BR112014016048A2 - métodos de formação de ésteres de pinacol do ácido 4-cloro-2-fluoro-3-fenilborônico substituído e métodos de usar os mesmos - Google Patents

métodos de formação de ésteres de pinacol do ácido 4-cloro-2-fluoro-3-fenilborônico substituído e métodos de usar os mesmos

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Publication number
BR112014016048A2
BR112014016048A2 BR112014016048A BR112014016048A BR112014016048A2 BR 112014016048 A2 BR112014016048 A2 BR 112014016048A2 BR 112014016048 A BR112014016048 A BR 112014016048A BR 112014016048 A BR112014016048 A BR 112014016048A BR 112014016048 A2 BR112014016048 A2 BR 112014016048A2
Authority
BR
Brazil
Prior art keywords
fluoro
chloro
substituted
methods
phenylboronic acid
Prior art date
Application number
BR112014016048A
Other languages
English (en)
Other versions
BR112014016048B8 (pt
BR112014016048B1 (pt
BR112014016048A8 (pt
Inventor
Oppenheimer Jossian
Original Assignee
Dow Agrosciences Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dow Agrosciences Llc filed Critical Dow Agrosciences Llc
Publication of BR112014016048A2 publication Critical patent/BR112014016048A2/pt
Publication of BR112014016048A8 publication Critical patent/BR112014016048A8/pt
Publication of BR112014016048B1 publication Critical patent/BR112014016048B1/pt
Publication of BR112014016048B8 publication Critical patent/BR112014016048B8/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/803—Processes of preparation
    • C07D213/807—Processes of preparation by oxidation of pyridines or condensed pyridines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F1/00—Compounds containing elements of Groups 1 or 11 of the Periodic Table
    • C07F1/02—Lithium compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/04—Esters of boric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyridine Compounds (AREA)

Abstract

resumo patente de invenção: "métodos de formação de ésteres de pinacol do ácido 4-cloro-2-fluoro-3-fenilborônico substituído e métodos de usar os mesmos". a presente invenção refere-se a métodos que incluem a formação de ésteres de pinacol do ácido 4-cloro-2-fluoro-3-fenilborônico substituído. o método compreende contatar um 1-cloro-3-fluoro-2-benzeno substituído com um alquil lítio para formar um 1-cloro-3-fluoro-2-benzeno substituído litizado. o 1-cloro-3-fluoro-2-benzeno substituído litizado é contatado com um derivado de ácido borônico eletrofílico para formar um 4-cloro-2-fluoro-3-fenilboronato substituído. o 4-cloro-2-fluoro-3-fenilboronato substituído é reagido com uma base aquosa para formar um (4-cloro-2-fluoro-3-fenil substituído)tri-hidroxiborato. o (4-cloro-2-fluoro-3-fenil substituído)tri-hidroxiborato é reagido com um ácido para formar um ácido 4-cloro-2-fluoro-3-fenilborônico substituído. o ácido 4-cloro-2-fluoro-3-fenilborônico substituído é reagido com o 2,3-dimetil-2,3-butanodiol para formar ésteres de pinacol do ácido 4-cloro-2-fluoro-3-fenilborônico substituído. os métodos de usar ésteres de pinacol do ácido 4-cloro-2-fluoro-3-fenilborônico substituído para produzir 6-(4-cloro-2-fluoro-3-fenil substituído)-4-aminopicolinato também são divulgados.
BR112014016048A 2011-12-30 2012-12-20 Métodos para formação e uso de ésteres de pinacol do ácido 4-cloro-2-flúor-3-substituído-fenilborônico e de 2-(4-cloro-2-flúor-3-metoxifenil)-4,4,5,5-tetrametil1,3,2-dioxaborolano, e éster de pinacol do ácido 4cloro-2-flúor-3-substituído-fenilborônico BR112014016048B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161582173P 2011-12-30 2011-12-30
PCT/US2012/070967 WO2013101665A1 (en) 2011-12-30 2012-12-20 Methods of forming 4-chloro-2-fluoro-3-substituted-phenylboronic acid pinacol esters and methods of using the same

Publications (4)

