BR112013028453B8 - Uso de uma composição de revestimento, formas de dosagem farmacêuticas ou nutracêuticas gastrorresistentes, e composição do polímero do núcleo/invólucro - Google Patents

Uso de uma composição de revestimento, formas de dosagem farmacêuticas ou nutracêuticas gastrorresistentes, e composição do polímero do núcleo/invólucro

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Publication number
BR112013028453B8
BR112013028453B8 BR112013028453A BR112013028453A BR112013028453B8 BR 112013028453 B8 BR112013028453 B8 BR 112013028453B8 BR 112013028453 A BR112013028453 A BR 112013028453A BR 112013028453 A BR112013028453 A BR 112013028453A BR 112013028453 B8 BR112013028453 B8 BR 112013028453B8
Authority
BR
Brazil
Prior art keywords
core
coating composition
dosage forms
polymer composition
pharmaceutical
Prior art date
Application number
BR112013028453A
Other languages
English (en)
Other versions
BR112013028453A2 (pt
BR112013028453B1 (pt
Inventor
Hermes Florian
Meier Christian
Hendrik Schattka Jan
Original Assignee
Evonik Roehm Gmbh
Roehm Gmbh
Evonik Degussa Gmbh
Evonik Operations Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Evonik Roehm Gmbh, Roehm Gmbh, Evonik Degussa Gmbh, Evonik Operations Gmbh filed Critical Evonik Roehm Gmbh
Publication of BR112013028453A2 publication Critical patent/BR112013028453A2/pt
Publication of BR112013028453B1 publication Critical patent/BR112013028453B1/pt
Publication of BR112013028453B8 publication Critical patent/BR112013028453B8/pt

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F2/00—Processes of polymerisation
    • C08F2/12—Polymerisation in non-solvents
    • C08F2/16—Aqueous medium
    • C08F2/22—Emulsion polymerisation
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/10—Esters
    • C08F220/12—Esters of monohydric alcohols or phenols
    • C08F220/16—Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms
    • C08F220/18—Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms with acrylic or methacrylic acids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F265/00—Macromolecular compounds obtained by polymerising monomers on to polymers of unsaturated monocarboxylic acids or derivatives thereof as defined in group C08F20/00
    • C08F265/04—Macromolecular compounds obtained by polymerising monomers on to polymers of unsaturated monocarboxylic acids or derivatives thereof as defined in group C08F20/00 on to polymers of esters
    • C08F265/06—Polymerisation of acrylate or methacrylate esters on to polymers thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2207/00—Properties characterising the ingredient of the composition
    • C08L2207/53—Core-shell polymer

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

COMPOSIÇÃO DE REVESTIMENTO ADEQUADA PARA FORMAS DE DOSAGEM FARMACÊUTICAS OU NUTRACÊUTICAS. A presente invenção refere-se a uma composição de revestimento adequada para o revestimento da forma de dosagem farmacêutica ou nutracêutica, que compreende um núcleo que compreende um ou mais ingredientes ativos farmacêuticos ou nutracêuticos, em que a composição de revestimento é composta por, pelo menos, 20% em peso de uma composição do polímero do núcleo/invólucro entérico derivada a partir de um processo de polimerização em emulsão, em que o núcleo da composição do polímero do núcleo/invólucro é formado por um copolímero ou um polímero reticulado, insolúvel em água e o invólucro da composição do polímero do núcleo/invólucro é formado por meio de um polímero ou copolímero aniônico.
BR112013028453A 2011-06-17 2011-06-17 Uso de uma composição de revestimento, formas de dosagem farmacêuticas ou nutracêuticas gastrorresistentes, e composição do polímero do núcleo/invólucro BR112013028453B8 (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP2011/060097 WO2012171576A1 (en) 2011-06-17 2011-06-17 Coating composition suitable for pharmaceutical or nutraceutical dosage forms

Publications (3)

Publication Number Publication Date
BR112013028453A2 BR112013028453A2 (pt) 2017-01-24
BR112013028453B1 BR112013028453B1 (pt) 2021-10-19
BR112013028453B8 true BR112013028453B8 (pt) 2022-07-05

Family

ID=44627081

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112013028453A BR112013028453B8 (pt) 2011-06-17 2011-06-17 Uso de uma composição de revestimento, formas de dosagem farmacêuticas ou nutracêuticas gastrorresistentes, e composição do polímero do núcleo/invólucro

