MX340947B - Metodos para la produccion de 4-amino-3-cloro-6-(4-cloro-2-fluor-3 -metoxifenil) piridin-2-carboxilato de metilo. - Google Patents

Metodos para la produccion de 4-amino-3-cloro-6-(4-cloro-2-fluor-3 -metoxifenil) piridin-2-carboxilato de metilo.

Info

Publication number
MX340947B
MX340947B MX2014008019A MX2014008019A MX340947B MX 340947 B MX340947 B MX 340947B MX 2014008019 A MX2014008019 A MX 2014008019A MX 2014008019 A MX2014008019 A MX 2014008019A MX 340947 B MX340947 B MX 340947B
Authority
MX
Mexico
Prior art keywords
chloro
fluoro
carboxylate
methoxyphenyl
pyridine
Prior art date
Application number
MX2014008019A
Other languages
English (en)
Other versions
MX2014008019A (es
Inventor
Oppenheimer Jossian
V M Emonds Mark
W Derstine Christopher
C Clouse Robert
Original Assignee
Dow Agrosciences Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dow Agrosciences Llc filed Critical Dow Agrosciences Llc
Publication of MX2014008019A publication Critical patent/MX2014008019A/es
Publication of MX340947B publication Critical patent/MX340947B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/803—Processes of preparation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Métodos para la producción de 4-amino-3-cloro-6-(4-cloro-2-fluor-3 - metoxifenil)piridin-2-carboxilato de metilo. Un método comprende el agregado de metil isobutil cetona a una solución acuosa que comprende ácido 4-cloro-2-fluor-3- metoxifenil- bórico para formar una fase orgánica que comprende el ácido 4-cloro-2-fluor-3-metoxifenil bórico y una fase acuosa. La fase orgánica y la fase acuosa se separan. El ácido 4-cloro-2-fluor-3-metoxifenilbórico se hace reaccionar con 4-(acetilamino)-3,6-dicloropiridin-2-carboxilato de metilo en metil isobutil cetona para producir 4-(acetilamino)-3-cloro-6-(4-c loro-2-fluor-3-metoxifenil)piridin-2- carboxilato de metilo, que se desacetila para producir 4-amino-3-cloro-6-(4-cloro-2-fluor-3-m etoxifenilo)piridin-2-carboxilato de metilo.
MX2014008019A 2011-12-30 2012-12-28 Metodos para la produccion de 4-amino-3-cloro-6-(4-cloro-2-fluor-3 -metoxifenil) piridin-2-carboxilato de metilo. MX340947B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161582166P 2011-12-30 2011-12-30
PCT/US2012/072071 WO2013102078A1 (en) 2011-12-30 2012-12-28 Methods of producing methyl 4-amino-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylate

Publications (2)

Publication Number Publication Date
MX2014008019A MX2014008019A (es) 2014-12-08
MX340947B true MX340947B (es) 2016-08-01

Family

ID=48695351

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014008019A MX340947B (es) 2011-12-30 2012-12-28 Metodos para la produccion de 4-amino-3-cloro-6-(4-cloro-2-fluor-3 -metoxifenil) piridin-2-carboxilato de metilo.

Country Status (16)

Country Link
US (1) US8754110B2 (es)
EP (1) EP2797890B1 (es)
JP (1) JP6092250B2 (es)
KR (1) KR102065543B1 (es)
AR (1) AR089628A1 (es)
AU (1) AU2012362268B2 (es)
BR (1) BR112014015962B8 (es)
CA (1) CA2861611C (es)
CO (1) CO7010843A2 (es)
IL (1) IL233412B (es)
IN (1) IN2014DN05767A (es)
MX (1) MX340947B (es)
NZ (1) NZ627192A (es)
PL (1) PL2797890T3 (es)
RU (1) RU2616621C2 (es)
WO (1) WO2013102078A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104114562A (zh) * 2011-12-30 2014-10-22 陶氏益农公司 形成4-氯-2-氟-3-取代的苯基硼酸频哪醇酯的方法及其使用方法
US20140170058A1 (en) * 2012-12-13 2014-06-19 Dow Agrosciences Llc Process for the removal of palladium from 4-amino-3-halo-5-fluoro-6-(aryl) pyridine-2-carboxylates and 4-amino-3-halo-6-(aryl)pyridine-2-carboxylates
UY35728A (es) 2013-09-05 2015-04-30 Dow Agrosciences Llc ?métodos para producir arenos borilados?.
TW201625354A (zh) 2014-06-16 2016-07-16 陶氏農業科學公司 用於製備氧硼基化芳烴之方法
WO2016191245A1 (en) * 2015-05-22 2016-12-01 Dow Agrosciences Llc Recovery and/or reuse of palladium catalyst after a suzuki coupling
CN105851037B (zh) * 2016-05-17 2018-09-07 陕西上格之路生物科学有限公司 一种含氟氯吡啶酯的三元除草组合物
BR112018073348B8 (pt) * 2016-05-19 2023-05-16 Dow Agrosciences Llc Métodos para preparar 6-aril-4-aminopicolinatos e 2-aril-6-aminopirimidina-4-carboxilatos por acoplamento direto de suzuki

