CH344731A - Verfahren zur Herstellung von neuen, am Indolstickstoff alkylierten Derivaten der Lysergsäure-Reihe - Google Patents

Verfahren zur Herstellung von neuen, am Indolstickstoff alkylierten Derivaten der Lysergsäure-Reihe

Info

Publication number
CH344731A
CH344731A CH344731DA CH344731A CH 344731 A CH344731 A CH 344731A CH 344731D A CH344731D A CH 344731DA CH 344731 A CH344731 A CH 344731A
Authority
CH
Switzerland
Prior art keywords
alkylated
production
acid series
new derivatives
lysergic acid
Prior art date
Application number
Other languages
English (en)
Inventor
Albert Dr Hofmann
Franz Dr Troxler
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of CH344731A publication Critical patent/CH344731A/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D457/00Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • C07D457/06Lysergic acid amides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CH344731D 1956-05-18 1956-05-18 Verfahren zur Herstellung von neuen, am Indolstickstoff alkylierten Derivaten der Lysergsäure-Reihe CH344731A (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH3337756 1956-05-18

Publications (1)

Publication Number Publication Date
CH344731A true CH344731A (de) 1960-02-29

Family

ID=4502931

Family Applications (2)

Application Number Title Priority Date Filing Date
CH344731D CH344731A (de) 1956-05-18 1956-05-18 Verfahren zur Herstellung von neuen, am Indolstickstoff alkylierten Derivaten der Lysergsäure-Reihe
CH351277D CH351277A (de) 1956-05-18 1957-03-20 Verfahren zur Herstellung von neuen am Indolstickstoff allylierten Derivaten der Dihydrolysergsäure-Reihe

Family Applications After (1)

Application Number Title Priority Date Filing Date
CH351277D CH351277A (de) 1956-05-18 1957-03-20 Verfahren zur Herstellung von neuen am Indolstickstoff allylierten Derivaten der Dihydrolysergsäure-Reihe

Country Status (3)

Country Link
US (3) US3113133A (de)
CH (2) CH344731A (de)
GB (1) GB811964A (de)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3249617A (en) * 1966-05-03 Alkylated d-lyserglc acid
US3228939A (en) * 1966-01-11 Methyl and i,g-dimethyl-ergoline ii derivatives
US3251846A (en) * 1966-05-17 G-dimethyosoergolenyl-b
US3218323A (en) * 1965-11-16 Esters of i,g-dimethyl-b-ergolenyl carbamic acid
US3190884A (en) * 1965-06-22 Chz-chz-cn
US3236852A (en) * 1966-02-22 Esters of g-methyl- and i,g-dimethyl. ergoline
US3346580A (en) * 1967-10-10 Lysergic acid amides
CH344731A (de) * 1956-05-18 1960-02-29 Sandoz Ag Verfahren zur Herstellung von neuen, am Indolstickstoff alkylierten Derivaten der Lysergsäure-Reihe
US3131189A (en) * 1961-10-16 1964-04-28 Pure Oil Co Preparation of quaternary ammonium betaine salts
AT251200B (de) * 1962-07-13 1966-12-27 Farmaceutici Italia Verfahren zur Herstellung neuer Derivate von Dihydro-D-lysergsäureamid und 1-Methyl-dihydro-D-lysergsäureamid
GB1067513A (en) * 1963-08-29 1967-05-03 Sandoz Ltd Derivatives of ergolene
US3239530A (en) * 1964-01-13 1966-03-08 Sandoz Ltd Process for lysergic acid hydrazides
CH469006A (de) * 1965-07-07 1969-02-28 Sandoz Ag Verfahren zur Herstellung neuer synthetischer Alkaloide
US3681497A (en) * 1966-06-07 1972-08-01 Spofa Vereinigte Pharma Werke Therapeutic methods of employing hydrogen maleate salt of n-(d-6-methyl-8-isoergolenyl)-n{40 ,n{40 -diethyl-carbamide
CH508628A (de) * 1968-06-25 1971-06-15 Sandoz Ag Verfahren zur Herstellung neuer heterocyclischer Verbindungen
US3846433A (en) * 1969-05-06 1974-11-05 Sandoz Ltd Process for preparing ergot alkaloids
CH517099A (de) * 1969-06-20 1971-12-31 Sandoz Ag Verfahren zur Herstellung neuer Mutterkornpeptidalkaloide
US4165376A (en) * 1971-01-29 1979-08-21 Lake Shore Roentgenology, Ltd. Treatment of the acute after-effects resulting from alcohol ingestion
CH573936A5 (de) * 1971-08-05 1976-03-31 Spofa Vereinigte Pharma Werke
US3875167A (en) * 1972-05-26 1975-04-01 Research Corp Synthesis of thalicarpine
DE2330912C3 (de) * 1972-06-22 1979-01-11 Societa Farmaceutici Italia S.P.A., Mailand (Italien) Verfahren zur Herstellung von Bromergolinverbindungen
US3904633A (en) * 1973-02-05 1975-09-09 Richter Gedeon Vegyeszet Lysergic amides
USRE30218E (en) * 1974-12-06 1980-02-19 Eli Lilly And Company 8,8-Disubstituted-6-methylergolines and related compounds
USRE30219E (en) * 1974-12-06 1980-02-19 Eli Lilly And Company Method of preparing 8,8-disubstituted-6-methylergolines and related compounds
US3968111A (en) * 1974-12-06 1976-07-06 Eli Lilly And Company 8,8-Disubstituted-6-methylergolines and related compounds
US4138565A (en) * 1975-05-31 1979-02-06 Sandoz Ltd. Stable solutions and processes for their preparation
YU40004B (en) * 1977-07-21 1985-06-30 Lek Tovarna Farmacevtskih Praocess for preparing n-substituted esters of 9,10-dihydrlysergic acid
DD146460A1 (de) * 1979-11-14 1981-02-11 Reni Bartsch Verfahren zur herstellung 1-benzylierter ergometrinderivate
US4315937A (en) * 1979-11-28 1982-02-16 Sandoz Ltd. Ergots and their use in treating minimal brain dysfunction
US4526892A (en) * 1981-03-03 1985-07-02 Farmitalia Carlo Erba, S.P.A. Dimethylaminoalkyl-3-(ergoline-8'βcarbonyl)-ureas
CS231214B1 (en) * 1982-03-12 1984-10-15 Antonin Cerny Processing method of 1-substituted n+l8alpha-ergoline+p-n,diethyl urea
DE3362248D1 (en) * 1982-04-13 1986-04-03 Erba Farmitalia Ergoline derivatives, process for producing the ergoline derivatives and pharmaceutical compositions containing them
US4563461A (en) * 1983-03-10 1986-01-07 Eli Lilly And Company Selective method for blocking 5HT2 receptors
FR2584721B1 (fr) * 1985-07-11 1987-10-02 Rhone Poulenc Sante Procede de preparation des derives n-methyles du dihydrolysergate de methyle ou du methoxylumilysergate de methyle
US4713384A (en) * 1985-10-01 1987-12-15 Eli Lilly And Company Selective method for blocking 5HT2 receptors
US4714704A (en) * 1985-10-01 1987-12-22 Eli Lilly And Company Alkoxy cycloalkanol esters of dihydrolysergic acid useful as 5HT receptor antagonists
US4968802A (en) * 1985-10-01 1990-11-06 Eli Lilly And Company Process of making alkoxy cycloalkanol esters of dihydrolysergic acid
