MX340947B - Metodos para la produccion de 4-amino-3-cloro-6-(4-cloro-2-fluor-3 -metoxifenil) piridin-2-carboxilato de metilo. - Google Patents

Metodos para la produccion de 4-amino-3-cloro-6-(4-cloro-2-fluor-3 -metoxifenil) piridin-2-carboxilato de metilo.

Info

Publication number
MX340947B
MX340947B MX2014008019A MX2014008019A MX340947B MX 340947 B MX340947 B MX 340947B MX 2014008019 A MX2014008019 A MX 2014008019A MX 2014008019 A MX2014008019 A MX 2014008019A MX 340947 B MX340947 B MX 340947B
Authority
MX
Mexico
Prior art keywords
chloro
fluoro
carboxylate
methoxyphenyl
pyridine
Prior art date
Application number
MX2014008019A
Other languages
English (en)
Other versions
MX2014008019A (es
Inventor
Oppenheimer Jossian
V M Emonds Mark
W Derstine Christopher
C Clouse Robert
Original Assignee
Dow Agrosciences Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dow Agrosciences Llc filed Critical Dow Agrosciences Llc
Publication of MX2014008019A publication Critical patent/MX2014008019A/es
Publication of MX340947B publication Critical patent/MX340947B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/803—Processes of preparation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Métodos para la producción de 4-amino-3-cloro-6-(4-cloro-2-fluor-3 - metoxifenil)piridin-2-carboxilato de metilo. Un método comprende el agregado de metil isobutil cetona a una solución acuosa que comprende ácido 4-cloro-2-fluor-3- metoxifenil- bórico para formar una fase orgánica que comprende el ácido 4-cloro-2-fluor-3-metoxifenil bórico y una fase acuosa. La fase orgánica y la fase acuosa se separan. El ácido 4-cloro-2-fluor-3-metoxifenilbórico se hace reaccionar con 4-(acetilamino)-3,6-dicloropiridin-2-carboxilato de metilo en metil isobutil cetona para producir 4-(acetilamino)-3-cloro-6-(4-c loro-2-fluor-3-metoxifenil)piridin-2- carboxilato de metilo, que se desacetila para producir 4-amino-3-cloro-6-(4-cloro-2-fluor-3-m etoxifenilo)piridin-2-carboxilato de metilo.
MX2014008019A 2011-12-30 2012-12-28 Metodos para la produccion de 4-amino-3-cloro-6-(4-cloro-2-fluor-3 -metoxifenil) piridin-2-carboxilato de metilo. MX340947B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161582166P 2011-12-30 2011-12-30
PCT/US2012/072071 WO2013102078A1 (en) 2011-12-30 2012-12-28 Methods of producing methyl 4-amino-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylate

Publications (2)

Publication Number Publication Date
MX2014008019A MX2014008019A (es) 2014-12-08
MX340947B true MX340947B (es) 2016-08-01

Family

ID=48695351

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014008019A MX340947B (es) 2011-12-30 2012-12-28 Metodos para la produccion de 4-amino-3-cloro-6-(4-cloro-2-fluor-3 -metoxifenil) piridin-2-carboxilato de metilo.

Country Status (16)

Country Link
US (1) US8754110B2 (es)
EP (1) EP2797890B1 (es)
JP (1) JP6092250B2 (es)
KR (1) KR102065543B1 (es)
AR (1) AR089628A1 (es)
AU (1) AU2012362268B2 (es)
BR (1) BR112014015962B8 (es)
CA (1) CA2861611C (es)
CO (1) CO7010843A2 (es)
IL (1) IL233412B (es)
IN (1) IN2014DN05767A (es)
MX (1) MX340947B (es)
NZ (1) NZ627192A (es)
PL (1) PL2797890T3 (es)
RU (1) RU2616621C2 (es)
WO (1) WO2013102078A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2861631C (en) * 2011-12-30 2021-05-04 Dow Agrosciences Llc Methods of forming 4-chloro-2-fluoro-3-substituted-phenylboronic acid pinacol esters and methods of using the same
US20140170058A1 (en) * 2012-12-13 2014-06-19 Dow Agrosciences Llc Process for the removal of palladium from 4-amino-3-halo-5-fluoro-6-(aryl) pyridine-2-carboxylates and 4-amino-3-halo-6-(aryl)pyridine-2-carboxylates
JP6434522B2 (ja) 2013-09-05 2018-12-05 ダウ アグロサイエンシィズ エルエルシー ホウ素化アレーンを生成する方法
TW201625354A (zh) 2014-06-16 2016-07-16 陶氏農業科學公司 用於製備氧硼基化芳烴之方法
BR112017019207A2 (pt) * 2015-05-22 2018-04-24 Dow Agrosciences Llc recuperação e/ou reutilização de catalisador de paládio após acoplamento de suzuki
CN105851037B (zh) * 2016-05-17 2018-09-07 陕西上格之路生物科学有限公司 一种含氟氯吡啶酯的三元除草组合物
KR20190007048A (ko) * 2016-05-19 2019-01-21 다우 아그로사이언시즈 엘엘씨 직접 스즈키 커플링에 의한 6-아릴-4-아미노피콜리네이트 및 2-아릴-6-아미노피리미딘-4-카르복실레이트의 합성

