MX349530B - Metodos para producir particulas de virus con glucosilacion simplificada de proteinas de superficie. - Google Patents
Metodos para producir particulas de virus con glucosilacion simplificada de proteinas de superficie.Info
- Publication number
- MX349530B MX349530B MX2013004996A MX2013004996A MX349530B MX 349530 B MX349530 B MX 349530B MX 2013004996 A MX2013004996 A MX 2013004996A MX 2013004996 A MX2013004996 A MX 2013004996A MX 349530 B MX349530 B MX 349530B
- Authority
- MX
- Mexico
- Prior art keywords
- methods
- production
- virus particles
- surface proteins
- glycosylation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C07K14/08—RNA viruses
- C07K14/11—Orthomyxoviridae, e.g. influenza virus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/005—Glycopeptides, glycoproteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01096—Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase (3.2.1.96)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16061—Methods of inactivation or attenuation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16121—Viruses as such, e.g. new isolates, mutants or their genomic sequences
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16123—Virus like particles [VLP]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16151—Methods of production or purification of viral material
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
- G01N2333/08—RNA viruses
- G01N2333/11—Orthomyxoviridae, e.g. influenza virus
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Communicable Diseases (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente invención se refiere a métodos para producción de partículas de virus con glucosilación simplificada en proteínas estructurales o de superficie. Cuando se utilizan como objetivos para producción de vacunas, la naturaleza conservada de dichos sitios genera vacunas que son más sensibles a mutaciones víricas. Se describe el uso de inhibidores de glucosilación para producción de virus con perfiles de glucosilación simplificados. Se proporciona una descripción de ejemplo de los virus de la influenza y métodos para producción de partículas de virus de influenza monoglucosilada. Se proporcionan métodos para producción de formas monoglucosiladas de virus de influenza A, NIBRG-14 (H5N1).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US41025710P | 2010-11-04 | 2010-11-04 | |
PCT/US2011/059449 WO2012061776A1 (en) | 2010-11-04 | 2011-11-04 | Methods for producing virus particles with simplified glycosylation of surface proteins |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2013004996A MX2013004996A (es) | 2014-02-27 |
MX349530B true MX349530B (es) | 2017-08-02 |
Family
ID=46024856
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2013004996A MX349530B (es) | 2010-11-04 | 2011-11-04 | Metodos para producir particulas de virus con glucosilacion simplificada de proteinas de superficie. |
Country Status (17)
Country | Link |
---|---|
US (2) | US9403878B2 (es) |
EP (1) | EP2635693B1 (es) |
JP (2) | JP6166178B2 (es) |
KR (2) | KR101927421B1 (es) |
CN (2) | CN108165534A (es) |
AU (2) | AU2011323141B2 (es) |
BR (1) | BR112013011198B1 (es) |
CA (2) | CA2854619C (es) |
CL (1) | CL2013001219A1 (es) |
CO (1) | CO6781543A2 (es) |
DK (1) | DK2635693T3 (es) |
ES (1) | ES2831256T3 (es) |
IL (1) | IL226143B (es) |
MX (1) | MX349530B (es) |
RU (1) | RU2607452C2 (es) |
TW (1) | TWI537385B (es) |
WO (1) | WO2012061776A1 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103200961B (zh) | 2009-03-27 | 2017-10-27 | 中央研究院 | 抗病毒免疫的方法和组合物 |
TWI537385B (zh) | 2010-11-04 | 2016-06-11 | 中央研究院 | 產生具簡單醣基化之表面蛋白質之病毒顆粒的方法 |
US20180128545A1 (en) * | 2016-11-08 | 2018-05-10 | Berry Metal Company | Modular furnace cooling wall |
WO2023238756A1 (ja) * | 2022-06-07 | 2023-12-14 | 国立大学法人 東京大学 | ウイルス粒子検出方法、情報処理装置及びウイルス粒子検出プログラム |
Family Cites Families (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3953592A (en) * | 1973-09-27 | 1976-04-27 | Recherche Et Industrie Therapeutiques (R.I.T.) | Live influenza virus vaccines and preparation thereof |
US4318903A (en) * | 1978-07-12 | 1982-03-09 | Smithkline-Rit | Live influenza virus vaccine and the preparation thereof |
US4338296A (en) * | 1979-10-16 | 1982-07-06 | Smithkline-Rit | Influenza virus and process of producing a vaccine therefrom |
