CO6781543A2 - Métodos para producir partículas de virus con glucosilación simplificada de proteínas de superficie - Google Patents
Métodos para producir partículas de virus con glucosilación simplificada de proteínas de superficieInfo
- Publication number
- CO6781543A2 CO6781543A2 CO13111806A CO13111806A CO6781543A2 CO 6781543 A2 CO6781543 A2 CO 6781543A2 CO 13111806 A CO13111806 A CO 13111806A CO 13111806 A CO13111806 A CO 13111806A CO 6781543 A2 CO6781543 A2 CO 6781543A2
- Authority
- CO
- Colombia
- Prior art keywords
- methods
- virus particles
- surface proteins
- glycosylation
- simplified
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/005—Glycopeptides, glycoproteins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C07K14/08—RNA viruses
- C07K14/11—Orthomyxoviridae, e.g. influenza virus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01096—Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase (3.2.1.96)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16061—Methods of inactivation or attenuation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16121—Viruses as such, e.g. new isolates, mutants or their genomic sequences
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16123—Virus like particles [VLP]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16151—Methods of production or purification of viral material
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
- G01N2333/08—RNA viruses
- G01N2333/11—Orthomyxoviridae, e.g. influenza virus
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts
Abstract
Se proporcionan métodos para producción de partículas de virus con glucosilación simplificada en proteínas estructurales o de superficie. Cuando se utilizan como objetivos para producción de vacunas, la naturaleza conservada de dichos sitios genera vacunas que son más sensibles a mutaciones víricas. Se describe el uso de inhibidores de glucosilación para producción de virus con perfiles de glucosilación simplificados. Se proporciona una descripción de ejemplo de los virus de la influenza y métodos para producción de partículas de virus de influenza monoglucosilada. Se proporcionan métodos para producción de formas monoglucosiladas de virus de influenza A, NIBRG-14 (H5N1).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US41025710P | 2010-11-04 | 2010-11-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO6781543A2 true CO6781543A2 (es) | 2013-10-31 |
Family
ID=46024856
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO13111806A CO6781543A2 (es) | 2010-11-04 | 2013-05-03 | Métodos para producir partículas de virus con glucosilación simplificada de proteínas de superficie |
Country Status (17)
Country | Link |
---|---|
US (2) | US9403878B2 (es) |
EP (1) | EP2635693B1 (es) |
JP (2) | JP6166178B2 (es) |
KR (2) | KR102156209B1 (es) |
CN (2) | CN108165534A (es) |
AU (2) | AU2011323141B2 (es) |
BR (1) | BR112013011198B1 (es) |
CA (2) | CA2854619C (es) |
CL (1) | CL2013001219A1 (es) |
CO (1) | CO6781543A2 (es) |
DK (1) | DK2635693T3 (es) |
ES (1) | ES2831256T3 (es) |
IL (1) | IL226143B (es) |
MX (1) | MX349530B (es) |
RU (1) | RU2607452C2 (es) |
TW (1) | TWI537385B (es) |
WO (1) | WO2012061776A1 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2756206A1 (en) | 2009-03-27 | 2010-09-30 | Academia Sinica | Methods and compositions for immunization against virus |
TWI537385B (zh) | 2010-11-04 | 2016-06-11 | 中央研究院 | 產生具簡單醣基化之表面蛋白質之病毒顆粒的方法 |
US20180128545A1 (en) * | 2016-11-08 | 2018-05-10 | Berry Metal Company | Modular furnace cooling wall |
WO2023238756A1 (ja) * | 2022-06-07 | 2023-12-14 | 国立大学法人 東京大学 | ウイルス粒子検出方法、情報処理装置及びウイルス粒子検出プログラム |
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US3953592A (en) * | 1973-09-27 | 1976-04-27 | Recherche Et Industrie Therapeutiques (R.I.T.) | Live influenza virus vaccines and preparation thereof |
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EP0272253A4 (en) * | 1986-03-07 | 1990-02-05 | Massachusetts Inst Technology | METHOD FOR IMPROVING GLYCOPROTE INSTABILITY. |
