BR112013033125A8 - Sistema de ligação que aumenta seletivamente a biotividade de compostos fenólicos em um sítio alvo; par de reagentes estabilizados para transporte aquoso a um sítio alvo; formulação farmacêutica; kit; uso do sistema; composição; e suplemento alimentar - Google Patents

Sistema de ligação que aumenta seletivamente a biotividade de compostos fenólicos em um sítio alvo; par de reagentes estabilizados para transporte aquoso a um sítio alvo; formulação farmacêutica; kit; uso do sistema; composição; e suplemento alimentar

Info

Publication number
BR112013033125A8
BR112013033125A8 BR112013033125A BR112013033125A BR112013033125A8 BR 112013033125 A8 BR112013033125 A8 BR 112013033125A8 BR 112013033125 A BR112013033125 A BR 112013033125A BR 112013033125 A BR112013033125 A BR 112013033125A BR 112013033125 A8 BR112013033125 A8 BR 112013033125A8
Authority
BR
Brazil
Prior art keywords
target site
kit
composition
food supplement
phenolic compounds
Prior art date
Application number
BR112013033125A
Other languages
English (en)
Other versions
BR112013033125A2 (pt
Inventor
l huang Alexander
Wu Gin
Original Assignee
Liveleaf Inc
Liveleaf Holdings Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Liveleaf Inc, Liveleaf Holdings Llc filed Critical Liveleaf Inc
Publication of BR112013033125A2 publication Critical patent/BR112013033125A2/pt
Publication of BR112013033125A8 publication Critical patent/BR112013033125A8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/40—Peroxides
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7024—Esters of saccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7032—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a polyol, i.e. compounds having two or more free or esterified hydroxy groups, including the hydroxy group involved in the glycosidic linkage, e.g. monoglucosyldiacylglycerides, lactobionic acid, gangliosides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/22—Anacardiaceae (Sumac family), e.g. smoketree, sumac or poison oak
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/82—Theaceae (Tea family), e.g. camellia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2200/00—Function of food ingredients
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Nutrition Science (AREA)
  • Polymers & Plastics (AREA)
  • Otolaryngology (AREA)
  • Pain & Pain Management (AREA)
  • Food Science & Technology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)

Abstract

SISTEMA DE LIGAÇÃO PARA UTILIZAÇÃO NA MORTE DE BACTÉRIAS RESISTENTES AOS ANTIBIÓTICOS; KIT; USO DO SISTEMA; COMPOSIÇÃO; E SUPLEMENTO ALIMENTAR. Os ensinamentos aqui providos se referem de modo geral, a sistemas de ligação acionados no local que, de maneira seletiva, aumentam a bioatividade de compostos fenólicos em locais alvo. Os sistemas podem incluir um composto fenólico ligado a uma espécie reativa de oxigênio, em que o composto fenólico e a espécie reativa de oxigênio podem reagir em uma área alvo na presença de uma enzima oxidorredutase. Os sistemas podem ser utilizados, por exemplo, como uma antitoxina, um antiinflamatório ou um antimicrobiano. Os usos podem incluir o tratamento de uma condição gastrointestinal, um tecido dérmico danificado, ou um tecido da mucosa danificado, assim como na promoção de saúde gastrointestinal que pode, por exemplo, resultar no alívio de desconforto gastrointestinal ou, talvez, criando um ganho de peso em um animal.
BR112013033125A 2011-06-24 2012-06-22 Sistema de ligação que aumenta seletivamente a biotividade de compostos fenólicos em um sítio alvo; par de reagentes estabilizados para transporte aquoso a um sítio alvo; formulação farmacêutica; kit; uso do sistema; composição; e suplemento alimentar BR112013033125A8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13/135,124 US8722040B2 (en) 2011-06-24 2011-06-24 Site-activated binding systems that selectively increase the bioactivity of phenolic compounds at target sites
PCT/US2012/043900 WO2012178127A2 (en) 2011-06-24 2012-06-22 Site-activated binding systems that selectively increase the bioactivity of phenolic compounds at target sites

Publications (2)

Publication Number Publication Date
BR112013033125A2 BR112013033125A2 (pt) 2017-01-24
BR112013033125A8 true BR112013033125A8 (pt) 2023-02-07

