BR112012028766A2 - processo para a preparação de complexos de insulina e zinco - Google Patents
processo para a preparação de complexos de insulina e zincoInfo
- Publication number
- BR112012028766A2 BR112012028766A2 BR112012028766A BR112012028766A BR112012028766A2 BR 112012028766 A2 BR112012028766 A2 BR 112012028766A2 BR 112012028766 A BR112012028766 A BR 112012028766A BR 112012028766 A BR112012028766 A BR 112012028766A BR 112012028766 A2 BR112012028766 A2 BR 112012028766A2
- Authority
- BR
- Brazil
- Prior art keywords
- insulin
- preparation
- zinc complexes
- solution
- insulin derivative
- Prior art date
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 6
- 238000000034 method Methods 0.000 title abstract 3
- 102000004877 Insulin Human genes 0.000 title abstract 2
- 108090001061 Insulin Proteins 0.000 title abstract 2
- 229940125396 insulin Drugs 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 150000003751 zinc Chemical class 0.000 title abstract 2
- 239000004026 insulin derivative Substances 0.000 abstract 2
- 238000009472 formulation Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000003756 stirring Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/30—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Inorganic Chemistry (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10162368 | 2010-05-10 | ||
| US33349710P | 2010-05-11 | 2010-05-11 | |
| PCT/EP2011/057388 WO2011141407A1 (en) | 2010-05-10 | 2011-05-09 | Process for the preparation of insulin-zinc complexes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112012028766A2 true BR112012028766A2 (pt) | 2017-06-13 |
Family
ID=42732779
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112012028766A BR112012028766A2 (pt) | 2010-05-10 | 2011-05-09 | processo para a preparação de complexos de insulina e zinco |
Country Status (12)
| Country | Link |
|---|---|
| US (5) | US20130143803A1 (https=) |
| EP (1) | EP2569002B1 (https=) |
| JP (2) | JP6249773B2 (https=) |
| KR (2) | KR20160105979A (https=) |
| CN (2) | CN102883743A (https=) |
| AU (1) | AU2011252127B2 (https=) |
| BR (1) | BR112012028766A2 (https=) |
| CA (1) | CA2795091A1 (https=) |
| ES (1) | ES2612468T3 (https=) |
| MX (1) | MX2012012943A (https=) |
| RU (1) | RU2572214C2 (https=) |
| WO (1) | WO2011141407A1 (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006082204A1 (en) | 2005-02-02 | 2006-08-10 | Novo Nordisk A/S | Insulin derivatives |
| JP4808785B2 (ja) | 2005-12-28 | 2011-11-02 | ノボ・ノルデイスク・エー／エス | インスリン組成物および組成物の製造方法 |
| EP1991576B1 (en) | 2006-02-27 | 2010-09-29 | Novo Nordisk A/S | Insulin derivatives |
| EP2024390B1 (en) | 2006-05-09 | 2015-08-19 | Novo Nordisk A/S | Insulin derivative |
| MX2008014061A (es) | 2006-05-09 | 2008-11-14 | Novo Nordisk As | Derivado de insulina. |
| US9034818B2 (en) | 2007-06-13 | 2015-05-19 | Novo Nordisk A/S | Pharmaceutical formulations comprising an insulin derivative |
| US8710000B2 (en) | 2007-11-08 | 2014-04-29 | Novo Nordisk A/S | Insulin derivative |
| AU2009309623B9 (en) | 2008-10-30 | 2014-10-02 | Novo Nordisk A/S | Treating diabetes melitus using insulin injections with less than daily injection frequency |
| DK2632478T3 (da) | 2010-10-27 | 2019-10-07 | Novo Nordisk As | Behandling af diabetes melitus under anvendelse af insulinindsprøjtninger indgivet med varierende indsprøjtningsintervaller |
| JP6755175B2 (ja) * | 2013-03-20 | 2020-09-16 | ノヴォ ノルディスク アー／エス | インスリン投薬レジメン |
| JP2016519127A (ja) | 2013-04-30 | 2016-06-30 | ノヴォ ノルディスク アー／エス | 新規投与レジメン |
| AU2014333979B2 (en) * | 2013-10-07 | 2018-02-15 | Novo Nordisk A/S | Novel derivative of an insulin analogue |
| AR099569A1 (es) | 2014-02-28 | 2016-08-03 | Novo Nordisk As | Derivados de insulina y los usos médicos de estos |
| DK3006045T3 (en) | 2014-10-07 | 2017-07-17 | Cyprumed Gmbh | Pharmaceutical formulations for oral administration of peptide or protein drugs |
| WO2019110797A1 (fr) * | 2017-12-07 | 2019-06-13 | Adocia | Compositions sous forme d'une solution aqueuse injectable comprenant de l'amyline, un agoniste au recepteur de l'amyline ou un analogue d'amyline et un co-polyaminoacide |
| WO2019110788A1 (fr) | 2017-12-07 | 2019-06-13 | Adocia | Compositions sous forme d'une solution aqueuse injectable comprenant de l'amyline, un agoniste au recepteur de l'amyline ou un analogue d'amyline et un co-polyaminoacide |
| CN111315766B (zh) * | 2018-02-01 | 2023-05-12 | 江苏恒瑞医药股份有限公司 | 含人胰岛素类似物的酰化衍生物的药物组合物及其制备方法 |
| KR20210016400A (ko) | 2018-05-24 | 2021-02-15 | 지앙수 헨그루이 메디슨 컴퍼니 리미티드 | 재조합 인간 인슐린 또는 그 유사체의 전구체를 제조하는 방법 |
| US10335464B1 (en) | 2018-06-26 | 2019-07-02 | Novo Nordisk A/S | Device for titrating basal insulin |
| SG11202106167XA (en) | 2018-12-11 | 2021-07-29 | Sanofi Sa | Insulin conjugates |
| US12343383B2 (en) | 2019-07-12 | 2025-07-01 | Novo Nordisk A/S | High concentration insulin formulation |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1212679B (de) * | 1957-08-03 | 1966-03-17 | Novo Terapeutisk Labor As | Verfahren zur Herstellung von Insulinloesungen |
| GB1042194A (en) * | 1962-04-30 | 1966-09-14 | Olin Mathieson | Insulin preparations |
| US3868358A (en) * | 1971-04-30 | 1975-02-25 | Lilly Co Eli | Protamine-insulin product |
| DK113585D0 (da) * | 1985-03-12 | 1985-03-12 | Novo Industri As | Nye peptider |
| PH25772A (en) * | 1985-08-30 | 1991-10-18 | Novo Industri As | Insulin analogues, process for their preparation |
| US4764592A (en) * | 1987-04-23 | 1988-08-16 | Eli Lilly And Company | Crystalline human proinsulin and process for its production |
| KR910700262A (ko) | 1988-12-23 | 1991-03-14 | 안네 제케르 | 사람 인슐린 유사체 |
| PT93057B (pt) | 1989-02-09 | 1995-12-29 | Lilly Co Eli | Processo para a preparacao de analogos da insulina |
| CZ287945B6 (cs) * | 1993-09-17 | 2001-03-14 | Novo Nordisk A/S | Inzulinový derivát a farmaceutický prostředek s jeho obsahem pro léčení diabetu |
| US7097845B2 (en) * | 1997-04-23 | 2006-08-29 | Jacob Sten Petersen | Combinations of antigen and mucosal binding component for inducing specific immunological tolerance |
| MXPA06001283A (es) | 2003-08-05 | 2006-04-11 | Novo Nordisk As | Derivados de insulina novedosos. |
| SI2107069T1 (sl) * | 2003-08-05 | 2013-04-30 | Novo Nordisk A/S | Novi inzulinski derivati |
| JP4808785B2 (ja) * | 2005-12-28 | 2011-11-02 | ノボ・ノルデイスク・エー／エス | インスリン組成物および組成物の製造方法 |
| US9034818B2 (en) * | 2007-06-13 | 2015-05-19 | Novo Nordisk A/S | Pharmaceutical formulations comprising an insulin derivative |
| TWI451876B (zh) * | 2008-06-13 | 2014-09-11 | Lilly Co Eli | 聚乙二醇化之離脯胰島素化合物 |
-
2011
- 2011-05-09 US US13/696,897 patent/US20130143803A1/en not_active Abandoned
- 2011-05-09 CN CN201180023303XA patent/CN102883743A/zh active Pending
- 2011-05-09 AU AU2011252127A patent/AU2011252127B2/en not_active Ceased
- 2011-05-09 WO PCT/EP2011/057388 patent/WO2011141407A1/en not_active Ceased
- 2011-05-09 KR KR1020167023293A patent/KR20160105979A/ko not_active Ceased
- 2011-05-09 CN CN201611166272.4A patent/CN107029212A/zh active Pending
- 2011-05-09 JP JP2013509525A patent/JP6249773B2/ja active Active
- 2011-05-09 CA CA2795091A patent/CA2795091A1/en not_active Withdrawn
- 2011-05-09 ES ES11718398.8T patent/ES2612468T3/es active Active
- 2011-05-09 KR KR1020127029547A patent/KR20130092972A/ko not_active Ceased
- 2011-05-09 BR BR112012028766A patent/BR112012028766A2/pt not_active Application Discontinuation
- 2011-05-09 MX MX2012012943A patent/MX2012012943A/es active IP Right Grant
- 2011-05-09 EP EP11718398.8A patent/EP2569002B1/en active Active
- 2011-05-09 RU RU2012148821/15A patent/RU2572214C2/ru not_active IP Right Cessation
-
2015
- 2015-03-19 US US14/662,874 patent/US20150250857A1/en not_active Abandoned
-
2017
- 2017-02-28 US US15/445,305 patent/US20170165327A1/en not_active Abandoned
- 2017-08-16 JP JP2017157054A patent/JP2017203042A/ja not_active Withdrawn
-
2020
- 2020-08-12 US US16/991,803 patent/US20210060132A1/en not_active Abandoned
-
2024
- 2024-05-24 US US18/674,042 patent/US20240307503A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| ES2612468T3 (es) | 2017-05-17 |
