BR112012021444A2 - polímero de amina reticulado, composição farmacêutica, método de redução do colesterol ldl sérico em um indivíduo, métodos para tratar doença, de remoção de sais biliares de um indivíduo, e para melhorar o controle glicêmico em um indivíduo, e, processo para preparar o polímero de aminas. - Google Patents
polímero de amina reticulado, composição farmacêutica, método de redução do colesterol ldl sérico em um indivíduo, métodos para tratar doença, de remoção de sais biliares de um indivíduo, e para melhorar o controle glicêmico em um indivíduo, e, processo para preparar o polímero de aminas.Info
- Publication number
- BR112012021444A2 BR112012021444A2 BR112012021444A BR112012021444A BR112012021444A2 BR 112012021444 A2 BR112012021444 A2 BR 112012021444A2 BR 112012021444 A BR112012021444 A BR 112012021444A BR 112012021444 A BR112012021444 A BR 112012021444A BR 112012021444 A2 BR112012021444 A2 BR 112012021444A2
- Authority
- BR
- Brazil
- Prior art keywords
- individual
- polymer
- bile salts
- preparing
- pharmaceutical composition
- Prior art date
Links
- 229920000642 polymer Polymers 0.000 title abstract 6
- 150000001412 amines Chemical class 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 4
- 239000003833 bile salt Substances 0.000 title abstract 3
- 229940093761 bile salts Drugs 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- 238000008214 LDL Cholesterol Methods 0.000 title abstract 2
- 201000010099 disease Diseases 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 2
- 230000002641 glycemic effect Effects 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 210000002966 serum Anatomy 0.000 title abstract 2
- HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical compound C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 abstract 1
- 206010069703 Bile acid malabsorption Diseases 0.000 abstract 1
- 206010012735 Diarrhoea Diseases 0.000 abstract 1
- 208000035150 Hypercholesterolemia Diseases 0.000 abstract 1
- 208000003251 Pruritus Diseases 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 239000003613 bile acid Substances 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract 1
- 208000002551 irritable bowel syndrome Diseases 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F20/00—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride, ester, amide, imide or nitrile thereof
- C08F20/02—Monocarboxylic acids having less than ten carbon atoms, Derivatives thereof
- C08F20/52—Amides or imides
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F22/00—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical and containing at least one other carboxyl radical in the molecule; Salts, anhydrides, esters, amides, imides or nitriles thereof
- C08F22/36—Amides or imides
- C08F22/38—Amides
- C08F22/385—Monomers containing two or more (meth)acrylamide groups, e.g. N,N'-methylenebisacrylamide
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F222/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical and containing at least one other carboxyl radical in the molecule; Salts, anhydrides, esters, amides, imides, or nitriles thereof
- C08F222/36—Amides or imides
- C08F222/38—Amides
- C08F222/385—Monomers containing two or more (meth)acrylamide groups, e.g. N,N'-methylenebisacrylamide
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F226/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen
- C08F226/02—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen by a single or double bond to nitrogen
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F232/00—Copolymers of cyclic compounds containing no unsaturated aliphatic radicals in a side chain, and having one or more carbon-to-carbon double bonds in a carbocyclic ring system