US4762842A (en) * 1985-10-01 1988-08-09 Eli Lilly And Company Selective method for blocking 5HT2 receptors
US4713385A (en) * 1985-10-01 1987-12-15 Eli Lilly And Company Alkoxy and dialkoxyalkyl esters of dihydrolysergic acid and related compounds useful as 5HT receptor antagonists
US4810710A (en) * 1985-10-01 1989-03-07 Eli Lilly And Company 4-hydroxycyclohexyl 1-isopropyl-9,10-dihydro-lysergate for the treatment of migraine
US4906639A (en) * 1985-10-01 1990-03-06 Eli Lilly And Company Cycloalkanol esters of dihydrolysergic acid
US4772709A (en) * 1985-10-01 1988-09-20 Eli Lilly And Company Process of making ketoalkanol esters of dihydrolysergic acid
US4820713A (en) * 1985-10-01 1989-04-11 Eli Lilly And Company Ketoalkanol esters of dihydrolysergic acid useful as 5HT receptor antagonists
US4683236A (en) * 1985-10-01 1987-07-28 Eli Lilly And Company Cycloalkanol esters of dihydrolysergic acid useful as 5Ht2 receptor antagonists
US4847261A (en) * 1985-10-01 1989-07-11 Eli Lilly And Company Alkoxy cycloalkanol esters of dihydrolysergic acid having peripheral serotonin antagonists properties
US4939258A (en) * 1985-10-01 1990-07-03 Eli Lilly And Company Cycloalkanol esters of dihydrolysergic acid
US4845224A (en) * 1985-10-01 1989-07-04 Eli Lilly And Company Cycloalkanol esters of dihydrolysergic acid having peripheral serotonin antagonist properties
US4704396A (en) * 1985-12-20 1987-11-03 Eli Lilly And Company Phenacyl esters of 1-substituted-6-(substituted and unsubstituted) dihydrolysergic acids useful as 5HT receptor antagonists
US4704395A (en) * 1985-12-20 1987-11-03 Eli Lilly And Company Cyclic ether esters of 2-substituted-6-(substituted and unsubstituted) dihydrolysergic acid useful as 5HT receptor antagonists
US4683237A (en) * 1985-12-20 1987-07-28 Eli Lilly And Company Fluoroalkyl esters of dihydrolysergic acid useful as 5HT2 receptor antagonists
US4874766A (en) * 1986-09-22 1989-10-17 Janssen Pharmaceutica N.V. Method of promoting wound-healing
US4981859A (en) * 1987-06-15 1991-01-01 Cycloalkylamides of (8 beta )-1-alkyl-6-(substituted)ergolines
US4931447A (en) * 1987-06-15 1990-06-05 Eli Lilly And Company Cycloalkylamides of (8β)-1-alkyl-6-(substituted) ergolines
US4798834A (en) * 1987-08-31 1989-01-17 Eli Lilly And Company Optionally substituted (3β-9,10-didehydro-2,3-dihydro ergoline as serotonergic function enhancement
US6207396B1 (en) 1995-11-20 2001-03-27 Microgenics Corporation Immunoassay reagents and methods for determination of LSD and LSD metabolites
US5843682A (en) * 1995-11-20 1998-12-01 Boehringer Mannheim Corporation N-1-carboxyalkyl derivatives of LSD
DE10212564B4 (de) * 2002-03-12 2007-04-19 Neurobiotec Gmbh 1-Allyl-ergotalkaloid-Derivate und ihre Verwendung zur Prophylaxe und Therapie von Migräne
EP2515654A4 (de) 2009-12-23 2013-04-24 Map Pharmaceuticals Inc Neue ergolinanaloga
MX2013015373A (es) 2011-06-23 2014-02-11 Map Pharmaceuticals Inc Nuevos analogos de fluoroergolina.
WO2013095707A1 (en) 2011-12-19 2013-06-27 Map Pharmaceuticals, Inc. Novel iso-ergoline derivatives
SG11201403433PA (en) 2011-12-21 2014-07-30 Map Pharmaceuticals Inc Novel neuromodulatory compounds
US9012640B2 (en) 2012-06-22 2015-04-21 Map Pharmaceuticals, Inc. Cabergoline derivatives

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2265207A (en) * 1941-12-09 D-lysergic acid - d - l-bjtdroxybutyl
US2269145A (en) * 1939-06-16 1942-01-06 Upjohn Co Stabilized ergot alkaloid preparation
US2390575A (en) * 1944-05-01 1945-12-11 Lederle Lab Inc Stabilized solutions of ergot alkaloidal salts
US2796419A (en) * 1954-09-27 1957-06-18 Lilly Co Eli Lysergic acid, intermediates and preparation
US2997470A (en) * 1956-03-05 1961-08-22 Lilly Co Eli Lysergic acid amides
CH344731A (de) * 1956-05-18 1960-02-29 Sandoz Ag Verfahren zur Herstellung von neuen, am Indolstickstoff alkylierten Derivaten der Lysergsäure-Reihe

Also Published As

Publication number Publication date
US3218324A (en) 1965-11-16
US3113133A (en) 1963-12-03
US3388129A (en) 1968-06-11
CH351277A (de) 1961-01-15
GB811964A (en) 1959-04-15

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