BR112014017474A8 - dispositivo para uso na detecção de afinidades de ligação - Google Patents

dispositivo para uso na detecção de afinidades de ligação

Info

Publication number
BR112014017474A8
BR112014017474A8 BR112014017474A BR112014017474A BR112014017474A8 BR 112014017474 A8 BR112014017474 A8 BR 112014017474A8 BR 112014017474 A BR112014017474 A BR 112014017474A BR 112014017474 A BR112014017474 A BR 112014017474A BR 112014017474 A8 BR112014017474 A8 BR 112014017474A8
Authority
BR
Brazil
Prior art keywords
flat waveguide
binding sites
binding
binding affinities
detecting binding
Prior art date
Application number
BR112014017474A
Other languages
English (en)
Other versions
BR112014017474A2 (pt
BR112014017474B1 (pt
Inventor
Fattinger Christof
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR112014017474A2 publication Critical patent/BR112014017474A2/pt
Publication of BR112014017474A8 publication Critical patent/BR112014017474A8/pt
Publication of BR112014017474B1 publication Critical patent/BR112014017474B1/pt

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/55Specular reflectivity
    • G01N21/552Attenuated total reflection
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/7703Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
    • G01N21/774Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides the reagent being on a grating or periodic structure
    • G01N21/7743Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides the reagent being on a grating or periodic structure the reagent-coated grating coupling light in or out of the waveguide
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366Apparatus specially adapted for solid-phase testing
    • G01N33/54373Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plasma & Fusion (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Optical Integrated Circuits (AREA)

Abstract

resumo patente de invenção: "dispositivo para uso na detecção de afinidades de ligação". trata-se de um dispositivo para uso na detecção de afinidades de ligação que compreende um guia de onda plano (2) disposto em um substrato (3) e um acoplador óptico (4) para acoplar luz coerente (1) de um comprimento de onda predeterminado para o interior do guia de onda plano. a luz coerente se propaga através do guia de onda plano (2) com um campo evanescente (6) que se propaga ao longo de uma superfície externa (5) do guia de onda plano. a superfície externa (5) do guia de onda plano compreende sítios de ligação (7) na mesma capazes de ligar amostras-alvo (8) aos sítios de ligação (7) de modo que a luz do campo evanescente (6) seja espalhada pelas amostras-alvo (8) ligadas aos sítios de ligação (7). os sítios de ligação (7) são dispostos ao longo de uma pluralidade de linhas predeterminadas (9) que são dispostas de modo que a luz espalhada interfira de modo construtivo em uma localização de detecção predeterminada com uma diferença em comprimento de trajetória óptica que é um número inteiro múltiplo do comprimento de onda predeterminado. 21817378v1 1/1 21817378v1
BR112014017474-1A 2012-01-17 2013-01-17 sistema e dispositivo para uso na detecção de afinidades de ligação BR112014017474B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12151436.8 2012-01-17
EP12151436.8A EP2618130A1 (en) 2012-01-17 2012-01-17 Device for use in the detection of binding affinities
PCT/EP2013/050825 WO2013107811A1 (en) 2012-01-17 2013-01-17 Device for use in the detection of binding affinities

Publications (3)

Publication Number Publication Date
BR112014017474A2 BR112014017474A2 (pt) 2017-06-13
BR112014017474A8 true BR112014017474A8 (pt) 2017-07-04
BR112014017474B1 BR112014017474B1 (pt) 2020-11-10

Family

ID=47628121

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014017474-1A BR112014017474B1 (pt) 2012-01-17 2013-01-17 sistema e dispositivo para uso na detecção de afinidades de ligação

Country Status (11)

