BR112014017474A2 - dispositivo para uso na detecção de afinidades de ligação - Google Patents

dispositivo para uso na detecção de afinidades de ligação

Info

Publication number
BR112014017474A2
BR112014017474A2 BR112014017474A BR112014017474A BR112014017474A2 BR 112014017474 A2 BR112014017474 A2 BR 112014017474A2 BR 112014017474 A BR112014017474 A BR 112014017474A BR 112014017474 A BR112014017474 A BR 112014017474A BR 112014017474 A2 BR112014017474 A2 BR 112014017474A2
Authority
BR
Brazil
Prior art keywords
flat waveguide
binding sites
binding
binding affinities
detecting binding
Prior art date
Application number
BR112014017474A
Other languages
English (en)
Other versions
BR112014017474B1 (pt
BR112014017474A8 (pt
Inventor
Fattinger Christof
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR112014017474A2 publication Critical patent/BR112014017474A2/pt
Publication of BR112014017474A8 publication Critical patent/BR112014017474A8/pt
Publication of BR112014017474B1 publication Critical patent/BR112014017474B1/pt

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/55—Specular reflectivity
    • G01N21/552—Attenuated total reflection
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
    • G01N21/774—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides the reagent being on a grating or periodic structure
    • G01N21/7743—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides the reagent being on a grating or periodic structure the reagent-coated grating coupling light in or out of the waveguide
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Plasma & Fusion (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Optical Integrated Circuits (AREA)

Abstract

resumo patente de invenção: "dispositivo para uso na detecção de afinidades de ligação". trata-se de um dispositivo para uso na detecção de afinidades de ligação que compreende um guia de onda plano (2) disposto em um substrato (3) e um acoplador óptico (4) para acoplar luz coerente (1) de um comprimento de onda predeterminado para o interior do guia de onda plano. a luz coerente se propaga através do guia de onda plano (2) com um campo evanescente (6) que se propaga ao longo de uma superfície externa (5) do guia de onda plano. a superfície externa (5) do guia de onda plano compreende sítios de ligação (7) na mesma capazes de ligar amostras-alvo (8) aos sítios de ligação (7) de modo que a luz do campo evanescente (6) seja espalhada pelas amostras-alvo (8) ligadas aos sítios de ligação (7). os sítios de ligação (7) são dispostos ao longo de uma pluralidade de linhas predeterminadas (9) que são dispostas de modo que a luz espalhada interfira de modo construtivo em uma localização de detecção predeterminada com uma diferença em comprimento de trajetória óptica que é um número inteiro múltiplo do comprimento de onda predeterminado. 21817378v1 1/1 21817378v1
BR112014017474-1A 2012-01-17 2013-01-17 sistema e dispositivo para uso na detecção de afinidades de ligação BR112014017474B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12151436.8A EP2618130A1 (en) 2012-01-17 2012-01-17 Device for use in the detection of binding affinities
EP12151436.8 2012-01-17
PCT/EP2013/050825 WO2013107811A1 (en) 2012-01-17 2013-01-17 Device for use in the detection of binding affinities

Publications (3)

Publication Number Publication Date
BR112014017474A2 true BR112014017474A2 (pt) 2017-06-13
BR112014017474A8 BR112014017474A8 (pt) 2017-07-04
BR112014017474B1 BR112014017474B1 (pt) 2020-11-10

Family

ID=47628121

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014017474-1A BR112014017474B1 (pt) 2012-01-17 2013-01-17 sistema e dispositivo para uso na detecção de afinidades de ligação

Country Status (11)

Country Link
US (2) US10006866B2 (pt)
EP (2) EP2618130A1 (pt)
JP (1) JP6202401B2 (pt)
KR (1) KR102050118B1 (pt)
CN (1) CN104115000B (pt)
BR (1) BR112014017474B1 (pt)
CA (1) CA2860104C (pt)
HK (1) HK1199304A1 (pt)
MX (1) MX2014008372A (pt)
RU (1) RU2609184C2 (pt)
WO (1) WO2013107811A1 (pt)

