MX2016000420A - Dispositivo para el uso en la deteccion de afinidades de union. - Google Patents

Dispositivo para el uso en la deteccion de afinidades de union.

Info

Publication number
MX2016000420A
MX2016000420A MX2016000420A MX2016000420A MX2016000420A MX 2016000420 A MX2016000420 A MX 2016000420A MX 2016000420 A MX2016000420 A MX 2016000420A MX 2016000420 A MX2016000420 A MX 2016000420A MX 2016000420 A MX2016000420 A MX 2016000420A
Authority
MX
Mexico
Prior art keywords
detection
coherent light
binding sites
binding
diffracted
Prior art date
Application number
MX2016000420A
Other languages
English (en)
Other versions
MX351922B (es
Inventor
Christof Fattinger
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2016000420A publication Critical patent/MX2016000420A/es
Publication of MX351922B publication Critical patent/MX351922B/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/648—Specially adapted constructive features of fluorimeters using evanescent coupling or surface plasmon coupling for the excitation of fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Inorganic Chemistry (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Length Measuring Devices By Optical Means (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Optical Transform (AREA)

Abstract

La presente invención se relaciona con un dispositivo para el uso en la detección de las afinidades de unión, que comprende un sustrato (2) desprovisto de una guía de onda. El sustrato (2) tiene una superficie plana (21) que tiene arreglados en la misma una pluralidad de sitios de unión (31) capaces de unir con una molécula blanco (32). Los sitios de unión (31) se arreglan a lo largo de una pluralidad de líneas curvadas arregladas adyacentemente (4). Las líneas se espacian entre sí por una distancia para, en operación, causar que un haz de luz coherente (51) de una longitud de onda predeterminada incidente sobre los sitios de unión (31) con la molécula blanco unida (32) se difracte, de manera que las porciones difractadas (61) interfieran en una ubicación de detección predeterminada (62) con una diferencia en la longitud de ruta óptica, que es un entero múltiplo de la longitud de onda predeterminada de la luz coherente. El dispositivo además comprende una parada de haz (7) arreglado para prevenir la propagación de porciones no difractadas (63) del haz incidente de luz coherente (51) a la ubicación de detección (62).
MX2016000420A 2013-07-15 2014-07-14 Dispositivo para el uso en la detección de afinidades de unión. MX351922B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13176536.4A EP2827130A1 (en) 2013-07-15 2013-07-15 Device for use in the detection of binding affinities
PCT/EP2014/065013 WO2015007674A1 (en) 2013-07-15 2014-07-14 Device for use in the detection of binding affinities

Publications (2)

Publication Number Publication Date
MX2016000420A true MX2016000420A (es) 2016-05-12
MX351922B MX351922B (es) 2017-11-03

Family

ID=48915826

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016000420A MX351922B (es) 2013-07-15 2014-07-14 Dispositivo para el uso en la detección de afinidades de unión.

Country Status (11)

Country Link
US (1) US20160139115A1 (es)
EP (2) EP2827130A1 (es)
JP (1) JP6432845B2 (es)
KR (1) KR102254596B1 (es)
CN (1) CN105378462B (es)
BR (1) BR112016000518B1 (es)
CA (1) CA2917985C (es)
HK (1) HK1221769A1 (es)
MX (1) MX351922B (es)
RU (1) RU2655958C2 (es)
WO (1) WO2015007674A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2618130A1 (en) 2012-01-17 2013-07-24 F. Hoffmann-La Roche AG Device for use in the detection of binding affinities
CN111788473B (zh) * 2018-03-01 2024-09-06 弗·哈夫曼-拉罗切有限公司 用于检测结合亲和力的装置
WO2020127620A1 (en) 2018-12-20 2020-06-25 F. Hoffmann-La Roche Ag Detection of target nucleic acid by solid-phase molography
ES2749689B2 (es) 2019-07-17 2020-12-16 Univ Valencia Politecnica Dispositivo difractivo de analisis quimico y biologico
EP4045916A1 (en) * 2019-10-15 2022-08-24 ETH Zürich Artificial transmembrane proteins for detecting intracellular or intravesicular biomolecular interactions
WO2023187077A1 (en) 2022-03-30 2023-10-05 Miltenyi Biotec B.V. & Co. KG Parallelized optical biomolecule interaction analysis