Country Link
US (2) US10006866B2 (pt)
EP (2) EP2618130A1 (pt)
JP (1) JP6202401B2 (pt)
KR (1) KR102050118B1 (pt)
CN (1) CN104115000B (pt)
BR (1) BR112014017474B1 (pt)
CA (1) CA2860104C (pt)
HK (1) HK1199304A1 (pt)
MX (1) MX2014008372A (pt)
RU (1) RU2609184C2 (pt)
WO (1) WO2013107811A1 (pt)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2824446A1 (en) * 2013-07-12 2015-01-14 F. Hoffmann-La Roche AG Device for use in the detection of binding affinities
EP2827130A1 (en) * 2013-07-15 2015-01-21 F. Hoffmann-La Roche AG Device for use in the detection of binding affinities
EP3040750A1 (en) * 2014-12-29 2016-07-06 IMEC vzw Device and method for performing lens-free imaging
EP3241046B1 (en) * 2014-12-29 2023-01-25 IMEC vzw Light coupler
JP6538844B2 (ja) 2015-07-07 2019-07-03 古野電気株式会社 検体測定用チップ、検体測定装置、および検体測定方法
KR101754774B1 (ko) * 2015-12-29 2017-07-06 주식회사 스칼라팍스트롯 바이오 칩 및 바이오 칩의 제조 방법
EP3205512B1 (en) 2016-02-09 2018-06-13 CSEM Centre Suisse d'Electronique et de Microtechnique SA - Recherche et Développement Optical security device
WO2018143474A1 (ja) * 2017-02-06 2018-08-09 Tdk株式会社 光導波型センサーおよび物質検出方法
DE102017211910A1 (de) 2017-07-12 2019-01-17 Dr. Johannes Heidenhain Gmbh Diffraktiver Biosensor
WO2019068304A1 (en) 2017-10-02 2019-04-11 CSEM Centre Suisse d'Electronique et de Microtechnique SA - Recherche et Développement RESONANT WAVEGUIDE NETWORK AND ITS APPLICATIONS
US11946930B2 (en) 2018-03-01 2024-04-02 Hoffmann-La Roche Inc. Device for use in the detection of binding affinities
JP7278363B2 (ja) 2018-07-18 2023-05-19 ドクトル・ヨハネス・ハイデンハイン・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング 回折バイオセンサ
KR102080688B1 (ko) * 2018-10-23 2020-02-24 인하대학교 산학협력단 격자 결합기
RU2700584C1 (ru) * 2018-12-13 2019-09-18 Общество С Ограниченной Ответственностью "Апто-Фарм" Способ оценки сродства олигонуклеотида
US20220397573A1 (en) * 2019-09-17 2022-12-15 Hoffmann-La Roche Inc. Biomolecular Detection Device
DE102019134172A1 (de) 2019-12-12 2021-06-17 Dr. Johannes Heidenhain Gmbh Vorrichtung und Verfahren zur Einkopplung von Licht mit verschiedenen Wellenlängen in einen Wellenleiter
DE102020212031A1 (de) 2020-09-24 2022-03-24 Dr. Johannes Heidenhain Gmbh Vorrichtung und Verfahren zur Bestimmung der Intensität des in einem planaren Wellenleiter geführten Lichts IWG(x, y)
DE102020212029A1 (de) 2020-09-24 2022-03-24 Dr. Johannes Heidenhain Gmbh Vorrichtung und Verfahren zur simultanen Abbildung zweier Objektebenen
EP4264358A1 (de) * 2020-12-29 2023-10-25 Interherence GmbH Opto-elektronischer chip
EP4155709A1 (en) 2021-09-28 2023-03-29 Bayer AG On-line biomolecular interaction analysis for monitoring or controlling bioprocesses
WO2023187077A1 (en) 2022-03-30 2023-10-05 Miltenyi Biotec B.V. & Co. KG Parallelized optical biomolecule interaction analysis
EP4306940A1 (en) 2022-07-15 2024-01-17 lino Biotech AG Device for use in the detection of binding affinities

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4647544A (en) 1984-06-25 1987-03-03 Nicoli David F Immunoassay using optical interference detection
JP3162448B2 (ja) 1991-12-19 2001-04-25 松下電工株式会社 システム天井
JPH05172732A (ja) 1991-12-25 1993-07-09 Hitachi Electron Eng Co Ltd 液体中微粒子検出装置およびその検出方法
US6211954B1 (en) * 1996-03-30 2001-04-03 Novartis Ag Integrated optical luminescence sensor
US6586193B2 (en) * 1996-04-25 2003-07-01 Genicon Sciences Corporation Analyte assay using particulate labels
WO1998009156A1 (en) * 1996-08-29 1998-03-05 Novartis Ag Optical chemical / biochemical sensor
SE514512C2 (sv) * 1999-07-02 2001-03-05 Proximion Fiber Optics Ab Förfarande och anordning för koppling av ljus
PT1192448E (pt) * 1999-07-05 2007-01-31 Novartis Ag Processo para a utilização de uma plataforma de sensor
US6510263B1 (en) 2000-01-27 2003-01-21 Unaxis Balzers Aktiengesellschaft Waveguide plate and process for its production and microtitre plate
US6951715B2 (en) * 2000-10-30 2005-10-04 Sru Biosystems, Inc. Optical detection of label-free biomolecular interactions using microreplicated plastic sensor elements
US7264973B2 (en) * 2000-10-30 2007-09-04 Sru Biosystems, Inc. Label-free methods for performing assays using a colorimetric resonant optical biosensor
US20040186359A1 (en) * 2001-07-09 2004-09-23 Beaudoin Stephen P. Afinity biosensor for monitoring biological process
JP2003194697A (ja) * 2001-12-27 2003-07-09 Canon Inc グレーティングカップラを有する探針及びその製造方法、該探針を有するプローブ、及び該プローブを有する情報処理装置、表面観察装置、露光装置、該露光装置による光学素子
US6829073B1 (en) * 2003-10-20 2004-12-07 Corning Incorporated Optical reading system and method for spectral multiplexing of resonant waveguide gratings
US7319525B2 (en) * 2003-11-06 2008-01-15 Fortebio, Inc. Fiber-optic assay apparatus based on phase-shift interferometry
US7233391B2 (en) * 2003-11-21 2007-06-19 Perkinelmer Las, Inc. Optical device integrated with well
US7560708B2 (en) * 2005-07-18 2009-07-14 Koninklijke Philips Electronics N.V. Luminescence sensor using multi-layer substrate structure
JP2008014732A (ja) * 2006-07-04 2008-01-24 Tohoku Univ 表面プラズモン共鳴測定装置
US20100053610A1 (en) * 2008-08-29 2010-03-04 Kwangyeol Lee System and method for detecting molecules
EP2741074A1 (en) * 2012-12-04 2014-06-11 F. Hoffmann-La Roche AG Device for use in the detection of binding affinities
EP2757374A1 (en) * 2013-01-17 2014-07-23 F. Hoffmann-La Roche AG Method for preparing an outer surface of a planar waveguide to be capable of binding target samples along a plurality of predetermined lines and a planar waveguide
EP2824446A1 (en) * 2013-07-12 2015-01-14 F. Hoffmann-La Roche AG Device for use in the detection of binding affinities
EP2827130A1 (en) * 2013-07-15 2015-01-21 F. Hoffmann-La Roche AG Device for use in the detection of binding affinities