JPS62501263A (ja) | 1984-11-29 | 1987-05-21 | スクリツプス クリニツク アンド リサ−チ フアウンデ−シヨン | 脱グリコシル化ウイルス糖タンパク質に関連するポリペプチド類および抗体 |
WO1987005330A1 (en) * | 1986-03-07 | 1987-09-11 | Michel Louis Eugene Bergh | Method for enhancing glycoprotein stability |
NZ224422A (en) | 1987-05-05 | 1990-11-27 | Molecular Eng Ass | Composition adapted for intranasal immunisation against viral infection comprising a glycoprotein complexed with a lipid |
US6103238A (en) | 1992-03-13 | 2000-08-15 | President And Fellows Of Harvard College | Selectively deglycosylated human immunodeficiency virus type 1 envelope vaccines |
AU698878B2 (en) | 1993-11-04 | 1998-11-12 | Genimmune N.V. | Immunodominant human T-cell epitopes of hepatitis C virus |
US20020045594A1 (en) | 1997-02-14 | 2002-04-18 | Merck & Co., Inc. | Polynucleotide vaccine formulations |
US6908617B1 (en) | 1997-11-10 | 2005-06-21 | Dana-Farber Cancer Institute, Inc. | Glycosylated modified primate lentivirus envelope polypeptides |
AU4537100A (en) | 1999-05-12 | 2000-12-05 | Statens Serum Institut | Adjuvant combinations for immunization composition and vaccines |
FR2799974B1 (fr) | 1999-10-25 | 2001-11-30 | Aventis Pasteur | Complexe deglycosyle proteine env/cd4 et son utilisation pour la vaccination contre le vih |
WO2001074386A2 (en) * | 2000-04-03 | 2001-10-11 | The University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Cold-adapted equine influenza viruses |
CA2411968C (en) | 2000-06-30 | 2009-12-15 | Flanders Interuniversity Institute For Biotechnology (Vib) | Protein glycosylation modification in pichia pastoris |
FR2823222B1 (fr) | 2001-04-06 | 2004-02-06 | Merial Sas | Vaccin contre le virus de la fievre du nil |
CA2468295C (en) * | 2001-11-28 | 2010-08-03 | Neose Technologies, Inc. | Glycoprotein remodeling using endoglycanases |
US20030124652A1 (en) * | 2001-12-21 | 2003-07-03 | Novazyme Pharmaceuticals, Inc. | Methods of producing high mannose glycoproteins in complex carbohydrate deficient cells |
US7442375B2 (en) | 2002-12-13 | 2008-10-28 | Case Western Reserve University | Compositions of beta-defensin inducing agents |
CN103555670B (zh) * | 2004-12-23 | 2015-08-12 | 米迪缪尼有限公司 | 用于病毒增殖的非致瘤性mdck细胞系 |
CA2601797A1 (en) * | 2005-03-16 | 2006-09-21 | University Of Oxford | Mannose immunogens for hiv-1 |
RU2283139C1 (ru) * | 2005-03-21 | 2006-09-10 | Федеральное государственное унитарное предприятие "Научно-производственное объединение по медицинским иммунобиологическим препаратам "Микроген" Министерства здравоохранения Российской Федерации | Способ получения антигенов для вакцины против вирусов гриппа |
US20080118529A1 (en) | 2005-07-13 | 2008-05-22 | Gebbink Martijn Frans Ben Gera | Adjuvation Through Cross -Beta Structure |
CA2628725A1 (en) | 2005-11-15 | 2007-05-31 | Glycofi, Inc. | Production of glycoproteins with reduced o-glycosylation |
ES2310072B1 (es) | 2005-12-23 | 2009-11-16 | Proyecto De Biomedicina Cima, S.L. | Nuevos peptidos determinantes antigenicos t colaboradores (/dth). |
TW200745158A (en) | 2006-03-07 | 2007-12-16 | Vaxinnate Corp | Compositions that include hemagglutinin, methods of making and methods of use thereof |
CA2647632C (en) * | 2006-03-27 | 2017-06-27 | University Of Maryland Biotechnology Institute | Glycoprotein synthesis and remodeling by enzymatic transglycosylation |
US7507411B2 (en) | 2006-06-23 | 2009-03-24 | University Of Saskatchewan | Attenuated influenza NS1 variants |
WO2007150054A2 (en) | 2006-06-24 | 2007-12-27 | Mrugesh Shah | Immunogenic compositions having altered glycosylations |
JP2010500880A (ja) | 2006-08-14 | 2010-01-14 | マサチューセッツ・インスティテュート・オブ・テクノロジー | ヘマグルチニンポリペプチド、ならびにヘマグルチニンポリペプチドに関連する試薬および方法 |
WO2008112017A2 (en) | 2006-10-10 | 2008-09-18 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Healtand Human Services | Avian influenza vaccine |
CA2676028A1 (en) | 2007-01-18 | 2008-11-27 | Samuel Bogoch | Methods of determining lethality of pathogens and malignancies involving replikin peak genes |
US7928068B2 (en) | 2007-01-31 | 2011-04-19 | New York University | Methods for using GEP, a chondrogenic growth factor and target in cartilage disorders |
CN103200961B (zh) * | 2009-03-27 | 2017-10-27 | 中央研究院 | 抗病毒免疫的方法和组合物 |
BRPI1015019A2 (pt) * | 2009-04-20 | 2018-02-14 | Pfizer | controle de glicosilação de proteína e composições e métodos relacionada a ele. |