Family

ID=47362044

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112013033125A BR112013033125A8 (pt) 2011-06-24 2012-06-22 Sistema de ligação que aumenta seletivamente a biotividade de compostos fenólicos em um sítio alvo; par de reagentes estabilizados para transporte aquoso a um sítio alvo; formulação farmacêutica; kit; uso do sistema; composição; e suplemento alimentar

Country Status (17)

Country Link
US (6) US8722040B2 (pt)
EP (2) EP2723334A4 (pt)
JP (3) JP2014523883A (pt)
KR (1) KR20140061368A (pt)
CN (2) CN103764141A (pt)
AU (2) AU2012272661B2 (pt)
BR (1) BR112013033125A8 (pt)
CA (1) CA2840376A1 (pt)
CO (1) CO6862156A2 (pt)
HK (2) HK1197177A1 (pt)
MX (1) MX2013015439A (pt)
MY (1) MY189659A (pt)
PH (1) PH12018501201A1 (pt)
RU (1) RU2014101570A (pt)
SG (1) SG10201809283WA (pt)
WO (1) WO2012178127A2 (pt)
ZA (1) ZA201400532B (pt)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011500733A (ja) 2007-10-26 2011-01-06 ケマファー インコーポレーテッド 免疫応答を増強するための組成物および方法
US8734867B2 (en) 2007-12-28 2014-05-27 Liveleaf, Inc. Antibacterial having an extract of pomegranate combined with hydrogen peroxide
WO2010101844A1 (en) * 2009-03-04 2010-09-10 Metaactiv, Inc. Method and material for site activated complexing of biologic molecules
CA2771204C (en) 2009-04-30 2017-09-19 Chemaphor Inc. Methods and compositions for improving the health of animals
US9192635B2 (en) 2011-06-24 2015-11-24 Liveleaf, Inc. Method of treating damaged mucosal or gastrointestinal tissue by administering a composition comprising a mixture of pomegranate and green tea extracts and releasably bound hydrogen peroxide
US8722040B2 (en) 2011-06-24 2014-05-13 Liveleaf, Inc. Site-activated binding systems that selectively increase the bioactivity of phenolic compounds at target sites
CA3026687A1 (en) 2012-03-21 2013-09-26 Galleon Labs Llc Topically administered strontium-containing complexes for treating pain, pruritis and inflammation
US9283241B2 (en) * 2012-07-10 2016-03-15 Clemson University Treatment to render implants resistant to diabetes
US9526754B1 (en) * 2012-11-26 2016-12-27 Manuel Serrano Plant polyphenols extraction and activation thereof
US8716351B1 (en) 2012-12-23 2014-05-06 Liveleaf, Inc. Methods of treating gastrointestinal spasms
CN103223045A (zh) * 2013-04-08 2013-07-31 张宗升 中药组合物
CN103462987B (zh) * 2013-08-19 2015-11-18 江汉大学 表没食子儿茶素没食子酸酯硬脂酸酯的应用以及一种治疗银屑病的药物组合物
US20160250253A1 (en) * 2013-09-24 2016-09-01 Cosmederm Bioscience, Inc. Strontium-containing complexes for treating gastroesophageal reflux and barrett's esophagus
WO2015102003A1 (en) * 2014-01-05 2015-07-09 Bioharvest Ltd. Pomegranate derived cell culture and methods for preparing and using the same
US20170112877A1 (en) * 2014-06-13 2017-04-27 Alexander L. Huang Non-toxic agent for a broad-spectrum, bactericidal or bacteriostatic treatment of antibiotic-resistant bacteria in animals
US9173915B1 (en) * 2014-10-10 2015-11-03 Peter F. Kador Antioxidant eye drops
KR20170140298A (ko) * 2015-04-28 2017-12-20 아비바젠 인코포레이티드. 괴사성 장염 예방용 산화 카로티노이드 및 이의 성분
US10945974B2 (en) * 2015-06-01 2021-03-16 Xeno Biosciences Inc. Methods and compositions to modulate the gut microbiota and to manage weight
US11235002B2 (en) 2015-08-21 2022-02-01 Galleon Labs Llc Strontium based compositions and formulations for pain, pruritus, and inflammation
EP3439619A1 (en) * 2016-04-07 2019-02-13 University College Dublin, National University of Ireland, Dublin Treatment of inflammatory bowel disease
JP6918839B2 (ja) * 2016-05-20 2021-08-11 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル 概日時計の乱れに関連するマイクロバイオームの調節異常を処置するための方法及び医薬組成物
US11959125B2 (en) 2016-09-15 2024-04-16 Sun Genomics, Inc. Universal method for extracting nucleic acid molecules from a diverse population of one or more types of microbes in a sample
US20180112578A1 (en) 2016-10-24 2018-04-26 Ngk Insulators, Ltd. Porous material, honeycomb structure, and manufacturing method of porous material
KR102010475B1 (ko) * 2016-12-12 2019-08-13 친환경시험원 주식회사 성게류 회피도료 및 이의 제조방법
EP3675813A4 (en) * 2017-08-28 2021-03-24 Global Biolife Inc. METHOD AND COMPOSITION FOR PREVENTING AND TREATING VIRAL INFECTIONS
EP4110269A4 (en) * 2020-02-28 2024-01-17 Univ Emory PENTAGALLOYL GLUCOSE DERIVED FROM SCHINUS PLANTS AND METHODS OF USE
US20230340625A1 (en) * 2020-04-13 2023-10-26 Sun Genomics, Inc. Method and system for detecting and treating exposure to an infectious pathogen

