BR112014004827A2 - isopropilmalato sintase de nicotiana tabacum e métodos e usos dos mesmos - Google Patents
isopropilmalato sintase de nicotiana tabacum e métodos e usos dos mesmosInfo
- Publication number
- BR112014004827A2 BR112014004827A2 BR112014004827A BR112014004827A BR112014004827A2 BR 112014004827 A2 BR112014004827 A2 BR 112014004827A2 BR 112014004827 A BR112014004827 A BR 112014004827A BR 112014004827 A BR112014004827 A BR 112014004827A BR 112014004827 A2 BR112014004827 A2 BR 112014004827A2
- Authority
- BR
- Brazil
- Prior art keywords
- seq
- sequence
- vector
- polynucleotide
- identity
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
- C12N15/8245—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified carbohydrate or sugar alcohol metabolism, e.g. starch biosynthesis
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
- C12N15/8245—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified carbohydrate or sugar alcohol metabolism, e.g. starch biosynthesis
- C12N15/8246—Non-starch polysaccharides, e.g. cellulose, fructans, levans
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01H—NEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
- A01H5/00—Angiosperms, i.e. flowering plants, characterised by their plant parts; Angiosperms characterised otherwise than by their botanic taxonomy
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- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/18—Treatment of tobacco products or tobacco substitutes
- A24B15/20—Biochemical treatment
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
- C12N15/8218—Antisense, co-suppression, viral induced gene silencing [VIGS], post-transcriptional induced gene silencing [PTGS]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
- C12N15/8247—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified lipid metabolism, e.g. seed oil composition
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
- C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y203/00—Acyltransferases (2.3)
- C12Y203/03—Acyl groups converted into alkyl on transfer (2.3.3)
- C12Y203/03013—2-Isopropylmalate synthase (2.3.3.13)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Nutrition Science (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Physiology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Botany (AREA)
- Developmental Biology & Embryology (AREA)
- Environmental Sciences (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Manufacture Of Tobacco Products (AREA)
Abstract
abstract the present invention relates to a mutant, non-naturally occurring or transgenic plant cell comprising: (i) at least one polynucleotide comprising, consisting or consisting essentially of a sequence encoding an isopropylmalate synthase and having at least 60% sequence identity to seq id no:1 or seq id no:10 or seq id no: 12 or seq id no:14; or (ii) a polypeptide encoded by said polynucleotide(s); or (iii) a polypeptide having at least 60% sequence identity to seq id no:2 or seq id no:11 or seq id no:13 or seq id no:15; or (iv) a construct, vector or expression vector comprising said polynucleotide sequence(s), optionally wherein said construct, vector or expression vector additionally comprises a promoter comprising, consisting or consisting essentially of the sequence set forth in seq id no:8 or a variant thereof with at least about 60% identity thereto or a trichome