BR112013033125A8 - Sistema de ligação que aumenta seletivamente a biotividade de compostos fenólicos em um sítio alvo; par de reagentes estabilizados para transporte aquoso a um sítio alvo; formulação farmacêutica; kit; uso do sistema; composição; e suplemento alimentar - Google Patents
Sistema de ligação que aumenta seletivamente a biotividade de compostos fenólicos em um sítio alvo; par de reagentes estabilizados para transporte aquoso a um sítio alvo; formulação farmacêutica; kit; uso do sistema; composição; e suplemento alimentarInfo
- Publication number
- BR112013033125A8 BR112013033125A8 BR112013033125A BR112013033125A BR112013033125A8 BR 112013033125 A8 BR112013033125 A8 BR 112013033125A8 BR 112013033125 A BR112013033125 A BR 112013033125A BR 112013033125 A BR112013033125 A BR 112013033125A BR 112013033125 A8 BR112013033125 A8 BR 112013033125A8
- Authority
- BR
- Brazil
- Prior art keywords
- target site
- kit
- composition
- food supplement
- phenolic compounds
- Prior art date
Links
- 150000002989 phenols Chemical class 0.000 title abstract 4
- 235000015872 dietary supplement Nutrition 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 239000003153 chemical reaction reagent Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 239000003642 reactive oxygen metabolite Substances 0.000 abstract 2
- 241000894006 Bacteria Species 0.000 abstract 1
- 206010017943 Gastrointestinal conditions Diseases 0.000 abstract 1
- 102000004316 Oxidoreductases Human genes 0.000 abstract 1
- 108090000854 Oxidoreductases Proteins 0.000 abstract 1
- 206010000059 abdominal discomfort Diseases 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 230000000845 anti-microbial effect Effects 0.000 abstract 1
- 230000001147 anti-toxic effect Effects 0.000 abstract 1
- 239000004599 antimicrobial Substances 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 230000002500 effect on skin Effects 0.000 abstract 1
- 230000002496 gastric effect Effects 0.000 abstract 1
- 210000004400 mucous membrane Anatomy 0.000 abstract 1
- 230000001737 promoting effect Effects 0.000 abstract 1
- 210000001519 tissue Anatomy 0.000 abstract 1
Classifications
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
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- A—HUMAN NECESSITIES
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
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- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
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- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
-
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- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
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- A61K31/365—Lactones
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- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
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- A61K31/7032—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a polyol, i.e. compounds having two or more free or esterified hydroxy groups, including the hydroxy group involved in the glycosidic linkage, e.g. monoglucosyldiacylglycerides, lactobionic acid, gangliosides
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- A23V2200/00—Function of food ingredients
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
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- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Nutrition Science (AREA)
- Inorganic Chemistry (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Obesity (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Dermatology (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Communicable Diseases (AREA)
- Hematology (AREA)
- Otolaryngology (AREA)
- Pulmonology (AREA)
- Hospice & Palliative Care (AREA)
Abstract
SISTEMA DE LIGAÇÃO PARA UTILIZAÇÃO NA MORTE DE BACTÉRIAS RESISTENTES AOS ANTIBIÓTICOS; KIT; USO DO SISTEMA; COMPOSIÇÃO; E SUPLEMENTO ALIMENTAR. Os ensinamentos aqui providos se referem de modo geral, a sistemas de ligação acionados no local que, de maneira seletiva, aumentam a bioatividade de compostos fenólicos em locais alvo. Os sistemas podem incluir um composto fenólico ligado a uma espécie reativa de oxigênio, em que o composto fenólico e a espécie reativa de oxigênio podem reagir em uma área alvo na presença de uma enzima oxidorredutase. Os sistemas podem ser utilizados, por exemplo, como uma antitoxina, um antiinflamatório ou um antimicrobiano. Os usos podem incluir o tratamento de uma condição gastrointestinal, um tecido dérmico danificado, ou um tecido da mucosa danificado, assim como na promoção de saúde gastrointestinal que pode, por exemplo, resultar no alívio de desconforto gastrointestinal ou, talvez, criando um ganho de peso em um animal.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13/135,124 US8722040B2 (en) | 2011-06-24 | 2011-06-24 | Site-activated binding systems that selectively increase the bioactivity of phenolic compounds at target sites |
