BR112016029756A2 - ?método para produzir um composto? - Google Patents

?método para produzir um composto?

Info

Publication number
BR112016029756A2
BR112016029756A2 BR112016029756A BR112016029756A BR112016029756A2 BR 112016029756 A2 BR112016029756 A2 BR 112016029756A2 BR 112016029756 A BR112016029756 A BR 112016029756A BR 112016029756 A BR112016029756 A BR 112016029756A BR 112016029756 A2 BR112016029756 A2 BR 112016029756A2
Authority
BR
Brazil
Prior art keywords
formula
amino
represented
producing
reacting
Prior art date
Application number
BR112016029756A
Other languages
English (en)
Other versions
BR112016029756B1 (pt
Inventor
Araki Koichi
Aizawa Ryo
Original Assignee
Agro Kanesho Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agro Kanesho Co Ltd filed Critical Agro Kanesho Co Ltd
Publication of BR112016029756A2 publication Critical patent/BR112016029756A2/pt
Publication of BR112016029756B1 publication Critical patent/BR112016029756B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/803—Processes of preparation
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Environmental Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Zoology (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

a presente invenção provê um método para produzir ácido 2-amino-6-metilnicotínico representado pela fórmula [i], em que o método de produção compreende: (a) reagir 2-cloro-3-ciano-6-metilpiridina representada pela fórmula [ii] em uma solução aquosa de amônia para obter uma solução de reação contendo 2-amino-6-metil-nicotinamida representada pela fórmula [iii]; e (b) remover a amônia da solução de reação, então reagir a 2-amino-6-metilnicotinamida representada pela fórmula [iii] com uma base para produzir o ácido 2-amino-6-metilnicotínico representado pela fórmula [i].
BR112016029756-3A 2014-06-27 2014-06-27 método para produzir um composto BR112016029756B1 (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/JP2014/067260 WO2015198486A1 (ja) 2014-06-27 2014-06-27 ２－アミノ－６－メチルニコチン酸の製造方法

Publications (2)

Publication Number Publication Date
BR112016029756A2 true BR112016029756A2 (pt) 2017-08-22
BR112016029756B1 BR112016029756B1 (pt) 2021-05-04

Family

ID=54937605

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112016029756-3A BR112016029756B1 (pt) 2014-06-27 2014-06-27 método para produzir um composto

Country Status (10)

Country Link
US (1) US9902697B2 (pt)
EP (1) EP3162796B1 (pt)
JP (1) JP6219516B2 (pt)
KR (1) KR101849274B1 (pt)
CN (1) CN106458908B (pt)
BR (1) BR112016029756B1 (pt)
RU (1) RU2658916C1 (pt)
TW (1) TWI565696B (pt)
WO (1) WO2015198486A1 (pt)
ZA (1) ZA201700478B (pt)

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4327219A (en) 1980-04-21 1982-04-27 The Lummus Company Nicotinamide production
US4963561A (en) 1990-02-28 1990-10-16 Sterling Drug Inc. Imidazopyridines, their preparation and use
ZA97905B (en) * 1996-02-09 1997-08-01 Reilly Ind Inc Continuous processes for the hydrolysis of cyanopyridines under substantially adiabatic conditions.
JP4795022B2 (ja) 2003-09-30 2011-10-19 エーザイ・アール・アンド・ディー・マネジメント株式会社 ヘテロ環化合物を含有する新規な抗真菌剤
US20090227799A1 (en) 2004-08-09 2009-09-10 Kazutaka Nakamoto Novel Antimalarial Agent Containing Heterocyclic Compound
KR20060071812A (ko) * 2004-12-22 2006-06-27 주식회사 엘지생명과학 신규한 3-(2-아미노-6-피리디닐)-4-히드록시페닐 아민유도체
CN102702194A (zh) 2005-12-21 2012-10-03 雅培制药有限公司 抗病毒化合物
EP1971611B1 (en) 2005-12-21 2012-10-10 Abbott Laboratories Anti-viral compounds
WO2007076034A2 (en) 2005-12-21 2007-07-05 Abbott Laboratories Anti-viral compounds
CA2672737A1 (en) 2006-12-20 2008-11-06 Abbott Laboratories Anti-viral compounds
CA2680356A1 (en) 2007-04-20 2008-10-30 Lonza Ag Method for the hydrolysis of heteroaromatic nitriles in aqueous fluids
FR2928070A1 (fr) 2008-02-27 2009-09-04 Sumitomo Chemical Co Composition agricole, utilisation d'un compose pour sa production et procede pour matriser ou prevenir les maladies des plantes.
CN101812016B (zh) 2009-02-23 2013-01-16 浙江海翔药业股份有限公司 一种制备依托昔布中间体-6-甲基烟酸及其酯的方法
ES2665561T3 (es) 2012-07-04 2018-04-26 Agro-Kanesho Co., Ltd. Derivado de éster de ácido 2-aminonicotínico y bactericida que contiene el mismo como ingrediente activo

Also Published As

Publication number Publication date
KR101849274B1 (ko) 2018-04-16
BR112016029756B1 (pt) 2021-05-04
RU2658916C1 (ru) 2018-06-26
US9902697B2 (en) 2018-02-27
CN106458908A (zh) 2017-02-22
EP3162796A4 (en) 2018-01-03
EP3162796A1 (en) 2017-05-03
JPWO2015198486A1 (ja) 2017-04-20
US20170129858A1 (en) 2017-05-11
CN106458908B (zh) 2018-11-06
JP6219516B2 (ja) 2017-10-25
TW201600509A (zh) 2016-01-01
TWI565696B (zh) 2017-01-11
KR20170015864A (ko) 2017-02-09
EP3162796B1 (en) 2021-06-09
ZA201700478B (en) 2018-04-25
WO2015198486A1 (ja) 2015-12-30

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Legal Events

Date Code Title Description
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 27/06/2014, OBSERVADAS AS CONDICOES LEGAIS.