BR112013033339A2 - análogos de fluorergolina - Google Patents

análogos de fluorergolina

Info

Publication number
BR112013033339A2
BR112013033339A2 BR112013033339A BR112013033339A BR112013033339A2 BR 112013033339 A2 BR112013033339 A2 BR 112013033339A2 BR 112013033339 A BR112013033339 A BR 112013033339A BR 112013033339 A BR112013033339 A BR 112013033339A BR 112013033339 A2 BR112013033339 A2 BR 112013033339A2
Authority
BR
Brazil
Prior art keywords
compounds
methods
receptors
compositions disclosed
agonizing
Prior art date
Application number
BR112013033339A
Other languages
English (en)
Inventor
Jian Zhang
Robert O Cook
Thomas A Armer
Original Assignee
Map Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Map Pharmaceuticals Inc filed Critical Map Pharmaceuticals Inc
Publication of BR112013033339A2 publication Critical patent/BR112013033339A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/02—Ergot alkaloids of the cyclic peptide type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

Abstract

abstract provided herein are novel fluoroergoline derivatives and compositions thereof. in other embodiments, provided herein are methods of treatment, prevention, or amelioration of a variety of medical disorders such as, for example, migraine using the compounds and compositions disclosed herein. in still other embodiments, provided herein are methods of agonizing receptors such as, for example, the 5 ht1d and/or the 5 ht1b receptor, without agonizing the 5 ht2b receptor using the compounds and compositions disclosed herein. in still other embodiments, provided herein are methods of antagonizing or inhibiting activity at receptors such as, for example, the adrenergic alpha2a and/or the alpha2b receptors using the compounds and compositions disclosed herein. tradução do resumo resumo pedido de invenção: "análogos de fluorergolina". são fornecidos neste documento novos derivados de fluorergolina e composições dos mesmos. em outras modalidades, são fornecidos aqui métodos para tratamento, prevenção ou melhoria de uma variedade de distúrbios médicos tais como, por exemplo, enxaqueca, usando os compostos e as composições divulgadas neste documento. em ainda outras modalidades, são fornecidos neste documento métodos de agonizar receptores, tal como, por exemplo, o receptor 5 htid e/ou 5 ht1b, sem agonizar o receptor 5-ht2b usando os compostos e as composições divulgadas neste documento. em ainda outras modalidades, são fornecidos neste documento métodos de antagonizar ou inibir a atividade em receptores tais como, por exemplo, os receptores alfa2a e/ou o alfa2b adrenérgicos usando os compostos e as composições divulgadas neste documento.
BR112013033339A 2011-06-23 2012-06-22 análogos de fluorergolina BR112013033339A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161571299P 2011-06-23 2011-06-23
PCT/US2012/043677 WO2012177962A1 (en) 2011-06-23 2012-06-22 Novel fluoroergoline analogs

Publications (1)

Publication Number Publication Date
BR112013033339A2 true BR112013033339A2 (pt) 2016-08-16

Family

ID=47362423

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112013033339A BR112013033339A2 (pt) 2011-06-23 2012-06-22 análogos de fluorergolina

Country Status (13)

Country Link
US (6) US8604035B2 (pt)
EP (1) EP2723735A4 (pt)
JP (1) JP2014517076A (pt)
KR (1) KR20140042868A (pt)
CN (1) CN103827113A (pt)
AU (1) AU2012272780A1 (pt)
BR (1) BR112013033339A2 (pt)
CA (1) CA2838991A1 (pt)
CL (1) CL2013003686A1 (pt)
MX (1) MX2013015373A (pt)
RU (1) RU2013158449A (pt)
WO (1) WO2012177962A1 (pt)
ZA (1) ZA201309245B (pt)

