AR089539A1 - Metodos de formacion de esteres pinacolicos de acido 4-cloro-2-fluoro-3-sustituido-fenilboronico y sus metodos de uso - Google Patents

Metodos de formacion de esteres pinacolicos de acido 4-cloro-2-fluoro-3-sustituido-fenilboronico y sus metodos de uso

Info

Publication number
AR089539A1
AR089539A1 ARP120105068A ARP120105068A AR089539A1 AR 089539 A1 AR089539 A1 AR 089539A1 AR P120105068 A ARP120105068 A AR P120105068A AR P120105068 A ARP120105068 A AR P120105068A AR 089539 A1 AR089539 A1 AR 089539A1
Authority
AR
Argentina
Prior art keywords
substituted
fluoro
chloro
methods
pinacolic
Prior art date
Application number
ARP120105068A
Other languages
English (en)
Original Assignee
Dow Agrosciences Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dow Agrosciences Llc filed Critical Dow Agrosciences Llc
Publication of AR089539A1 publication Critical patent/AR089539A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/803—Processes of preparation
    • C07D213/807—Processes of preparation by oxidation of pyridines or condensed pyridines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F1/00—Compounds containing elements of Groups 1 or 11 of the Periodic Table
    • C07F1/02—Lithium compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/04—Esters of boric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyridine Compounds (AREA)

Abstract

Los métodos incluyen la formación de ésteres pinacólicos de ácido 4-cloro-2-fluoro-3-sustituido-fenilborónico. El método comprende poner en contacto un 1-cloro-3-fluoro-2-sustituido-benceno con un alquil-litio para formar un 1-cloro-3-fluoro-2-sustituido-benceno litiado. El 1-cloro-3-fluoro-2-sustituido-benceno litiado se pone en contacto con un derivado de ácido borónico electrofílico para formar un 4-cloro-2-fluoro-3-sustituido-fenilboronato. El 4-cloro-2-fluoro-3-sustituido-fenilboronato se hace reaccionar con una base acuosa para formar un (4-cloro-2-fluoro-3-sustituido-fenil) trihidroxiborato, El (4-cloro-2-fluoro-3-sustituido-fenil) trihidroxiborato se hace reaccionar con un ácido para formar un ácido 4-cloro-2-fluoro-3-sustituido-fenilborónico. El ácido 4-cloro-2-fluoro-3-sustituido-fenilborónico se hace reaccionar con 2,3-dimetil-2,3-butanodiol para formar ésteres pinacólicos de ácido 4-cloro-2-fluoro-3-sustituido-fenilborónico. Los métodos de uso de ésteres pinacólicos de ácido 4-cloro-2-fluoro-3-sustituido-fenilborónico para producir 6-(4-cloro-2-fluoro-3-sustituido-fenil)-4-aminopicolinatos también se describen.
ARP120105068A 2011-12-30 2012-12-28 Metodos de formacion de esteres pinacolicos de acido 4-cloro-2-fluoro-3-sustituido-fenilboronico y sus metodos de uso AR089539A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161582173P 2011-12-30 2011-12-30

Publications (1)

Publication Number Publication Date
AR089539A1 true AR089539A1 (es) 2014-08-27

Family

ID=48695350

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP120105068A AR089539A1 (es) 2011-12-30 2012-12-28 Metodos de formacion de esteres pinacolicos de acido 4-cloro-2-fluoro-3-sustituido-fenilboronico y sus metodos de uso

Country Status (17)

Country Link
US (2) US8912339B2 (es)
EP (1) EP2797933B1 (es)
JP (2) JP6290788B2 (es)
KR (1) KR102062343B1 (es)
CN (1) CN104114562A (es)
AR (1) AR089539A1 (es)
AU (1) AU2012362698B2 (es)
BR (1) BR112014016048B8 (es)
CA (1) CA2861631C (es)
CO (1) CO7020930A2 (es)
IL (1) IL233413A (es)
IN (1) IN2014DN05647A (es)
MX (1) MX341834B (es)
NZ (1) NZ627041A (es)
PL (1) PL2797933T3 (es)
RU (1) RU2625800C2 (es)
WO (1) WO2013101665A1 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2012362268B2 (en) * 2011-12-30 2016-11-17 Corteva Agriscience Llc Methods of producing methyl 4-amino-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylate
CN104114562A (zh) * 2011-12-30 2014-10-22 陶氏益农公司 形成4-氯-2-氟-3-取代的苯基硼酸频哪醇酯的方法及其使用方法
UY35728A (es) 2013-09-05 2015-04-30 Dow Agrosciences Llc ?métodos para producir arenos borilados?.
TW201625354A (zh) 2014-06-16 2016-07-16 陶氏農業科學公司 用於製備氧硼基化芳烴之方法
WO2016191245A1 (en) * 2015-05-22 2016-12-01 Dow Agrosciences Llc Recovery and/or reuse of palladium catalyst after a suzuki coupling
CN108654692A (zh) * 2018-04-16 2018-10-16 苏州大学 正丁基锂在催化酮和硼烷硼氢化反应中的应用
CN108503660A (zh) * 2018-04-16 2018-09-07 苏州大学 苯胺基锂在催化醛和硼烷硼氢化反应中的应用
CN108404984A (zh) * 2018-04-16 2018-08-17 苏州大学 正丁基锂在催化醛和硼烷硼氢化反应中的应用
CN108503659A (zh) * 2018-04-16 2018-09-07 苏州大学 利用2,6-二异丙基苯胺基锂制备硼酸酯的方法
CN108409772A (zh) * 2018-04-16 2018-08-17 南通纺织丝绸产业技术研究院 基于醛制备硼酸酯的方法
CN108373480A (zh) * 2018-04-16 2018-08-07 苏州大学 利用对甲基苯胺基锂制备硼酸酯的方法
CN108558925A (zh) * 2018-04-16 2018-09-21 南通纺织丝绸产业技术研究院 2,6-二异丙基苯胺基锂在催化酮和硼烷硼氢化反应中的应用
CN108383863A (zh) * 2018-04-16 2018-08-10 苏州大学 2,6-二异丙基苯胺基锂在制备硼酸酯中的应用
CN108329339A (zh) * 2018-04-16 2018-07-27 苏州大学张家港工业技术研究院 2,6-二甲基苯胺基锂在催化酮和硼烷硼氢化反应中的应用
CN108273550A (zh) * 2018-04-16 2018-07-13 苏州大学张家港工业技术研究院 对甲基苯胺基锂在催化酮和硼烷硼氢化反应中的应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ337951A (en) * 1997-04-09 2000-02-28 Commw Scient Ind Res Org Process for covalently coupling organic compounds utilizing diboron derivatives for preparation of an aryl boronic acid
BRPI0611415A2 (pt) * 2005-05-25 2010-09-08 Microbia Inc ácidos fosfÈnicos de 4-(bifenilil)azetidin-2-ona e processo para a produção dos mesmos
CA2626103C (en) * 2006-01-13 2013-07-30 Dow Agrosciences Llc 6-(poly-substituted aryl)-4-aminopicolinates and their use as herbicides
US7964758B2 (en) * 2006-02-13 2011-06-21 Nissan Chemical Industries, Ltd. Process for production of 2-(substituted phenyl)-3,3,3-trifluoropropene compound
EP2099807B1 (en) * 2006-11-30 2014-01-01 Senseonics, Incorporated Oxidation resistant indicator molecules
KR20100023040A (ko) * 2007-06-21 2010-03-03 쉐링 코포레이션 폴리사이클릭 구아닌 유도체 및 이의 용도
WO2009023438A1 (en) 2007-08-13 2009-02-19 Dow Agrosciences Llc 2-(2-fluoro-substituted phenyl)-6-amino-5-chloro-4-pyrimidinecarboxylates and their use as herbicides
AR068145A1 (es) * 2007-08-30 2009-11-04 Dow Agrosciences Llc 2- (fenil sustituido )-6-amino-5-alcoxi, tiolcoxi y aminoalquil-4- pirimidina carboxilatos, sus usos como herbicidas y composicion herbicida
BRPI0817626B8 (pt) * 2007-10-02 2022-06-28 Dow Agrosciences Llc ácidos 2-substituído-6-amino-5-alquil, alquenil ou alquinil-4-pirimidinacarboxílicos e ácidos 6-substituído-4-amino-3-alquil, alquenil ou aquinil picolínicos, composição herbicida que os compreende e método de controlar vegetação indesejável
MX2010007619A (es) * 2008-01-11 2010-08-04 Dow Agrosciences Llc Proceso para la desprotonacion y funcionalizacion selectiva de 1-fluoro-2-sustituido-3-clorobencenos.
NZ620043A (en) * 2011-07-26 2016-02-26 Dow Agrosciences Llc Methods of isolating 4-chloro-2-fluoro-3-substituted-phenylboronic acids
CN104114562A (zh) * 2011-12-30 2014-10-22 陶氏益农公司 形成4-氯-2-氟-3-取代的苯基硼酸频哪醇酯的方法及其使用方法
AU2012362268B2 (en) * 2011-12-30 2016-11-17 Corteva Agriscience Llc Methods of producing methyl 4-amino-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylate

Also Published As

Publication number Publication date
JP2018104447A (ja) 2018-07-05
AU2012362698B2 (en) 2017-08-24
MX2014008017A (es) 2014-12-08
EP2797933A4 (en) 2015-08-12
CN104114562A (zh) 2014-10-22
CA2861631C (en) 2021-05-04
US8912339B2 (en) 2014-12-16
IN2014DN05647A (es) 2015-04-03
US20150203514A1 (en) 2015-07-23
BR112014016048A2 (pt) 2017-06-13
RU2014131414A (ru) 2016-02-20
KR102062343B1 (ko) 2020-01-02
IL233413A0 (en) 2014-08-31
CA2861631A1 (en) 2013-07-04
PL2797933T3 (pl) 2018-01-31
EP2797933A1 (en) 2014-11-05
WO2013101665A1 (en) 2013-07-04
EP2797933B1 (en) 2017-08-16
US9422313B2 (en) 2016-08-23
CO7020930A2 (es) 2014-08-11
AU2012362698A1 (en) 2014-07-24
BR112014016048B8 (pt) 2022-10-11
BR112014016048B1 (pt) 2019-12-03
BR112014016048A8 (pt) 2017-07-04
KR20140117442A (ko) 2014-10-07
JP2015507631A (ja) 2015-03-12
MX341834B (es) 2016-09-05
NZ627041A (en) 2016-07-29
RU2625800C2 (ru) 2017-07-19
US20130172565A1 (en) 2013-07-04
JP6290788B2 (ja) 2018-03-07
IL233413A (en) 2017-12-31

Similar Documents

Publication Publication Date Title
AR089539A1 (es) Metodos de formacion de esteres pinacolicos de acido 4-cloro-2-fluoro-3-sustituido-fenilboronico y sus metodos de uso
TWD192190S (zh) 電池組(二)
TWD192191S (zh) 電池組(一)
TWD166000S (zh) 銷售點基座（一）
TWD165363S (zh) 錶殼
TWD163720S (zh) 可攜式電子裝置之部分
TWD157377S (zh) 充電座
ECSP14005975A (es) Anticuerpos anti-PHF-tau y sus usos
TWD165141S (zh) 手鐲
CL2015000757A1 (es) Una proteina
TWD163717S (zh) 可攜式電子裝置之部分
PH12014501627A1 (en) Locating and relocating device
CO7111275A2 (es) Inhibidores de dgat1 de éter cíclico de cabeza de puente
UY33984A (es) Uso de 2,3-dihidroimidazo [1,2-c] quinazolinas sustituidas
PE20160090A1 (es) Metodos para sintetizar un analogo de la prostaciclina
TWD163719S (zh) 可攜式電子裝置之部分
CR20150555A (es) Nuevos derivados de pirrolo[2,3-d]pirimidina
EA201491266A1 (ru) Способ получения сульфоната внутреннего олефина
UY33167A (es) DERIVADOS DE 5-OXO-5,8-DIHIDRO-PIRIDO[2,3d]PIRIMIDINA, SU PREPARACION y SU APLICACIÓN EN TERAPÉUTICA
TWD168993S (zh) 母連接器
WO2015066612A3 (en) Cross-coupling of unactivated secondary boronic acids
TWD169462S (zh) 公連接器
DOP2015000062A (es) Derivados de macrólidos, su preparación y su uso terapéutico
BR112014014432A2 (pt) método para produzir um composto
UY33507A (es) Proceso para la preparacion de sales de enolato de 4-fluoro-2-hidroximetileno-3-oxo-butiratos

Legal Events

Date Code Title Description
FG Grant, registration