Country Status (16)

Country Link
US (1) US9668977B2 (pt)
EP (1) EP2720681B1 (pt)
JP (1) JP5832645B2 (pt)
KR (1) KR101799625B1 (pt)
CN (1) CN103501767A (pt)
AU (1) AU2011370763A1 (pt)
BR (1) BR112013028453B8 (pt)
CA (1) CA2839494C (pt)
ES (1) ES2617402T3 (pt)
HU (1) HUE033117T2 (pt)
IL (1) IL228397A (pt)
MX (1) MX353426B (pt)
PL (1) PL2720681T3 (pt)
RU (1) RU2599023C2 (pt)
SI (1) SI2720681T1 (pt)
WO (1) WO2012171576A1 (pt)

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CN105943519A (zh) * 2016-06-22 2016-09-21 福建省微生物研究所 一种苯磺贝他斯汀掩味颗粒
RU2749905C2 (ru) * 2016-08-15 2021-06-18 Эвоник Оперейшнс Гмбх Содержащие функциональные группы полиалкил(мет)акрилаты, обладающие улучшенной деэмульгирующей способностью
CN111936121A (zh) 2017-11-17 2020-11-13 赢创运营有限公司 制备包衣硬壳胶囊的方法
SG11202005947RA (en) 2018-05-24 2020-07-29 Celanese Eva Performance Polymers Corp Implantable device for sustained release of a macromolecular drug compound
AU2019275409A1 (en) 2018-05-24 2020-07-16 Celanese Eva Performance Polymers Llc Implantable device for sustained release of a macromolecular drug compound
CN109232795A (zh) * 2018-09-21 2019-01-18 佛山市森昂生物科技有限公司 一种防水型高韧性包衣材料的制备方法
EP3962465A1 (en) 2019-04-30 2022-03-09 Evonik Operations GmbH Pellet and multi-unit pellet system (mups)
KR20240012433A (ko) 2021-05-25 2024-01-29 에보니크 오퍼레이션즈 게엠베하 변형 방출 코팅을 갖는 경질 쉘 캡슐
CN117377466A (zh) 2021-05-25 2024-01-09 赢创运营有限公司 防止胃液流入的硬壳胶囊
EP4176874A1 (en) 2021-11-09 2023-05-10 Evonik Operations GmbH Pharmaceutical or nutraceutical composition with an alcohol resistant single layer coating system
WO2023174722A1 (en) 2022-03-15 2023-09-21 Evonik Operations Gmbh Pre-functionalized hard shell capsule with accelerated drug release at ph value 5 to 5.5
WO2023214016A1 (en) 2022-05-06 2023-11-09 Evonik Operations Gmbh Dosage form with drug release at ph 3 to 6 using double coating system with at least one release acceleration agent

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Also Published As

Publication number Publication date
EP2720681B1 (en) 2016-11-23
KR101799625B1 (ko) 2017-11-20
AU2011370763A1 (en) 2013-10-03
BR112013028453A2 (pt) 2017-01-24
WO2012171576A1 (en) 2012-12-20
PL2720681T3 (pl) 2017-05-31
JP2014517018A (ja) 2014-07-17
IL228397A0 (en) 2013-12-31
RU2014101228A (ru) 2015-07-27
CN103501767A (zh) 2014-01-08
KR20140041545A (ko) 2014-04-04
SI2720681T1 (sl) 2017-03-31
JP5832645B2 (ja) 2015-12-16
IL228397A (en) 2017-07-31
EP2720681A1 (en) 2014-04-23
CA2839494A1 (en) 2012-12-20
MX353426B (es) 2018-01-12
HUE033117T2 (en) 2017-11-28
CA2839494C (en) 2018-11-06
RU2599023C2 (ru) 2016-10-10
US9668977B2 (en) 2017-06-06
US20140079792A1 (en) 2014-03-20
BR112013028453B1 (pt) 2021-10-19
ES2617402T3 (es) 2017-06-19
MX2013014143A (es) 2014-01-23

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B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
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Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B06T Formal requirements before examination [chapter 6.20 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 17/06/2011, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO.

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B25D Requested change of name of applicant approved

Owner name: EVONIK OPERATIONS GMBH (DE)

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 13A ANUIDADE.