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7145040B2 (en) * 2004-07-02 2006-12-05 Bristol-Myers Squibb Co. Process for the preparation of amino acids useful in the preparation of peptide receptor modulators
AU2007204825B2 (en) * 2006-01-13 2011-07-14 Corteva Agriscience Llc 6-(poly-substituted aryl)-4-aminopicolinates and their use as herbicides
WO2007082076A1 (en) 2006-01-13 2007-07-19 Dow Agrosciences Llc 2-(poly-substituted aryl)-6-amino-5-halo-4-pyrimidinecarboxylic acids and their use as herbicides
CN102786480B (zh) * 2007-10-02 2016-02-10 陶氏益农公司 2-取代的-6-氨基-5-烷基、烯基或炔基-嘧啶-4-羧酸及其作为除草剂的用途
DK2231678T3 (da) * 2008-01-11 2013-10-28 Dow Agrosciences Llc Fremgangsmåde til selektiv deprotonisering og funktionalisering af 1-fluor-2-substituerede 3-chlorbenzener
GB0902474D0 (en) * 2009-02-13 2009-04-01 Syngenta Ltd Chemical compounds
US8252938B2 (en) * 2009-06-08 2012-08-28 Dow Agrosciences, Llc. Process for the preparation of 6-(aryl)-4-aminopicolinates
CA2780203A1 (en) * 2009-11-19 2011-05-26 Lexicon Pharmaceuticals, Inc. Process for the preparation of substituted phenylalanines
CA2861631C (en) * 2011-12-30 2021-05-04 Dow Agrosciences Llc Methods of forming 4-chloro-2-fluoro-3-substituted-phenylboronic acid pinacol esters and methods of using the same
US20140170058A1 (en) * 2012-12-13 2014-06-19 Dow Agrosciences Llc Process for the removal of palladium from 4-amino-3-halo-5-fluoro-6-(aryl) pyridine-2-carboxylates and 4-amino-3-halo-6-(aryl)pyridine-2-carboxylates

Also Published As

Publication number Publication date
MX2014008019A (es) 2014-12-08
RU2014131451A (ru) 2016-02-20
CO7010843A2 (es) 2014-07-31
EP2797890A1 (en) 2014-11-05
RU2616621C2 (ru) 2017-04-18
PL2797890T3 (pl) 2017-06-30
IL233412B (en) 2019-01-31
EP2797890B1 (en) 2016-10-05
US8754110B2 (en) 2014-06-17
AR089628A1 (es) 2014-09-03
AU2012362268B2 (en) 2016-11-17
AU2012362268A1 (en) 2014-07-31
BR112014015962B8 (pt) 2022-10-11
KR20140117444A (ko) 2014-10-07
JP2015504059A (ja) 2015-02-05
BR112014015962B1 (pt) 2019-12-17
CA2861611A1 (en) 2013-07-04
NZ627192A (en) 2015-09-25
KR102065543B1 (ko) 2020-01-13
BR112014015962A2 (pt) 2017-06-13
EP2797890A4 (en) 2015-09-23
WO2013102078A1 (en) 2013-07-04
IL233412A0 (en) 2014-08-31
JP6092250B2 (ja) 2017-03-08
IN2014DN05767A (es) 2015-04-10
US20130172566A1 (en) 2013-07-04
BR112014015962A8 (pt) 2017-07-04
CA2861611C (en) 2020-04-21

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