MX351922B - Dispositivo para el uso en la detección de afinidades de unión. - Google Patents
Dispositivo para el uso en la detección de afinidades de unión.Info
- Publication number
- MX351922B MX351922B MX2016000420A MX2016000420A MX351922B MX 351922 B MX351922 B MX 351922B MX 2016000420 A MX2016000420 A MX 2016000420A MX 2016000420 A MX2016000420 A MX 2016000420A MX 351922 B MX351922 B MX 351922B
- Authority
- MX
- Mexico
- Prior art keywords
- detection
- coherent light
- binding sites
- binding
- diffracted
- Prior art date
Links
- 238000001514 detection method Methods 0.000 title abstract 4
- 230000001427 coherent effect Effects 0.000 abstract 3
- 239000000758 substrate Substances 0.000 abstract 2
- 230000003287 optical effect Effects 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/47—Scattering, i.e. diffuse reflection
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/648—Specially adapted constructive features of fluorimeters using evanescent coupling or surface plasmon coupling for the excitation of fluorescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Inorganic Chemistry (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Length Measuring Devices By Optical Means (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Optical Transform (AREA)
Abstract
La presente invención se relaciona con un dispositivo para el uso en la detección de las afinidades de unión, que comprende un sustrato (2) desprovisto de una guía de onda. El sustrato (2) tiene una superficie plana (21) que tiene arreglados en la misma una pluralidad de sitios de unión (31) capaces de unir con una molécula blanco (32). Los sitios de unión (31) se arreglan a lo largo de una pluralidad de líneas curvadas arregladas adyacentemente (4). Las líneas se espacian entre sí por una distancia para, en operación, causar que un haz de luz coherente (51) de una longitud de onda predeterminada incidente sobre los sitios de unión (31) con la molécula blanco unida (32) se difracte, de manera que las porciones difractadas (61) interfieran en una ubicación de detección predeterminada (62) con una diferencia en la longitud de ruta óptica, que es un entero múltiplo de la longitud de onda predeterminada de la luz coherente. El dispositivo además comprende una parada de haz (7) arreglado para prevenir la propagación de porciones no difractadas (63) del haz incidente de luz coherente (51) a la ubicación de detección (62).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13176536.4A EP2827130A1 (en) | 2013-07-15 | 2013-07-15 | Device for use in the detection of binding affinities |
PCT/EP2014/065013 WO2015007674A1 (en) | 2013-07-15 | 2014-07-14 | Device for use in the detection of binding affinities |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2016000420A MX2016000420A (es) | 2016-05-12 |
MX351922B true MX351922B (es) | 2017-11-03 |
Family
ID=48915826
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2016000420A MX351922B (es) | 2013-07-15 | 2014-07-14 | Dispositivo para el uso en la detección de afinidades de unión. |
Country Status (11)
Country | Link |
---|---|
US (1) | US20160139115A1 (es) |
EP (2) | EP2827130A1 (es) |
JP (1) | JP6432845B2 (es) |
KR (1) | KR102254596B1 (es) |
CN (1) | CN105378462B (es) |
BR (1) | BR112016000518B1 (es) |
CA (1) | CA2917985C (es) |
HK (1) | HK1221769A1 (es) |
MX (1) | MX351922B (es) |
RU (1) | RU2655958C2 (es) |
WO (1) | WO2015007674A1 (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2618130A1 (en) * | 2012-01-17 | 2013-07-24 | F. Hoffmann-La Roche AG | Device for use in the detection of binding affinities |
WO2019166562A1 (en) | 2018-03-01 | 2019-09-06 | F. Hoffmann-La Roche Ag | Device for use in the detection of binding affinities |
US20220298555A1 (en) * | 2018-12-20 | 2022-09-22 | Roche Molecular Systems, Inc. | Detection of target nucleic acid by solid-phase molography |
ES2749689B2 (es) | 2019-07-17 | 2020-12-16 | Univ Valencia Politecnica | Dispositivo difractivo de analisis quimico y biologico |
US20240083974A1 (en) * | 2019-10-15 | 2024-03-14 | ETH Zürich | Artificial Transmembrane Proteins for Detecting Intracellular or Intravesicular Biomolecular Interactions |
