BR112014017474A2 - device for use in detecting binding affinities - Google Patents

device for use in detecting binding affinities

Info

Publication number
BR112014017474A2
BR112014017474A2 BR112014017474A BR112014017474A BR112014017474A2 BR 112014017474 A2 BR112014017474 A2 BR 112014017474A2 BR 112014017474 A BR112014017474 A BR 112014017474A BR 112014017474 A BR112014017474 A BR 112014017474A BR 112014017474 A2 BR112014017474 A2 BR 112014017474A2
Authority
BR
Brazil
Prior art keywords
flat waveguide
binding sites
binding
binding affinities
detecting binding
Prior art date
Application number
BR112014017474A
Other languages
Portuguese (pt)
Other versions
BR112014017474B1 (en
BR112014017474A8 (en
Inventor
Fattinger Christof
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR112014017474A2 publication Critical patent/BR112014017474A2/en
Publication of BR112014017474A8 publication Critical patent/BR112014017474A8/en
Publication of BR112014017474B1 publication Critical patent/BR112014017474B1/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/55—Specular reflectivity
    • G01N21/552—Attenuated total reflection
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
    • G01N21/774—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides the reagent being on a grating or periodic structure
    • G01N21/7743—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides the reagent being on a grating or periodic structure the reagent-coated grating coupling light in or out of the waveguide
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings

Abstract

resumo patente de invenção: "dispositivo para uso na detecção de afinidades de ligação". trata-se de um dispositivo para uso na detecção de afinidades de ligação que compreende um guia de onda plano (2) disposto em um substrato (3) e um acoplador óptico (4) para acoplar luz coerente (1) de um comprimento de onda predeterminado para o interior do guia de onda plano. a luz coerente se propaga através do guia de onda plano (2) com um campo evanescente (6) que se propaga ao longo de uma superfície externa (5) do guia de onda plano. a superfície externa (5) do guia de onda plano compreende sítios de ligação (7) na mesma capazes de ligar amostras-alvo (8) aos sítios de ligação (7) de modo que a luz do campo evanescente (6) seja espalhada pelas amostras-alvo (8) ligadas aos sítios de ligação (7). os sítios de ligação (7) são dispostos ao longo de uma pluralidade de linhas predeterminadas (9) que são dispostas de modo que a luz espalhada interfira de modo construtivo em uma localização de detecção predeterminada com uma diferença em comprimento de trajetória óptica que é um número inteiro múltiplo do comprimento de onda predeterminado. 21817378v1 1/1 21817378v1patent summary: "device for use in detecting binding affinities". It is a device for use in detecting binding affinities which comprises a flat waveguide (2) disposed on a substrate (3) and an optical coupler (4) for coupling coherent light (1) of a wavelength. within the flat waveguide. coherent light propagates through the flat waveguide (2) with an evanescent field (6) that propagates along an outer surface (5) of the flat waveguide. the outer surface (5) of the flat waveguide comprises binding sites (7) therein capable of binding target samples (8) to the binding sites (7) so that the evanescent field light (6) is scattered throughout target samples (8) linked to the binding sites (7). the binding sites (7) are arranged along a plurality of predetermined lines (9) which are arranged so that scattered light constructively interferes with a predetermined sensing location with a difference in optical path length which is a multiple integer of the predetermined wavelength. 21817378v1 1/1 21817378v1

BR112014017474-1A 2012-01-17 2013-01-17 system and device for use in detecting binding affinities BR112014017474B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12151436.8A EP2618130A1 (en) 2012-01-17 2012-01-17 Device for use in the detection of binding affinities
EP12151436.8 2012-01-17
PCT/EP2013/050825 WO2013107811A1 (en) 2012-01-17 2013-01-17 Device for use in the detection of binding affinities

Publications (3)

Publication Number Publication Date
BR112014017474A2 true BR112014017474A2 (en) 2017-06-13
BR112014017474A8 BR112014017474A8 (en) 2017-07-04
BR112014017474B1 BR112014017474B1 (en) 2020-11-10

Family

ID=47628121

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014017474-1A BR112014017474B1 (en) 2012-01-17 2013-01-17 system and device for use in detecting binding affinities

Country Status (11)