promoter. ---------------------------------------------------------------------------- tradução do resumo resumo patente de invenção: "isopropilmalato síntese de nicotiana ta-bacum e métodos e usos da mesma". a presente invenção refere-se a uma célula de planta transgênica ou ocorrendo não-naturalmente, mutante, compreendendo: (i) pelo menos um polinucleotídeo compreendendo, consistindo ou consistindo essencialmente em uma seqüência codificando uma isopropil malato sintase e tendo pelo menos 60% de identidade de seqüência para seq id no: 1 ou seq id no: 10 ou seq id no: 12 ou seq id no: 14; ou (ii) um polipeptídeo codificado pelo dito polinucleotídeo(s); ou (iii) um polipeptídeo tendo pelo menos 60% de identidade de se-qüência para seq id no:2 ou seq id no: 11 ou seq id no: 13 ou seq id no: 15; ou (iv) uma construção, vetor ou vetor de expressão compreendendo a dita seqüencia(s) de polinucleotídeo, opcionalmente onde a dita construção, vetor ou vetor de expressão adicionalmente compreende um promotor compre-endendo, consistindo ou consistindo essencialmente na seqüência mostrada em seq id no: 8 ou uma sua variante com pelo menos cerca de 60% de iden-tidade para a mesma ou um promotor trichome.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP11179882A EP2565265A1 (en) | 2011-09-02 | 2011-09-02 | Isopropylmalate synthase from Nicotiana tabacum and methods and uses thereof |
PCT/EP2012/003662 WO2013029799A1 (en) | 2011-09-02 | 2012-08-31 | Isopropylmalate synthase from nicotiana tabacum and methods and uses thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112014004827A2 true BR112014004827A2 (pt) | 2017-04-04 |
BR112014004827A8 BR112014004827A8 (pt) | 2018-03-13 |
Family
ID=46832334
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112014004827A BR112014004827A8 (pt) | 2011-09-02 | 2012-08-31 | isopropilmalato síntese de nicotiana tabacum e métodos e usos da mesma. |
Country Status (18)
Country | Link |
---|---|
US (1) | US10287599B2 (pt) |
EP (3) | EP2565265A1 (pt) |
JP (2) | JP2014531200A (pt) |
KR (1) | KR102012993B1 (pt) |
CN (1) | CN103958673B (pt) |
AU (1) | AU2012301349B2 (pt) |
BR (1) | BR112014004827A8 (pt) |
ES (1) | ES2742271T3 (pt) |
IL (1) | IL231101B (pt) |
IN (1) | IN2014CN01706A (pt) |
MX (1) | MX365497B (pt) |
MY (1) | MY172423A (pt) |
PL (1) | PL2751262T3 (pt) |
RU (1) | RU2644238C2 (pt) |
SG (1) | SG11201400209UA (pt) |
TR (1) | TR201910626T4 (pt) |
UA (1) | UA116437C2 (pt) |
WO (1) | WO2013029799A1 (pt) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR112019016390A2 (pt) * | 2017-02-07 | 2020-04-07 | University Of Kentucky Research Foundation | método para aumentar o teor de éster de sacarose de uma planta de tabaco, uso de um gene de síntese de diterpenos, método para produzir uma planta de tabaco, planta de tabaco, material de propagação de plantas de tabaco, uso, folha colhida, folha de tabaco processada, material de tabaco curado, mistura de tabaco, produto da indústria do tabaco e artigo |
CN108070594B (zh) * | 2017-12-22 | 2020-10-27 | 河南农业大学 | 烟草腺毛ttr1启动子、其表达载体及其应用 |
JP7463284B2 (ja) | 2018-03-28 | 2024-04-08 | フィリップ・モーリス・プロダクツ・ソシエテ・アノニム | 植物におけるアミノ酸含有量の調節 |
US11591609B2 (en) | 2018-03-28 | 2023-02-28 | Philip Morris Products S.A. | Modulating reducing sugar content in a plant |
JP2022515435A (ja) | 2018-12-30 | 2022-02-18 | フィリップ・モーリス・プロダクツ・ソシエテ・アノニム | 硝酸レダクターゼの突然変異による植物における硝酸塩レベルの調節 |
CN110610743A (zh) * | 2019-08-16 | 2019-12-24 | 广东省生态环境技术研究所 | 一种构建铬还原酶蛋白数据库的方法 |