WO2023187078A1 (en) | 2022-03-30 | 2023-10-05 | Miltenyi Biotec B.V. & Co. KG | White light scattering in optical biomolecule interaction analysis |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1984002578A1 (en) * | 1982-12-21 | 1984-07-05 | Comtech Res Unit | Assay technique |
US4647544A (en) * | 1984-06-25 | 1987-03-03 | Nicoli David F | Immunoassay using optical interference detection |
GB8423204D0 (en) * | 1984-09-14 | 1984-10-17 | Comtech Res Unit | Assay technique and equipment |
US4876208A (en) * | 1987-01-30 | 1989-10-24 | Yellowstone Diagnostics Corporation | Diffraction immunoassay apparatus and method |
US5061076A (en) * | 1989-01-31 | 1991-10-29 | Enzo Diagnostics, Inc. | Time-resolved fluorometer |
CA1337173C (en) * | 1989-04-28 | 1995-10-03 | Westaim Biomedical Corp. | Thin film diagnostic device |
US5413939A (en) * | 1993-06-29 | 1995-05-09 | First Medical, Inc. | Solid-phase binding assay system for interferometrically measuring analytes bound to an active receptor |
US6586193B2 (en) * | 1996-04-25 | 2003-07-01 | Genicon Sciences Corporation | Analyte assay using particulate labels |
AU736340B2 (en) * | 1996-04-25 | 2001-07-26 | Genicon Sciences Corporation | Analyte assay using particulate labels |
ATE244883T1 (de) * | 1999-09-15 | 2003-07-15 | Suisse Electronique Microtech | Integriert-optischer sensor |
JP4999249B2 (ja) * | 2000-03-22 | 2012-08-15 | アクセラ インコーポレーテッド | 複数アナライトのアッセイ方法およびアッセイ装置 |
WO2003005890A2 (en) * | 2001-07-09 | 2003-01-23 | Arizona Board Of Regents A Body Corporate Acting On Behalf Of Arizona State University | Affinity biosensor for monitoring of biological process |
US7098041B2 (en) * | 2001-12-11 | 2006-08-29 | Kimberly-Clark Worldwide, Inc. | Methods to view and analyze the results from diffraction-based diagnostics |
US20060078890A1 (en) * | 2004-10-08 | 2006-04-13 | Ole Isacson | Methods for identifying parkinson's disease therapeutics |
WO2009013706A2 (en) * | 2007-07-26 | 2009-01-29 | Koninklijke Philips Electronics N. V. | Microelectronic sensor device for optical examinations with total internal reflection |
CN101809445A (zh) * | 2007-09-28 | 2010-08-18 | 皇家飞利浦电子股份有限公司 | 用于检测目标成分的传感器设备 |
FR2935804B1 (fr) * | 2008-09-11 | 2012-11-02 | Innopsys | Procede de recherche d'au moins un analyte dans un milieu susceptible de le contenir |
EP2618130A1 (en) * | 2012-01-17 | 2013-07-24 | F. Hoffmann-La Roche AG | Device for use in the detection of binding affinities |
-
2013
- 2013-07-15 EP EP13176536.4A patent/EP2827130A1/en not_active Ceased
-
2014
- 2014-07-14 BR BR112016000518-0A patent/BR112016000518B1/pt active IP Right Grant
- 2014-07-14 MX MX2016000420A patent/MX351922B/es active IP Right Grant
- 2014-07-14 EP EP14738835.9A patent/EP3022547B1/en active Active
- 2014-07-14 CA CA2917985A patent/CA2917985C/en active Active
- 2014-07-14 CN CN201480039852.XA patent/CN105378462B/zh active Active
- 2014-07-14 KR KR1020167003574A patent/KR102254596B1/ko active IP Right Grant
- 2014-07-14 WO PCT/EP2014/065013 patent/WO2015007674A1/en active Application Filing
- 2014-07-14 US US14/904,923 patent/US20160139115A1/en not_active Abandoned
- 2014-07-14 RU RU2016104220A patent/RU2655958C2/ru active
- 2014-07-14 JP JP2016526559A patent/JP6432845B2/ja active Active
-
2016
- 2016-08-19 HK HK16109951.0A patent/HK1221769A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
RU2016104220A (ru) | 2017-08-18 |
HK1221769A1 (zh) | 2017-06-09 |
CN105378462A (zh) | 2016-03-02 |
BR112016000518B1 (pt) | 2020-10-13 |
WO2015007674A1 (en) | 2015-01-22 |
CA2917985A1 (en) | 2015-01-22 |
JP2016526690A (ja) | 2016-09-05 |
EP3022547B1 (en) | 2018-12-12 |
EP3022547A1 (en) | 2016-05-25 |
RU2655958C2 (ru) | 2018-05-30 |
CN105378462B (zh) | 2019-01-25 |
US20160139115A1 (en) | 2016-05-19 |
RU2016104220A3 (es) | 2018-03-27 |
KR20160033142A (ko) | 2016-03-25 |
MX2016000420A (es) | 2016-05-12 |
KR102254596B1 (ko) | 2021-05-24 |
EP2827130A1 (en) | 2015-01-21 |
JP6432845B2 (ja) | 2018-12-05 |
CA2917985C (en) | 2023-01-03 |
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Legal Events
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FG | Grant or registration |