BR112013011198A2 - métodos para produzir partículas virais com glicosilação simplificada de proteínas de superfície. - Google Patents

métodos para produzir partículas virais com glicosilação simplificada de proteínas de superfície.

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Publication number
BR112013011198A2
BR112013011198A2 BR112013011198A BR112013011198A BR112013011198A2 BR 112013011198 A2 BR112013011198 A2 BR 112013011198A2 BR 112013011198 A BR112013011198 A BR 112013011198A BR 112013011198 A BR112013011198 A BR 112013011198A BR 112013011198 A2 BR112013011198 A2 BR 112013011198A2
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BR
Brazil
Prior art keywords
methods
producing
surface proteins
glycosylation
simplified
Prior art date
Application number
BR112013011198A
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English (en)
Other versions
BR112013011198B1 (pt
Inventor
Che Ma
Chi-Huey Wong
Yung-Chieh Tseng
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Academia Sinica
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Application filed by Academia Sinica filed Critical Academia Sinica
Publication of BR112013011198A2 publication Critical patent/BR112013011198A2/pt
Publication of BR112013011198B1 publication Critical patent/BR112013011198B1/pt

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    • C—CHEMISTRY; METALLURGY
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    • C12P21/00—Preparation of peptides or proteins
    • C12P21/005—Glycopeptides, glycoproteins
    • C—CHEMISTRY; METALLURGY
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    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
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    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/08—RNA viruses
    • C07K14/11—Orthomyxoviridae, e.g. influenza virus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01096—Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase (3.2.1.96)
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    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16061—Methods of inactivation or attenuation
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    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16123—Virus like particles [VLP]
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    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16151—Methods of production or purification of viral material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08—RNA viruses
    • G01N2333/11—Orthomyxoviridae, e.g. influenza virus
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    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

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  • Life Sciences & Earth Sciences (AREA)
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  • Pulmonology (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

métodos para produzir partículas virais com glicosilação simplificada de proteínas de superfície. os métodos para a produção de partículas de vírus com a glicosilação simplificada em proteínas estruturais ou de superfície são fornecidos. quando usados como alvos para a produção de vacinas, a natureza conservada de tais locais gera vacinas que são menos sensíveis às mutações virais. o uso de inibidores de glicosilação para a produção de vírus com perfis de glicosilação simplificados são divulgados. uma divulgação exemplar dos vírus influenza e métodos para a produção de partículas de vírus influenza monoglicosilado ser fornecido. os métodos para a produção de formas de monoglicosilado de vírus influenza a, nibrg-14 (h5n1) são fornecidos.
BR112013011198-4A 2010-11-04 2011-11-04 Métodos para produzir vírus influenza monoglicosilado e antígeno viral monoglicosilado, antígeno ha do vírus influenza monoglicosilado e seu uso BR112013011198B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41025710P 2010-11-04 2010-11-04
US61/410,257 2010-11-04
PCT/US2011/059449 WO2012061776A1 (en) 2010-11-04 2011-11-04 Methods for producing virus particles with simplified glycosylation of surface proteins

Publications (2)

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BR112013011198A2 true BR112013011198A2 (pt) 2016-07-05
BR112013011198B1 BR112013011198B1 (pt) 2022-03-15

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BR112013011198-4A BR112013011198B1 (pt) 2010-11-04 2011-11-04 Métodos para produzir vírus influenza monoglicosilado e antígeno viral monoglicosilado, antígeno ha do vírus influenza monoglicosilado e seu uso

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US (2) US9403878B2 (pt)
EP (1) EP2635693B1 (pt)
JP (2) JP6166178B2 (pt)
KR (2) KR101927421B1 (pt)
CN (2) CN103476942A (pt)
AU (2) AU2011323141B2 (pt)
BR (1) BR112013011198B1 (pt)
CA (2) CA2854619C (pt)
CL (1) CL2013001219A1 (pt)
CO (1) CO6781543A2 (pt)
DK (1) DK2635693T3 (pt)
ES (1) ES2831256T3 (pt)
IL (1) IL226143B (pt)
MX (1) MX349530B (pt)
RU (1) RU2607452C2 (pt)
TW (1) TWI537385B (pt)
WO (1) WO2012061776A1 (pt)

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TWI537385B (zh) 2010-11-04 2016-06-11 中央研究院 產生具簡單醣基化之表面蛋白質之病毒顆粒的方法
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CL2013001219A1 (es) 2014-04-04
KR102156209B1 (ko) 2020-09-17
CA3147075A1 (en) 2012-05-10
RU2607452C2 (ru) 2017-01-10
MX349530B (es) 2017-08-02
DK2635693T3 (da) 2020-12-21
TW201307560A (zh) 2013-02-16
AU2011323141B2 (en) 2016-04-07
IL226143B (en) 2020-04-30
WO2012061776A1 (en) 2012-05-10
EP2635693A4 (en) 2014-05-07
CA2854619C (en) 2022-02-01
KR20180132981A (ko) 2018-12-12
KR20130115292A (ko) 2013-10-21
JP6166178B2 (ja) 2017-07-19
US9920347B2 (en) 2018-03-20
US20140011188A1 (en) 2014-01-09
CN103476942A (zh) 2013-12-25
US9403878B2 (en) 2016-08-02
AU2016204276B2 (en) 2017-10-26
JP6773513B2 (ja) 2020-10-21
ES2831256T3 (es) 2021-06-08
TWI537385B (zh) 2016-06-11
JP2014500012A (ja) 2014-01-09
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IL226143A0 (en) 2013-06-27
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