WO2011044152A1 (en) * | 2009-10-05 | 2011-04-14 | The United States Of America As Represented By The Secretary, Department Of Health And Human Services Office Of Technology Transfer | Protection against pandemic and seasonal strains of influenza |
TWI537385B (zh) | 2010-11-04 | 2016-06-11 | 中央研究院 | 產生具簡單醣基化之表面蛋白質之病毒顆粒的方法 |
-
2011
- 2011-11-03 TW TW100140208A patent/TWI537385B/zh active
- 2011-11-04 MX MX2013004996A patent/MX349530B/es active IP Right Grant
- 2011-11-04 RU RU2013125590A patent/RU2607452C2/ru active
- 2011-11-04 CN CN201711437066.7A patent/CN108165534A/zh active Pending
- 2011-11-04 KR KR1020137014380A patent/KR101927421B1/ko active IP Right Grant
- 2011-11-04 CA CA2854619A patent/CA2854619C/en active Active
- 2011-11-04 US US13/883,752 patent/US9403878B2/en active Active
- 2011-11-04 BR BR112013011198-4A patent/BR112013011198B1/pt active IP Right Grant
- 2011-11-04 DK DK11838917.0T patent/DK2635693T3/da active
- 2011-11-04 CN CN2011800639804A patent/CN103476942A/zh active Pending
- 2011-11-04 CA CA3147075A patent/CA3147075A1/en active Pending
- 2011-11-04 AU AU2011323141A patent/AU2011323141B2/en active Active
- 2011-11-04 ES ES11838917T patent/ES2831256T3/es active Active
- 2011-11-04 WO PCT/US2011/059449 patent/WO2012061776A1/en active Application Filing
- 2011-11-04 KR KR1020187035131A patent/KR102156209B1/ko active IP Right Grant
- 2011-11-04 EP EP11838917.0A patent/EP2635693B1/en active Active
- 2011-11-04 JP JP2013537890A patent/JP6166178B2/ja active Active
-
2013
- 2013-05-02 IL IL226143A patent/IL226143B/en active IP Right Grant
- 2013-05-03 CL CL2013001219A patent/CL2013001219A1/es unknown
- 2013-05-03 CO CO13111806A patent/CO6781543A2/es unknown
-
2016
- 2016-05-26 US US15/164,968 patent/US9920347B2/en active Active
- 2016-06-23 AU AU2016204276A patent/AU2016204276B2/en active Active
- 2016-10-11 JP JP2016200454A patent/JP6773513B2/ja active Active
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP4349404A3 (en) | Respiratory virus vaccines | |
EP4233898A3 (en) | Influenza mrna vaccines | |
MX2018004916A (es) | Vacuna contra el virus de la influenza de amplio espectro. | |
AU2014310935B2 (en) | Combination vaccine | |
MX2021006342A (es) | Mutantes de virus de influenza y usos para los mismos. | |
HK1214509A1 (zh) | 穏定的人類免疫缺陷病毒 包膜蛋白基因 三聚體疫苗及其使用方法 | |
MX2021001053A (es) | Vacunas contra virus de la influenza y sus usos. | |
MX354750B (es) | PARTÍCULAS PSEUDO-VIRALES (PPVs) QUE COMPRENDEN GLICOPROTEÍNAS DEL VIRUS DE LA RABIA. | |
AU2016204276A1 (en) | Methods for producing virus particles with simplified glycosylation of surface proteins | |
EP3143144A4 (en) | VIRUS LIKE VESICLES (VLVs) BASED VACCINES TO PREVENT OR TREAT CHRONIC HEPATITIS B VIRUS (HBV) INFECTION | |
MX360470B (es) | Uso de inhibidores de oxido nitrico sintasa inducible para aumentar el rendimiento viral en el cultivo. | |
NZ739260A (en) | Inactivated canine influenza vaccines and methods of making and uses thereof | |
BR112012022939A2 (pt) | composição farmacêutica para uso em um método de imunização de um indivíduo em necessidade do mesmo contra um vírus influenza | |
CL2016003181A1 (es) | Vacunas de virus varicela zóster inactivado, métodos de producción y uso de las mismas (divisional de sol. n° 360-13). | |
MX363464B (es) | Vacunas contra influenza h5. | |
EP3699186A4 (en) | H3N2 INFLUENZA VIRUS MUTANT HEMAGGLUTININ MUTANT AND ITS USE | |
WO2012024283A3 (en) | Universal influenza a vaccines | |
MX360161B (es) | Proceso para preparar compuestos antiviricos. | |
EP3599247A3 (en) | Recombinant hemagglutinin protein of influenza virus and vaccine containing the same | |
WO2012162342A3 (en) | Influenza vaccines containing modified adenovirus vectors | |
MX2015010763A (es) | Proteinas h5 del virus de la gripe h5n1 para uso como un medicamento. | |
IN2011CH03893A (es) | ||
SG11201400629UA (en) | An in-vitro process for the quick determination of the infection status of an infection with an influenza virus type | |
WO2017011620A3 (en) | Methods and compositions related to increasing the fidelity of influenza a virus for vaccine development | |
WO2013041877A3 (en) | Influenza virus mutant expressing a haemagglutinin protein without functional signal sequence for use as vaccine |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration |