BR112014015962A2 - métodos de produzir 4-amino-3-cloro-6-(4-cloro-2-fluoro-3-metoxifenil)piridina-2-carboxilato de metila - Google Patents

métodos de produzir 4-amino-3-cloro-6-(4-cloro-2-fluoro-3-metoxifenil)piridina-2-carboxilato de metila

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Publication number
BR112014015962A2
BR112014015962A2 BR112014015962A BR112014015962A BR112014015962A2 BR 112014015962 A2 BR112014015962 A2 BR 112014015962A2 BR 112014015962 A BR112014015962 A BR 112014015962A BR 112014015962 A BR112014015962 A BR 112014015962A BR 112014015962 A2 BR112014015962 A2 BR 112014015962A2
Authority
BR
Brazil
Prior art keywords
chloro
fluoro
carboxylate
methoxyphenyl
pyridine
Prior art date
Application number
BR112014015962A
Other languages
English (en)
Other versions
BR112014015962B8 (pt
BR112014015962B1 (pt
BR112014015962A8 (pt
Inventor
W Derstine Christopher
Oppenheimer Jossian
V M Emonds Mark
C Clouse Robert
Original Assignee
Dow Agrosciences Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dow Agrosciences Llc filed Critical Dow Agrosciences Llc
Publication of BR112014015962A2 publication Critical patent/BR112014015962A2/pt
Publication of BR112014015962A8 publication Critical patent/BR112014015962A8/pt
Publication of BR112014015962B1 publication Critical patent/BR112014015962B1/pt
Publication of BR112014015962B8 publication Critical patent/BR112014015962B8/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/803—Processes of preparation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

resumo patente de invenção: "métodos de produzir 4-amino-3-cloro-6-(4-cloro-2-fluoro-3-metoxifenil) piridina-2-carboxilato de metila". a presente invenção refere-se a método de produzir 4-amino-3-cloro-6-(4-cloro-2-fluoro-3-metoxifenil)piridina-2-carboxilato de metila. um método compreende adicionar metil isobutil cetona a uma solução aquosa compreendendo ácido 4-cloro-2-fluoro-3-metoxifenil-borônico para formar uma fase orgânica compreendendo o ácido 4-cloro-2-fluoro-3-metoxifenilborônico e uma fase aquosa. a fase orgânica e a fase aquosa são separadas. o ácido 4-cloro-2-fluoro-3-metoxifenilborônico é reagido com 4-(acetilamino)-3,6-dicloropiridina-2-carboxilato de metila em metil isobutil cetona para produzir 4-(acetilamino)-3-cloro-6-(4-cloro-2-fluoro-3-metoxifenil)piridina-2-carboxilato de metila, que é desacetilado para produzir 4-amino-3-cloro-6-(4-cloro-2-fluoro -3-metoxifenil)piridina-2-carboxilato de metila.
BR112014015962A 2011-12-30 2012-12-28 Métodos para produzir 4-amino-3-cloro-6-(4-cloro-2-flúor-3-metóxi-fenil)piridina-2-carboxilato de metila BR112014015962B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161582166P 2011-12-30 2011-12-30
PCT/US2012/072071 WO2013102078A1 (en) 2011-12-30 2012-12-28 Methods of producing methyl 4-amino-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylate

Publications (4)

Publication Number Publication Date
BR112014015962A2 true BR112014015962A2 (pt) 2017-06-13
BR112014015962A8 BR112014015962A8 (pt) 2017-07-04
BR112014015962B1 BR112014015962B1 (pt) 2019-12-17
BR112014015962B8 BR112014015962B8 (pt) 2022-10-11

Family

ID=48695351

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014015962A BR112014015962B8 (pt) 2011-12-30 2012-12-28 Métodos para produzir 4-amino-3-cloro-6-(4-cloro-2-flúor-3-metóxi-fenil)piridina-2-carboxilato de metila

Country Status (16)