Family Cites Families (102)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1844018A (en) 1929-04-18 1932-02-09 Mead Res Engineering Company Method of preparing tanning substances
DE530650C (de) 1930-12-09 1931-07-31 Hoffmann La Roche & Co Akt Ges Verfahren zur Herstellung von Protocatechualdehyd und seinen Substitutionsprodukten
US1965458A (en) 1932-05-18 1934-07-03 Hoffmann La Roche Process for the manufacture of aromatic hydroxy aldehydes
US3484248A (en) 1967-07-03 1969-12-16 Lipton Inc Thomas J Alkaline conversion of green tea using hydrogen peroxide
GB1204585A (en) 1968-01-23 1970-09-09 Tenco Brooke Bond Ltd Improvements in or relating to the fermentation of tea
US3817835A (en) 1969-03-26 1974-06-18 Squibb & Sons Inc Process for the production of antimicrobial agents
US3692904A (en) 1970-05-25 1972-09-19 Daiichi Seiyaku Co Method for treating scours in domestic livestock
US3824184A (en) 1970-09-04 1974-07-16 Economics Lab Slime control in industrial waters
GB1377396A (en) 1971-04-26 1974-12-18 Unilever Ltd Instant tea powder
IT986371B (it) 1972-06-02 1975-01-30 Degussa Procedimento per la produzione di percarbonato alcalino
US3860694A (en) 1972-08-31 1975-01-14 Du Pont Process for the preparation of perhydrates
JPS5429599B2 (pt) 1974-12-28 1979-09-25
SE7601543L (sv) 1975-02-21 1976-08-23 Snam Progetti Forfarande for extrahering av fenoler och oligosackarider ur vegetabiliskt material
US4171280A (en) 1977-11-03 1979-10-16 The Clorox Company Powder percarbonate bleach and formation thereof
US4514334A (en) 1979-05-31 1985-04-30 General Electric Company Polyphenolic compounds
FR2486523A1 (fr) 1980-07-11 1982-01-15 Rhone Poulenc Ind Procede de preparation de polyphenols comportant eventuellement un groupement aldehyde
US4623465A (en) 1981-04-20 1986-11-18 Massachusetts Institute Of Technology Removal of combined organic substances from aqueous solutions
US4472302A (en) 1983-03-09 1984-09-18 Merck & Co., Inc. Heat shock process for the isolation of bacterial protein
US4472602A (en) 1983-08-11 1984-09-18 At&T Technologies, Inc. Telephone set with transducer/ringer
US5141611A (en) 1985-05-16 1992-08-25 Memtec Limited Removing and recovering plant polyphenols
US4829001A (en) 1985-11-08 1989-05-09 Minnesota Mining And Manufacturing Company Enzymatic neutralization of hydrogen peroxide
US4647952A (en) 1985-11-13 1987-03-03 The Mead Corporation Phenolic developer resins
US5296376A (en) 1986-11-04 1994-03-22 Imperial Chemical Industries Plc DNA, constructs, cells and plants derived therefrom
US4966762A (en) 1988-10-06 1990-10-30 Fmc Corporation Process for manufacturing a soda ash peroxygen carrier
US5231193A (en) 1989-03-29 1993-07-27 Kikkoman Corporation Process for producing ellagic acid
JPH0791302B2 (ja) 1989-03-29 1995-10-04 キッコーマン株式会社 エラグ酸の製造法
JP3005012B2 (ja) * 1990-02-23 2000-01-31 三井農林株式会社 抗生物質耐性ブドウ球菌感染予防剤
US5756090A (en) 1991-02-21 1998-05-26 Eoe, Inc. Oxygen activatable formulations for disinfection or sterilization
US5389369A (en) 1991-02-21 1995-02-14 Exoxemis, Inc. Halo peroxidase containing compositions for killing yeast and sporular microorganisms
US5208010A (en) 1991-06-17 1993-05-04 Dental Concepts Inc. Tooth whitening dentifrice
US5260021A (en) 1992-06-29 1993-11-09 Allergan, Inc. Hydrogen peroxide-containing gels and contact lens disinfecting using same
JPH07503376A (ja) 1992-07-30 1995-04-13 ケイヘーネ・エヌ・ベー Ｄｎａ構築物並びにそれから誘導される細胞及び植物
DK144392D0 (da) 1992-12-01 1992-12-01 Novo Nordisk As Aktivering af enzymer
US5328706A (en) 1993-04-29 1994-07-12 Endico Felix W Food manufacturing process utilizing hydrogen peroxide for microbial control
US6068862A (en) 1993-06-30 2000-05-30 Taiyo Kagaku Co., Ltd. Tea-derived feed additive and animal feed containing the same
US5653746A (en) 1994-03-08 1997-08-05 Meadox Medicals, Inc. Radially expandable tubular prosthesis
US5661170A (en) 1994-03-21 1997-08-26 Woodward Laboratories, Inc. Antimicrobial compositions and methods for using the same
US5614501A (en) 1994-07-21 1997-03-25 The University Of Montana Compositions and methods for animal husbandry and for treating gastrointestinal disorders