- C08F232/08—Copolymers of cyclic compounds containing no unsaturated aliphatic radicals in a side chain, and having one or more carbon-to-carbon double bonds in a carbocyclic ring system having condensed rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Polymers & Plastics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Dermatology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
- Hydrogenated Pyridines (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30781410P | 2010-02-24 | 2010-02-24 | |
| US30781110P | 2010-02-24 | 2010-02-24 | |
| PCT/US2011/026099 WO2011106542A2 (en) | 2010-02-24 | 2011-02-24 | Crosslinked polyvrnylamine, poly all ylamine, and polyethyleneimine for use as bile acid sequestrants |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112012021444A2 true BR112012021444A2 (pt) | 2016-05-31 |
Family
ID=44310840
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112012021444A BR112012021444A2 (pt) | 2010-02-24 | 2011-02-24 | polímero de amina reticulado, composição farmacêutica, método de redução do colesterol ldl sérico em um indivíduo, métodos para tratar doença, de remoção de sais biliares de um indivíduo, e para melhorar o controle glicêmico em um indivíduo, e, processo para preparar o polímero de aminas. |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US9181364B2 (enExample) |
| EP (2) | EP2998329A3 (enExample) |
| JP (3) | JP5865847B2 (enExample) |
| CN (2) | CN105017481B (enExample) |
| AU (2) | AU2011220742B2 (enExample) |
| BR (1) | BR112012021444A2 (enExample) |
| CA (1) | CA2790999C (enExample) |
| ES (1) | ES2549513T3 (enExample) |
| WO (1) | WO2011106542A2 (enExample) |
Families Citing this family (26)
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| EP2539389B1 (en) | 2010-02-24 | 2017-12-20 | Relypsa, Inc. | Amine polymers for use as bile acid sequestrants |
| WO2013087237A1 (en) * | 2011-12-13 | 2013-06-20 | Synthon Bv | Purification of sevelamer and related polyallylamines |
| KR102081560B1 (ko) | 2012-02-09 | 2020-02-25 | 라이프 테크놀로지스 코포레이션 | 친수성 중합체성 입자 및 그의 제조 방법 |
| KR20150130492A (ko) * | 2013-03-15 | 2015-11-23 | 젠자임 코포레이션 | 개선된 최종 당화 산물(ａｇｅ) 전구체의 격리제 |
| KR102633597B1 (ko) * | 2013-06-05 | 2024-02-06 | 트리시다, 인크. | 경구 투여를 위한 양성자-결합 중합체 |
| US10435528B2 (en) | 2013-09-17 | 2019-10-08 | Aquanano Llc | High-capacity anion exchange materials |
| CN103585632A (zh) * | 2013-11-19 | 2014-02-19 | 韩源平 | 胆汁酸螯合剂或/和维生素d在制备防治非酒精性脂肪性肝病药物中的应用 |
| US20170095432A1 (en) | 2014-06-13 | 2017-04-06 | United Therapeutics Corporation | Treprostinil formulations |
| KR20240008418A (ko) | 2014-12-10 | 2024-01-18 | 트리시다, 인크. | 경구 투여용 양성자-결합 폴리머 |
| MA41202A (fr) | 2014-12-18 | 2017-10-24 | Genzyme Corp | Copolymères polydiallymine réticulé pour le traitement du diabète de type 2 |
| US9868826B2 (en) | 2015-07-02 | 2018-01-16 | Life Technologies Corporation | Polymer substrates formed from carboxy functional acrylamide |
| CN108135835A (zh) * | 2015-08-06 | 2018-06-08 | 约翰霍普金斯大学 | 用于治疗代谢紊乱的组合物和方法 |
| AU2017261337A1 (en) | 2016-05-06 | 2018-11-15 | Tricida, Inc. | Compositions for and method of treating acid-base disorders |
| CN106309436A (zh) * | 2016-07-25 | 2017-01-11 | 宁波大学 | 可用作乙酰胆碱酯酶抑制剂的色胺衍生物及其用途 |
| BR112019013364A2 (pt) | 2016-12-28 | 2020-04-14 | Fujifilm Corp | emulsão de polímero contendo átomo de nitrogênio ou sal do mesmo, método de produção para o mesmo e método de produção para partículas |
| TW201922267A (zh) | 2017-10-16 | 2019-06-16 | 日商富士軟片股份有限公司 | 高磷血症治療劑 |
| TW201922268A (zh) | 2017-10-16 | 2019-06-16 | 日商富士軟片股份有限公司 | 高磷血症治療劑及粒子 |