BR112022005589A2 (pt) | 2019-10-01 | 2022-06-28 | Philip Morris Products Sa | Modulação do teor de açúcar e aminoácidos em uma planta (sultr3) |
JP2022550383A (ja) | 2019-10-01 | 2022-12-01 | フィリップ・モーリス・プロダクツ・ソシエテ・アノニム | 植物における還元糖含有量の調節(inv) |
AU2021252558A1 (en) * | 2020-04-07 | 2022-11-10 | Board Of Trustees Of Michigan State University | Improving plant nutritional value and growth through enhancement of essential amino acid levels |
KR102527102B1 (ko) * | 2021-03-05 | 2023-04-28 | 씨제이제일제당 주식회사 | 이소프로필말레이트 신타제 변이체 및 이를 이용한 l-류신의 생산 방법 |
WO2023036691A1 (en) | 2021-09-10 | 2023-03-16 | Philip Morris Products S.A. | Modulating alkaloid profiles in nicotiana tabacum |
WO2023117661A1 (en) | 2021-12-20 | 2023-06-29 | Philip Morris Products S.A. | Increasing anatabine in tobacco leaf by regulating methyl putrescine oxidase |
WO2023117701A1 (en) | 2021-12-21 | 2023-06-29 | Philip Morris Products S.A. | Modulation of nicotine production by alteration of nicotinamidase expression or function in plants |
WO2024079137A1 (en) | 2022-10-13 | 2024-04-18 | Philip Morris Products S.A. | Increasing leaf biomass and nitrogen use efficiency by regulating ntp2 |
Family Cites Families (20)
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US2766145A (en) * | 1954-07-26 | 1956-10-09 | Reynolds Tobacco Co R | Tobacco |
JPS5231959B2 (pt) * | 1973-10-27 | 1977-08-18 | ||
US5260281A (en) | 1992-05-01 | 1993-11-09 | The United States Of America As Represented By The Secretary Of Agriculture | Biological pesticide derived from Nicotiana plants |
RU2143496C1 (ru) | 1993-06-30 | 1999-12-27 | Моген Интернэшнл Н.В. | Продуцирование трегалозы в растениях |
IL114551A0 (en) | 1994-07-11 | 1995-11-27 | Us Agriculture | Chemically synthesized sugar esters for the control of soft bodied arthropods |
US5716837A (en) | 1995-02-10 | 1998-02-10 | Monsanto Company | Expression of sucrose phosphorylase in plants |
US5750848A (en) | 1996-08-13 | 1998-05-12 | Monsanto Company | DNA sequence useful for the production of polyhydroxyalkanoates |
US6586661B1 (en) | 1997-06-12 | 2003-07-01 | North Carolina State University | Regulation of quinolate phosphoribosyl transferase expression by transformation with a tobacco quinolate phosphoribosyl transferase nucleic acid |
AU3266800A (en) | 1999-03-15 | 2000-10-04 | Her Majesty In Right Of Canada As Represented By The Minister Of Agriculture And Agri-Food Canada | Method for producing polyhydroxyalkanoates in recombinant organisms |
US7025066B2 (en) * | 2002-10-31 | 2006-04-11 | Jerry Wayne Lawson | Method of reducing the sucrose ester concentration of a tobacco mixture |
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CA2644273A1 (en) | 2006-04-05 | 2008-03-27 | Metanomics Gmbh | Process for the production of a fine chemical |
BRPI0717355B1 (pt) | 2006-10-13 | 2018-01-16 | North Carolina State University | Método para obtenção de uma planta transgênica de nicotina, método para obtenção de uma semente; construto de ácido nucléico recombinante; método de redução da conversão de nicotina em nornicotina em uma planta de nicotina |
RU2324737C1 (ru) * | 2006-10-18 | 2008-05-20 | Институт цитологии и генетики Сибирского отделения Российской академии наук (СО РАН) | Способ получения трансгенных растений табака с повышенным содержанием пролина |