Country Link
US (1) US8754110B2 (pt)
EP (1) EP2797890B1 (pt)
JP (1) JP6092250B2 (pt)
KR (1) KR102065543B1 (pt)
AR (1) AR089628A1 (pt)
AU (1) AU2012362268B2 (pt)
BR (1) BR112014015962B8 (pt)
CA (1) CA2861611C (pt)
CO (1) CO7010843A2 (pt)
IL (1) IL233412B (pt)
IN (1) IN2014DN05767A (pt)
MX (1) MX340947B (pt)
NZ (1) NZ627192A (pt)
PL (1) PL2797890T3 (pt)
RU (1) RU2616621C2 (pt)
WO (1) WO2013102078A1 (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8912339B2 (en) * 2011-12-30 2014-12-16 Dow Agrosciences, Llc. Methods of forming 4-chloro-2-fluoro-3-substituted-phenylboronic acid pinacol esters and methods of using the same
US20140170058A1 (en) * 2012-12-13 2014-06-19 Dow Agrosciences Llc Process for the removal of palladium from 4-amino-3-halo-5-fluoro-6-(aryl) pyridine-2-carboxylates and 4-amino-3-halo-6-(aryl)pyridine-2-carboxylates
JP6434522B2 (ja) 2013-09-05 2018-12-05 ダウ アグロサイエンシィズ エルエルシー ホウ素化アレーンを生成する方法
TW201625354A (zh) 2014-06-16 2016-07-16 陶氏農業科學公司 用於製備氧硼基化芳烴之方法
EP3297436A4 (en) * 2015-05-22 2018-12-26 Dow AgroSciences LLC Recovery and/or reuse of palladium catalyst after a suzuki coupling
CN105851037B (zh) * 2016-05-17 2018-09-07 陕西上格之路生物科学有限公司 一种含氟氯吡啶酯的三元除草组合物
CN109415319A (zh) * 2016-05-19 2019-03-01 美国陶氏益农公司 通过直接苏楚基偶联合成芳基羧酸酯

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7145040B2 (en) 2004-07-02 2006-12-05 Bristol-Myers Squibb Co. Process for the preparation of amino acids useful in the preparation of peptide receptor modulators
KR101350071B1 (ko) * 2006-01-13 2014-01-14 다우 아그로사이언시즈 엘엘씨 6-(다-치환 아릴)-4-아미노피콜리네이트 및 그의제초제로서의 용도
CN102977036B (zh) 2006-01-13 2017-05-03 美国陶氏益农公司 2‑(多取代芳基)‑6‑氨基‑5‑卤代‑4‑嘧啶甲酸及其作为除草剂的用途
DK2332914T3 (da) * 2007-10-02 2013-06-17 Dow Agrosciences Llc Substituerede 4-aminopicolinsyrer og deres anvendelse som herbicider
KR101599566B1 (ko) * 2008-01-11 2016-03-03 다우 아그로사이언시즈 엘엘씨 1-플루오로-2-치환된-3-클로로벤젠의 선택적 탈양성자화 및 관능화 방법
GB0902474D0 (en) * 2009-02-13 2009-04-01 Syngenta Ltd Chemical compounds
US8252938B2 (en) * 2009-06-08 2012-08-28 Dow Agrosciences, Llc. Process for the preparation of 6-(aryl)-4-aminopicolinates
CA2780203A1 (en) * 2009-11-19 2011-05-26 Lexicon Pharmaceuticals, Inc. Process for the preparation of substituted phenylalanines
US8912339B2 (en) * 2011-12-30 2014-12-16 Dow Agrosciences, Llc. Methods of forming 4-chloro-2-fluoro-3-substituted-phenylboronic acid pinacol esters and methods of using the same
US20140170058A1 (en) * 2012-12-13 2014-06-19 Dow Agrosciences Llc Process for the removal of palladium from 4-amino-3-halo-5-fluoro-6-(aryl) pyridine-2-carboxylates and 4-amino-3-halo-6-(aryl)pyridine-2-carboxylates

Also Published As

Publication number Publication date
BR112014015962B8 (pt) 2022-10-11
EP2797890A4 (en) 2015-09-23
PL2797890T3 (pl) 2017-06-30
RU2616621C2 (ru) 2017-04-18
WO2013102078A1 (en) 2013-07-04
AU2012362268A1 (en) 2014-07-31
BR112014015962B1 (pt) 2019-12-17
BR112014015962A8 (pt) 2017-07-04
IL233412A0 (en) 2014-08-31
KR20140117444A (ko) 2014-10-07
CA2861611A1 (en) 2013-07-04
AU2012362268B2 (en) 2016-11-17
EP2797890A1 (en) 2014-11-05
IL233412B (en) 2019-01-31
RU2014131451A (ru) 2016-02-20
CO7010843A2 (es) 2014-07-31
US20130172566A1 (en) 2013-07-04
MX340947B (es) 2016-08-01
IN2014DN05767A (pt) 2015-04-10
AR089628A1 (es) 2014-09-03
CA2861611C (en) 2020-04-21
JP2015504059A (ja) 2015-02-05
EP2797890B1 (en) 2016-10-05
NZ627192A (en) 2015-09-25
US8754110B2 (en) 2014-06-17
JP6092250B2 (ja) 2017-03-08
KR102065543B1 (ko) 2020-01-13
MX2014008019A (es) 2014-12-08

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 28/12/2012, OBSERVADAS AS CONDICOES LEGAIS.

B25D Requested change of name of applicant approved

Owner name: CORTEVA AGRISCIENCE LLC (US)