BR112013018046B1 - Conjugado peptídico, composição farmacêutica, métodos in vitro para bloquear sinalização por um ou mais membros de família citocina-yc e para inibir ligação de citocina-yc a subunidade-yc e uso de conjugado peptídico ou de composição farmacêutica - Google Patents

Conjugado peptídico, composição farmacêutica, métodos in vitro para bloquear sinalização por um ou mais membros de família citocina-yc e para inibir ligação de citocina-yc a subunidade-yc e uso de conjugado peptídico ou de composição farmacêutica Download PDF

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Publication number
BR112013018046B1
BR112013018046B1 BR112013018046-3A BR112013018046A BR112013018046B1 BR 112013018046 B1 BR112013018046 B1 BR 112013018046B1 BR 112013018046 A BR112013018046 A BR 112013018046A BR 112013018046 B1 BR112013018046 B1 BR 112013018046B1
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Brazil
Prior art keywords
cytokine
peptide
amino acid
peptide conjugate
cytokines
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BR112013018046-3A
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English (en)
Portuguese (pt)
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BR112013018046A2 (pt
Inventor
Yutaka Tagaya
Nazli Azimi
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Bioniz, Llc
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Publication of BR112013018046A2 publication Critical patent/BR112013018046A2/pt
Publication of BR112013018046B1 publication Critical patent/BR112013018046B1/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
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BR112013018046-3A 2011-01-18 2012-01-17 Conjugado peptídico, composição farmacêutica, métodos in vitro para bloquear sinalização por um ou mais membros de família citocina-yc e para inibir ligação de citocina-yc a subunidade-yc e uso de conjugado peptídico ou de composição farmacêutica BR112013018046B1 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161433890P 2011-01-18 2011-01-18
US61/433,890 2011-01-18
US201161527049P 2011-08-24 2011-08-24
US61/527,049 2011-08-24
PCT/US2012/021566 WO2012099886A1 (en) 2011-01-18 2012-01-17 Compositions and mehthods for modulating gamma-c-cytokine activity

Publications (2)

Publication Number Publication Date
BR112013018046A2 BR112013018046A2 (pt) 2020-01-21
BR112013018046B1 true BR112013018046B1 (pt) 2023-01-31

Family

ID=46516044

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112013018046-3A BR112013018046B1 (pt) 2011-01-18 2012-01-17 Conjugado peptídico, composição farmacêutica, métodos in vitro para bloquear sinalização por um ou mais membros de família citocina-yc e para inibir ligação de citocina-yc a subunidade-yc e uso de conjugado peptídico ou de composição farmacêutica

Country Status (19)

Country Link
US (10) US9133244B2 (enExample)
EP (3) EP4461742A3 (enExample)
JP (4) JP6395379B2 (enExample)
CN (2) CN103501805B (enExample)
AU (3) AU2012207456C1 (enExample)
BR (1) BR112013018046B1 (enExample)
CA (1) CA2824515C (enExample)
CY (1) CY1122846T1 (enExample)
DK (2) DK2665486T3 (enExample)
ES (2) ES2778053T3 (enExample)
FI (1) FI3636274T3 (enExample)
HR (1) HRP20200470T1 (enExample)
LT (1) LT2665486T (enExample)
PL (2) PL3636274T3 (enExample)
PT (2) PT3636274T (enExample)
RS (1) RS60050B1 (enExample)
SI (1) SI2665486T1 (enExample)
SM (1) SMT202000142T1 (enExample)
WO (1) WO2012099886A1 (enExample)

Families Citing this family (23)

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ES2778053T3 (es) 2011-01-18 2020-08-07 Bioniz Llc Composiciones para modular la actividad de la citocina gamma-c
WO2015089217A2 (en) 2013-12-10 2015-06-18 Bionz, Llc Methods of developing selective peptide antagonists
CN104789527B (zh) * 2015-05-15 2018-05-29 江苏杰晟生物科技有限公司 一种自体自然杀伤细胞鸡尾酒式培养的制备方法及其试剂盒产品
KR102654684B1 (ko) 2015-10-09 2024-04-04 바이오니즈 테라퓨틱스, 아이엔씨. 감마-ｃ-사이토카인 활성의 조정
WO2017190684A1 (zh) * 2016-05-06 2017-11-09 王牧林 白细胞介素组合及其用途
AU2018250210B2 (en) * 2017-04-07 2022-04-28 Bioniz Therapeutics, Inc. Stable modulators of gamma-c-cytokine activity
TW202408577A (zh) * 2018-07-19 2024-03-01 國立大學法人東京大學 Ｈｔｌｖ－１關聯性脊髓病（ｈａｍ）之治療或防預劑、及ｈａｍ之治療方法
WO2020023702A1 (en) 2018-07-25 2020-01-30 AskGene Pharma, Inc. Novel il-21 prodrugs and methods of use thereof
EP4023667A1 (en) 2018-08-06 2022-07-06 Medikine, Inc. Il-2 receptor binding compounds
WO2020176478A1 (en) 2019-02-25 2020-09-03 The University Of Chicago Methods and compositions for treating inflammatory and autoimmune conditions with ecm-affinity peptides linked to anti-inflammatory agents
US12030936B2 (en) 2019-05-03 2024-07-09 Bioniz Therapeutics, Inc. Modulating the effects of gamma-c-cytokine signaling for the treatment of alopecia and alopecia associated disorders
US11845801B2 (en) 2019-06-12 2023-12-19 AskGene Pharma, Inc. IL-15 prodrugs and methods of use thereof
KR102265435B1 (ko) * 2019-08-20 2021-06-15 주식회사 케어젠 피부 미백 활성을 갖는 펩타이드 및 이의 용도
CA3160133A1 (en) 2019-11-05 2021-05-14 Medikine, Inc. Il-2rbyc binding compounds
BR112022008750A2 (pt) 2019-11-05 2022-07-19 Medikine Inc Composto de ligação de receptor duplo, composição farmacêutica, método para tratar uma doença em um paciente, método para expandir células imunes, método para reforçar uma vacina, método para modificar a resposta imune e ácido nucleico
JP2023512687A (ja) 2020-02-03 2023-03-28 メディカイン、インコーポレイテッド ＩＬ－７Ｒα結合化合物
CA3166816A1 (en) 2020-02-03 2021-08-12 William J. Dower Il-7r.alpha..gamma.c binding compounds
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