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US8710092B2 (en) 2009-12-23 2014-04-29 Map Pharmaceuticals, Inc. Substituted indolo 4,3 FG quinolines useful for treating migraine
BR112013033339A2 (pt) 2011-06-23 2016-08-16 Map Pharmaceuticals Inc análogos de fluorergolina
SG11201403434YA (en) 2011-12-19 2014-09-26 Map Pharmaceuticals Inc Novel iso-ergoline derivatives
EP2793583A4 (en) 2011-12-21 2015-08-12 Map Pharmaceuticals Inc NOVEL NEUROMODULATORY CONNECTIONS
US9012640B2 (en) 2012-06-22 2015-04-21 Map Pharmaceuticals, Inc. Cabergoline derivatives
CN105189492A (zh) 2012-11-19 2015-12-23 萨克·W·金 麦角灵衍生物作为多巴胺受体调节剂
US20140179706A1 (en) * 2012-12-21 2014-06-26 Map Pharmaceuticals, Inc. Fluoroergoline derivatives and uses thereof
EP2934529A1 (en) * 2012-12-21 2015-10-28 MAP Pharmaceuticals, Inc. Novel ergoline derivatives and uses thereof
AU2013361337A1 (en) * 2012-12-21 2015-07-09 Map Pharmaceuticals, Inc. 8'-Hydroxy-Dihydroergotamine compounds and compositions
WO2014100353A1 (en) * 2012-12-21 2014-06-26 Map Pharmaceuticals, Inc. 8'-hydroxy-dihydroergotamine compounds and compositions
BR112017015487A2 (pt) 2015-01-20 2018-01-30 Xoc Pharmaceuticals Inc Composto; composição; método de tratamento e/ou prevenção de enxaqueca, als, doença de alzheimer, doença de parkinson, distúrbios extrapirimidais, depressão, náusea, êmese, síndrome das pernas inquietas, insônia, agressão, doença de huntington, doença cardiopulmonar, fibrogênese, hipertensão arterial pulmonar, ansiedade, dependências a drogas, distonia, parassonia ou hiperlactinemia em um indivíduo; métodos de agonização dos receptores d2, 5-ht1d, 5-ht1a e 5-ht2c, em um indivíduo; método de antagonização do receptor d3 em um indivíduo; métodos de agonização seletiva dos receptores 5 -ht1d, e 5-ht2c, método de fornecimento de atividade de antagonista funcional no receptor 5 -ht2b ou no receptor 5-ht7, ou em ambos, em um indivíduo; método de fornecimento de atividade de antagonista funcional nos receptores adrenérgicos em um indivíduo
MX2017009406A (es) 2015-01-20 2018-01-18 Xoc Pharmaceuticals Inc Compuestos de tipo isoergolina y usos de estos.
BR112019025420A2 (pt) 2017-06-01 2020-06-16 Xoc Pharmaceuticals, Inc. Compostos policíclicos e usos destes
GB2571696B (en) 2017-10-09 2020-05-27 Compass Pathways Ltd Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced
WO2020212948A1 (en) 2019-04-17 2020-10-22 Compass Pathfinder Limited Methods of treating neurocognitive disorders, chronic pain and reducing inflammation

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US20120329806A1 (en) 2012-12-27
US20140073647A1 (en) 2014-03-13
US8604035B2 (en) 2013-12-10
US20140073790A1 (en) 2014-03-13
US8933093B2 (en) 2015-01-13
WO2012177962A1 (en) 2012-12-27
JP2014517076A (ja) 2014-07-17
US20150099755A1 (en) 2015-04-09
US8841448B2 (en) 2014-09-23
EP2723735A1 (en) 2014-04-30
CA2838991A1 (en) 2012-12-27
KR20140042868A (ko) 2014-04-07
AU2012272780A1 (en) 2014-01-09
EP2723735A4 (en) 2015-02-18
ZA201309245B (en) 2015-08-26
RU2013158449A (ru) 2015-07-27
US20150368275A1 (en) 2015-12-24
US20140066450A1 (en) 2014-03-06
US8927567B2 (en) 2015-01-06
US9365591B2 (en) 2016-06-14
US9150593B2 (en) 2015-10-06
CL2013003686A1 (es) 2014-08-29

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