PCT/US2012/043900 WO2012178127A2 (en) | 2011-06-24 | 2012-06-22 | Site-activated binding systems that selectively increase the bioactivity of phenolic compounds at target sites |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112013033125A2 BR112013033125A2 (pt) | 2017-01-24 |
BR112013033125A8 true BR112013033125A8 (pt) | 2023-02-07 |
Family
ID=47362044
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112013033125A BR112013033125A8 (pt) | 2011-06-24 | 2012-06-22 | Sistema de ligação que aumenta seletivamente a biotividade de compostos fenólicos em um sítio alvo; par de reagentes estabilizados para transporte aquoso a um sítio alvo; formulação farmacêutica; kit; uso do sistema; composição; e suplemento alimentar |
Country Status (17)
Country | Link |
---|---|
US (6) | US8722040B2 (pt) |
EP (2) | EP2723334A4 (pt) |
JP (3) | JP2014523883A (pt) |
KR (1) | KR20140061368A (pt) |
CN (2) | CN107126440A (pt) |
AU (2) | AU2012272661B2 (pt) |
BR (1) | BR112013033125A8 (pt) |
CA (1) | CA2840376A1 (pt) |
CO (1) | CO6862156A2 (pt) |
HK (2) | HK1197177A1 (pt) |
MX (1) | MX2013015439A (pt) |
MY (1) | MY189659A (pt) |
PH (1) | PH12018501201A1 (pt) |
RU (1) | RU2014101570A (pt) |
SG (1) | SG10201809283WA (pt) |
WO (1) | WO2012178127A2 (pt) |
ZA (1) | ZA201400532B (pt) |
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JP2011500733A (ja) | 2007-10-26 | 2011-01-06 | ケマファー インコーポレーテッド | 免疫応答を増強するための組成物および方法 |
US8734867B2 (en) | 2007-12-28 | 2014-05-27 | Liveleaf, Inc. | Antibacterial having an extract of pomegranate combined with hydrogen peroxide |
CN102421891B (zh) * | 2009-03-04 | 2015-11-25 | 生命之叶公司 | 用于生物分子的位点活化络合的方法与物质 |
AU2010242502B2 (en) | 2009-04-30 | 2016-11-10 | Avivagen Inc. | Methods and compositions for improving the health of animals |
US8722040B2 (en) | 2011-06-24 | 2014-05-13 | Liveleaf, Inc. | Site-activated binding systems that selectively increase the bioactivity of phenolic compounds at target sites |
US9192635B2 (en) | 2011-06-24 | 2015-11-24 | Liveleaf, Inc. | Method of treating damaged mucosal or gastrointestinal tissue by administering a composition comprising a mixture of pomegranate and green tea extracts and releasably bound hydrogen peroxide |
US9333185B2 (en) | 2012-03-21 | 2016-05-10 | Cosmederm Bioscience, Inc. | Topically administered strontium-containing complexes for treating pain, pruritis and inflammation |
US9283241B2 (en) * | 2012-07-10 | 2016-03-15 | Clemson University | Treatment to render implants resistant to diabetes |
US9526754B1 (en) * | 2012-11-26 | 2016-12-27 | Manuel Serrano | Plant polyphenols extraction and activation thereof |
US8716351B1 (en) | 2012-12-23 | 2014-05-06 | Liveleaf, Inc. | Methods of treating gastrointestinal spasms |
CN103223045A (zh) * | 2013-04-08 | 2013-07-31 | 张宗升 | 中药组合物 |
CN103462987B (zh) * | 2013-08-19 | 2015-11-18 | 江汉大学 | 表没食子儿茶素没食子酸酯硬脂酸酯的应用以及一种治疗银屑病的药物组合物 |
US20160250253A1 (en) * | 2013-09-24 | 2016-09-01 | Cosmederm Bioscience, Inc. | Strontium-containing complexes for treating gastroesophageal reflux and barrett's esophagus |
WO2015102003A1 (en) * | 2014-01-05 | 2015-07-09 | Bioharvest Ltd. | Pomegranate derived cell culture and methods for preparing and using the same |
WO2015192136A1 (en) * | 2014-06-13 | 2015-12-17 | Liveleaf, Inc. | Non-toxic agent for a broad-spectrum, bactericidal or bacteriostatic treatment of antibiotic-resistant bacteria in animals |
US9173915B1 (en) * | 2014-10-10 | 2015-11-03 | Peter F. Kador | Antioxidant eye drops |
DK3288546T3 (da) * | 2015-04-28 | 2022-01-24 | Avivagen Inc | Oxiderede karotinoider og bestanddele deraf til forebyggelse af nekrotisk enteritis |
WO2016196440A1 (en) * | 2015-06-01 | 2016-12-08 | Xeno Biosciences Inc. | Methods and compositions to modulate the gut microbiota and to manage weight |
US11235002B2 (en) | 2015-08-21 | 2022-02-01 | Galleon Labs Llc | Strontium based compositions and formulations for pain, pruritus, and inflammation |
JP2019510805A (ja) * | 2016-04-07 | 2019-04-18 | ユニバーシティ・カレッジ・ダブリン,ナショナル・ユニバーシティ・オブ・アイルランド,ダブリン | 炎症性腸疾患の治療 |
US11364219B2 (en) * | 2016-05-20 | 2022-06-21 | Inserm (Institut Nation De La Santé Et De La Recherche Médicale) | Methods and pharmaceutical compositions for treating microbiome dysregulations associated with circadian clock disruption |
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US20180112578A1 (en) | 2016-10-24 | 2018-04-26 | Ngk Insulators, Ltd. | Porous material, honeycomb structure, and manufacturing method of porous material |
KR102010475B1 (ko) * | 2016-12-12 | 2019-08-13 | 친환경시험원 주식회사 | 성게류 회피도료 및 이의 제조방법 |
AU2017429594B2 (en) | 2017-08-28 | 2024-05-30 | Global Biolife Inc. | Method and composition for preventing and treating viral infections |
EP4110269A4 (en) * | 2020-02-28 | 2024-01-17 | Emory University | PENTAGALLOYL GLUCOSE DERIVED FROM SCHINUS PLANTS AND METHODS OF USE |
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