Publication Number Publication Date
BR112014016048A2 true BR112014016048A2 (pt) 2017-06-13
BR112014016048A8 BR112014016048A8 (pt) 2017-07-04
BR112014016048B1 BR112014016048B1 (pt) 2019-12-03
BR112014016048B8 BR112014016048B8 (pt) 2022-10-11

Family

ID=48695350

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014016048A BR112014016048B8 (pt) 2011-12-30 2012-12-20 Métodos para formação e uso de ésteres de pinacol do ácido 4-cloro-2-flúor-3-substituído-fenilborônico e de 2-(4-cloro-2-flúor-3-metoxifenil)-4,4,5,5-tetrametil1,3,2-dioxaborolano, e éster de pinacol do ácido 4cloro-2-flúor-3-substituído-fenilborônico

Country Status (17)

Country Link
US (2) US8912339B2 (pt)
EP (1) EP2797933B1 (pt)
JP (2) JP6290788B2 (pt)
KR (1) KR102062343B1 (pt)
CN (1) CN104114562A (pt)
AR (1) AR089539A1 (pt)
AU (1) AU2012362698B2 (pt)
BR (1) BR112014016048B8 (pt)
CA (1) CA2861631C (pt)
CO (1) CO7020930A2 (pt)
IL (1) IL233413A (pt)
IN (1) IN2014DN05647A (pt)
MX (1) MX341834B (pt)
NZ (1) NZ627041A (pt)
PL (1) PL2797933T3 (pt)
RU (1) RU2625800C2 (pt)
WO (1) WO2013101665A1 (pt)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2012362268B2 (en) * 2011-12-30 2016-11-17 Corteva Agriscience Llc Methods of producing methyl 4-amino-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylate
CN104114562A (zh) * 2011-12-30 2014-10-22 陶氏益农公司 形成4-氯-2-氟-3-取代的苯基硼酸频哪醇酯的方法及其使用方法
UY35728A (es) 2013-09-05 2015-04-30 Dow Agrosciences Llc ?métodos para producir arenos borilados?.
TW201625354A (zh) 2014-06-16 2016-07-16 陶氏農業科學公司 用於製備氧硼基化芳烴之方法
WO2016191245A1 (en) * 2015-05-22 2016-12-01 Dow Agrosciences Llc Recovery and/or reuse of palladium catalyst after a suzuki coupling
CN108654692A (zh) * 2018-04-16 2018-10-16 苏州大学 正丁基锂在催化酮和硼烷硼氢化反应中的应用
CN108503660A (zh) * 2018-04-16 2018-09-07 苏州大学 苯胺基锂在催化醛和硼烷硼氢化反应中的应用
CN108404984A (zh) * 2018-04-16 2018-08-17 苏州大学 正丁基锂在催化醛和硼烷硼氢化反应中的应用
CN108503659A (zh) * 2018-04-16 2018-09-07 苏州大学 利用2,6-二异丙基苯胺基锂制备硼酸酯的方法
CN108409772A (zh) * 2018-04-16 2018-08-17 南通纺织丝绸产业技术研究院 基于醛制备硼酸酯的方法
CN108373480A (zh) * 2018-04-16 2018-08-07 苏州大学 利用对甲基苯胺基锂制备硼酸酯的方法
CN108558925A (zh) * 2018-04-16 2018-09-21 南通纺织丝绸产业技术研究院 2,6-二异丙基苯胺基锂在催化酮和硼烷硼氢化反应中的应用
CN108383863A (zh) * 2018-04-16 2018-08-10 苏州大学 2,6-二异丙基苯胺基锂在制备硼酸酯中的应用
CN108329339A (zh) * 2018-04-16 2018-07-27 苏州大学张家港工业技术研究院 2,6-二甲基苯胺基锂在催化酮和硼烷硼氢化反应中的应用
CN108273550A (zh) * 2018-04-16 2018-07-13 苏州大学张家港工业技术研究院 对甲基苯胺基锂在催化酮和硼烷硼氢化反应中的应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ337951A (en) * 1997-04-09 2000-02-28 Commw Scient Ind Res Org Process for covalently coupling organic compounds utilizing diboron derivatives for preparation of an aryl boronic acid
BRPI0611415A2 (pt) * 2005-05-25 2010-09-08 Microbia Inc ácidos fosfÈnicos de 4-(bifenilil)azetidin-2-ona e processo para a produção dos mesmos
CA2626103C (en) * 2006-01-13 2013-07-30 Dow Agrosciences Llc 6-(poly-substituted aryl)-4-aminopicolinates and their use as herbicides
US7964758B2 (en) * 2006-02-13 2011-06-21 Nissan Chemical Industries, Ltd. Process for production of 2-(substituted phenyl)-3,3,3-trifluoropropene compound
EP2099807B1 (en) * 2006-11-30 2014-01-01 Senseonics, Incorporated Oxidation resistant indicator molecules
KR20100023040A (ko) * 2007-06-21 2010-03-03 쉐링 코포레이션 폴리사이클릭 구아닌 유도체 및 이의 용도
WO2009023438A1 (en) 2007-08-13 2009-02-19 Dow Agrosciences Llc 2-(2-fluoro-substituted phenyl)-6-amino-5-chloro-4-pyrimidinecarboxylates and their use as herbicides
AR068145A1 (es) * 2007-08-30 2009-11-04 Dow Agrosciences Llc 2- (fenil sustituido )-6-amino-5-alcoxi, tiolcoxi y aminoalquil-4- pirimidina carboxilatos, sus usos como herbicidas y composicion herbicida
BRPI0817626B8 (pt) * 2007-10-02 2022-06-28 Dow Agrosciences Llc ácidos 2-substituído-6-amino-5-alquil, alquenil ou alquinil-4-pirimidinacarboxílicos e ácidos 6-substituído-4-amino-3-alquil, alquenil ou aquinil picolínicos, composição herbicida que os compreende e método de controlar vegetação indesejável
MX2010007619A (es) * 2008-01-11 2010-08-04 Dow Agrosciences Llc Proceso para la desprotonacion y funcionalizacion selectiva de 1-fluoro-2-sustituido-3-clorobencenos.
NZ620043A (en) * 2011-07-26 2016-02-26 Dow Agrosciences Llc Methods of isolating 4-chloro-2-fluoro-3-substituted-phenylboronic acids
CN104114562A (zh) * 2011-12-30 2014-10-22 陶氏益农公司 形成4-氯-2-氟-3-取代的苯基硼酸频哪醇酯的方法及其使用方法
AU2012362268B2 (en) * 2011-12-30 2016-11-17 Corteva Agriscience Llc Methods of producing methyl 4-amino-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylate

Also Published As

Publication number Publication date
JP2018104447A (ja) 2018-07-05
AU2012362698B2 (en) 2017-08-24
MX2014008017A (es) 2014-12-08
EP2797933A4 (en) 2015-08-12
CN104114562A (zh) 2014-10-22
CA2861631C (en) 2021-05-04
US8912339B2 (en) 2014-12-16
IN2014DN05647A (pt) 2015-04-03
AR089539A1 (es) 2014-08-27
US20150203514A1 (en) 2015-07-23
RU2014131414A (ru) 2016-02-20
KR102062343B1 (ko) 2020-01-02
IL233413A0 (en) 2014-08-31
CA2861631A1 (en) 2013-07-04
PL2797933T3 (pl) 2018-01-31
EP2797933A1 (en) 2014-11-05
WO2013101665A1 (en) 2013-07-04
EP2797933B1 (en) 2017-08-16
US9422313B2 (en) 2016-08-23
CO7020930A2 (es) 2014-08-11
AU2012362698A1 (en) 2014-07-24
BR112014016048B8 (pt) 2022-10-11
BR112014016048B1 (pt) 2019-12-03
BR112014016048A8 (pt) 2017-07-04
KR20140117442A (ko) 2014-10-07
JP2015507631A (ja) 2015-03-12
MX341834B (es) 2016-09-05
NZ627041A (en) 2016-07-29
RU2625800C2 (ru) 2017-07-19
US20130172565A1 (en) 2013-07-04
JP6290788B2 (ja) 2018-03-07
IL233413A (en) 2017-12-31

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06T Formal requirements before examination [chapter 6.20 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 20/12/2012, OBSERVADAS AS CONDICOES LEGAIS. (CO) 20 (VINTE) ANOS CONTADOS A PARTIR DE 20/12/2012, OBSERVADAS AS CONDICOES LEGAIS

B25D Requested change of name of applicant approved

Owner name: CORTEVA AGRISCIENCE LLC (US)