JP3245307B2 (ja) * 1994-07-26 2002-01-15 三井農林株式会社 抗菌剤
TW449485B (en) 1995-03-31 2001-08-11 Colgate Palmolive Co Skin care products containing anti itching/anti irritant agents
US5824414A (en) 1995-04-28 1998-10-20 Mitsui Chemicals, Inc. Preparation of spherical polyphenol particles
US5839369A (en) 1995-10-20 1998-11-24 Eastman Kodak Company Method of controlled laser imaging of zirconia alloy ceramic lithographic member to provide localized melting in exposed areas
US6063428A (en) 1996-02-26 2000-05-16 The Procter & Gamble Company Green tea extract subjected to cation exchange treatment and nanofiltration to improve clarity and color
US6297273B1 (en) * 1996-04-02 2001-10-02 Mars, Inc. Use of cocoa solids having high cocoa polyphenol content in tabletting compositions and capsule filling compositions
JP3320307B2 (ja) 1996-06-06 2002-09-03 株式会社エス・ディー・エス バイオテック フェノール性化合物等の高分子化方法及びその利用
US6642277B1 (en) 1996-09-20 2003-11-04 The Howard Foundation Food supplements containing polyphenols
EP0935417B1 (en) 1996-10-16 2009-05-06 Napo Pharmaceuticals, Inc. Enteric formulations of proanthocyanidin polymer antidiarrheal compositions
US6436342B1 (en) 1996-11-13 2002-08-20 The Procter & Gamble Company Sprayable disinfecting compositions and processes for disinfecting surfaces therewith
WO1998023716A2 (en) 1996-11-25 1998-06-04 Unilever N.V. Enzymatic oxidation process
US5891440A (en) 1996-12-31 1999-04-06 Lansky; Ephraim Philip Phytoestrogen supplement prepared from pomegranate seeds and a herbal mixture or coconut milk
GB9721139D0 (en) 1997-10-07 1997-12-03 Glaxo Group Ltd Medicaments
JP4137224B2 (ja) 1998-03-31 2008-08-20 天野エンザイム株式会社 酵素による蛋白質の架橋法
US6071541A (en) 1998-07-31 2000-06-06 Murad; Howard Pharmaceutical compositions and methods for managing skin conditions
WO2000020406A1 (en) 1998-10-06 2000-04-13 Research Development Foundation ANTIBACTERIAL AND ANTIFUNGAL FLAVANONES FROM $i(EYSENHARDTIA TEXANA)
US20030078212A1 (en) 1998-10-30 2003-04-24 Jia-He Li Pharmaceutical compositions containing poly(adp-ribose) glycohydrolase inhibitors and methods of using the same
US6630163B1 (en) 1999-04-22 2003-10-07 Howard Murad Method of treating dermatological disorders with fruit extracts
JP2000328443A (ja) * 1999-05-18 2000-11-28 Ito En Ltd 茶ポリフェノール固着繊維の抗菌用途
US7297344B1 (en) 1999-05-27 2007-11-20 Euro-Celtique, S.A. Preparations for the promotion of wound healing in the upper respiratory tract and/or ear
US7504251B2 (en) 1999-06-03 2009-03-17 Biobalance Llc Bacterial strain, processed plant extracts, compositions containing same, processes for their preparation and their therapeutic and industrial applications
US6242010B1 (en) * 1999-07-21 2001-06-05 Thione International, Inc. Synergistic antioxidant compositions in management of hemorrhoids and other ano-rectal inflammatory conditions
GB9918028D0 (en) 1999-07-30 1999-09-29 Unilever Plc Skin care composition
KR100366608B1 (ko) 2000-02-15 2003-01-09 마스터진(주) 형질전환 식물체로부터 생산된 재조합 인간 파필로마바이러스 백신
US20020034553A1 (en) 2000-09-19 2002-03-21 Janice Zayas Skin healing, conditioning and enhancing lotion
US7381427B2 (en) 2001-02-09 2008-06-03 Mickey Miller Seborrheic keratosis treatment
US20030044474A1 (en) 2001-08-03 2003-03-06 Shaklee Corporation High molecular weight, lipophilic, orally ingestible bioactive agents in formulations having improved bioavailability
EP1312412B1 (en) 2001-11-20 2013-03-13 Mitsubishi Gas Chemical Company, Inc. Process for producing hydrogen-containing gas
US20040001665A1 (en) 2002-07-01 2004-01-01 Majd Zoorob Optical device
WO2004050795A2 (en) 2002-11-27 2004-06-17 Tufts University Antioxidant-functionalized polymers
US20040228831A1 (en) 2003-05-15 2004-11-18 Belinka Benjamin A. Polymeric conjugates for tissue activated drug delivery
US20080118602A1 (en) 2004-01-16 2008-05-22 Venkatraj Venkatrao Narayanan Process for the Manufacture of a Tea Product and Products Obtained Thereby
CA2559813A1 (en) 2004-03-16 2005-09-22 Combi Co. Antidiarrheal agent for livestock and poultry
CN1956726B (zh) 2004-03-23 2011-04-13 生命线营养健康公司 用于缓解哺乳动物炎症及氧化应激的组合物和方法
WO2005099721A2 (en) 2004-04-15 2005-10-27 The Regents Of The University Of California Compositions comprising plant-derived polyphenolic compounds and inhibitors of reactive oxygen species and methods of using thereof
US20060024385A1 (en) 2004-07-27 2006-02-02 Pedersen Mark A Metabolic capacity enhancing compositions and methods for use in a mammal
US20060024339A1 (en) 2004-07-29 2006-02-02 Howard Murad Methods of managing the redness associated with a dermatological condition
WO2006038893A1 (en) 2004-10-06 2006-04-13 Agency For Science, Technology And Research Oxidation of phenolic compound with hydrogen peroxide generated in the presence of the phenolic compound
US20060165812A1 (en) 2005-01-21 2006-07-27 Amershire Investment Corporation Method and topical formulation for treating headaches
US8128967B2 (en) 2005-03-08 2012-03-06 Mitsui Norin Co., Ltd. Polyphenol coxib combinations and methods
CN101291579A (zh) 2005-05-27 2008-10-22 中央佛罗里达大学研究基金会有限公司 阿米巴病的植物疫苗
WO2007003068A1 (fr) 2005-06-30 2007-01-11 Hangzhou Lixin Biotechnology Co. Ltd. Additif pour nourriture, procédé de préparation de celui-ci et application de celui-ci
JP5167461B2 (ja) * 2005-09-16 2013-03-21 国立医薬品食品衛生研究所長 炎症性腸疾患予防剤
US20070110812A1 (en) 2005-11-14 2007-05-17 Bausch & Lomb Incorporated Ophthalmic composition for dry eye therapy
WO2007079331A2 (en) 2005-12-13 2007-07-12 Richard Paul Bonfiglio Antibacterial oral rinse formulation for preventing coronary artery disease
US20090093440A1 (en) 2005-12-20 2009-04-09 Howard Murad Fragranced Therapeutic Delivery System
US20080194518A1 (en) * 2005-12-23 2008-08-14 MOOKERJEE Pradip Antimicrobial Compositions
WO2007090096A2 (en) 2006-01-27 2007-08-09 Rdx Technologies, Inc. Electrochemical methods for redox control to preserve, stabilize and activate compounds
US20100278759A1 (en) 2006-02-08 2010-11-04 Howard Murad Topical Therapeutic Delivery System
AU2007248182B2 (en) 2006-05-01 2013-05-23 Napo Pharmaceuticals, Inc. Method for treatment of constipation-predominant irritable bowel syndrome
US20080003314A1 (en) 2006-06-29 2008-01-03 Indivi Wine Usa, Llc Germinated seeds possessing increased water-soluble polyphenols and method of manufacturing
WO2008079898A1 (en) 2006-12-20 2008-07-03 Pharmwest, Inc. Methods and topical formulations comprising colloidal metal for treating or preventing skin conditions
CA2696438C (en) 2007-08-16 2015-12-08 The University Of Chicago The use of azelaic acid for priming a plant to induce a resistance response against a pathogen
US8734867B2 (en) 2007-12-28 2014-05-27 Liveleaf, Inc. Antibacterial having an extract of pomegranate combined with hydrogen peroxide
WO2009114810A2 (en) * 2008-03-14 2009-09-17 The Florida International Uinversity Board Of Trustees Use of ellagitannins as inhibitors of bacterial quorum sensing
WO2010018418A1 (en) 2008-08-12 2010-02-18 Novatech D.O.O. Formulation based on micronized clinoptilolite as therapeutic agent providing highly bioavailable silicon
JP4811454B2 (ja) * 2008-12-02 2011-11-09 村田機械株式会社 搬送台車システム及び搬送台車への走行経路の指示方法
WO2010101844A1 (en) 2009-03-04 2010-09-10 Metaactiv, Inc. Method and material for site activated complexing of biologic molecules
WO2010138082A1 (en) * 2009-05-29 2010-12-02 Agency For Science, Technology And Research Flavonoid hydrogel
CN101822275B (zh) 2009-10-19 2013-05-01 成都中医药大学 一种农药组合物及其制备方法和用途
US20120329736A1 (en) 2011-06-24 2012-12-27 Huang Alexander L Treatment for gastrointestinal disorders using a selective, site-activated binding system
US20120328711A1 (en) 2011-06-24 2012-12-27 Huang Alexander L Antimicrobial system for selective, site-activated binding at target sites
US9192635B2 (en) 2011-06-24 2015-11-24 Liveleaf, Inc. Method of treating damaged mucosal or gastrointestinal tissue by administering a composition comprising a mixture of pomegranate and green tea extracts and releasably bound hydrogen peroxide
US8722040B2 (en) 2011-06-24 2014-05-13 Liveleaf, Inc. Site-activated binding systems that selectively increase the bioactivity of phenolic compounds at target sites