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0112721B1 (en) * 1982-12-21 1988-05-18 Ares-Serono N.V. Assay technique
US4647544A (en) * 1984-06-25 1987-03-03 Nicoli David F Immunoassay using optical interference detection
GB8423204D0 (en) * 1984-09-14 1984-10-17 Comtech Res Unit Assay technique and equipment
US4876208A (en) * 1987-01-30 1989-10-24 Yellowstone Diagnostics Corporation Diffraction immunoassay apparatus and method
US5061076A (en) * 1989-01-31 1991-10-29 Enzo Diagnostics, Inc. Time-resolved fluorometer
CA1337173C (en) * 1989-04-28 1995-10-03 Westaim Biomedical Corp. Thin film diagnostic device
US5413939A (en) 1993-06-29 1995-05-09 First Medical, Inc. Solid-phase binding assay system for interferometrically measuring analytes bound to an active receptor
JP2000510582A (ja) * 1996-04-25 2000-08-15 ゼニコン・サイエンシーズ・コーポレーション 微粒子標識を使用した分析物アッセイ
US6586193B2 (en) * 1996-04-25 2003-07-01 Genicon Sciences Corporation Analyte assay using particulate labels
DE69909480T2 (de) * 1999-09-15 2004-04-15 Csem Centre Suisse D'electronique Et De Microtechnique S.A. Integriert-optischer Sensor
CA2403427C (en) * 2000-03-22 2013-04-30 M. Cynthia Goh Method and apparatus for assay for multiple analytes
US20040186359A1 (en) * 2001-07-09 2004-09-23 Beaudoin Stephen P. Afinity biosensor for monitoring biological process
US7098041B2 (en) * 2001-12-11 2006-08-29 Kimberly-Clark Worldwide, Inc. Methods to view and analyze the results from diffraction-based diagnostics
US20060078890A1 (en) * 2004-10-08 2006-04-13 Ole Isacson Methods for identifying parkinson's disease therapeutics
CN101821606A (zh) * 2007-07-26 2010-09-01 皇家飞利浦电子股份有限公司 以全内反射进行光学检测的微电子传感器设备
WO2009040746A1 (en) * 2007-09-28 2009-04-02 Koninklijke Philips Electronics N.V. Sensor device for the detection of target components
FR2935804B1 (fr) * 2008-09-11 2012-11-02 Innopsys Procede de recherche d'au moins un analyte dans un milieu susceptible de le contenir
EP2618130A1 (en) * 2012-01-17 2013-07-24 F. Hoffmann-La Roche AG Device for use in the detection of binding affinities

Also Published As

Publication number Publication date
CA2917985C (en) 2023-01-03
KR102254596B1 (ko) 2021-05-24
KR20160033142A (ko) 2016-03-25
RU2016104220A (ru) 2017-08-18
CN105378462B (zh) 2019-01-25
HK1221769A1 (zh) 2017-06-09
JP6432845B2 (ja) 2018-12-05
EP3022547A1 (en) 2016-05-25
CN105378462A (zh) 2016-03-02
BR112016000518B1 (pt) 2020-10-13
RU2655958C2 (ru) 2018-05-30
EP2827130A1 (en) 2015-01-21
RU2016104220A3 (es) 2018-03-27
MX351922B (es) 2017-11-03
EP3022547B1 (en) 2018-12-12
CA2917985A1 (en) 2015-01-22
JP2016526690A (ja) 2016-09-05
US20160139115A1 (en) 2016-05-19
WO2015007674A1 (en) 2015-01-22

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