BR112015014964A2 - novos derivados de metisergida - Google Patents

novos derivados de metisergida

Info

Publication number
BR112015014964A2
BR112015014964A2 BR112015014964A BR112015014964A BR112015014964A2 BR 112015014964 A2 BR112015014964 A2 BR 112015014964A2 BR 112015014964 A BR112015014964 A BR 112015014964A BR 112015014964 A BR112015014964 A BR 112015014964A BR 112015014964 A2 BR112015014964 A2 BR 112015014964A2
Authority
BR
Brazil
Prior art keywords
new
compounds
methods
methysergide
derivatives
Prior art date
Application number
BR112015014964A
Other languages
English (en)
Inventor
Zhang Jian
Wu Libo
Original Assignee
Map Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Map Pharmaceuticals Inc filed Critical Map Pharmaceuticals Inc
Publication of BR112015014964A2 publication Critical patent/BR112015014964A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • C07D457/06—Lysergic acid amides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

resumo novos derivados de metisergida fornecidos neste documento são novos derivados de metisergida e composições da mesma. em outras modalidades, fornecidos neste documento são métodos de tratamento, prevenção ou melhoria de uma variedade de distúrbios médicos ou sintomas dos mesmos, tais como, enxaqueca e doença de parkinson usando os compostos e as composições divulgadas neste documento. em ainda outras modalidades, aqui apresentados, tais como, por exemplo, são métodos para antagonizar o receptor 5-ht2b sem agonizar o receptor 5-ht2b usando os compostos e as composições divulgadas neste documento. em ainda outras modalidades, fornecidos neste documento, tais como, por exemplo, são métodos de agonizar o receptor 5-ht1a usando os compostos e as composições divulgadas neste documento.
BR112015014964A 2012-12-21 2013-12-19 novos derivados de metisergida BR112015014964A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261745131P 2012-12-21 2012-12-21
US201361753328P 2013-01-16 2013-01-16
PCT/US2013/076424 WO2014100354A1 (en) 2012-12-21 2013-12-19 Novel methysergide derivatives

Publications (1)

Publication Number Publication Date
BR112015014964A2 true BR112015014964A2 (pt) 2017-07-11

Family

ID=50975329

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015014964A BR112015014964A2 (pt) 2012-12-21 2013-12-19 novos derivados de metisergida

Country Status (9)

Country Link
US (2) US8895743B2 (pt)
EP (1) EP2934143A4 (pt)
JP (1) JP2016503795A (pt)
AU (1) AU2013361340A1 (pt)
BR (1) BR112015014964A2 (pt)
CA (1) CA2895829A1 (pt)
IL (1) IL239492A0 (pt)
SG (1) SG11201504931SA (pt)
WO (1) WO2014100354A1 (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2013158449A (ru) * 2011-06-23 2015-07-27 Мэп Фармасьютикалс, Инк. Новые фторэрголиновые аналоги
US9868732B2 (en) * 2015-01-08 2018-01-16 Justin Kirkland Process of synthesizing 2-bromo-LSD
WO2016118539A2 (en) 2015-01-20 2016-07-28 Xoc Pharmaceuticls, Inc. Isoergoline compounds and uses thereof
US9657020B2 (en) 2015-01-20 2017-05-23 Xoc Pharmaceuticals, Inc. Ergoline compounds and uses thereof
ES2886045T3 (es) * 2017-04-11 2021-12-16 Ceva Sante Animale Sarpogrelato para su uso en un método para el tratamiento de cardiopatías en mamíferos
AU2018275873A1 (en) 2017-06-01 2019-12-19 Xoc Pharmaceuticals, Inc. Ergoline derivatives for use in medicine
WO2023225043A1 (en) * 2022-05-18 2023-11-23 Kuleon Llc Tricyclic and tetracyclic serotonin receptor modulators and methods of making and using the same

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Also Published As

Publication number Publication date
US20140179730A1 (en) 2014-06-26
IL239492A0 (en) 2015-08-31
WO2014100354A1 (en) 2014-06-26
US8895743B2 (en) 2014-11-25
EP2934143A1 (en) 2015-10-28
EP2934143A4 (en) 2016-06-15
CA2895829A1 (en) 2014-06-26
US20150038525A1 (en) 2015-02-05
SG11201504931SA (en) 2015-07-30
JP2016503795A (ja) 2016-02-08
AU2013361340A1 (en) 2015-07-09

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]