RU2324736C1 (ru) | 2006-10-18 | 2008-05-20 | Институт цитологии и генетики Сибирского отделения Российской академии наук (СО РАН) | Способ получения трансгенных растений табака с повышенным содержанием пролина |
CN101939431B (zh) | 2007-11-12 | 2015-01-28 | 北卡罗来纳州立大学 | 通过修饰特定细胞色素p450基因改变烟草生物碱含量 |
WO2009074325A1 (en) | 2007-12-13 | 2009-06-18 | Philip Morris Products S.A. | Transgenic plants modified for reduced cadmium transport, derivative products, and related methods |
WO2010042575A1 (en) | 2008-10-08 | 2010-04-15 | Monsanto Technology Llc | Transgenic plants with enhanced agronomic traits |
US7883371B1 (en) | 2009-07-22 | 2011-02-08 | Hon Hai Precision Ind. Co., Ltd. | Electrical connector with improved contact footprints |
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2011
- 2011-09-02 EP EP11179882A patent/EP2565265A1/en not_active Ceased
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2012
- 2012-08-31 ES ES12758404T patent/ES2742271T3/es active Active
- 2012-08-31 WO PCT/EP2012/003662 patent/WO2013029799A1/en active Application Filing
- 2012-08-31 CN CN201280053787.7A patent/CN103958673B/zh active Active
- 2012-08-31 KR KR1020147008614A patent/KR102012993B1/ko active IP Right Grant
- 2012-08-31 JP JP2014527530A patent/JP2014531200A/ja active Pending
- 2012-08-31 RU RU2014112234A patent/RU2644238C2/ru active
- 2012-08-31 BR BR112014004827A patent/BR112014004827A8/pt not_active Application Discontinuation
- 2012-08-31 MY MYPI2014700466A patent/MY172423A/en unknown
- 2012-08-31 SG SG11201400209UA patent/SG11201400209UA/en unknown
- 2012-08-31 US US14/241,185 patent/US10287599B2/en active Active
- 2012-08-31 EP EP12758404.3A patent/EP2751262B1/en active Active
- 2012-08-31 UA UAA201403274A patent/UA116437C2/uk unknown
- 2012-08-31 AU AU2012301349A patent/AU2012301349B2/en not_active Ceased
- 2012-08-31 IN IN1706CHN2014 patent/IN2014CN01706A/en unknown
- 2012-08-31 EP EP19178884.3A patent/EP3578645A1/en active Pending
- 2012-08-31 MX MX2014002497A patent/MX365497B/es active IP Right Grant
- 2012-08-31 TR TR2019/10626T patent/TR201910626T4/tr unknown
- 2012-08-31 PL PL12758404T patent/PL2751262T3/pl unknown
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2014
- 2014-02-24 IL IL231101A patent/IL231101B/en active IP Right Grant
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2018
- 2018-06-29 JP JP2018124909A patent/JP7000265B2/ja active Active
Also Published As
Publication number | Publication date |
---|---|
MX365497B (es) | 2019-06-05 |
BR112014004827A8 (pt) | 2018-03-13 |
TR201910626T4 (tr) | 2019-08-21 |
EP3578645A1 (en) | 2019-12-11 |
JP7000265B2 (ja) | 2022-02-04 |
ES2742271T3 (es) | 2020-02-13 |
AU2012301349A1 (en) | 2014-03-20 |
IL231101A0 (en) | 2014-04-30 |
US10287599B2 (en) | 2019-05-14 |
EP2751262B1 (en) | 2019-06-12 |
EP2751262A1 (en) | 2014-07-09 |
KR20140067082A (ko) | 2014-06-03 |
SG11201400209UA (en) | 2014-03-28 |
PL2751262T3 (pl) | 2020-01-31 |
AU2012301349B2 (en) | 2015-09-17 |
RU2644238C2 (ru) | 2018-02-08 |
US20140352706A1 (en) | 2014-12-04 |
IL231101B (en) | 2018-10-31 |
WO2013029799A1 (en) | 2013-03-07 |
KR102012993B1 (ko) | 2019-08-21 |
MY172423A (en) | 2019-11-25 |
UA116437C2 (uk) | 2018-03-26 |
CN103958673B (zh) | 2021-10-26 |
EP2565265A1 (en) | 2013-03-06 |
RU2014112234A (ru) | 2015-10-10 |
MX2014002497A (es) | 2014-12-04 |
IN2014CN01706A (pt) | 2015-05-29 |
CN103958673A (zh) | 2014-07-30 |
JP2014531200A (ja) | 2014-11-27 |
JP2018186820A (ja) | 2018-11-29 |
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