| US11266684B2 (en) | 2017-11-03 | 2022-03-08 | Tricida, Inc. | Compositions for and method of treating acid-base disorders |
| US11590161B2 (en) | 2018-08-13 | 2023-02-28 | Viscera Labs, Inc. | Therapeutic composition and methods |
| US11524029B2 (en) | 2018-08-13 | 2022-12-13 | Viscera Labs, Inc. | Therapeutic composition and methods |
| JP7539374B2 (ja) * | 2018-09-20 | 2024-08-23 | グライセンド， インコーポレイテッド | ボロン酸ポリマーおよび使用方法 |
| CN110511322B (zh) * | 2019-08-29 | 2020-10-02 | 西北大学 | 一种快速葡萄糖响应的互穿网络聚合物微凝胶及其制备方法 |
| AU2020348451A1 (en) | 2019-09-20 | 2022-04-21 | Glyscend, Inc. | Substituted phenyl boronic acid containing polymers and methods of use |
| CN116615488A (zh) * | 2020-12-18 | 2023-08-18 | 汉阳大学校产学协力团 | 新型基于聚芴的交联共聚物及制备其的方法和使用其的碱性燃料电池用阴离子交换膜 |
| WO2024040380A1 (zh) * | 2022-08-22 | 2024-02-29 | 中美华世通生物医药科技(武汉)股份有限公司 | 铵盐聚合物及其制备方法和作为胆汁酸螯合剂的用途 |
| WO2024220742A1 (en) * | 2023-04-20 | 2024-10-24 | Vasorx, Inc. | Conjugated polyethyleneimine compounds and compositions, and uses thereof for the treatment of atherosclerosis, cardiovascular, and lung disease |
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| BR112012021448A2 (pt) | 2010-02-24 | 2016-05-31 | Relypsa Inc | polímero de amina, método para tratar doença, método de remoção de sais biliares de um indivíduo animal, método para melhorar o controle glicêmico em um indivíduo, e, processo para preparar o polímero de amina. |
| EP2539389B1 (en) | 2010-02-24 | 2017-12-20 | Relypsa, Inc. | Amine polymers for use as bile acid sequestrants |
-
2011
- 2011-02-24 JP JP2012555152A patent/JP5865847B2/ja not_active Expired - Fee Related
- 2011-02-24 ES ES11707038.3T patent/ES2549513T3/es active Active
- 2011-02-24 CN CN201510370335.7A patent/CN105017481B/zh not_active Expired - Fee Related
- 2011-02-24 CA CA2790999A patent/CA2790999C/en not_active Expired - Fee Related
- 2011-02-24 CN CN201180020656.4A patent/CN102858817B/zh not_active Expired - Fee Related
- 2011-02-24 WO PCT/US2011/026099 patent/WO2011106542A2/en not_active Ceased
- 2011-02-24 AU AU2011220742A patent/AU2011220742B2/en not_active Ceased
- 2011-02-24 US US13/581,049 patent/US9181364B2/en active Active
- 2011-02-24 EP EP15180706.2A patent/EP2998329A3/en not_active Withdrawn
- 2011-02-24 BR BR112012021444A patent/BR112012021444A2/pt not_active Application Discontinuation
- 2011-02-24 EP EP11707038.3A patent/EP2539380B1/en not_active Not-in-force
-
2014
- 2014-11-25 JP JP2014237462A patent/JP2015038225A/ja not_active Withdrawn
-
2015
- 2015-10-30 US US14/928,517 patent/US10272103B2/en active Active
-
2016
- 2016-05-25 AU AU2016203432A patent/AU2016203432B2/en not_active Ceased
- 2016-11-28 JP JP2016229926A patent/JP6247740B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US10272103B2 (en) | 2019-04-30 |
| EP2539380B1 (en) | 2015-08-19 |
| CN102858817A (zh) | 2013-01-02 |
| ES2549513T3 (es) | 2015-10-28 |
| JP2017048398A (ja) | 2017-03-09 |
| AU2011220742B2 (en) | 2016-02-25 |
| JP6247740B2 (ja) | 2017-12-13 |
| CN102858817B (zh) | 2015-09-02 |
| AU2011220742A1 (en) | 2012-09-13 |
| AU2016203432B2 (en) | 2018-07-26 |
| US9181364B2 (en) | 2015-11-10 |
| AU2016203432A1 (en) | 2016-06-16 |
| US20160051576A1 (en) | 2016-02-25 |
| JP2015038225A (ja) | 2015-02-26 |
| US20130022570A1 (en) | 2013-01-24 |
| CA2790999C (en) | 2019-05-14 |
| JP2013520561A (ja) | 2013-06-06 |
| WO2011106542A2 (en) | 2011-09-01 |
| CA2790999A1 (en) | 2011-09-01 |
| CN105017481B (zh) | 2018-10-02 |
| EP2539380A2 (en) | 2013-01-02 |
| JP5865847B2 (ja) | 2016-02-17 |
| WO2011106542A3 (en) | 2011-11-10 |
| EP2998329A3 (en) | 2016-04-06 |
| CN105017481A (zh) | 2015-11-04 |
| EP2998329A2 (en) | 2016-03-23 |
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