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ATE290592T1 (de) | 1993-11-04 | 2005-03-15 | Innogenetics Nv | Von menschlichen t-zellen immunodominante epitopen des virus der c-hepatitis |
US20020045594A1 (en) | 1997-02-14 | 2002-04-18 | Merck & Co., Inc. | Polynucleotide vaccine formulations |
US6908617B1 (en) | 1997-11-10 | 2005-06-21 | Dana-Farber Cancer Institute, Inc. | Glycosylated modified primate lentivirus envelope polypeptides |
DK1183044T3 (da) | 1999-05-12 | 2007-12-27 | Statens Seruminstitut | Adjuvanskombinationer til immunisering og vacciner |
FR2799974B1 (fr) | 1999-10-25 | 2001-11-30 | Aventis Pasteur | Complexe deglycosyle proteine env/cd4 et son utilisation pour la vaccination contre le vih |
EP1267920B1 (en) | 2000-04-03 | 2007-01-03 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Compositions comprising cold-adapted equine influenza viruses for the treatment of existing viral infections of the respiratory system. |
DK1294910T3 (da) | 2000-06-30 | 2009-03-02 | Vib Vzw | Protein glykosyleringsmodifikation i Pichia Pastoris |
FR2823222B1 (fr) | 2001-04-06 | 2004-02-06 | Merial Sas | Vaccin contre le virus de la fievre du nil |
EP1461445B1 (en) * | 2001-11-28 | 2008-08-20 | Neose Technologies, Inc. | Glycoprotein remodeling using endoglycanases |
US20030124652A1 (en) * | 2001-12-21 | 2003-07-03 | Novazyme Pharmaceuticals, Inc. | Methods of producing high mannose glycoproteins in complex carbohydrate deficient cells |
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ATE547511T1 (de) * | 2004-12-23 | 2012-03-15 | Medimmune Llc | Nichttumorbildende mdck-zellinie zur vermehrung von viren |
EP2058004A1 (en) * | 2005-03-16 | 2009-05-13 | University of Oxford | Mannose immunogens for HIV-1 |
RU2283139C1 (ru) * | 2005-03-21 | 2006-09-10 | Федеральное государственное унитарное предприятие "Научно-производственное объединение по медицинским иммунобиологическим препаратам "Микроген" Министерства здравоохранения Российской Федерации | Способ получения антигенов для вакцины против вирусов гриппа |
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CA2756206A1 (en) * | 2009-03-27 | 2010-09-30 | Academia Sinica | Methods and compositions for immunization against virus |
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TWI537385B (zh) | 2010-11-04 | 2016-06-11 | 中央研究院 | 產生具簡單醣基化之表面蛋白質之病毒顆粒的方法 |
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2011
- 2011-11-03 TW TW100140208A patent/TWI537385B/zh active
- 2011-11-04 WO PCT/US2011/059449 patent/WO2012061776A1/en active Application Filing
- 2011-11-04 CN CN201711437066.7A patent/CN108165534A/zh active Pending
- 2011-11-04 BR BR112013011198-4A patent/BR112013011198B1/pt active IP Right Grant
- 2011-11-04 EP EP11838917.0A patent/EP2635693B1/en active Active
- 2011-11-04 JP JP2013537890A patent/JP6166178B2/ja active Active
- 2011-11-04 AU AU2011323141A patent/AU2011323141B2/en active Active
- 2011-11-04 KR KR1020187035131A patent/KR102156209B1/ko active IP Right Grant
- 2011-11-04 MX MX2013004996A patent/MX349530B/es active IP Right Grant
- 2011-11-04 US US13/883,752 patent/US9403878B2/en active Active
- 2011-11-04 ES ES11838917T patent/ES2831256T3/es active Active
- 2011-11-04 CA CA2854619A patent/CA2854619C/en active Active
- 2011-11-04 KR KR1020137014380A patent/KR101927421B1/ko active IP Right Grant
- 2011-11-04 RU RU2013125590A patent/RU2607452C2/ru active
- 2011-11-04 DK DK11838917.0T patent/DK2635693T3/da active
- 2011-11-04 CA CA3147075A patent/CA3147075A1/en active Pending
- 2011-11-04 CN CN2011800639804A patent/CN103476942A/zh active Pending
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2013
- 2013-05-02 IL IL226143A patent/IL226143B/en active IP Right Grant
- 2013-05-03 CL CL2013001219A patent/CL2013001219A1/es unknown
- 2013-05-03 CO CO13111806A patent/CO6781543A2/es unknown
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2016
- 2016-05-26 US US15/164,968 patent/US9920347B2/en active Active
- 2016-06-23 AU AU2016204276A patent/AU2016204276B2/en active Active
- 2016-10-11 JP JP2016200454A patent/JP6773513B2/ja active Active
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