Also Published As

Publication number Publication date
MX2013015439A (es) 2014-10-17
EP2723334A4 (en) 2014-11-19
BR112013033125A2 (pt) 2017-01-24
RU2014101570A (ru) 2015-07-27
AU2012272661B2 (en) 2017-05-11
WO2012178127A3 (en) 2013-04-04
HK1243355A1 (zh) 2018-07-13
US20140199412A1 (en) 2014-07-17
CO6862156A2 (es) 2014-02-10
KR20140061368A (ko) 2014-05-21
ZA201400532B (en) 2014-10-29
US20160074435A1 (en) 2016-03-17
CN103764141A (zh) 2014-04-30
CA2840376A1 (en) 2012-12-27
SG10201809283WA (en) 2018-11-29
US20140227367A1 (en) 2014-08-14
EP3569231A1 (en) 2019-11-20
JP2014523883A (ja) 2014-09-18
AU2017208298B2 (en) 2018-09-13
US20200276231A1 (en) 2020-09-03
CN107126440A (zh) 2017-09-05
JP2017110016A (ja) 2017-06-22
US8790640B1 (en) 2014-07-29
EP2723334A2 (en) 2014-04-30
US8722040B2 (en) 2014-05-13
WO2012178127A2 (en) 2012-12-27
AU2012272661A1 (en) 2014-02-06
HK1197177A1 (en) 2015-01-09
PH12018501201A1 (en) 2019-02-18
MY189659A (en) 2022-02-23
US20230106996A1 (en) 2023-04-06
US20120328593A1 (en) 2012-12-27
JP2018199682A (ja) 2018-12-20
AU2017208298A1 (en) 2017-08-17