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7145040B2 (en) * 2004-07-02 2006-12-05 Bristol-Myers Squibb Co. Process for the preparation of amino acids useful in the preparation of peptide receptor modulators
CN102977036B (zh) 2006-01-13 2017-05-03 美国陶氏益农公司 2‑(多取代芳基)‑6‑氨基‑5‑卤代‑4‑嘧啶甲酸及其作为除草剂的用途
CA2626103C (en) 2006-01-13 2013-07-30 Dow Agrosciences Llc 6-(poly-substituted aryl)-4-aminopicolinates and their use as herbicides
BRPI0817626B8 (pt) * 2007-10-02 2022-06-28 Dow Agrosciences Llc ácidos 2-substituído-6-amino-5-alquil, alquenil ou alquinil-4-pirimidinacarboxílicos e ácidos 6-substituído-4-amino-3-alquil, alquenil ou aquinil picolínicos, composição herbicida que os compreende e método de controlar vegetação indesejável
MX2010007619A (es) * 2008-01-11 2010-08-04 Dow Agrosciences Llc Proceso para la desprotonacion y funcionalizacion selectiva de 1-fluoro-2-sustituido-3-clorobencenos.
GB0902474D0 (en) * 2009-02-13 2009-04-01 Syngenta Ltd Chemical compounds
US8252938B2 (en) 2009-06-08 2012-08-28 Dow Agrosciences, Llc. Process for the preparation of 6-(aryl)-4-aminopicolinates
WO2011063072A2 (en) * 2009-11-19 2011-05-26 Lexicon Pharmaceuticals, Inc. Process for the preparation of substituted phenylalanines
CN104114562A (zh) * 2011-12-30 2014-10-22 陶氏益农公司 形成4-氯-2-氟-3-取代的苯基硼酸频哪醇酯的方法及其使用方法
US20140170058A1 (en) * 2012-12-13 2014-06-19 Dow Agrosciences Llc Process for the removal of palladium from 4-amino-3-halo-5-fluoro-6-(aryl) pyridine-2-carboxylates and 4-amino-3-halo-6-(aryl)pyridine-2-carboxylates

Also Published As

Publication number Publication date
BR112014015962B8 (pt) 2022-10-11
EP2797890B1 (en) 2016-10-05
JP6092250B2 (ja) 2017-03-08
AR089628A1 (es) 2014-09-03
AU2012362268A1 (en) 2014-07-31
WO2013102078A1 (en) 2013-07-04
JP2015504059A (ja) 2015-02-05
IL233412A0 (en) 2014-08-31
RU2014131451A (ru) 2016-02-20
MX2014008019A (es) 2014-12-08
RU2616621C2 (ru) 2017-04-18
NZ627192A (en) 2015-09-25
IL233412B (en) 2019-01-31
BR112014015962A8 (pt) 2017-07-04
EP2797890A4 (en) 2015-09-23
CO7010843A2 (es) 2014-07-31
KR102065543B1 (ko) 2020-01-13
IN2014DN05767A (es) 2015-04-10
AU2012362268B2 (en) 2016-11-17
BR112014015962B1 (pt) 2019-12-17
BR112014015962A2 (pt) 2017-06-13
KR20140117444A (ko) 2014-10-07
US20130172566A1 (en) 2013-07-04
US8754110B2 (en) 2014-06-17
CA2861611C (en) 2020-04-21
EP2797890A1 (en) 2014-11-05
PL2797890T3 (pl) 2017-06-30
CA2861611A1 (en) 2013-07-04

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