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EP2824446A1 (en) * 2013-07-12 2015-01-14 F. Hoffmann-La Roche AG Device for use in the detection of binding affinities
EP2827130A1 (en) * 2013-07-15 2015-01-21 F. Hoffmann-La Roche AG Device for use in the detection of binding affinities
EP3040750A1 (en) * 2014-12-29 2016-07-06 IMEC vzw Device and method for performing lens-free imaging
US10564362B2 (en) * 2014-12-29 2020-02-18 Imec Vzw Light coupler with microstructures asymmetrically distributed along longitudinal axis
JP6538844B2 (ja) 2015-07-07 2019-07-03 古野電気株式会社 検体測定用チップ、検体測定装置、および検体測定方法
KR101754774B1 (ko) * 2015-12-29 2017-07-06 주식회사 스칼라팍스트롯 바이오 칩 및 바이오 칩의 제조 방법
EP3205512B1 (en) 2016-02-09 2018-06-13 CSEM Centre Suisse d'Electronique et de Microtechnique SA - Recherche et Développement Optical security device
WO2018143474A1 (ja) * 2017-02-06 2018-08-09 Tdk株式会社 光導波型センサーおよび物質検出方法
DE102017211910A1 (de) 2017-07-12 2019-01-17 Dr. Johannes Heidenhain Gmbh Diffraktiver Biosensor
EP3692399B1 (en) 2017-10-02 2023-06-07 CSEM Centre Suisse d'Electronique et de Microtechnique SA - Recherche et Développement Resonant waveguide grating and applications thereof
EP3759470B1 (en) * 2018-03-01 2023-06-28 F. Hoffmann-La Roche AG System for use in the detection of binding affinities
CN112424584A (zh) 2018-07-18 2021-02-26 约翰内斯·海德汉博士有限公司 衍射生物传感器
KR102080688B1 (ko) * 2018-10-23 2020-02-24 인하대학교 산학협력단 격자 결합기
RU2700584C1 (ru) * 2018-12-13 2019-09-18 Общество С Ограниченной Ответственностью "Апто-Фарм" Способ оценки сродства олигонуклеотида
CN114341623A (zh) * 2019-09-17 2022-04-12 豪夫迈·罗氏有限公司 生物分子检测装置
DE102019134172A1 (de) 2019-12-12 2021-06-17 Dr. Johannes Heidenhain Gmbh Vorrichtung und Verfahren zur Einkopplung von Licht mit verschiedenen Wellenlängen in einen Wellenleiter
DE102020212031A1 (de) * 2020-09-24 2022-03-24 Dr. Johannes Heidenhain Gmbh Vorrichtung und Verfahren zur Bestimmung der Intensität des in einem planaren Wellenleiter geführten Lichts IWG(x, y)
DE102020212029A1 (de) 2020-09-24 2022-03-24 Dr. Johannes Heidenhain Gmbh Vorrichtung und Verfahren zur simultanen Abbildung zweier Objektebenen
WO2022144102A1 (de) * 2020-12-29 2022-07-07 Interherence GmbH Opto-elektronischer chip
EP4155709A1 (en) 2021-09-28 2023-03-29 Bayer AG On-line biomolecular interaction analysis for monitoring or controlling bioprocesses
WO2023187077A1 (en) 2022-03-30 2023-10-05 Miltenyi Biotec B.V. & Co. KG Parallelized optical biomolecule interaction analysis
EP4306940A1 (en) 2022-07-15 2024-01-17 lino Biotech AG Device for use in the detection of binding affinities

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US4647544A (en) * 1984-06-25 1987-03-03 Nicoli David F Immunoassay using optical interference detection
JP3162448B2 (ja) 1991-12-19 2001-04-25 松下電工株式会社 システム天井
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EP2741074A1 (en) * 2012-12-04 2014-06-11 F. Hoffmann-La Roche AG Device for use in the detection of binding affinities
EP2757374A1 (en) * 2013-01-17 2014-07-23 F. Hoffmann-La Roche AG Method for preparing an outer surface of a planar waveguide to be capable of binding target samples along a plurality of predetermined lines and a planar waveguide
EP2824446A1 (en) * 2013-07-12 2015-01-14 F. Hoffmann-La Roche AG Device for use in the detection of binding affinities
EP2827130A1 (en) * 2013-07-15 2015-01-21 F. Hoffmann-La Roche AG Device for use in the detection of binding affinities

Also Published As

Publication number Publication date
US20140363901A1 (en) 2014-12-11
US10684227B2 (en) 2020-06-16
CA2860104C (en) 2020-02-25
EP2805149B1 (en) 2021-12-08
EP2618130A1 (en) 2013-07-24
HK1199304A1 (en) 2015-06-26
RU2014133427A (ru) 2016-03-10
CN104115000B (zh) 2016-11-23
JP2015503757A (ja) 2015-02-02
CN104115000A (zh) 2014-10-22
CA2860104A1 (en) 2013-07-25
MX2014008372A (es) 2014-09-26
BR112014017474B1 (pt) 2020-11-10
BR112014017474A8 (pt) 2017-07-04
WO2013107811A1 (en) 2013-07-25
KR20140114364A (ko) 2014-09-26
US20180364174A1 (en) 2018-12-20
RU2609184C2 (ru) 2017-01-30
KR102050118B1 (ko) 2019-11-28
EP2805149A1 (en) 2014-11-26
US10006866B2 (en) 2018-06-26
JP6202401B2 (ja) 2017-09-27

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 17/01/2013, OBSERVADAS AS CONDICOES LEGAIS.