Country Link
US (2) US10006866B2 (en)
EP (2) EP2618130A1 (en)
JP (1) JP6202401B2 (en)
KR (1) KR102050118B1 (en)
CN (1) CN104115000B (en)
BR (1) BR112014017474B1 (en)
CA (1) CA2860104C (en)
HK (1) HK1199304A1 (en)
MX (1) MX2014008372A (en)
RU (1) RU2609184C2 (en)
WO (1) WO2013107811A1 (en)

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EP2827130A1 (en) * 2013-07-15 2015-01-21 F. Hoffmann-La Roche AG Device for use in the detection of binding affinities
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KR101754774B1 (en) * 2015-12-29 2017-07-06 주식회사 스칼라팍스트롯 Biochip and Method of manufacturing the Biochip
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WO2018143474A1 (en) * 2017-02-06 2018-08-09 Tdk株式会社 Optical-waveguide-type sensor, and substance detection method
DE102017211910A1 (en) 2017-07-12 2019-01-17 Dr. Johannes Heidenhain Gmbh Diffractive biosensor
CN111512189B (en) 2017-10-02 2023-02-21 瑞士Csem电子显微技术研发中心 Resonant waveguide grating and application thereof
CN111788473A (en) * 2018-03-01 2020-10-16 弗·哈夫曼-拉罗切有限公司 Device for detecting binding affinity
US20210270736A1 (en) * 2018-07-18 2021-09-02 Dr. Johannes Heidenhain Gmbh Diffractive biosensor
KR102080688B1 (en) * 2018-10-23 2020-02-24 인하대학교 산학협력단 Grating coupler
RU2700584C1 (en) * 2018-12-13 2019-09-18 Общество С Ограниченной Ответственностью "Апто-Фарм" Method for assessing the affinity of an oligonucleotide
CN114341623A (en) * 2019-09-17 2022-04-12 豪夫迈·罗氏有限公司 Biomolecule detection device
DE102019134172A1 (en) 2019-12-12 2021-06-17 Dr. Johannes Heidenhain Gmbh Device and method for coupling light with different wavelengths into a waveguide
DE102020212029A1 (en) 2020-09-24 2022-03-24 Dr. Johannes Heidenhain Gmbh Device and method for the simultaneous imaging of two object planes
DE102020212031A1 (en) 2020-09-24 2022-03-24 Dr. Johannes Heidenhain Gmbh Device and method for determining the intensity of light guided in a planar waveguide IWG(x, y)
WO2022144102A1 (en) * 2020-12-29 2022-07-07 Interherence GmbH Optoelectronic chip
EP4155709A1 (en) 2021-09-28 2023-03-29 Bayer AG On-line biomolecular interaction analysis for monitoring or controlling bioprocesses
WO2023187078A1 (en) 2022-03-30 2023-10-05 Miltenyi Biotec B.V. & Co. KG White light scattering in optical biomolecule interaction analysis
EP4306940A1 (en) 2022-07-15 2024-01-17 lino Biotech AG Device for use in the detection of binding affinities

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Also Published As

Publication number Publication date
WO2013107811A1 (en) 2013-07-25
KR20140114364A (en) 2014-09-26
RU2609184C2 (en) 2017-01-30
US20180364174A1 (en) 2018-12-20
CA2860104C (en) 2020-02-25
EP2805149B1 (en) 2021-12-08
BR112014017474B1 (en) 2020-11-10
MX2014008372A (en) 2014-09-26
RU2014133427A (en) 2016-03-10
CN104115000B (en) 2016-11-23
JP2015503757A (en) 2015-02-02
CN104115000A (en) 2014-10-22
JP6202401B2 (en) 2017-09-27
US20140363901A1 (en) 2014-12-11
EP2805149A1 (en) 2014-11-26
CA2860104A1 (en) 2013-07-25
EP2618130A1 (en) 2013-07-24
HK1199304A1 (en) 2015-06-26
US10684227B2 (en) 2020-06-16
US10006866B2 (en) 2018-06-26
KR102050118B1 (en) 2019-11-28
BR112014017474A8 (en) 2017-07-04

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 17/01/2013, OBSERVADAS AS CONDICOES LEGAIS.