | 2013-01-17 | sistema e dispositivo para uso na detecção de afinidades de ligação |
Country Status (11)
Country | Link |
---|---|
US (2) | US10006866B2 (pt) |
EP (2) | EP2618130A1 (pt) |
JP (1) | JP6202401B2 (pt) |
KR (1) | KR102050118B1 (pt) |
CN (1) | CN104115000B (pt) |
BR (1) | BR112014017474B1 (pt) |
CA (1) | CA2860104C (pt) |
HK (1) | HK1199304A1 (pt) |
MX (1) | MX2014008372A (pt) |
RU (1) | RU2609184C2 (pt) |
WO (1) | WO2013107811A1 (pt) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2824446A1 (en) * | 2013-07-12 | 2015-01-14 | F. Hoffmann-La Roche AG | Device for use in the detection of binding affinities |
EP2827130A1 (en) * | 2013-07-15 | 2015-01-21 | F. Hoffmann-La Roche AG | Device for use in the detection of binding affinities |
EP3040750A1 (en) * | 2014-12-29 | 2016-07-06 | IMEC vzw | Device and method for performing lens-free imaging |
EP3241046B1 (en) * | 2014-12-29 | 2023-01-25 | IMEC vzw | Light coupler |
JP6538844B2 (ja) | 2015-07-07 | 2019-07-03 | 古野電気株式会社 | 検体測定用チップ、検体測定装置、および検体測定方法 |
KR101754774B1 (ko) * | 2015-12-29 | 2017-07-06 | 주식회사 스칼라팍스트롯 | 바이오 칩 및 바이오 칩의 제조 방법 |
EP3205512B1 (en) | 2016-02-09 | 2018-06-13 | CSEM Centre Suisse d'Electronique et de Microtechnique SA - Recherche et Développement | Optical security device |
WO2018143474A1 (ja) * | 2017-02-06 | 2018-08-09 | Tdk株式会社 | 光導波型センサーおよび物質検出方法 |
DE102017211910A1 (de) | 2017-07-12 | 2019-01-17 | Dr. Johannes Heidenhain Gmbh | Diffraktiver Biosensor |
WO2019068304A1 (en) | 2017-10-02 | 2019-04-11 | CSEM Centre Suisse d'Electronique et de Microtechnique SA - Recherche et Développement | RESONANT WAVEGUIDE NETWORK AND ITS APPLICATIONS |
US11946930B2 (en) | 2018-03-01 | 2024-04-02 | Hoffmann-La Roche Inc. | Device for use in the detection of binding affinities |
JP7278363B2 (ja) | 2018-07-18 | 2023-05-19 | ドクトル・ヨハネス・ハイデンハイン・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング | 回折バイオセンサ |
KR102080688B1 (ko) * | 2018-10-23 | 2020-02-24 | 인하대학교 산학협력단 | 격자 결합기 |
RU2700584C1 (ru) * | 2018-12-13 | 2019-09-18 | Общество С Ограниченной Ответственностью "Апто-Фарм" | Способ оценки сродства олигонуклеотида |
US20220397573A1 (en) * | 2019-09-17 | 2022-12-15 | Hoffmann-La Roche Inc. | Biomolecular Detection Device |
DE102019134172A1 (de) | 2019-12-12 | 2021-06-17 | Dr. Johannes Heidenhain Gmbh | Vorrichtung und Verfahren zur Einkopplung von Licht mit verschiedenen Wellenlängen in einen Wellenleiter |
DE102020212031A1 (de) | 2020-09-24 | 2022-03-24 | Dr. Johannes Heidenhain Gmbh | Vorrichtung und Verfahren zur Bestimmung der Intensität des in einem planaren Wellenleiter geführten Lichts IWG(x, y) |
DE102020212029A1 (de) | 2020-09-24 | 2022-03-24 | Dr. Johannes Heidenhain Gmbh | Vorrichtung und Verfahren zur simultanen Abbildung zweier Objektebenen |
EP4264358A1 (de) * | 2020-12-29 | 2023-10-25 | Interherence GmbH | Opto-elektronischer chip |
EP4155709A1 (en) | 2021-09-28 | 2023-03-29 | Bayer AG | On-line biomolecular interaction analysis for monitoring or controlling bioprocesses |
WO2023187077A1 (en) | 2022-03-30 | 2023-10-05 | Miltenyi Biotec B.V. & Co. KG | Parallelized optical biomolecule interaction analysis |
EP4306940A1 (en) | 2022-07-15 | 2024-01-17 | lino Biotech AG | Device for use in the detection of binding affinities |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4647544A (en) | 1984-06-25 | 1987-03-03 | Nicoli David F | Immunoassay using optical interference detection |
JP3162448B2 (ja) | 1991-12-19 | 2001-04-25 | 松下電工株式会社 | システム天井 |
JPH05172732A (ja) | 1991-12-25 | 1993-07-09 | Hitachi Electron Eng Co Ltd | 液体中微粒子検出装置およびその検出方法 |
US6211954B1 (en) * | 1996-03-30 | 2001-04-03 | Novartis Ag | Integrated optical luminescence sensor |
US6586193B2 (en) * | 1996-04-25 | 2003-07-01 | Genicon Sciences Corporation | Analyte assay using particulate labels |
WO1998009156A1 (en) * | 1996-08-29 | 1998-03-05 | Novartis Ag | Optical chemical / biochemical sensor |
SE514512C2 (sv) * | 1999-07-02 | 2001-03-05 | Proximion Fiber Optics Ab | Förfarande och anordning för koppling av ljus |
PT1192448E (pt) * | 1999-07-05 | 2007-01-31 | Novartis Ag | Processo para a utilização de uma plataforma de sensor |
US6510263B1 (en) | 2000-01-27 | 2003-01-21 | Unaxis Balzers Aktiengesellschaft | Waveguide plate and process for its production and microtitre plate |
US6951715B2 (en) * | 2000-10-30 | 2005-10-04 | Sru Biosystems, Inc. | Optical detection of label-free biomolecular interactions using microreplicated plastic sensor elements |
US7264973B2 (en) * | 2000-10-30 | 2007-09-04 | Sru Biosystems, Inc. | Label-free methods for performing assays using a colorimetric resonant optical biosensor |
US20040186359A1 (en) * | 2001-07-09 | 2004-09-23 | Beaudoin Stephen P. | Afinity biosensor for monitoring biological process |
JP2003194697A (ja) * | 2001-12-27 | 2003-07-09 | Canon Inc | グレーティングカップラを有する探針及びその製造方法、該探針を有するプローブ、及び該プローブを有する情報処理装置、表面観察装置、露光装置、該露光装置による光学素子 |
US6829073B1 (en) * | 2003-10-20 | 2004-12-07 | Corning Incorporated | Optical reading system and method for spectral multiplexing of resonant waveguide gratings |
US7319525B2 (en) * | 2003-11-06 | 2008-01-15 | Fortebio, Inc. | Fiber-optic assay apparatus based on phase-shift interferometry |
US7233391B2 (en) * | 2003-11-21 | 2007-06-19 | Perkinelmer Las, Inc. | Optical device integrated with well |
US7560708B2 (en) * | 2005-07-18 | 2009-07-14 | Koninklijke Philips Electronics N.V. | Luminescence sensor using multi-layer substrate structure |
JP2008014732A (ja) * | 2006-07-04 | 2008-01-24 | Tohoku Univ | 表面プラズモン共鳴測定装置 |
US20100053610A1 (en) * | 2008-08-29 | 2010-03-04 | Kwangyeol Lee | System and method for detecting molecules |
EP2741074A1 (en) * | 2012-12-04 | 2014-06-11 | F. Hoffmann-La Roche AG | Device for use in the detection of binding affinities |
EP2757374A1 (en) * | 2013-01-17 | 2014-07-23 | F. Hoffmann-La Roche AG | Method for preparing an outer surface of a planar waveguide to be capable of binding target samples along a plurality of predetermined lines and a planar waveguide |
EP2824446A1 (en) * | 2013-07-12 | 2015-01-14 | F. Hoffmann-La Roche AG | Device for use in the detection of binding affinities |
EP2827130A1 (en) * | 2013-07-15 | 2015-01-21 | F. Hoffmann-La Roche AG | Device for use in the detection of binding affinities |
-
2012
- 2012-01-17 EP EP12151436.8A patent/EP2618130A1/en not_active Ceased
-
2013
- 2013-01-17 US US14/372,707 patent/US10006866B2/en active Active
- 2013-01-17 RU RU2014133427A patent/RU2609184C2/ru active
- 2013-01-17 MX MX2014008372A patent/MX2014008372A/es active IP Right Grant
- 2013-01-17 WO PCT/EP2013/050825 patent/WO2013107811A1/en active Application Filing
- 2013-01-17 BR BR112014017474-1A patent/BR112014017474B1/pt active IP Right Grant
- 2013-01-17 EP EP13701736.4A patent/EP2805149B1/en active Active
- 2013-01-17 CN CN201380005873.5A patent/CN104115000B/zh active Active
- 2013-01-17 CA CA2860104A patent/CA2860104C/en active Active
- 2013-01-17 KR KR1020147019349A patent/KR102050118B1/ko active IP Right Grant
- 2013-01-17 JP JP2014551651A patent/JP6202401B2/ja active Active
-
2014
- 2014-12-23 HK HK14112863.3A patent/HK1199304A1/xx unknown
-
2018
- 2018-06-13 US US16/007,497 patent/US10684227B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
RU2609184C2 (ru) | 2017-01-30 |
HK1199304A1 (en) | 2015-06-26 |
CN104115000A (zh) | 2014-10-22 |
US10684227B2 (en) | 2020-06-16 |
JP2015503757A (ja) | 2015-02-02 |
WO2013107811A1 (en) | 2013-07-25 |
US10006866B2 (en) | 2018-06-26 |
EP2805149B1 (en) | 2021-12-08 |
KR20140114364A (ko) | 2014-09-26 |
KR102050118B1 (ko) | 2019-11-28 |
US20180364174A1 (en) | 2018-12-20 |
RU2014133427A (ru) | 2016-03-10 |
EP2805149A1 (en) | 2014-11-26 |
BR112014017474A2 (pt) | 2017-06-13 |
CA2860104A1 (en) | 2013-07-25 |
US20140363901A1 (en) | 2014-12-11 |
JP6202401B2 (ja) | 2017-09-27 |
CA2860104C (en) | 2020-02-25 |
MX2014008372A (es) | 2014-09-26 |
EP2618130A1 (en) | 2013-07-24 |
BR112014017474B1 (pt) | 2020-11-10 |
CN104115000B (zh) | 2016-11-23 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 17/01/2013, OBSERVADAS AS CONDICOES LEGAIS. |