Similar Documents

Publication Publication Date Title
BR112013033125A8 (pt) Sistema de ligação que aumenta seletivamente a biotividade de compostos fenólicos em um sítio alvo; par de reagentes estabilizados para transporte aquoso a um sítio alvo; formulação farmacêutica; kit; uso do sistema; composição; e suplemento alimentar
GT201000160A (es) Derivados de aminobenzamida como agentes útiles para el control de parásitos de animales
ES2531083T3 (es) Formulaciones estables de polipéptidos y usos de las mismas
BRPI1007379B8 (pt) composições farmacêuticas para o tratamento ou prevenção de infecções orais por e. coli
BRPI0813450A2 (pt) Composto, composição, combinação, formulação farmacêutica, e, métodos para inibir uma enzima, para exterminar ou prevenir o crescimento de um microorganismo e para tratar e/ou prevenir uma doença em um animal
CL2015001945A1 (es) (divisional de la solicitud n° 1567-2013) combinaciones de principios activos que comprenden piridiletilbenzamidas y otros principios activos.
CL2012000181A1 (es) Composicion antimicrobiana para extender la vida util del agua, alimentos o ingredientes de alimentos que comprende 1% a 99% en peso de ácidos orgánicos en solucion acuosa, 0-20% de peso de terpenos y 0-5% de surfactantes; método para extender la vida util del agua, alimentos o ingredientes de alimentos.
BR112015006568A2 (pt) composições e bactéria de ácido láctico
BR112013003045A2 (pt) composto e composição farmacêutica e respectivos usos, recipiente estéril e método para preparar composição farmacêutica para administração
BR112012017564A2 (pt) Formulação antimicrobiana
MXPA02002308A (es) Composicion para el tratamiento de infecciones de humanos y animales.
CR11472A (es) 4-(4-ciano-2-tioaril)dihidropirimidinonas y su uso
CL2008003582A1 (es) Uso de una composicion farmaceutica que contiene cisteamina o cistamina en la preparacion de un medicamento util para el tratamiento de una enfermedad de higado graso no alcholico (nafld) o esteatohepatitis no alcoholica (nash).
CL2010001260A1 (es) Composicion farmaceutica que comprende una sal de estroncio y vitamina d y una ciclodextrina, donde la relacion masica entre la cantidad de vitamina d y la cantidad de ciclodextrina esta comprendida entre 1/40 y 1/800, util para tratar o prevenir osteoporosis.
GT200600109A (es) Derivados de acido pirimidincarboxilico y su uso
BR112012006107A2 (pt) formulações nasais, de ferida e de pele e métodos para controle de staphylococci e outras bactérias gram-positivas resistentes a antibiótico
EA201100899A1 (ru) Димерные производные авермектина и милбемицина
AR057081A1 (es) Medios para la fabricacion de cuero
SV2006002290A (es) Nonadepsipeptidos acilados ii ref. bhc041327-sv
BRPI0813159A8 (pt) Composição parasiticida veterinária, método para o tratamento ou controle de uma infecção ou infestação parasiticidas em um animal homeotérmico, e, uso de uma composição
MX2010002812A (es) Composiciones alimenticias que contienen extractos de melisa.
HRP20190562T1 (hr) Sastavi za liječenje zaraze srčanim crvom
BR112012018801A2 (pt) composição e processo para o controle de doenças de plantas
BR112012006569A2 (pt) preparados pesticidas contendo derivados de ácido pirrolidona-4-carboxílico.
WO2007096150A3 (en) Organic compounds

Legal Events

Date Code Title Description
B15I Others concerning applications: loss of priority
B12F Other appeals [chapter 12.6 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B12B Appeal against refusal [chapter 12.2 patent gazette]
B25A Requested transfer of rights approved

Owner name: LIVELEAF HOLDINGS LLC (US)

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 8A ANUIDADE

B08G Application fees: restoration [chapter 8.7 patent gazette]