Also Published As

Publication number Publication date
RU2609184C2 (ru) 2017-01-30
HK1199304A1 (en) 2015-06-26
CN104115000A (zh) 2014-10-22
US10684227B2 (en) 2020-06-16
JP2015503757A (ja) 2015-02-02
WO2013107811A1 (en) 2013-07-25
US10006866B2 (en) 2018-06-26
EP2805149B1 (en) 2021-12-08
KR20140114364A (ko) 2014-09-26
KR102050118B1 (ko) 2019-11-28
US20180364174A1 (en) 2018-12-20
RU2014133427A (ru) 2016-03-10
EP2805149A1 (en) 2014-11-26
BR112014017474A2 (pt) 2017-06-13
CA2860104A1 (en) 2013-07-25
US20140363901A1 (en) 2014-12-11
JP6202401B2 (ja) 2017-09-27
CA2860104C (en) 2020-02-25
MX2014008372A (es) 2014-09-26
EP2618130A1 (en) 2013-07-24
BR112014017474B1 (pt) 2020-11-10
CN104115000B (zh) 2016-11-23

Similar Documents

Publication Publication Date Title
BR112014017474A8 (pt) dispositivo para uso na detecção de afinidades de ligação
BR112015007717A2 (pt) dispositivo para uso na detecção de afinidades de ligação
EP3807620A4 (en) MEASUREMENT TECHNOLOGY FOR REFRACTION INDEXINHOMOGENITY BETWEEN PLATES OF AN OPTICAL LIGHT GUIDE ELEMENT (LOE)
AR091335A1 (es) Metodos y dispositivos para determinar opticamente una caracteristica de una sustancia
AR090687A1 (es) Metodos y dispositivos para determinar opticamente una caracteristica de una sustancia
BR112015028926A2 (pt) dispositivo para uso na detecção de afinidades de ligação
BR112017013680A2 (pt) sistema óptico
PL430153A1 (pl) Interferometr falowodowy
BR112015001310A2 (pt) analisador de característica portátil
BR112014027286A2 (pt) sensor para sensoreamento de uma amostra, espectroscópio de ressonância paramagnética de elétron, e, sistema de medição
BRPI0909791A8 (pt) Cartucho, dispositivo sensor e método para detecção de componentes alvo em uma amostra líquida, e, uso do cartucho ou do dispositivo sensor.
AR091336A1 (es) Metodos y dispositivos para determinar opticamente una caracteristica de una sustancia
BR112013033211A2 (pt) sistema de medição ótico com unidade de filtro para extrair radiação eletromagnética
BR112014031981A2 (pt) método para a visualização de um lúmen ramificado; e sistema para o monitoramento de um vaso sanguíneo
BR112014007440A2 (pt) lâmina de reagentes unificada e métodos para detectar a presença ou ausência de ponta de pipeta dentro da bainha de pipeta e para determinar o comprimento de ponta de pipeta dentro de bainha de pipeta da mesma
EA201492196A1 (ru) Оптический датчик на основе микроэлектромеханической системы
BR112014021206A2 (pt) Sistemas e métodos de localizador de colar de revestimento ópticos
BR112014002109A2 (pt) sensor de fibra ótica e método para aderir uma fibra ótica a um substrato
BR112015015950A2 (pt) sistemas e métodos do sensor de deformação a laser em fibra com realimentação distribuída para monitoramento de campo em de subsuperfície
BR112013001060A2 (pt) dispositivo de detecção
JP2018530013A5 (pt)
BR112013029795A2 (pt) dispositivo de acoplamento para condutor de fibra óptica
FR3014169B1 (fr) Guides d'ondes optiques d'eclairage d'une jauge a 360°
MX351922B (es) Dispositivo para el uso en la detección de afinidades de unión.
MX2021008133A (es) Guias de ondas opticas y acopladores para suministrar luz a un conjunto de elementos fotonicos.

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 17/01/2013, OBSERVADAS AS CONDICOES LEGAIS.