| US20130143803A1 (en) | 2013-06-06 |
| US20240307503A1 (en) | 2024-09-19 |
| AU2011252127A1 (en) | 2012-11-01 |
| JP6249773B2 (ja) | 2017-12-20 |
| AU2011252127B2 (en) | 2014-02-20 |
| MX2012012943A (es) | 2012-11-29 |
| EP2569002A1 (en) | 2013-03-20 |
| US20150250857A1 (en) | 2015-09-10 |
| KR20160105979A (ko) | 2016-09-08 |
| US20210060132A1 (en) | 2021-03-04 |
| CA2795091A1 (en) | 2011-11-17 |
| US20170165327A1 (en) | 2017-06-15 |
| WO2011141407A1 (en) | 2011-11-17 |
| KR20130092972A (ko) | 2013-08-21 |
| CN102883743A (zh) | 2013-01-16 |
| JP2013526501A (ja) | 2013-06-24 |
| EP2569002B1 (en) | 2016-10-26 |
| CN107029212A (zh) | 2017-08-11 |
| JP2017203042A (ja) | 2017-11-16 |
| RU2572214C2 (ru) | 2015-12-27 |
| RU2012148821A (ru) | 2014-06-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR112012028766A2 (pt) | processo para a preparação de complexos de insulina e zinco | |
| MY160249A (en) | Fatty acid fumarate derivatives and their uses | |
| AU2018260825A1 (en) | Compositions and Methods for Lowering Levels of High-Sensitivity (hs-CRP) in a Subject | |
| MY156938A (en) | Hexafluoroisopropyl carbamate derivatives, their preparation and their therapeutic application | |
| BR112013000675A2 (pt) | nanopartícula, processo para produzir uma nanopartícula compreendendo uma matriz de zeína e um aminoácido básico, processo para produzir uma nanopartícula compreendendo uma matriz de zeína, e um aminoácido básico e um composto biologicamente ativo solúvel em gordura, composição e produto alimentar | |
| NZ732777A (en) | Ionizable cationic lipid for rna delivery | |
| EP4332576A3 (en) | Synergistic enhancement of the delivery of nucleic acids via blended formulations | |
| BRPI0908421B8 (pt) | solução estável de um composto farmacêutico | |
| CU20130137A7 (es) | Derivados de ácido 3- fenilpropiónico ramificados y su uso | |
| EA201201648A1 (ru) | Стимуляторы sgc | |
| MX357780B (es) | Derivados policíclicos, proceso para su preparación y su uso farmacéutico. | |
| AR081060A1 (es) | Procedimiento para preparar 4-{4-[({[4-cloro-3-(trifluorometil)fenil]amino}carbonil)amino]-3-fluorofenoxi}-n-metilpiridin-2-carboxamida | |
| CO6771409A2 (es) | Acidos 1-bencilcicloalquilcarboxilicos sustituidos y su uso | |
| BR112015028278A2 (pt) | processo para a preparação de eritrócitos carregados com uma ou mais substâncias de interesse farmacêutico e eritrócitos assim obtidos | |
| BRPI0918360A8 (pt) | Composto, composição farmacêutica e usos de um composto | |
| BR112012014151A8 (pt) | produto de proteína e processo para a preparação de um produto de proteína injetável | |
| MX387845B (es) | Polímeros enlazados al proton para administracion oral. | |
| AU2012245910A8 (en) | Microfluidic system for controlling the concentration of molecules for stimulating a target | |
| BR112013001301A2 (pt) | processo para preparar uma composição líquida farmacêutica compreendendo imunoglobulina g humana e composição líquida farmacêutica contendo imunoglobulina g humana | |
| EA201490175A1 (ru) | Составы дезоксихолевой кислоты и ее солей | |
| AU2015275248B2 (en) | Legumain activated doxorubicin derivative as well as preparation method and application thereof | |
| PH12015502556A1 (en) | Modified release formulation | |
| PH12014500859A1 (en) | Pharmaceutical compositions comprising dgla and/or 15-hetre and methods of use thereof | |
| BR112013018298A2 (pt) | compostos para a redução da produção de beta-amiloides | |
| BR102012028120B8 (pt) | Uso de um ou mais derivados de ingenol, composição farmacêutica e medicamento |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
| B06T | Formal requirements before examination [chapter 6.20 patent gazette] | ||
| B11E | Dismissal acc. art. 34 of ipl - requirements for examination incomplete | ||
| B11T | Dismissal of application maintained [chapter 11.20 patent gazette] | ||
| B350 | Update of information on the portal [chapter 15.35 patent gazette] |