BR112016012347A2 - Dispositivo óptico para o processamento de luz de entrada, aparelho de detecção, método para o processamento de luz de entrada, e, uso do dispositivo óptico - Google Patents

Dispositivo óptico para o processamento de luz de entrada, aparelho de detecção, método para o processamento de luz de entrada, e, uso do dispositivo óptico Download PDF

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Publication number
BR112016012347A2
BR112016012347A2 BR112016012347-6A BR112016012347A BR112016012347A2 BR 112016012347 A2 BR112016012347 A2 BR 112016012347A2 BR 112016012347 A BR112016012347 A BR 112016012347A BR 112016012347 A2 BR112016012347 A2 BR 112016012347A2
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BR
Brazil
Prior art keywords
optical device
input light
processing input
openings
substrate
Prior art date
Application number
BR112016012347-6A
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English (en)
Other versions
BR112016012347B1 (pt
Inventor
Joseph Hubertina Barbara Schleipen Johannes
Wimberger-Friedl Reinhold
Jan Van Der Zaag Pieter
Paul Urbach Hendrik
Sarkar Mitradeep
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Koninklijke Philips N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Koninklijke Philips N.V. filed Critical Koninklijke Philips N.V.
Publication of BR112016012347A2 publication Critical patent/BR112016012347A2/pt
Publication of BR112016012347B1 publication Critical patent/BR112016012347B1/pt

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/648—Specially adapted constructive features of fluorimeters using evanescent coupling or surface plasmon coupling for the excitation of fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
    • G01N21/774—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides the reagent being on a grating or periodic structure
    • G01N21/7743—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides the reagent being on a grating or periodic structure the reagent-coated grating coupling light in or out of the waveguide
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N2021/7769—Measurement method of reaction-produced change in sensor
    • G01N2021/7773—Reflection
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N2021/7769—Measurement method of reaction-produced change in sensor
    • G01N2021/7786—Fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/06—Illumination; Optics
    • G01N2201/061—Sources
    • G01N2201/06113—Coherent sources; lasers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/06—Illumination; Optics
    • G01N2201/068—Optics, miscellaneous
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/08—Optical fibres; light guides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • General Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plasma & Fusion (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Diffracting Gratings Or Hologram Optical Elements (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Polarising Elements (AREA)
  • Photometry And Measurement Of Optical Pulse Characteristics (AREA)
  • Optical Integrated Circuits (AREA)

Abstract

a invenção refere-se a um dispositivo óptico (110) e a um aparelho de detecção correspondente (100) que pode, por exemplo, ser usado para monitorar a replicação de sequências de nucleotídeos em uma superfície. em uma modalidade preferencial, o dispositivo óptico (110) compreende um substrato de guia de ondas (130) com uma grade de arame (140) sobre uma superfície de fundo (132), sendo que as aberturas (141) da grade de arame estão em pelo menos uma direção (x) menor que um comprimento de onda característico (¿) de luz de entrada (il). além disso, uma estrutura difrativa (120) é disposta sobre a superfície oposta (131) do substrato (130) para acoplar luz de entrada (il) ao substrato (130) de modo que ocorra interferência construtiva nas aberturas (141). dessa forma, ondas evanescentes podem ser geradas com alta eficiência nessas aberturas, permitindo, por exemplo, uma excitação específica de superfície de fluorescência (fl) que pode ser detectada por um detector (160).
BR112016012347-6A 2013-12-03 2014-11-25 Dispositivo óptico para o processamento de luz de entrada, aparelho de detecção e método para o processamento de luz de entrada BR112016012347B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13195407.5 2013-12-03
EP13195407 2013-12-03
PCT/EP2014/075444 WO2015082247A1 (en) 2013-12-03 2014-11-25 Biosensor comprising waveguide

Publications (2)

Publication Number Publication Date
BR112016012347A2 true BR112016012347A2 (pt) 2020-05-26
BR112016012347B1 BR112016012347B1 (pt) 2020-12-15

Family

ID=49683600

Family Applications (1)

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BR112016012347-6A BR112016012347B1 (pt) 2013-12-03 2014-11-25 Dispositivo óptico para o processamento de luz de entrada, aparelho de detecção e método para o processamento de luz de entrada

Country Status (7)

Country Link
US (1) US10330598B2 (pt)
EP (1) EP3077799B1 (pt)
JP (1) JP6491664B2 (pt)
CN (1) CN105793692B (pt)
BR (1) BR112016012347B1 (pt)
RU (1) RU2687847C1 (pt)
WO (1) WO2015082247A1 (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10119915B2 (en) * 2015-04-09 2018-11-06 Visera Technologies Company Limited Detection device for specimens
EP3669018A4 (en) 2017-08-18 2021-05-26 Nautilus Biotechnology, Inc. Binding reagent selection methods
EP3884048A4 (en) 2018-11-20 2022-08-17 Nautilus Biotechnology, Inc. DESIGN AND SELECTION OF AFFINITY REAGENTS
CN109839365A (zh) * 2019-03-26 2019-06-04 中国计量大学 一种基于硅基中红外亚波长光栅波导的气体传感器
DE102019206361A1 (de) * 2019-05-03 2020-11-05 Audi Ag Spektrometrievorrichtung zur nichtinvasiven Messung von zumindest einem medizinischen Kennwert an einem biologischen Gewebe
CN113109900B (zh) * 2021-03-15 2022-06-07 中国科学院苏州生物医学工程技术研究所 一种集成零模波导芯片及其制备方法
WO2024130117A1 (en) 2022-12-15 2024-06-20 Adaptyx Biosciences, Inc. Systems and methods for analyte detection

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001002839A1 (en) * 1999-07-05 2001-01-11 Novartis Ag Sensor platform, apparatus incorporating the platform, and process using the platform
DE19957682A1 (de) * 1999-12-01 2001-06-07 Deutsche Telekom Ag Vorrichtung zur optischen Spektroskopie und Verfahren zu dessen Herstellung
US20070014017A1 (en) * 2002-12-19 2007-01-18 Oc Oerlikon Balzers Ag Method for generating electromagnetic field distributions
EP1922419A4 (en) 2005-06-10 2010-11-17 Life Technologies Corp METHOD AND SYSTEM FOR GENETIC MULTIPLEX ANALYSIS
CN1940529B (zh) * 2005-09-29 2010-09-01 株式会社东芝 光波导型生物化学传感器芯片及其制造方法
WO2008078264A1 (en) 2006-12-21 2008-07-03 Koninklijke Philips Electronics N.V. Wiregrid waveguide
WO2009001245A1 (en) 2007-06-27 2008-12-31 Koninklijke Philips Electronics N.V. Improved sensors using sub-wavelength apertures or slits.
WO2009107041A1 (en) * 2008-02-25 2009-09-03 Koninklijke Philips Electronics N.V. Optical sensor for measuring emission light from an analyte
CN102150033A (zh) * 2008-09-09 2011-08-10 皇家飞利浦电子股份有限公司 改进的线栅衬底结构和用于制造这种衬底的方法
AU2009292629B2 (en) 2008-09-16 2014-03-20 Pacific Biosciences Of California, Inc. Substrates and optical systems and methods of use thereof
US8367159B2 (en) 2009-09-11 2013-02-05 Pacific Biosciences Of California, Inc. Methods for producing ZMWs with islands of functionality
US8865078B2 (en) * 2010-06-11 2014-10-21 Industrial Technology Research Institute Apparatus for single-molecule detection
US20140080729A1 (en) 2011-03-22 2014-03-20 Research Triangle Institute, International Optical sensing device for sensing analytes and related apparatus and methods

Also Published As

Publication number Publication date
CN105793692B (zh) 2019-09-13
US10330598B2 (en) 2019-06-25
US20160299077A1 (en) 2016-10-13
CN105793692A (zh) 2016-07-20
EP3077799A1 (en) 2016-10-12
EP3077799B1 (en) 2021-01-06
BR112016012347B1 (pt) 2020-12-15
JP6491664B2 (ja) 2019-03-27
JP2017501442A (ja) 2017-01-12
WO2015082247A1 (en) 2015-06-11
RU2687847C1 (ru) 2019-05-16

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B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 25/11/2014, OBSERVADAS AS CONDICOES LEGAIS.

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 9A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2750 DE 19-09-2023 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.